Nanovaccine that activates the NLRP3 inflammasome enhances tumor specific activation of anti-cancer immunity

IL-1 and IL-1ra are key regulators of the inflammatory response to RNA vaccines

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Immunostimulatory Polymers as Adjuvants, Immunotherapies, and Delivery Systems

(2022) Adam M. Weiss et al.   MACROMOLECULES

Inflammasomes and adaptive immune responses

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Select hyperactivating NLRP3 ligands enhance the TH1- and TH17-inducing potential of human type 2 conventional dendritic cells

(2021) Lukas Hatscher et al.   Science Signaling

Cancer Vaccines, Adjuvants, and Delivery Systems

(2021) Samantha J. Paston et al.   Frontiers in Immunology

The AIM2 and NLRP3 inflammasomes trigger IL-1–mediated antitumor effects during radiation

(2021) Chuanhui Han et al.   Science Immunology

NLRP3 Inflammasome: A Promising Therapeutic Target for Drug-Induced Toxicity

(2021) Shanshan Wei et al.   Frontiers in Cell and Developmental Biology

Biodistribution of extracellular vesicles following administration into animals: A systematic review

(2021) Matthew Kang et al.   Journal of Extracellular Vesicles

Peptide–TLR-7/8a conjugate vaccines chemically programmed for nanoparticle self-assembly enhance CD8 T-cell immunity to tumor antigens

(2020) Geoffrey M. Lynn et al.   NATURE BIOTECHNOLOGY

Nanomedicine-mediated alteration of the pharmacokinetic profile of small molecule cancer immunotherapeutics

(2020) Simon Van Herck et al.   ACTA PHARMACOLOGICA SINICA

A bi-adjuvant nanovaccine that potentiates immunogenicity of neoantigen for combination immunotherapy of colorectal cancer

(2020) Qianqian Ni et al.   Science Advances

IL-18BP is a secreted immune checkpoint and barrier to IL-18 immunotherapy

(2020) Ting Zhou et al.   NATURE

Proton-driven transformable nanovaccine for cancer immunotherapy

(2020) Ningqiang Gong et al.   Nature Nanotechnology

Baseline IFN-γ and IL-10 expression in PBMCs could predict response to PD-1 checkpoint inhibitors in advanced melanoma patients

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Increased vaccine tolerability and protection via NF-κB modulation

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Mitigation of Hydrophobicity-Induced Immunotoxicity by Sugar Poly(orthoesters)

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Targeted antibody and cytokine cancer immunotherapies through collagen affinity

(2019) Jun Ishihara et al.   Science Translational Medicine

At the bench: Engineering the next generation of cancer vaccines

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Current challenges for cancer vaccine adjuvant development

(2018) William S. Bowen et al.   Expert Review of Vaccines

Effective Combination Adjuvants Engage Both TLR and Inflammasome Pathways To Promote Potent Adaptive Immune Responses

(2018) Emilie Seydoux et al.   JOURNAL OF IMMUNOLOGY

A facile approach to enhance antigen response for personalized cancer vaccination

(2018) Aileen Weiwei Li et al.   NATURE MATERIALS

Immunomodulation of the NLRP3 Inflammasome through Structure-Based Activator Design and Functional Regulation via Lysosomal Rupture

(2018) Saikat Manna et al.   ACS Central Science

Nanoparticle-Conjugate TLR7/8 Agonist Localized Immunotherapy Provokes Safe Antitumoral Responses

(2018) Lutz Nuhn et al.   ADVANCED MATERIALS

Physical activation of innate immunity by spiky particles

(2018) Ji Wang et al.   Nature Nanotechnology

An immunogenic personal neoantigen vaccine for patients with melanoma

(2017) Patrick A. Ott et al.   NATURE

P2X7 receptor and NLRP3 inflammasome activation in head and neck cancer

(2017) Ju Young Bae et al.   Oncotarget

Augmentation of Immune Checkpoint Cancer Immunotherapy with IL18

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Designer vaccine nanodiscs for personalized cancer immunotherapy

(2016) Rui Kuai et al.   NATURE MATERIALS

Enhancing Endosomal Escape for Intracellular Delivery of Macromolecular Biologic Therapeutics

(2016) Peter Lönn et al.   Scientific Reports

The Nlrp3 Inflammasome Suppresses Colorectal Cancer Metastatic Growth in the Liver by Promoting Natural Killer Cell Tumoricidal Activity

(2015) Jeremy Dupaul-Chicoine et al.   IMMUNITY

Neoantigens in cancer immunotherapy

(2015) T. N. Schumacher et al.   SCIENCE

Combination therapy targeting toll like receptors 7, 8 and 9 eliminates large established tumors

(2014) By Zhao et al.   Journal for ImmunoTherapy of Cancer

Self-Assembled Peptide Amphiphile Micelles Containing a Cytotoxic T-Cell Epitope Promote a Protective Immune Response In Vivo

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The pharmacokinetics of Toll-like receptor agonists and the impact on the immune system

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Uptake of particulate vaccine adjuvants by dendritic cells activates the NALP3 inflammasome

(2009) Fiona A. Sharp et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA