Inhibition of Human Coronaviruses by Combinations of Host-Targeted and Direct-Acting Antivirals

Valproate-coenzyme A conjugate blocks opening of receptor binding domains in the spike trimer of SARS-CoV-2 through an allosteric mechanism

(2023) Federica Maschietto et al.   Computational and Structural Biotechnology Journal

Exposure to valproic acid is associated with less pulmonary infiltrates and improvements in diverse clinical outcomes and laboratory parameters in patients hospitalized with COVID-19

(2022) Julio Collazos et al.   PLoS One

Alternatives to animal models and their application in the discovery of species susceptibility to SARS-CoV-2 and other respiratory infectious pathogens: A review

(2022) Sandra Runft et al.   VETERINARY PATHOLOGY

Molnupiravir and Nirmatrelvir-Ritonavir: Oral COVID Antiviral Drugs

(2022) Louis D Saravolatz et al.   CLINICAL INFECTIOUS DISEASES

Combinations of Host- and Virus-Targeting Antiviral Drugs Confer Synergistic Suppression of SARS-CoV-2

(2022) Jessica Wagoner et al.   Microbiology Spectrum

Loss of furin cleavage site attenuates SARS-CoV-2 pathogenesis

(2021) Bryan A. Johnson et al.   NATURE

Plitidepsin has potent preclinical efficacy against SARS-CoV-2 by targeting the host protein eEF1A

(2021) Kris M. White et al.   SCIENCE

An Update on Antiviral Therapy Against SARS-CoV-2: How Far Have We Come?

(2021) Omkar Indari et al.   Frontiers in Pharmacology

A Comprehensive Review of Viral Characteristics, Transmission, Pathophysiology, Immune Response, and Management of SARS-CoV-2 and COVID-19 as a Basis for Controlling the Pandemic

(2021) Chris R. Triggle et al.   Frontiers in Immunology

Rapamycin: Drug Repurposing in SARS-CoV-2 Infection

(2021) Jiri Patocka et al.   Pharmaceuticals

An oral SARS-CoV-2 M pro inhibitor clinical candidate for the treatment of COVID-19

(2021) Dafydd R. Owen et al.   SCIENCE

Drug Combinations as a First Line of Defense against Coronaviruses and Other Emerging Viruses

(2021) Judith M. White et al.   mBio

Molnupiravir: A new candidate for COVID‐19 treatment

(2021) Fariba Pourkarim et al.   Pharmacology Research & Perspectives

Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro

(2020) Manli Wang et al.   CELL RESEARCH

A new coronavirus associated with human respiratory disease in China

(2020) Fan Wu et al.   NATURE

Clinical trials of repurposed antivirals for SARS-CoV-2

(2020) Miguel Angel Martinez   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Remdesivir, lopinavir, emetine, and homoharringtonine inhibit SARS-CoV-2 replication in vitro

(2020) Ka-Tim Choy et al.   ANTIVIRAL RESEARCH

Correction to Remdesivir: A Review of Its Discovery and Development Leading to Human Clinical Trials for Treatment of COVID-19

(2020) Richard T. Eastman et al.   ACS Central Science

Efficacy of Remdesivir in COVID-19

(2020) Erin K. McCreary et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Characteristics of SARS-CoV-2 and COVID-19

(2020) Ben Hu et al.   NATURE REVIEWS MICROBIOLOGY

Synergistic and Antagonistic Drug Combinations against SARS-CoV-2

(2020) Tesia Bobrowski et al.   MOLECULAR THERAPY

Successful treatment of hepatitis C virus infection with direct‐acting antivirals during hematopoietic cell transplant

(2019) Hayley E. Cunningham et al.   Transplant Infectious Disease

Broad spectrum antiviral remdesivir inhibits human endemic and zoonotic deltacoronaviruses with a highly divergent RNA dependent RNA polymerase

(2019) Ariane J. Brown et al.   ANTIVIRAL RESEARCH

Reinfection with the hepatitis C virus in men who have sex with men after successful treatment with direct-acting antivirals in Germany: Current incidence rates compared with rates during the interferon era

(2019) Patrick Ingiliz et al.   CLINICAL INFECTIOUS DISEASES

Inhibition of Porcine Viruses by Different Cell-Targeted Antiviral Drugs

(2019) Patricia de León et al.   Frontiers in Microbiology

Clinical Infections by Herpesviruses in Patients Treated with Valproic Acid: A Nested Case-Control Study in the Spanish Primary Care Database, BIFAP

(2019) Gil et al.   Journal of Clinical Medicine

The HIV-1 Reverse Transcriptase A62V Mutation Influences Replication Fidelity and Viral Fitness in the Context of Multi-Drug-Resistant Mutations

(2018) José Maldonado et al.   Viruses-Basel

Interactions of lauryl gallate with phospholipid components of biological membranes

(2016) Małgorzata Jurak et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Approved Antiviral Drugs over the Past 50 Years

(2016) Erik De Clercq et al.   CLINICAL MICROBIOLOGY REVIEWS

HCV1b genome evolution under selective pressure of the cyclophilin inhibitor alisporivir during the DEB-025-HCV-203 phase II clinical trial

(2016) Lize Cuypers et al.   INFECTION GENETICS AND EVOLUTION

Inhibition of herpes virus infection in oligodendrocyte cultured cells by valproic acid

(2016) A.J. Crespillo et al.   VIRUS RESEARCH

Inhibition of multiplication of the prototypic arenavirus LCMV by valproic acid

(2013) Ángela Vázquez-Calvo et al.   ANTIVIRAL RESEARCH

Valproic Acid Attenuates Lipopolysaccharide-Induced Acute Lung Injury in Mice

(2013) Mu-huo Ji et al.   INFLAMMATION

The Small Molecules AZD0530 and Dasatinib Inhibit Dengue Virus RNA Replication via Fyn Kinase

(2013) M. de Wispelaere et al.   JOURNAL OF VIROLOGY

Evaluation of Anti-herpetic and Antioxidant Activities, and Cytotoxic and Genotoxic Effects of Synthetic Alkyl-Esters of Gallic Acid

(2012) Luciane Savi et al.   ARZNEIMITTEL-FORSCHUNG-DRUG RESEARCH

Broad-spectrum antiviral that interferes with de novo pyrimidine biosynthesis

(2011) H.-H. Hoffmann et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Drug Combination Studies and Their Synergy Quantification Using the Chou-Talalay Method

(2010) T.-C. Chou   CANCER RESEARCH

The Hepatitis C Virus (HCV) NS4B RNA Binding Inhibitor Clemizole Is Highly Synergistic with HCV Protease Inhibitors

(2010) Shirit Einav et al.   JOURNAL OF INFECTIOUS DISEASES

Inhibition of Enveloped Virus Infection of Cultured Cells by Valproic Acid

(2010) A. Vazquez-Calvo et al.   JOURNAL OF VIROLOGY

Dynamic Innate Immune Responses of Human Bronchial Epithelial Cells to Severe Acute Respiratory Syndrome-Associated Coronavirus Infection

(2010) Tomoki Yoshikawa et al.   PLoS One

Structure–function studies for the panacea, valproic acid

(2009) Nicole Terbach et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Valproic Acid is Neuroprotective in the Rotenone Rat Model of Parkinson’s Disease: Involvement of α-Synuclein

(2009) Barbara Monti et al.   NEUROTOXICITY RESEARCH

Preclinicalversusclinical drug combination studies

(2008) Ting-Chao Chou   LEUKEMIA & LYMPHOMA