Efficacy and safety of adjunctive padsevonil in adults with drug‐resistant focal epilepsy: Results from two double‐blind, randomized, placebo‐controlled trials

Functional characterization of the antiepileptic drug candidate, padsevonil, on GABA A receptors

(2020) Isabelle Niespodziany et al.   EPILEPSIA

Effect of lifetime antiepileptic drug treatment history on efficacy and tolerability of adjunctive brivaracetam in adults with focal seizures: post-hoc analysis of a randomized, placebo-controlled trial

(2020) Pavel Klein et al.   EPILEPSY RESEARCH

Pharmacological Profile of the Novel Antiepileptic Drug Candidate Padsevonil: Characterization in Rodent Seizure and Epilepsy Models

(2019) Karine Leclercq et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Pharmacological Profile of the Novel Antiepileptic Drug Candidate Padsevonil: Interactions with Synaptic Vesicle 2 Proteins and the GABAA Receptor

(2019) Martyn Wood et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Safety and efficacy of adjunctive cenobamate (YKP3089) in patients with uncontrolled focal seizures: a multicentre, double-blind, randomised, placebo-controlled, dose-response trial

(2019) Gregory L Krauss et al.   LANCET NEUROLOGY

The Benzodiazepine Binding Sites of GABA A Receptors

(2018) Erwin Sigel et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Treatment Outcomes in Patients With Newly Diagnosed Epilepsy Treated With Established and New Antiepileptic Drugs

(2018) Zhibin Chen et al.   JAMA Neurology

The Burden of Severely Drug-Refractory Epilepsy: A Comparative Longitudinal Evaluation of Mortality, Morbidity, Resource Use, and Cost Using German Health Insurance Data

(2017) Adam Strzelczyk et al.   Frontiers in Neurology

What can we do for people with drug-resistant epilepsy?

(2016) Jerome Engel   NEUROLOGY

Clobazam: A Safe, Efficacious, and Newly Rediscovered Therapeutic for Epilepsy

(2015) Angela C. Gauthier et al.   CNS Neuroscience & Therapeutics

The consequences of refractory epilepsy and its treatment

(2014) Kenneth D. Laxer et al.   EPILEPSY & BEHAVIOR

Clobazam and Its Active Metabolite N-desmethylclobazam Display Significantly Greater Affinities for α2- versus α1-GABAA–Receptor Complexes

(2014) Henrik Sindal Jensen et al.   PLoS One

Pharmacoresistant epilepsy: Unmet needs in solving the puzzle(s)

(2013) Donald F. Weaver et al.   EPILEPSIA

Adjunctive perampanel for refractory partial-onset seizures: Randomized phase III study 304

(2012) J. A. French et al.   NEUROLOGY

Patterns of treatment response in newly diagnosed epilepsy

(2012) M. J. Brodie et al.   NEUROLOGY

Examining the Clinical Utility of Lacosamide

(2010) Steve Chung et al.   CNS DRUGS