Alternatives to animal models and their application in the discovery of species susceptibility to SARS-CoV-2 and other respiratory infectious pathogens: A review

Tropism of SARS-CoV-2, SARS-CoV and influenza virus in canine tissue explants

(2021) Christine H T Bui et al.   JOURNAL OF INFECTIOUS DISEASES

Loss of furin cleavage site attenuates SARS-CoV-2 pathogenesis

(2021) Bryan A. Johnson et al.   NATURE

Susceptibility of white-tailed deer (Odocoileus virginianus) to SARS-CoV-2

(2021) Mitchell V. Palmer et al.   JOURNAL OF VIROLOGY

Camostat mesylate inhibits SARS-CoV-2 activation by TMPRSS2-related proteases and its metabolite GBPA exerts antiviral activity

(2021) Markus Hoffmann et al.   EBioMedicine

Human nasal and lung tissues infected ex vivo with SARS-CoV-2 provide insights into differential tissue-specific and virus-specific innate immune responses in the upper and lower respiratory tract

(2021) Or Alfi et al.   JOURNAL OF VIROLOGY

New SARS-CoV-2 Variants — Clinical, Public Health, and Vaccine Implications

(2021) Salim S. Abdool Karim et al.   NEW ENGLAND JOURNAL OF MEDICINE

Vascular Inflammation Is Associated with Loss of Aquaporin 1 Expression on Endothelial Cells and Increased Fluid Leakage in SARS-CoV-2 Infected Golden Syrian Hamsters

(2021) Lisa Allnoch et al.   Viruses-Basel

The serotonin reuptake inhibitor Fluoxetine inhibits SARS-CoV-2 in human lung tissue

(2021) Melissa Zimniak et al.   Scientific Reports

Mink, SARS-CoV-2, and the Human-Animal Interface

(2021) Florence Fenollar et al.   Frontiers in Microbiology

Vasculitis and Neutrophil Extracellular Traps in Lungs of Golden Syrian Hamsters With SARS-CoV-2

(2021) Kathrin Becker et al.   Frontiers in Immunology

Review on the Vascularization of Organoids and Organoids-on-a-Chip

(2021) Xingli Zhao et al.   Frontiers in Bioengineering and Biotechnology

Microdissected Tissue vs Tissue Slices—A Comparative Study of Tumor Explant Models Cultured On-Chip and Off-Chip

(2021) Dina Dorrigiv et al.   Cancers

Applications and Approaches for 3D Precision-cut Lung Slices: Disease Modeling and Drug Discovery

(2020) Hani N Alsafadi et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus–Infected Pneumonia in Wuhan, China

(2020) Dawei Wang et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Composition and divergence of coronavirus spike proteins and host ACE2 receptors predict potential intermediate hosts of SARS-CoV-2

(2020) Zhixin Liu et al.   JOURNAL OF MEDICAL VIROLOGY

Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding

(2020) Roujian Lu et al.   LANCET

Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China

(2020) Chaolin Huang et al.   LANCET

A new coronavirus associated with human respiratory disease in China

(2020) Fan Wu et al.   NATURE

A pneumonia outbreak associated with a new coronavirus of probable bat origin

(2020) Peng Zhou et al.   NATURE

A Novel Coronavirus from Patients with Pneumonia in China, 2019

(2020) Na Zhu et al.   NEW ENGLAND JOURNAL OF MEDICINE

Inhibition of SARS-CoV-2 Infections in Engineered Human Tissues Using Clinical-Grade Soluble Human ACE2

(2020) Vanessa Monteil et al.   CELL

SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor

(2020) Markus Hoffmann et al.   CELL

Comparative replication and immune activation profiles of SARS-CoV-2 and SARS-CoV in human lungs: an ex vivo study with implications for the pathogenesis of COVID-19

(2020) Hin Chu et al.   CLINICAL INFECTIOUS DISEASES

Probable Pangolin Origin of SARS-CoV-2 Associated with the COVID-19 Outbreak

(2020) Tao Zhang et al.   CURRENT BIOLOGY

Understanding SARS‐CoV‐2 endocytosis for COVID‐19 drug repurposing

(2020) Oleg O. Glebov   FEBS Journal

Extra-respiratory manifestations of COVID-19

(2020) Chih-Cheng Lai et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

SARS-CoV-2 spike protein favors ACE2 from Bovidae and Cricetidae

(2020) Junwen Luan et al.   JOURNAL OF MEDICAL VIROLOGY

Predicting the angiotensin converting enzyme 2 (ACE2) utilizing capability as the receptor of SARS-CoV-2

(2020) Ye Qiu et al.   MICROBES AND INFECTION

Viral and host factors related to the clinical outcome of COVID-19

(2020) Xiaonan Zhang et al.   NATURE

Isolation of SARS-CoV-2-related coronavirus from Malayan pangolins

(2020) Kangpeng Xiao et al.   NATURE

Identifying SARS-CoV-2 related coronaviruses in Malayan pangolins

(2020) Tommy Tsan-Yuk Lam et al.   NATURE

Respiratory disease in rhesus macaques inoculated with SARS-CoV-2

(2020) Vincent J. Munster et al.   NATURE

Infection of dogs with SARS-CoV-2

(2020) Thomas H. C. Sit et al.   NATURE

Infection of bat and human intestinal organoids by SARS-CoV-2

(2020) Jie Zhou et al.   NATURE MEDICINE

Transmission of SARS-CoV-2 in Domestic Cats

(2020) Peter J. Halfmann et al.   NEW ENGLAND JOURNAL OF MEDICINE

Cell entry mechanisms of SARS-CoV-2

(2020) Jian Shang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Enhanced isolation of SARS-CoV-2 by TMPRSS2-expressing cells

(2020) Shutoku Matsuyama et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Susceptibility of ferrets, cats, dogs, and other domesticated animals to SARS–coronavirus 2

(2020) Jianzhong Shi et al.   SCIENCE

Comparative pathogenesis of COVID-19, MERS, and SARS in a nonhuman primate model

(2020) Barry Rockx et al.   SCIENCE

An orally bioavailable broad-spectrum antiviral inhibits SARS-CoV-2 in human airway epithelial cell cultures and multiple coronaviruses in mice

(2020) Timothy P. Sheahan et al.   Science Translational Medicine

Are pangolins the intermediate host of the 2019 novel coronavirus (SARS-CoV-2)?

(2020) Ping Liu et al.   PLoS Pathogens

Recapitulation of SARS-CoV-2 infection and cholangiocyte damage with human liver ductal organoids

(2020) Bing Zhao et al.   Protein & Cell

Tropism, replication competence, and innate immune responses of the coronavirus SARS-CoV-2 in human respiratory tract and conjunctiva: an analysis in ex-vivo and in-vitro cultures

(2020) Kenrie P Y Hui et al.   Lancet Respiratory Medicine

SARS-CoV-2 infects human neural progenitor cells and brain organoids

(2020) Bao-Zhong Zhang et al.   CELL RESEARCH

A Human Pluripotent Stem Cell-based Platform to Study SARS-CoV-2 Tropism and Model Virus Infection in Human Cells and Organoids

(2020) Liuliu Yang et al.   Cell Stem Cell

SARS-CoV-2 infection in farmed minks, the Netherlands, April and May 2020

(2020) Nadia Oreshkova et al.   Eurosurveillance

SARS-coronavirus-2 replication in Vero E6 cells: replication kinetics, rapid adaptation and cytopathology

(2020) Natacha S. Ogando et al.   JOURNAL OF GENERAL VIROLOGY

ACE2 and TMPRSS2 variation in savanna monkeys (Chlorocebus spp.): Potential risk for zoonotic/anthroponotic transmission of SARS-CoV-2 and a potential model for functional studies

(2020) Christopher A. Schmitt et al.   PLoS One

Morphogenesis and cytopathic effect of SARS-CoV-2 infection in human airway epithelial cells

(2020) Na Zhu et al.   Nature Communications

First Reported Cases of SARS-CoV-2 Infection in Companion Animals — New York, March–April 2020

(2020) Alexandra Newman et al.   MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT

Lions, Tigers and Kittens too: ACE2 and susceptibility to CoVID-19

(2020) Sabateeshan Mathavarajah et al.   Evolution Medicine and Public Health

Organoid technology demonstrates effects of potential drugs for COVID‐19 on the lung regeneration

(2020) Jianhai Wang et al.   CELL PROLIFERATION

SARS-CoV-2 Infection of Pluripotent Stem Cell-Derived Human Lung Alveolar Type 2 Cells Elicits a Rapid Epithelial-Intrinsic Inflammatory Response

(2020) Jessie Huang et al.   Cell Stem Cell

Three-dimensional human alveolar stem cell culture models reveal infection response to SARS-CoV-2

(2020) Jeonghwan Youk et al.   Cell Stem Cell

Broad host range of SARS-CoV-2 predicted by comparative and structural analysis of ACE2 in vertebrates

(2020) Joana Damas et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Experimental infection of domestic dogs and cats with SARS-CoV-2: Pathogenesis, transmission, and response to reexposure in cats

(2020) Angela M. Bosco-Lauth et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Potential zoonotic sources of SARS‐CoV‐2 infections

(2020) Wendy K. Jo et al.   Transboundary and Emerging Diseases

From People to Panthera: Natural SARS-CoV-2 Infection in Tigers and Lions at the Bronx Zoo

(2020) Denise McAloose et al.   mBio

Susceptibility of tree shrew to SARS-CoV-2 infection

(2020) Yuan Zhao et al.   Scientific Reports

The Potential Intermediate Hosts for SARS-CoV-2

(2020) Jie Zhao et al.   Frontiers in Microbiology

SARS-CoV-2 Induces a More Robust Innate Immune Response and Replicates Less Efficiently Than SARS-CoV in the Human Intestines: An Ex Vivo Study With Implications on Pathogenesis of COVID-19

(2020) Hin Chu et al.   Cellular and Molecular Gastroenterology and Hepatology

Optimization of the isolation procedure and culturing conditions for hepatic stellate cells obtained from mouse

(2020) Thanh Minh Dang et al.   BIOSCIENCE REPORTS

SARS-CoV-2 replicates in respiratory ex vivo organ cultures of domestic ruminant species

(2020) Giovanni Di Teodoro et al.   VETERINARY MICROBIOLOGY

Bordetella bronchiseptica promotes adherence, colonization, and cytotoxicity of Streptococcus suis in a porcine precision-cut lung slice model

(2020) Désirée Vötsch et al.   Virulence

Host metabolism dysregulation and cell tropism identification in human airway and alveolar organoids upon SARS-CoV-2 infection

(2020) Rongjuan Pei et al.   Protein & Cell

Susceptibility of rabbits to SARS-CoV-2

(2020) Anna Z. Mykytyn et al.   Emerging Microbes & Infections

Optimization of an air-liquid interface in vitro cell co-culture model to estimate the hazard of aerosol exposures

(2020) Rui-Wen He et al.   JOURNAL OF AEROSOL SCIENCE

Generation of lung organoids from human pluripotent stem cells in vitro

(2019) Alyssa J. Miller et al.   Nature Protocols

Derivation of adult canine intestinal organoids for translational research in gastroenterology

(2019) Lawrance Chandra et al.   BMC BIOLOGY

Organoids are promising tools for species‐specific in vitro toxicological studies

(2019) Justyna Augustyniak et al.   JOURNAL OF APPLIED TOXICOLOGY

The formation of intestinal organoids in a hanging drop culture

(2018) Malgorzata Panek et al.   CYTOTECHNOLOGY

Organoids

(2018) Natalie de Souza   NATURE METHODS

A novel method for expansion and differentiation of mouse tracheal epithelial cells in culture

(2018) Evelien Eenjes et al.   Scientific Reports

Experimental infection of dromedaries with Middle East respiratory syndrome-Coronavirus is accompanied by massive ciliary loss and depletion of the cell surface receptor dipeptidyl peptidase 4

(2018) Ann-Kathrin Haverkamp et al.   Scientific Reports

Developing a 3D intestinal epithelium model for livestock species

(2018) Hayley Derricott et al.   CELL AND TISSUE RESEARCH

Temporal differentiation of bovine airway epithelial cells grown at an air-liquid interface

(2018) Daniel Cozens et al.   Scientific Reports

Targeting of the Nasal Mucosa by Japanese Encephalitis Virus for Non-Vector-Borne Transmission

(2018) Obdulio García-Nicolás et al.   JOURNAL OF VIROLOGY

Human lung tissue provides highly relevant data about efficacy of new anti-asthmatic drugs

(2018) Olga Danov et al.   PLoS One

Comparison of mono- and co-infection by swine influenza A viruses and porcine respiratory coronavirus in porcine precision-cut lung slices

(2017) Tanja Krimmling et al.   RESEARCH IN VETERINARY SCIENCE

Disease Modeling in Stem Cell-Derived 3D Organoid Systems

(2017) Devanjali Dutta et al.   TRENDS IN MOLECULAR MEDICINE

Access to a main alphaherpesvirus receptor, located basolaterally in the respiratory epithelium, is masked by intercellular junctions

(2017) Jolien Van Cleemput et al.   Scientific Reports

Assessment of long-term cultivated human precision-cut lung slices as an ex vivo system for evaluation of chronic cytotoxicity and functionality

(2017) Vanessa Neuhaus et al.   Journal of Occupational Medicine and Toxicology

WRN conditioned media is sufficient forin vitropropagation of intestinal organoids from large farm and small companion animals

(2017) Robin H. Powell et al.   Biology Open

Long-Term Adult Feline Liver Organoid Cultures for Disease Modeling of Hepatic Steatosis

(2017) Hedwig S. Kruitwagen et al.   Stem Cell Reports

Temporal dynamics of ovine airway epithelial cell differentiation at an air-liquid interface

(2017) Nicky O’Boyle et al.   PLoS One

Modeling Development and Disease with Organoids

(2016) Hans Clevers   CELL

A species-specific activation of Toll-like receptor signaling in bovine and sheep bronchial epithelial cells triggered by Mycobacterial infections

(2016) Yan Ma et al.   MOLECULAR IMMUNOLOGY

Use of a feline respiratory epithelial cell culture system grown at the air–liquid interface to characterize the innate immune response following feline herpesvirus 1 infection

(2016) Rahul K. Nelli et al.   VIRUS RESEARCH

Concise Review: Organoids Are a Powerful Tool for the Study of Liver Disease and Personalized Treatment Design in Humans and Animals

(2016) Sathidpak Nantasanti et al.   Stem Cells Translational Medicine

The differentiated airway epithelium infected by influenza viruses maintains the barrier function despite a dramatic loss of ciliated cells

(2016) Nai-Huei Wu et al.   Scientific Reports

Pulmonary epithelial barrier function: some new players and mechanisms

(2015) Kieran Brune et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Generation of Induced Pluripotent Stem Cells from Bovine Epithelial Cells and Partial Redirection Toward a Mammary PhenotypeIn Vitro

(2015) Diego Cravero et al.   Cellular Reprogramming

Dynamic Virus-Bacterium Interactions in a Porcine Precision-Cut Lung Slice Coinfection Model: Swine Influenza Virus Paves the Way for Streptococcus suis Infection in a Two-Step Process

(2015) F. Meng et al.   INFECTION AND IMMUNITY

The in vitro generation of lung and airway progenitor cells from human pluripotent stem cells

(2015) Sarah X L Huang et al.   Nature Protocols

Jaagsiekte sheep retrovirus infection of lung slice cultures

(2015) Chris Cousens et al.   Retrovirology

Passage-dependent morphological and phenotypical changes of a canine histiocytic sarcoma cell line (DH82 cells)

(2015) Franziska Heinrich et al.   VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY

Mycoplasma ovipneumoniae induces inflammatory response in sheep airway epithelial cells via a MyD88-dependent TLR signaling pathway

(2015) Di Xue et al.   VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY

In vitro generation of human pluripotent stem cell derived lung organoids

(2015) Briana R Dye et al.   eLife

Disease Modeling and Gene Therapy of Copper Storage Disease in Canine Hepatic Organoids

(2015) Sathidpak Nantasanti et al.   Stem Cell Reports

Newborn pig trachea cell line cultured in air-liquid interface conditions allows a partial in vitro representation of the porcine upper airway tissue

(2014) Mario Delgado-Ortega et al.   BMC CELL BIOLOGY

Bovine mammary stem cells: new perspective for dairy science

(2014) E. Martignani et al.   VETERINARY QUARTERLY

Type 2 alveolar cells are stem cells in adult lung

(2013) Christina E. Barkauskas et al.   JOURNAL OF CLINICAL INVESTIGATION

Paramyxovirus infections in ex vivo lung slice cultures of different host species

(2013) D. Tien Nguyen et al.   JOURNAL OF VIROLOGICAL METHODS

Cell Lineage Identification and Stem Cell Culture in a Porcine Model for the Study of Intestinal Epithelial Regeneration

(2013) Liara M. Gonzalez et al.   PLoS One

Differentiated swine airway epithelial cell cultures for the investigation of influenza A virus infection and replication

(2012) Allen C. Bateman et al.   Influenza and Other Respiratory Viruses

Evaluation of the antiviral activity of (1′S,2′R)-9-[[1′,2′-bis(hydroxymethyl)cycloprop-1′-yl]methyl]guanine (A-5021) against equine herpesvirus type 1 in cell monolayers and equine nasal mucosal explants

(2011) Sarah Glorieux et al.   ANTIVIRAL RESEARCH

Bronchoconstriction in nonhuman primates: a species comparison

(2011) S. Seehase et al.   JOURNAL OF APPLIED PHYSIOLOGY

Self-organizing optic-cup morphogenesis in three-dimensional culture

(2011) Mototsugu Eiraku et al.   NATURE

Generation of anterior foregut endoderm from human embryonic and induced pluripotent stem cells

(2011) Michael D Green et al.   NATURE BIOTECHNOLOGY

Infection of Differentiated Porcine Airway Epithelial Cells by Influenza Virus: Differential Susceptibility to Infection by Porcine and Avian Viruses

(2011) Darsaniya Punyadarsaniya et al.   PLoS One

Immunological characterization of the equine airway epithelium and of a primary equine airway epithelial cell culture model

(2011) Ayshea M. Quintana et al.   VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY

Equine alphaherpesviruses (EHV-1 and EHV-4) differ in their efficiency to infect mononuclear cells during early steps of infection in nasal mucosal explants

(2011) Annelies P. Vandekerckhove et al.   VETERINARY MICROBIOLOGY

Effect of cyclic AMP-elevating agents on airway ciliary beat frequency in central and lateral airways in rat precision-cut lung slices

(2010) Andrea Wohlsen et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

In vitrolung slices: a powerful approach for assessment of lung pathophysiology

(2010) Teresa A Liberati et al.   EXPERT REVIEW OF MOLECULAR DIAGNOSTICS

Evidence of an epithelial stem/progenitor cell hierarchy in the adult mouse lung

(2010) J. L. McQualter et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Replication of avian, human and swine influenza viruses in porcine respiratory explants and association with sialic acid distribution

(2010) Sjouke GM Van Poucke et al.   Virology Journal

The Role of Scgb1a1+ Clara Cells in the Long-Term Maintenance and Repair of Lung Airway, but Not Alveolar, Epithelium

(2009) Emma L. Rawlins et al.   Cell Stem Cell

Equine bronchial epithelial cells differentiate into ciliated and mucus producing cells in vitro

(2009) Ute E. Schwab et al.   IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL

Comparative Pathogenesis of an Avian H5N2 and a Swine H1N1 Influenza Virus in Pigs

(2009) Annebel De Vleeschauwer et al.   PLoS One

Basal cells as stem cells of the mouse trachea and human airway epithelium

(2009) J. R. Rock et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Differential Sensitivity of Differentiated Epithelial Cells to Respiratory Viruses Reveals Different Viral Strategies of Host Infection

(2008) K. Goris et al.   JOURNAL OF VIROLOGY

Different replication characteristics of historical pseudorabies virus strains in porcine respiratory nasal mucosa explants

(2008) Sarah Glorieux et al.   VETERINARY MICROBIOLOGY

Domestic Pigs Have Low Susceptibility to H5N1 Highly Pathogenic Avian Influenza Viruses

(2008) Aleksandr S. Lipatov et al.   PLoS Pathogens