期刊
JOURNAL OF MOLECULAR ENDOCRINOLOGY
卷 66, 期 1, 页码 R1-R14出版社
BIOSCIENTIFICA LTD
DOI: 10.1530/JME-20-0196
关键词
aging; nuclear receptors; transcription factors; metabolism; mitochondrion
资金
- Canadian Institutes of Health Research [FDT156254]
- Fondation du cancer du sein du Quebec
- Terry Fox Research Institute
Aging is a degenerative process caused by the accumulation of cellular and tissue lesions, with deregulated mitochondrial function being a central regulator. Research highlights the importance of the PGC-1/ERR axis in age-related mitochondrial deregulation and tissue dysfunction, suggesting pharmacological targeting of this axis may help alleviate the onset of aging and its adverse effects.
Aging is a degenerative process that results from the accumulation of cellular and tissue lesions, leading progressively to organ dysfunction and death. Although the biological basis of human aging remains unclear, a large amount of data points to deregulated mitochondrial function as a central regulator of this process. Mounting years of research on aging support the notion that the engendered age-related decline of mitochondria is associated with alterations in key pathways that regulate mitochondrial biology. Particularly, several studies in the last decade have emphasized the importance of the estrogen-related receptor (ERR) family of nuclear receptors, master regulators of mitochondrial function, and their transcriptional coactivators PGC-1s in this context. In this review, we summarize key discoveries implicating the PGC-1/ERR axis in age-associated mitochondrial deregulation and tissue dysfunction. Also, we highlight the pharmacological potential of targeting the PGC-1/ERR axis to alleviate the onset of aging and its adverse effects.
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