Mouse population genetics phenocopies heterogeneity of human Chd8 haploinsufficiency

Autism genes converge on asynchronous development of shared neuron classes

(2022) Bruna Paulsen et al.   NATURE

Genetic correlates of phenotypic heterogeneity in autism

(2022) Varun Warrier et al.   NATURE GENETICS

A phenotypic spectrum of autism is attributable to the combined effects of rare variants, polygenic risk and sex

(2022) Danny Antaki et al.   NATURE GENETICS

Genomics, convergent neuroscience and progress in understanding autism spectrum disorder

(2022) Helen Rankin Willsey et al.   NATURE REVIEWS NEUROSCIENCE

A diversity outbred F1 mouse model identifies host-intrinsic genetic regulators of response to immune checkpoint inhibitors

(2022) Justin B. Hackett et al.   OncoImmunology

Standing on the shoulders of mice

(2022) Kwat Medetgul-Ernar et al.   IMMUNITY

A Platform for Experimental Precision Medicine: The Extended BXD Mouse Family

(2021) David G. Ashbrook et al.   Cell Systems

The Mechanisms of CHD8 in Neurodevelopment and Autism Spectrum Disorders

(2021) Orly Weissberg et al.   Genes

Collaborative Cross mice reveal extreme epilepsy phenotypes and genetic loci for seizure susceptibility

(2020) Bin Gu et al.   EPILEPSIA

Mouse Genetic Reference Populations: Cellular Platforms for Integrative Systems Genetics

(2020) Emily Swanzey et al.   TRENDS IN GENETICS

Single-cell genomics identifies cell type–specific molecular changes in autism

(2019) Dmitry Velmeshev et al.   SCIENCE

Clinical phenotypes of carriers of mutations in CHD8 or its conserved target genes

(2019) Jennifer S. Beighley et al.   BIOLOGICAL PSYCHIATRY

The CHD8 overgrowth syndrome: A detailed evaluation of an emerging overgrowth phenotype in 27 patients

(2019) Philip J. Ostrowski et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART C-SEMINARS IN MEDICAL GENETICS

Rare variants in non-coding regulatory regions of the genome that affect gene expression in systemic lupus erythematosus

(2019) Sarah A. Jones et al.   Scientific Reports

Altered Neocortical Gene Expression, Brain Overgrowth and Functional Over-Connectivity in Chd8 Haploinsufficient Mice

(2018) Philipp Suetterlin et al.   CEREBRAL CORTEX

Sexually dimorphic behavior, neuronal activity, and gene expression in Chd8-mutant mice

(2018) Hwajin Jung et al.   NATURE NEUROSCIENCE

Harnessing Genetic Complexity to Enhance Translatability of Alzheimer’s Disease Mouse Models: A Path toward Precision Medicine

(2018) Sarah M. Neuner et al.   NEURON

Lost in Translation: Traversing the Complex Path from Genomics to Therapeutics in Autism Spectrum Disorder

(2018) Nenad Sestan et al.   NEURON

Modeling the quantitative nature of neurodevelopmental disorders using Collaborative Cross mice

(2018) Remco T. Molenhuis et al.   Molecular Autism

Characterization of Variability in Toxicokinetics and Toxicodynamics of Tetrachloroethylene Using the Collaborative Cross Mouse Population

(2017) Joseph A. Cichocki et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Quantitative trait locus mapping and analysis of heritable variation in affiliative social behavior and co-occurring traits

(2017) A. T. Knoll et al.   GENES BRAIN AND BEHAVIOR

Genomes of the Mouse Collaborative Cross

(2017) Anuj Srivastava et al.   GENETICS

Polygenic transmission disequilibrium confirms that common and rare variation act additively to create risk for autism spectrum disorders

(2017) Daniel J Weiner et al.   NATURE GENETICS

Targeted sequencing identifies 91 neurodevelopmental-disorder risk genes with autism and developmental-disability biases

(2017) Holly A F Stessman et al.   NATURE GENETICS

Germline Chd8 haploinsufficiency alters brain development in mouse

(2017) Andrea L Gompers et al.   NATURE NEUROSCIENCE

Chd8 Mutation Leads to Autistic-like Behaviors and Impaired Striatal Circuits

(2017) Randall J. Platt et al.   Cell Reports

Genomes of the Mouse Collaborative Cross

(2017) Anuj Srivastava et al.   GENETICS

Quantitative Trait Loci and a Novel Genetic Candidate for Fear Learning

(2016) A. T. Knoll et al.   JOURNAL OF NEUROSCIENCE

CHD8 haploinsufficiency results in autistic-like phenotypes in mice

(2016) Yuta Katayama et al.   NATURE

Advancing the understanding of autism disease mechanisms through genetics

(2016) Luis de la Torre-Ubieta et al.   NATURE MEDICINE

Genetic Background Limits Generalizability of Genotype-Phenotype Relationships

(2016) Laura J. Sittig et al.   NEURON

Sex and strain influence attribution of incentive salience to reward cues in mice

(2015) Price E. Dickson et al.   BEHAVIOURAL BRAIN RESEARCH

The Cognitive and Behavioral Phenotype of the 16p11.2 Deletion in a Clinically Ascertained Population

(2015) Ellen Hanson et al.   BIOLOGICAL PSYCHIATRY

Systems genetics of intravenous cocaine self-administration in the BXD recombinant inbred mouse panel

(2015) Price E. Dickson et al.   PSYCHOPHARMACOLOGY

Identification of genetic factors that modify motor performance and body weight using Collaborative Cross mice

(2015) Jian-Hua Mao et al.   Scientific Reports

The autism-associated gene chromodomain helicase DNA-binding protein 8 (CHD8) regulates noncoding RNAs and autism-related genes

(2015) B Wilkinson et al.   Translational Psychiatry

Disruptive CHD8 Mutations Define a Subtype of Autism Early in Development

(2014) Raphael Bernier et al.   CELL

The Collaborative Cross as a Resource for Modeling Human Disease: CC011/Unc, a New Mouse Model for Spontaneous Colitis

(2014) Allison R. Rogala et al.   MAMMALIAN GENOME

The role of de novo mutations in the genetics of autism spectrum disorders

(2014) Michael Ronemus et al.   NATURE REVIEWS GENETICS

Disentangling the heterogeneity of autism spectrum disorder through genetic findings

(2014) Shafali S. Jeste et al.   Nature Reviews Neurology

Melanoma susceptibility as a complex trait: genetic variation controls all stages of tumor progression

(2014) B Ferguson et al.   ONCOGENE

Host genetic diversity enables Ebola hemorrhagic fever pathogenesis and resistance

(2014) A. L. Rasmussen et al.   SCIENCE

Natural variation in maternal care shapes adult social behavior in rats

(2013) Emily J. Starr-Phillips et al.   DEVELOPMENTAL PSYCHOBIOLOGY

High-precision genetic mapping of behavioral traits in the diversity outbred mouse population

(2013) R. W. Logan et al.   GENES BRAIN AND BEHAVIOR

Out of the bottleneck: the Diversity Outcross and Collaborative Cross mouse populations in behavioral genetics research

(2013) Elissa J. Chesler   MAMMALIAN GENOME

Sequencing Chromosomal Abnormalities Reveals Neurodevelopmental Loci that Confer Risk across Diagnostic Boundaries

(2012) Michael E. Talkowski et al.   CELL

Systems Genetics of Metabolism: The Use of the BXD Murine Reference Panel for Multiscalar Integration of Traits

(2012) Pénélope A. Andreux et al.   CELL

The Genome Architecture of the Collaborative Cross Mouse Genetic Reference Population

(2012)   GENETICS

Status and access to the Collaborative Cross population

(2012) Catherine E. Welsh et al.   MAMMALIAN GENOME

Patterns and rates of exonic de novo mutations in autism spectrum disorders

(2012) Benjamin M. Neale et al.   NATURE

Ten Years of the Collaborative Cross

(2012) David W. Threadgill et al.   G3-Genes Genomes Genetics

Genetic Dissection of Behavioral Flexibility: Reversal Learning in Mice

(2011) Rick E. Laughlin et al.   BIOLOGICAL PSYCHIATRY

Mouse genomic variation and its effect on phenotypes and gene regulation

(2011) Thomas M. Keane et al.   NATURE

The conundrums of understanding genetic risks for autism spectrum disorders

(2011) Matthew W State et al.   NATURE NEUROSCIENCE

Herding cats: the sociology of data integration

(2010) Robert W. Williams   Frontiers in Neuroscience

The Collaborative Cross at Oak Ridge National Laboratory: developing a powerful resource for systems genetics

(2008) Elissa J. Chesler et al.   MAMMALIAN GENOME