Translational Neuroscience Approaches to Understanding Autism

Mouse models of fragile X-related disorders

(2023) Rob Willemsen et al.   Disease Models & Mechanisms

Mouse population genetics phenocopies heterogeneity of human Chd8 haploinsufficiency

(2023) Manal Tabbaa et al.   NEURON

Altered dendritic morphology in dorsolateral prefrontal cortex of nonhuman primates prenatally exposed to maternal immune activation

(2023) Kari L. Hanson et al.   BRAIN BEHAVIOR AND IMMUNITY

Twenty years of discoveries emerging from mouse models of autism

(2023) Jacqueline N. Crawley   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Heritability of social behavioral phenotypes and preliminary associations with autism spectrum disorder risk genes in rhesus macaques: A whole exome sequencing study

(2022) Chris Gunter et al.   Autism Research

Association of Amygdala Development with Different Forms of Anxiety in Autism Spectrum Disorder

(2022) Derek Sayre Andrews et al.   BIOLOGICAL PSYCHIATRY

Dissecting the molecular basis of human interneuron migration in forebrain assembloids from Timothy syndrome

(2022) Fikri Birey et al.   Cell Stem Cell

Nonhuman primate abnormal behavior: Etiology, assessment, and treatment

(2022) Corrine K. Lutz et al.   AMERICAN JOURNAL OF PRIMATOLOGY

Leveraging a translational research approach to drive diagnostic and treatment advances for autism

(2022) Karen J. Parker   MOLECULAR PSYCHIATRY

Drosophila functional screening of de novo variants in autism uncovers damaging variants and facilitates discovery of rare neurodevelopmental diseases

(2022) Paul C. Marcogliese et al.   Cell Reports

Egr1 Is Necessary for Forebrain Dopaminergic Signaling during Social Behavior

(2022) Alexandra Tallafuss et al.   eNeuro

Reduced childhood social attention in autism model marmosets predicts impaired social skills and inflexible behavior in adulthood

(2022) Akiko Nakagami et al.   Frontiers in Psychiatry

The Autism Biomarkers Consortium for Clinical Trials: Initial Evaluation of a Battery of Candidate EEG Biomarkers

(2022) Sara Jane Webb et al.   AMERICAN JOURNAL OF PSYCHIATRY

Maturation and circuit integration of transplanted human cortical organoids

(2022) Omer Revah et al.   NATURE

Rare coding variation provides insight into the genetic architecture and phenotypic context of autism

(2022) Jack M. Fu et al.   NATURE GENETICS

In Search of Biomarkers to Guide Interventions in Autism Spectrum Disorder: A Systematic Review

(2022) Mara Parellada et al.   AMERICAN JOURNAL OF PSYCHIATRY

Autism‐related language preferences of English ‐speaking individuals across the globe: A mixed methods investigation

(2022) Connor Tom Keating et al.   Autism Research

Adeno-associated virus (AAV)-based gene therapy products: What are toxicity studies in non-human primates showing us?

(2022) Paul Baldrick et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

Long-term maturation of human cortical organoids matches key early postnatal transitions

(2021) Aaron Gordon et al.   NATURE NEUROSCIENCE

Prenatal maternal infection and risk for autism in offspring: A meta‐analysis

(2021) Nina Tioleco et al.   Autism Research

Current Approaches and Future Directions for the Treatment of mTORopathies

(2021) Vasiliki Karalis et al.   DEVELOPMENTAL NEUROSCIENCE

The Gut-Brain-Microbiome Axis and Its Link to Autism: Emerging Insights and the Potential of Zebrafish Models

(2021) David M. James et al.   Frontiers in Cell and Developmental Biology

Zebrafish as a tool in the study of sleep and memory-related disorders

(2021) Stefani Altenhofen et al.   Current Neuropharmacology

Evolution of prefrontal cortex

(2021) Todd M. Preuss et al.   NEUROPSYCHOPHARMACOLOGY

Functional and molecular characterization of a non-human primate model of autism spectrum disorder shows similarity with the human disease

(2021) Satoshi Watanabe et al.   Nature Communications

Inborn Errors of Metabolism Associated With Autism Spectrum Disorders: Approaches to Intervention

(2021) Tamara Žigman et al.   Frontiers in Neuroscience

Advancing Autism Research From Mice to Marmosets: Behavioral Development of Offspring Following Prenatal Maternal Immune Activation

(2021) Danielle Santana-Coelho et al.   Frontiers in Psychiatry

Safety, efficacy and biodistribution of an engineered hepatotropic Adeno-Associated Virus mediated gene therapy for Ornithine Transcarbamylase Deficiency in Cynomolgus monkeys

(2021) Julien Baruteau et al.   Molecular Therapy-Methods & Clinical Development

Phenotypic analysis of catastrophic childhood epilepsy genes

(2021) Aliesha Griffin et al.   Communications Biology

Alterations in Connectome Dynamics in Autism Spectrum Disorder: A Harmonized Mega- and Meta-analysis Study Using the Autism Brain Imaging Data Exchange Dataset

(2021) Yapei Xie et al.   BIOLOGICAL PSYCHIATRY

Comparison of SHANK3 deficiency in animal models: phenotypes, treatment strategies, and translational implications

(2021) Jan Philipp Delling et al.   Journal of Neurodevelopmental Disorders

Maternal Immune Activation during Pregnancy Alters Postnatal Brain Growth and Cognitive Development in Nonhuman Primate Offspring

(2021) Roza M. Vlasova et al.   JOURNAL OF NEUROSCIENCE

The neuropathology of autism: A systematic review of post-mortem studies of autism and related disorders

(2021) Rana Fetit et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Prevalence and Characteristics of Autism Spectrum Disorder Among Children Aged 8 Years — Autism and Developmental Disabilities Monitoring Network, 11 Sites, United States, 2018

(2021) Matthew J. Maenner et al.   MMWR Surveillance Summaries

A psychometrically robust screening tool to rapidly identify socially impaired monkeys in the general population

(2020) Catherine F. Talbot et al.   Autism Research

Expanded encyclopaedias of DNA elements in the human and mouse genomes

(2020) Jill E. Moore et al.   NATURE

Early developmental changes in visual social engagement in infant rhesus monkeys

(2020) Arick Wang et al.   Developmental Cognitive Neuroscience

Opportunities and limitations of genetically modified nonhuman primate models for neuroscience research

(2020) Guoping Feng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Xenopus leads the way: Frogs as a pioneering model to understand the human brain

(2020) Cameron R. T. Exner et al.   GENESIS

Generation of human striatal organoids and cortico-striatal assembloids from human pluripotent stem cells

(2020) Yuki Miura et al.   NATURE BIOTECHNOLOGY

Prenatal valproate in rodents as a tool to understand the neural underpinnings of social dysfunctions in autism spectrum disorder

(2019) Anna Maria Tartaglione et al.   NEUROPHARMACOLOGY

Zebrafish Models of Neurodevelopmental Disorders: Limitations and Benefits of Current Tools and Techniques

(2019) Raquel Vaz et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Phenotypic Landscape of Schizophrenia-Associated Genes Defines Candidates and Their Shared Functions

(2019) Summer B. Thyme et al.   CELL

Whole-animal connectomes of both Caenorhabditis elegans sexes

(2019) Steven J. Cook et al.   NATURE

Atypical behaviour and connectivity in SHANK3-mutant macaques

(2019) Yang Zhou et al.   NATURE

Diagnosis and management of individuals with Fetal Valproate Spectrum Disorder; a consensus statement from the European Reference Network for Congenital Malformations and Intellectual Disability

(2019) Jill Clayton-Smith et al.   Orphanet Journal of Rare Diseases

Autism Spectrum Disorder-Related Syndromes: Modeling with Drosophila and Rodents

(2019) Ibuki Ueoka et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Zebrafish as a Model of Neurodevelopmental Disorders

(2019) Murilo S. de Abreu et al.   NEUROSCIENCE

Dissecting the Genetics of Autism Spectrum Disorders: A Drosophila Perspective

(2019) Paola Bellosta et al.   Frontiers in Physiology

Systematic phenomics analysis of autism-associated genes reveals parallel networks underlying reversible impairments in habituation

(2019) Troy A. McDiarmid et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cortical and Subcortical Brain Morphometry Differences Between Patients With Autism Spectrum Disorder and Healthy Individuals Across the Lifespan: Results From the ENIGMA ASD Working Group

(2018) Daan van Rooij et al.   AMERICAN JOURNAL OF PSYCHIATRY

Modeling autism in non-human primates: Opportunities and challenges

(2018) Hui Zhao et al.   Autism Research

Worms on the spectrum - C. elegans models in autism research

(2018) Kathrin Schmeisser et al.   EXPERIMENTAL NEUROLOGY

The valproic acid-induced rodent model of autism

(2018) Chiara Nicolini et al.   EXPERIMENTAL NEUROLOGY

Maternal autoantibody related autism: mechanisms and pathways

(2018) Karen L. Jones et al.   MOLECULAR PSYCHIATRY

Disrupted focal white matter integrity in autism spectrum disorder: A voxel-based meta-analysis of diffusion tensor imaging studies

(2018) Xin Di et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

CRISPR/Cas9-induced shank3b mutant zebrafish display autism-like behaviors

(2018) Chun-xue Liu et al.   Molecular Autism

Of Men and Mice: Modeling the Fragile X Syndrome

(2018) Regina Dahlhaus   Frontiers in Molecular Neuroscience

Maternal Immune Activation and Neuropsychiatric Illness: A Translational Research Perspective

(2018) Alan S. Brown et al.   AMERICAN JOURNAL OF PSYCHIATRY

Maternal inflammation and neurodevelopmental programming: A review of preclinical outcomes and implications for translational psychiatry

(2018) Serena B. Gumusoglu et al.   BIOLOGICAL PSYCHIATRY

5-HT release in nucleus accumbens rescues social deficits in mouse autism model

(2018) Jessica J. Walsh et al.   NATURE

Zebrafish Models of Neurodevelopmental Disorders: Past, Present, and Future

(2018) Catalina Sakai et al.   Frontiers in Molecular Neuroscience

Comprehensive functional genomic resource and integrative model for the human brain

(2018) Daifeng Wang et al.   SCIENCE

Naturally Occurring Nonhuman Primate Models of Psychosocial Processes

(2017) John P Capitanio   ILAR JOURNAL

A Presynaptic Function of Shank Protein inDrosophila

(2017) Song Wu et al.   JOURNAL OF NEUROSCIENCE

Risperidone and aripiprazole alleviate prenatal valproic acid-induced abnormalities in behaviors and dendritic spine density in mice

(2017) Yuta Hara et al.   PSYCHOPHARMACOLOGY

Replicable in vivo physiological and behavioral phenotypes of the Shank3B null mutant mouse model of autism

(2017) Sameer C. Dhamne et al.   Molecular Autism

Maternal infection during pregnancy and risk of autism spectrum disorders: A systematic review and meta-analysis

(2016) Hai-yin Jiang et al.   BRAIN BEHAVIOR AND IMMUNITY

Learning to Fish with Genetics: A Primer on the Vertebrate Model Danio rerio

(2016) N. G. Holtzman et al.   GENETICS

Shank Modulates Postsynaptic Wnt Signaling to Regulate Synaptic Development

(2016) K. P. Harris et al.   JOURNAL OF NEUROSCIENCE

Erratum: Pharmacological enhancement of mGlu5 receptors rescues behavioral deficits in SHANK3 knock-out mice

(2016) C Vicidomini et al.   MOLECULAR PSYCHIATRY

Adult restoration of Shank3 expression rescues selective autistic-like phenotypes

(2016) Yuan Mei et al.   NATURE

New models: Gene-editing boom means changing landscape for primate work

(2016) Cassandra Willyard   NATURE MEDICINE

Estrogens Suppress a Behavioral Phenotype in Zebrafish Mutants of the Autism Risk Gene, CNTNAP2

(2016) Ellen J. Hoffman et al.   NEURON

Endocannabinoid Modulation of Orbitostriatal Circuits Gates Habit Formation

(2016) Christina M. Gremel et al.   NEURON

The Macaque Social Responsiveness Scale (mSRS): A Rapid Screening Tool for Assessing Variability in the Social Responsiveness of Rhesus Monkeys (Macaca mulatta)

(2016) Eric J. Feczko et al.   PLoS One

The maternal interleukin-17a pathway in mice promotes autism-like phenotypes in offspring

(2016) G. B. Choi et al.   SCIENCE

Function Over Form: Modeling Groups of Inherited Neurological Conditions in Zebrafish

(2016) Robert A. Kozol et al.   Frontiers in Molecular Neuroscience

Maternal Immune Activation in Nonhuman Primates Alters Social Attention in Juvenile Offspring

(2015) Christopher J. Machado et al.   BIOLOGICAL PSYCHIATRY

FOXG1-Dependent Dysregulation of GABA/Glutamate Neuron Differentiation in Autism Spectrum Disorders

(2015) Jessica Mariani et al.   CELL

Genetics on the Fly: A Primer on the Drosophila Model System

(2015) K. G. Hales et al.   GENETICS

A Transparent Window into Biology: A Primer on Caenorhabditis elegans

(2015) Ann K. Corsi et al.   GENETICS

Rapid reverse genetic screening using CRISPR in zebrafish

(2015) Arish N Shah et al.   NATURE METHODS

A Transparent Window into Biology: A Primer on Caenorhabditis elegans

(2015) Ann K. Corsi et al.   GENETICS

Why primate models matter

(2014) Kimberley A. Phillips et al.   AMERICAN JOURNAL OF PRIMATOLOGY

Disruptive CHD8 Mutations Define a Subtype of Autism Early in Development

(2014) Raphael Bernier et al.   CELL

Stereotypic Behavior in Nonhuman Primates as a Model for the Human Condition

(2014) C. K. Lutz   ILAR JOURNAL

Synaptic, transcriptional and chromatin genes disrupted in autism

(2014) Silvia De Rubeis et al.   NATURE

Activation of the Maternal Immune System During Pregnancy Alters Behavioral Development of Rhesus Monkey Offspring

(2013) Melissa D. Bauman et al.   BIOLOGICAL PSYCHIATRY

Coexpression Networks Implicate Human Midfetal Deep Cortical Projection Neurons in the Pathogenesis of Autism

(2013) A. Jeremy Willsey et al.   CELL

Integrative Functional Genomic Analyses Implicate Specific Molecular Pathways and Circuits in Autism

(2013) Neelroop N. Parikshak et al.   CELL

Social reward requires coordinated activity of nucleus accumbens oxytocin and serotonin

(2013) Gül Dölen et al.   NATURE

The zebrafish reference genome sequence and its relationship to the human genome

(2013) Kerstin Howe et al.   NATURE

Orbitofrontal and striatal circuits dynamically encode the shift between goal-directed and habitual actions

(2013) Christina M. Gremel et al.   Nature Communications

Maternal antibodies from mothers of children with autism alter brain growth and social behavior development in the rhesus monkey

(2013) M D Bauman et al.   Translational Psychiatry

Autism-specific maternal autoantibodies recognize critical proteins in developing brain

(2013) D Braunschweig et al.   Translational Psychiatry

Maternal immune activation causes age- and region-specific changes in brain cytokines in offspring throughout development

(2012) Paula A. Garay et al.   BRAIN BEHAVIOR AND IMMUNITY

Species-Dependent Posttranscriptional Regulation of NOS1 by FMRP in the Developing Cerebral Cortex

(2012) Kenneth Y. Kwan et al.   CELL

Of mice and monkeys: using non-human primate models to bridge mouse- and human-based investigations of autism spectrum disorders

(2012) Karli K Watson et al.   Journal of Neurodevelopmental Disorders

KCTD13 is a major driver of mirrored neuroanatomical phenotypes of the 16p11.2 copy number variant

(2012) Christelle Golzio et al.   NATURE

Absence of CNTNAP2 Leads to Epilepsy, Neuronal Migration Abnormalities, and Core Autism-Related Deficits

(2011) Olga Peñagarikano et al.   CELL

Rare De Novo Variants Associated with Autism Implicate a Large Functional Network of Genes Involved in Formation and Function of Synapses

(2011) Sarah R. Gilman et al.   NEURON

Face identity recognition in autism spectrum disorders: A review of behavioral studies

(2011) Sarah Weigelt et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Maternal infection and immune involvement in autism

(2011) Paul H. Patterson   TRENDS IN MOLECULAR MEDICINE

Social peers rescue autism-relevant sociability deficits in adolescent mice

(2010) Mu Yang et al.   Autism Research

Effects of prenatal infection on brain development and behavior: A review of findings from animal models

(2010) Patricia Boksa   BRAIN BEHAVIOR AND IMMUNITY

Facial expression recognition in rhesus monkeys, Macaca mulatta

(2009) Lisa A. Parr et al.   ANIMAL BEHAVIOUR

Social deficits, stereotypy and early emergence of repetitive behavior in the C58/J inbred mouse strain

(2009) Bryce C. Ryan et al.   BEHAVIOURAL BRAIN RESEARCH

Stereotypies and hyperactivity in rhesus monkeys exposed to IgG from mothers of children with autism

(2008) Loren A. Martin et al.   BRAIN BEHAVIOR AND IMMUNITY

Neurons derived from reprogrammed fibroblasts functionally integrate into the fetal brain and improve symptoms of rats with Parkinson's disease

(2008) M. Wernig et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neuroanatomy of autism

(2008) David G. Amaral et al.   TRENDS IN NEUROSCIENCES

Autism-like behavioral phenotypes in BTBR T+tf/J mice

(2007) H. G. McFarlane et al.   GENES BRAIN AND BEHAVIOR