Novel Fluorescently Labeled PACAP and VIP Highlight Differences between Peptide Internalization and Receptor Pharmacology

Community Guidelines for GPCR Ligand Bias: IUPHAR Review XX

(2022) Peter Kolb et al.   BRITISH JOURNAL OF PHARMACOLOGY

A distinctive ligand recognition mechanism by the human vasoactive intestinal polypeptide receptor 2

(2022) Yingna Xu et al.   Nature Communications

Development and Application of Subtype-Selective Fluorescent Antagonists for the Study of the Human Adenosine A1 Receptor in Living Cells

(2021) Eleonora Comeo et al.   JOURNAL OF MEDICINAL CHEMISTRY

Characterisation of agonist signalling profiles and agonist‐dependent antagonism at PACAP‐responsive receptors: Implications for drug discovery

(2021) Zoe Tasma et al.   BRITISH JOURNAL OF PHARMACOLOGY

Cryo-EM structures of PAC1 receptor reveal ligand binding mechanism

(2020) Jia Wang et al.   CELL RESEARCH

Toward a Structural Understanding of Class B GPCR Peptide Binding and Activation

(2020) Yi-Lynn Liang et al.   MOLECULAR CELL

Agonist bias and agonist‐dependent antagonism at corticotrophin releasing factor receptors

(2020) Zoe Tasma et al.   Pharmacology Research & Perspectives

Targeting pituitary adenylate cyclase-activating polypeptide (PACAP) with monoclonal antibodies in migraine prevention: a brief review

(2020) Cecilia Rustichelli et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

A phase 2, randomized, double-blind, placebo-controlled trial of AMG 301, a pituitary adenylate cyclase-activating polypeptide PAC1 receptor monoclonal antibody for migraine prevention

(2020) Messoud Ashina et al.   CEPHALALGIA

Fluorescent ligands for dopamine D2/D3 receptors

(2020) Anni Allikalt et al.   Scientific Reports

Pharmacologic Characterization of ALD1910, a Potent Humanized Monoclonal Antibody against the Pituitary Adenylate Cyclase Activating Peptide

(2019) Cristina Moldovan Loomis et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Internalized GPCRs as Potential Therapeutic Targets for the Management of Pain

(2019) Jeffri S. Retamal et al.   Frontiers in Molecular Neuroscience

Internalization of G-protein-coupled receptors: Implication in receptor function, physiology and diseases

(2018) Davide Calebiro et al.   BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM

β-Arrestin1 and 2 differentially regulate PACAP-induced PAC1 receptor signaling and trafficking

(2018) Yusuke Shintani et al.   PLoS One

Endosomal signaling of the receptor for calcitonin gene-related peptide mediates pain transmission

(2017) Rebecca E. Yarwood et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

GPCR-G Protein-β-Arrestin Super-Complex Mediates Sustained G Protein Signaling

(2016) Alex R.B. Thomsen et al.   CELL

G Protein-Coupled Receptor Endosomal Signaling and Regulation of Neuronal Excitability and Stress Responses: Signaling Options and Lessons From the PAC1 Receptor

(2016) Victor May et al.   JOURNAL OF CELLULAR PHYSIOLOGY

A structure–function study of PACAP using conformationally restricted analogs: Identification of PAC1 receptor-selective PACAP agonists

(2015) Irene Ramos-Álvarez et al.   PEPTIDES

PACAP-induced ERK activation in HEK cells expressing PAC1 receptors involves both receptor internalization and PKC signaling

(2014) Victor May et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Receptor activity-modifying protein-dependent effects of mutations in the calcitonin receptor-like receptor: implications for adrenomedullin and calcitonin gene-related peptide pharmacology

(2013) H A Watkins et al.   BRITISH JOURNAL OF PHARMACOLOGY

PACAP receptor pharmacology and agonist bias: analysis in primary neurons and glia from the trigeminal ganglia and transfected cells

(2013) C S Walker et al.   BRITISH JOURNAL OF PHARMACOLOGY

Pituitary Adenylate Cyclase 1 Receptor Internalization and Endosomal Signaling Mediate the Pituitary Adenylate Cyclase Activating Polypeptide-Induced Increase in Guinea Pig Cardiac Neuron Excitability

(2013) L. A. Merriam et al.   JOURNAL OF NEUROSCIENCE

Alternative Splicing of the Pituitary Adenylate Cyclase-Activating Polypeptide Receptor PAC1: Mechanisms of Fine Tuning of Brain Activity

(2013) Janna Blechman et al.   Frontiers in Endocrinology

Receptor-independent cellular uptake of pituitary adenylate cyclase-activating polypeptide

(2012) Ngoc-Duc Doan et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Pharmacology and functions of receptors for vasoactive intestinal peptide and pituitary adenylate cyclase-activating polypeptide: IUPHAR Review 1

(2012) Anthony J Harmar et al.   BRITISH JOURNAL OF PHARMACOLOGY

Molecular mechanism and physiological functions of clathrin-mediated endocytosis

(2011) Harvey T. McMahon et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

VIP and PACAP: recent insights into their functions/roles in physiology and disease from molecular and genetic studies

(2011) Terry W Moody et al.   Current Opinion in Endocrinology Diabetes and Obesity

Pituitary Adenylate Cyclase-activating Polypeptide (PACAP)/PAC1HOP1 Receptor Activation Coordinates Multiple Neurotrophic Signaling Pathways

(2010) Victor May et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

VPAC receptor mediated tumor cell targeting by protamine based nanoparticles

(2010) Anna Ortner et al.   JOURNAL OF DRUG TARGETING