Functional characterization of the antiepileptic drug candidate, padsevonil, on GABA A receptors

Pharmacological Profile of the Novel Antiepileptic Drug Candidate Padsevonil: Characterization in Rodent Seizure and Epilepsy Models

(2019) Karine Leclercq et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Pharmacological Profile of the Novel Antiepileptic Drug Candidate Padsevonil: Interactions with Synaptic Vesicle 2 Proteins and the GABAA Receptor

(2019) Martyn Wood et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

GABA A receptor: Positive and negative allosteric modulators

(2018) Richard W. Olsen   NEUROPHARMACOLOGY

The Benzodiazepine Binding Sites of GABA A Receptors

(2018) Erwin Sigel et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Evidence for a differential interaction of brivaracetam and levetiracetam with the synaptic vesicle 2A protein

(2016) Martyn D. Wood et al.   EPILEPSIA

Single dose efficacy evaluation of two partial benzodiazepine receptor agonists in photosensitive epilepsy patients: A placebo-controlled pilot study

(2016) Dorothée G.A. Kasteleijn-Nolst Trenité et al.   EPILEPSY RESEARCH

Deconstructing tolerance with clobazam

(2016) Barry E. Gidal et al.   NEUROLOGY

Clobazam: A Safe, Efficacious, and Newly Rediscovered Therapeutic for Epilepsy

(2015) Angela C. Gauthier et al.   CNS Neuroscience & Therapeutics

Seizure-related regulation of GABAA receptors in spontaneously epileptic rats

(2015) Marco I. González et al.   NEUROBIOLOGY OF DISEASE

Comprehensive overview: efficacy, tolerability, and cost-effectiveness of clobazam in Lennox–Gastaut syndrome

(2015) Michele Faulkner   Therapeutics and Clinical Risk Management

Brivaracetam Differentially Affects Voltage-Gated Sodium Currents Without Impairing Sustained Repetitive Firing in Neurons

(2014) Isabelle Niespodziany et al.   CNS Neuroscience & Therapeutics

Stable dosages of clobazam for Lennox-Gastaut syndrome are associated with sustained drop-seizure and total-seizure improvements over 3 years

(2014) Joan A. Conry et al.   EPILEPSIA

Modulation of the conformational state of the SV2A protein by an allosteric mechanism as evidenced by ligand binding assays

(2013) V Daniels et al.   BRITISH JOURNAL OF PHARMACOLOGY

The Pharmacology of Imepitoin: The First Partial Benzodiazepine Receptor Agonist Developed for the Treatment of Epilepsy

(2013) Chris Rundfeldt et al.   CNS DRUGS

Structure, Function, and Modulation of GABAAReceptors

(2012) Erwin Sigel et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Synchronization and desynchronization in epilepsy: controversies and hypotheses

(2012) Premysl Jiruska et al.   JOURNAL OF PHYSIOLOGY-LONDON

Beyond classical benzodiazepines: novel therapeutic potential of GABAA receptor subtypes

(2011) Uwe Rudolph et al.   NATURE REVIEWS DRUG DISCOVERY

Enhancement of GABAA-current run-down in the hippocampus occurs at the first spontaneous seizure in a model of temporal lobe epilepsy

(2010) M. Mazzuferi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Benefit of combination therapy in epilepsy: A review of the preclinical evidence with levetiracetam

(2008) Rafal M. Kaminski et al.   EPILEPSIA

International Union of Pharmacology. LXX. Subtypes of  -Aminobutyric AcidA Receptors: Classification on the Basis of Subunit Composition, Pharmacology, and Function. Update

(2008) R. W. Olsen et al.   PHARMACOLOGICAL REVIEWS