Refactoring and Heterologous Expression of Class III Lanthipeptide Biosynthetic Gene Clusters Lead to the Discovery of N,N-Dimethylated Lantibiotics from Firmicutes

Global analysis of biosynthetic gene clusters reveals conserved and unique natural products in entomopathogenic nematode-symbiotic bacteria

(2022) Yi-Ming Shi et al.   Nature Chemistry

Correlational networking guides the discovery of unclustered lanthipeptide protease-encoding genes

(2022) Dan Xue et al.   Nature Communications

Mechanism of Action of Ribosomally Synthesized and Post-Translationally Modified Peptides

(2022) Chayanid Ongpipattanakul et al.   CHEMICAL REVIEWS

Class V Lanthipeptide Cyclase Directs the Biosynthesis of a Stapled Peptide Natural Product

(2022) Zeng-Fei Pei et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A Natural Product Chemist's Guide to Unlocking Silent Biosynthetic Gene Clusters

(2021) Brett C. Covington et al.   Annual Review of Biochemistry

Identification and characterization of andalusicin: N-terminally dimethylated class III lantibiotic from Bacillus thuringiensis sv. andalousiensis

(2021) Anastasiia Grigoreva et al.   iScience

Biosynthesis of Gut‐Microbiota‐Derived Lantibiotics Reveals a Subgroup of S8 Family Proteases for Class III Leader Removal

(2021) Yingying Zhang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A regulated synthetic operon facilitates stable overexpression of multigene terpenoid pathway in Bacillus subtilis

(2020) Ingy I. Abdallah et al.   JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY

Cacaoidin, first member of the new lanthidin RiPP family

(2020) Francisco Javier Ortiz-López et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Precursor peptide-targeted mining of more than one hundred thousand genomes expands the lanthipeptide natural product family

(2020) Mark C. Walker et al.   BMC GENOMICS

Natural product discovery through microbial genome mining

(2020) Emma Kenshole et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Zn-dependent bifunctional proteases are responsible for leader peptide processing of class III lanthipeptides

(2019) Shaoming Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Salinipeptins: Integrated Genomic and Chemical Approaches Reveal Unusual d-Amino Acid-Containing Ribosomally Synthesized and Post-Translationally Modified Peptides (RiPPs) from a Great Salt Lake Streptomyces sp.

(2019) Zhuo Shang et al.   ACS Chemical Biology

Unlocking the trove of metabolic treasures: activating silent biosynthetic gene clusters in bacteria and fungi

(2019) Xiafei Zhang et al.   CURRENT OPINION IN MICROBIOLOGY

High production of a class III lantipeptide AmfS in Streptomyces griseus

(2016) Hideaki Takano et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

The Supersized Class III Lanthipeptide Stackepeptin Displays Motif Multiplication in the Core Peptide

(2015) Natalia A. Jungmann et al.   ACS Chemical Biology

Discovery of microbial natural products by activation of silent biosynthetic gene clusters

(2015) Peter J. Rutledge et al.   NATURE REVIEWS MICROBIOLOGY

Insights into Secondary Metabolism from a Global Analysis of Prokaryotic Biosynthetic Gene Clusters

(2014) Peter Cimermancic et al.   CELL

Involvement and Unusual Substrate Specificity of a Prolyl Oligopeptidase in Class III Lanthipeptide Maturation

(2013) Ginka H. Völler et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Structural and functional insight into an unexpectedly selective N-methyltransferase involved in plantazolicin biosynthesis

(2013) J. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Biosynthesis of the Class III Lantipeptide Catenulipeptin

(2012) Huan Wang et al.   ACS Chemical Biology

Curvopeptin: A New Lanthionine-Containing Class III Lantibiotic and its Co-substrate Promiscuous Synthetase

(2012) Bartlomiej Krawczyk et al.   CHEMBIOCHEM

Characterization of New Class III Lantibiotics-Erythreapeptin, Avermipeptin and Griseopeptin from Saccharopolyspora erythraea, Streptomyces avermitilis and Streptomyces griseus Demonstrates Stepwise N-Terminal Leader Processing

(2012) Ginka H. Völler et al.   CHEMBIOCHEM

Identification of the amino acid labionin and its desulfurised derivative in the type-III lantibiotic LabA2 by means of GC/MS

(2011) Alexander Pesic et al.   CHEMICAL COMMUNICATIONS

Labyrinthopeptins: A New Class of Carbacyclic Lantibiotics

(2010) Kathrin Meindl et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

In Vitro Biosynthesis of the Prepeptide of Type-III Lantibiotic Labyrinthopeptin A2 Including Formation of a CC Bond as a Post-Translational Modification

(2010) Wolfgang M. Müller et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Genome mining and genetic analysis of cypemycin biosynthesis reveal an unusual class of posttranslationally modified peptides

(2010) J. Claesen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA