Review
Medical Laboratory Technology
Priyanila Magesh, Sanu Thankachan, Thejaswini Venkatesh, Padmanaban S. Suresh
Summary: The fibroblasts in the breast tumor microenvironment are crucial for tumor progression and metastasis, as they provide energy to adjacent cancer cells through metabolic reprogramming and secrete growth factors to promote tumor growth and dissemination. Identifying effective strategies to target the reprogrammed metabolism and communication between fibroblasts and cancer cells could lead to promising anti-cancer therapeutics.
CLINICA CHIMICA ACTA
(2021)
Review
Biochemistry & Molecular Biology
Laura A. Wengert, Sarah J. Backe, Dimitra Bourboulia, Mehdi Mollapour, Mark R. Woodford
Summary: Mitochondrial function relies on molecular chaperones, including heat shock proteins (Hsps) such as Hsp90 and its chaperone TNF-receptor-associated protein-1 (TRAP1). TRAP1, primarily localized in mitochondria, plays a crucial role in cellular metabolic reprogramming and mitochondrial apoptosis. Upregulation of TRAP1 promotes the growth of cancer cells by enhancing glycolytic metabolism and inhibiting mitochondrial permeability transition, while attenuation of TRAP1 induces apoptosis in cancer cells. Furthermore, TRAP1 is subject to post-translational modifications that regulate its function and downstream effectors.
Review
Oncology
Sayani Patra, Naveed Elahi, Aaron Armorer, Swathi Arunachalam, Joshua Omala, Iman Hamid, Anthony W. Ashton, David Joyce, Xuanmao Jiao, Richard G. Pestell
Summary: Recent studies have shown that metabolic heterogeneity occurs at various levels within tumors, impacting tumor progression and response to treatment. Understanding the complex interactions between metabolic properties, oncogenes, and the tumor microenvironment is crucial for developing more effective personalized treatments for cancer patients.
FRONTIERS IN ONCOLOGY
(2021)
Review
Oncology
Seyedeh Sahar Mortazavi Farsani, Vivek Verma
Summary: New research reveals that not only cancer cells but also other cell types, including immune cells, exhibit the Warburg effect, converting glucose to lactate even in the presence of sufficient oxygen. Lactate plays a crucial role in metabolism and cell signaling, but high levels can inhibit immune cell function.
FRONTIERS IN ONCOLOGY
(2023)
Article
Cell Biology
Artemis Michail, Dimitrios Gkikas, Dimitris Stellas, Valeria Kaltezioti, Panagiotis K. Politis
Summary: Prox1 acts as a negative regulator in breast cancer by suppressing tumor growth and metabolism, and its high expression is associated with favorable prognosis. It exerts its anti-tumor effects by directly regulating c-Myc transcription and downstream genes, making it a potential therapeutic gene for breast cancer.
Editorial Material
Biochemistry & Molecular Biology
Madhulika Tripathi, Brijesh Kumar Singh
Summary: Orphan nuclear receptor estrogen-related receptor alpha (ERR alpha) plays a crucial role in regulating energy metabolism, but its hyperactivation in breast cancer leads to cell migration, proliferation, and tumour development. The study by Brindisi et al. reveals that cholesterol can activate ERR alpha endogenously, promoting breast cancer aggressiveness, highlighting the potential anti-tumour effects of cholesterol-lowering drugs like statins.
Review
Cell Biology
Shuhei Kamada, Toshihiko Takeiwa, Kazuhiro Ikeda, Kuniko Horie, Satoshi Inoue
Summary: Metabolic alterations play a critical role in cancers, with recent studies highlighting the importance of mitochondria-related pathways in cancer biology, including OXPHOS. Understanding breast cancer-related metabolic alterations can aid in developing cancer drugs, with COX7RP, glutamine metabolism, ERR family nuclear receptors, and PGC-1 being key players in energy production and cancer metabolism.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Oncology
Yuan Yuan, Huanyao Gao, Yongxian Zhuang, Lixuan Wei, Jia Yu, Zhe Zhang, Lili Zhang, Liewei Wang
Summary: NDUFA4L2 has been identified as a new biomarker and potential therapeutic target for TR HER2-positive breast cancer patients, with its overexpression enhancing cancer cells' resistance to trastuzumab treatment.
THERAPEUTIC ADVANCES IN MEDICAL ONCOLOGY
(2021)
Article
Cell Biology
Carla Luis, Barbara Guerra-Carvalho, Patricia C. Braga, Carla Guedes, Emilia Patricio, Marco G. Alves, Ruben Fernandes, Raquel Soares
Summary: The present study aims to investigate the impact of adipose tissue on metabolic impairment in breast cancer molecular subtypes. By exposing breast cancer cell lines representing different molecular subtypes to mature adipocyte secretome, distinct metabolic patterns were observed, with HER2+ cell lines showing similar metabolism compared to luminal A and triple negative cell lines, indicating molecular subtype-specific alterations in central metabolism.
Review
Oncology
Adrian Casas-Benito, Sonia Martinez-Herrero, Alfredo Martinez
Summary: Approximately a century ago, Otto Warburg discovered that cancer cells use a different metabolism called aerobic glycolysis or the Warburg effect. This metabolism allows cancer cells to produce more ATP and promotes cancer progression. Succinate, a Krebs cycle intermediate, has been found to have protumoral functions in cancer and could be a potential target for cancer therapy. However, further research is needed to explore its potential in cancer prevention and treatment.
Article
Cell Biology
Merve Kulbay, Bruno Johnson, Guillaume Ricaud, Marie-Noelle Seguin-Grignon, Jacques Bernier
Summary: This study reveals that DFF40 may regulate cell metabolism and mitochondrial integrity during cell death. DFF40-deficient cells exhibit increased resistance to apoptosis and display the Warburg effect phenotype. Additionally, DFF40 can translocate to the mitochondria following apoptosis induction.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2022)
Article
Cell Biology
Ya Fan, Jia Wang, Yuemei Xu, Yipin Wang, Tao Song, Xiubin Liang, Feng Jin, Dongming Su
Summary: Our study showed that HRD1 overexpression decreased aerobic glycolysis, inhibited breast cancer cell proliferation and invasion. HRD1 interacted with PFKP in the cytoplasm, leading to ubiquitination and degradation of PFKP and ultimately reducing its expression and activity in breast cancer cells. HRD1 suppressed breast cancer growth and metastasis in vivo through a PFKP-dependent mechanism.
CELL COMMUNICATION AND SIGNALING
(2021)
Review
Oncology
Rohan Wedam, Yoshimi Endo Greer, David J. Wisniewski, Sarah Weltz, Manjari Kundu, Donna Voeller, Stanley Lipkowitz
Summary: Mitochondria, known as the powerhouse of the cell, play a crucial role in energy production and various functions in cells. It has been found that mitochondrial function is reprogrammed in breast cancers to promote tumor progression. Targeting mitochondria has become a focus in breast cancer research, and ClpP agonists have emerged as a novel class of mitochondria-targeting drugs with potential therapeutic benefits in breast cancer treatment.
Editorial Material
Endocrinology & Metabolism
Russel J. Reiter, Ramaswamy Sharma, Qiang Ma
Summary: The circadian melatonin rhythm plays an essential role in reducing the development of diseases such as solid tumors by controlling the metabolism of cancer cells, switching them from aerobic glycolysis to mitochondrial oxidative phosphorylation.
JOURNAL OF PINEAL RESEARCH
(2021)
Article
Medicine, Research & Experimental
Kateryna Tarhonska, Beata Janasik, Joanna Roszak, Kornelia Kowalczyk, Monika Lesicka, Edyta Reszka, Edyta Wieczorek, Marcin Braun, Agnieszka Kolacinska-Wow, Jaroslaw Skokowski, Leszek Kalinowski, Ewa Jablonska
Summary: The association between cadmium and the Warburg effect in breast cancer was suggested by an observational study, although not confirmed in vitro. However, cadmium seems to interfere with tamoxifen treatment, which deserves further investigation in terms of its possible implication in intrinsic resistance to hormone therapy.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Biochemistry & Molecular Biology
Neah Likhite, Vikas Yadav, Eric J. Milliman, Danesh H. Sopariwala, Sabina Lorca, Nithya P. Narayana, Megha Sheth, Erin L. Reineke, Vincent Giguere, Vihang Narkar
MOLECULAR AND CELLULAR BIOLOGY
(2019)
Article
Multidisciplinary Sciences
Masahiro Morita, Nadeem Siddiqui, Salde Katsumura, Christcpher Rouya, Ola Larsson, Takeshi Nagashima, Bahareh Hekrnatnejad, Akinori Takahashi, Hiroshi Kiyonari, Mengwei Zang, Rene St-Arnaud, Yuichi Oike, Vincent Giguere, Ivan Tcpisirovic, Maliko Okada-Hatakeyama, Tadashi Yamamoto, Nahum Sonenberg
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2019)
Article
Cell Biology
Mathieu Vernier, Catherine R. Dufour, Shawn McGuirk, Charlotte Scholtes, Xiaojing Li, Guillaume Bourmeau, Hellen Kuasne, Morag Park, Julie St-Pierre, Etienne Audet-Walsh, Vincent Giguere
GENES & DEVELOPMENT
(2020)
Review
Endocrinology & Metabolism
Mathieu Vernier, Vincent Giguere
Summary: Aging is a degenerative process caused by the accumulation of cellular and tissue lesions, with deregulated mitochondrial function being a central regulator. Research highlights the importance of the PGC-1/ERR axis in age-related mitochondrial deregulation and tissue dysfunction, suggesting pharmacological targeting of this axis may help alleviate the onset of aging and its adverse effects.
JOURNAL OF MOLECULAR ENDOCRINOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Mathieu Vernier, Shawn McGuirk, Catherine R. Dufour, Liangxinyi Wan, Etienne Audet-Walsh, Julie St-Pierre, Vincent Giguere
Review
Biochemistry & Molecular Biology
Charlotte Scholtes, Vincent Giguere
Summary: The article discusses the generation and role of reactive oxygen species, highlighting the estrogen-related receptors as master regulators of ROS metabolism, which can contribute to uncovering new therapeutic strategies.
Article
Multidisciplinary Sciences
Allan Tran, Charlotte Scholtes, Mario Songane, Claudia Champagne, Luc Galarneau, Marie-Pier Levasseur, Nassima Fodil, Catherine Rosa Dufour, Vincent Giguere, Maya Saleh
Summary: ERR alpha plays a protective role in the intestine by promoting disease tolerance through transcriptional control of key genes involved in intestinal tissue homeostasis and repair. Loss of ERR alpha leads to increased colon inflammation and tissue damage.
SCIENTIFIC REPORTS
(2021)
Article
Multidisciplinary Sciences
Mathieu Paquette, Ming Yan, Josue M. J. Ramirez-Reyes, Leeanna El-Houjeiri, Marco Biondini, Catherine R. Dufour, Hyeonju Jeong, Alain Pacis, Vincent Giguere, Jennifer L. Estall, Peter M. Siegel, Etienne Audet-Walsh, Arnim Pause
Summary: FLCN protein activity could be a promising target for small molecule drugs to treat liver fibrosis by specifically activating autophagy, promoting the degradation of intracellular lipid stores, ultimately resulting in reduced hepatocellular damage and inflammation. These results show an unexpected role for Flcn in fatty liver disease progression and highlight new potential treatment strategies.
SCIENTIFIC REPORTS
(2021)
Review
Cell Biology
Charlotte Scholtes, Vincent Giguere
Summary: Nuclear receptors are transcription factors that regulate metabolic genes by transducing hormonal, nutrient, metabolite, and redox signals. They play a central role in the transcriptional control of energy metabolism and maintain cellular energy homeostasis by adapting gene expression to changing energetic demands. Nuclear receptors must cooperate with other factors, integrate signals from key metabolic pathways, and synchronize their activities with the biological clock to orchestrate a large ensemble of input signals.
NATURE REVIEWS MOLECULAR CELL BIOLOGY
(2022)
Article
Cell Biology
Catherine R. Dufour, Charlotte Scholtes, Ming Yan, Yonghong Chen, Lingwei Han, Ting Li, Hui Xia, Qiyun Deng, Mathieu Vernier, Vincent Giguere
Summary: An increasing number of studies support the direct role of nuclear mTOR in gene regulation and chromatin structure. However, the limited knowledge of chromatin-bound mTOR partners restricts our understanding of how nuclear mTOR controls transcription. This study comprehensively maps the mTOR chromatin-bound interactome in prostate cancer cellular models and identifies a 67-protein interaction network enriched with chromatin modifiers, transcription factors, and SUMOylation machinery. SUMO2/3 and nuclear pore protein NUP210 are among the strongest interactors, while the androgen receptor (AR) is the dominant androgen-inducible mTOR partner. Further investigation reveals the role of NUP210 in mTOR nuclear trafficking, the functional transcriptional module formed by mTOR, AR, and the nucleosome remodeling and deacetylase (NuRD) complex, and the androgen-dependent mTOR-SUMO2/3 promoter-enhancer association.
Review
Endocrinology & Metabolism
Vincent Giguere, Ronald M. Evans
Summary: This review highlights the landmark discovery of the retinoic acid receptor (RAR) and subsequent studies that have enriched our understanding of the molecular mechanisms by which a low-abundant dietary compound is essential for life.
JOURNAL OF MOLECULAR ENDOCRINOLOGY
(2022)
Editorial Material
Endocrinology & Metabolism
Vincent Giguere
JOURNAL OF MOLECULAR ENDOCRINOLOGY
(2022)
Article
Oncology
Yonghong Chen, Catherine R. Dufour, Lingwei Han, Ting Li, Hui Xia, Vincent Giguere
Summary: Dysregulation of mTOR signaling is critical in promoting prostate cancer growth. This study reveals that mTOR interacts with and phosphorylates HOXB13, leading to the regulation of a specific gene program with oncogenic implications in prostate cancer. These findings uncover a previously unknown molecular cascade and provide a potential therapeutic avenue for advanced prostate cancer management.
MOLECULAR CANCER RESEARCH
(2023)
Article
Biochemical Research Methods
Charlotte Scholtes, Catherine R. Dufour, Vincent Giguere
Summary: RIME is a technique for studying protein complexes on chromatin, and this article describes the specific steps for RIME analysis in the LNCaP cell line.
Review
Oncology
Vincent Giguere
Article
Biochemistry & Molecular Biology
Maruf Hasan, Henry Reyer, Michael Oster, Nares Trakooljul, Siriluck Ponsuksilli, Elizabeth Magowan, Dagmar -Christiane Fischer, Klaus Wimmers
Summary: UVB exposure can increase the supply of vitamin D in pig husbandry and does not affect the growth performance of the pigs. After exposure, there are changes in gene expression in the liver, with the pathways for vitamin D synthesis being preferentially initiated.
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Zhen Wang, Shu-ying Yi, Yuan-ying Zhang, Yu-di Wang, Han-lin Chen, Yi-jie Guo, Xin-ming Wei, Du-xiao Yang
Summary: Vitamin D can reverse S1P-induced cell death and alleviate EAE symptoms by regulating S1P levels and related signaling pathways.
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
(2024)
Correction
Biochemistry & Molecular Biology
Haixiao Chen, Xing Ji, Xinhua Hu, Lihua Chen, Haiyan Lv, Chengyun Xu, Dun Hong, Ximei Wu
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
(2024)
