The Hepatic Mitochondrial Pyruvate Carrier as a Regulator of Systemic Metabolism and a Therapeutic Target for Treating Metabolic Disease

Liver Zonation, Revisited

(2022) Jasmin Paris et al.   HEPATOLOGY

IL-6-induced FOXO1 activity determines the dynamics of metabolism in CD8 T cells cross-primed by liver sinusoidal endothelial cells

(2022) Michael Dudek et al.   Cell Reports

Paradoxical neuronal hyperexcitability in a mouse model of mitochondrial pyruvate import deficiency

(2022) Andres De La Rossa et al.   eLife

Identification of Novel Mitochondrial Pyruvate Carrier Inhibitors by Homology Modeling and Pharmacophore-Based Virtual Screening

(2022) Lamees Hegazy et al.   Biomedicines

Glutaminolysis is Essential for Myofibroblast Persistence and In Vivo Targeting Reverses Fibrosis and Cardiac Dysfunction in Heart Failure

(2022) Andrew A. Gibb et al.   CIRCULATION

Hepatic stellate cells in physiology and pathology

(2022) Dakota R. Kamm et al.   JOURNAL OF PHYSIOLOGY-LONDON

Key features of inhibitor binding to the human mitochondrial pyruvate carrier hetero-dimer

(2022) Sotiria Tavoulari et al.   Molecular Metabolism

Glutamine uptake and catabolism is required for myofibroblast formation and persistence

(2022) Andrew A. Gibb et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Dynamic Shifts in the Composition of Resident and Recruited Macrophages Influence Tissue Remodeling in NASH

(2021) Sabine Daemen et al.   Cell Reports

Development of Novel Mitochondrial Pyruvate Carrier Inhibitors to Treat Hair Loss

(2021) Xiaoguang Liu et al.   JOURNAL OF MEDICINAL CHEMISTRY

Novel insulin sensitizer MSDC-0602K improves insulinemia and fatty liver disease in mice, alone and in combination with liraglutide

(2021) Dakota R. Kamm et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Importance of Mitochondrial Pyruvate Carrier in Cancer Cell Metabolism and Tumorigenesis

(2021) Ainhoa Ruiz-Iglesias et al.   Cancers

Emerging therapeutic approaches for the treatment of NAFLD and type 2 diabetes mellitus

(2021) Daniel Ferguson et al.   Nature Reviews Endocrinology

Mitochondrial pyruvate carrier inhibitors improve metabolic parameters in diet-induced obese mice

(2021) Wesley T. Hodges et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification and characterization of novel MPC1 gene variants causing mitochondrial pyruvate carrier deficiency

(2021) Huafang Jiang et al.   JOURNAL OF INHERITED METABOLIC DISEASE

Transforming growth factor beta-1 upregulates glucose transporter 1 and glycolysis through canonical and noncanonical pathways in hepatic stellate cells

(2021) Ming-Yu Zhou et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Lactate supports a metabolic-epigenetic link in macrophage polarization

(2021) Jordan T. Noe et al.   Science Advances

Proline biosynthesis is a vent for TGFβ‐induced mitochondrial redox stress

(2020) Simon Schwörer et al.   EMBO JOURNAL

Regulations of Glycolytic Activities on Macrophages Functions in Tumor and Infectious Inflammation

(2020) Qing Yu et al.   Frontiers in Cellular and Infection Microbiology

NADPH and Glutathione Redox Link TCA Cycle Activity to Endoplasmic Reticulum Homeostasis

(2020) Erica R. Gansemer et al.   iScience

The Power of Plasticity—Metabolic Regulation of Hepatic Stellate Cells

(2020) Parth Trivedi et al.   Cell Metabolism

Wild-Type p53 Promotes Cancer Metabolic Switch by Inducing PUMA-Dependent Suppression of Oxidative Phosphorylation

(2019) Jinchul Kim et al.   CANCER CELL

Pyruvate-Carboxylase-Mediated Anaplerosis Promotes Antioxidant Capacity by Sustaining TCA Cycle and Redox Metabolism in Liver

(2019) David A. Cappel et al.   Cell Metabolism

The yeast mitochondrial pyruvate carrier is a hetero‐dimer in its functional state

(2019) Sotiria Tavoulari et al.   EMBO JOURNAL

Glucagon up‐regulates hepatic mitochondrial pyruvate carrier 1 through cAMP‐responsive element‐binding protein; inhibition of hepatic gluconeogenesis by ginsenoside Rb1

(2019) Meng‐Die Lou et al.   BRITISH JOURNAL OF PHARMACOLOGY

Impaired skeletal muscle mitochondrial pyruvate uptake rewires glucose metabolism to drive whole-body leanness

(2019) Arpit Sharma et al.   eLife

Disrupting Mitochondrial Pyruvate Uptake Directs Glutamine into the TCA Cycle away from Glutathione Synthesis and Impairs Hepatocellular Tumorigenesis

(2019) Sean C. Tompkins et al.   Cell Reports

Insulin sensitizer MSDC-0602K in non-alcoholic steatohepatitis: A randomized, double-blind, placebo-controlled phase IIb study

(2019) Stephen A. Harrison et al.   JOURNAL OF HEPATOLOGY

Mice deficient in pyruvate dehydrogenase kinase 4 are protected against acetaminophen-induced hepatotoxicity

(2019) Luqi Duan et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Pioglitazone improves hepatic mitochondrial function in a mouse model of nonalcoholic steatohepatitis

(2018) Srilaxmi Kalavalapalli et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Hedgehog-YAP Signaling Pathway Regulates Glutaminolysis to Control Activation of Hepatic Stellate Cells

(2018) Kuo Du et al.   GASTROENTEROLOGY

Uncoupling proteins 1 and 2 (UCP1 and UCP2) fromArabidopsis thalianaare mitochondrial transporters of aspartate, glutamate, and dicarboxylates

(2018) Magnus Monné et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Peroxisome Proliferator-Activated Receptor γ and Its Role in Adipocyte Homeostasis and Thiazolidinedione-Mediated Insulin Sensitization

(2018) Qiong A. Wang et al.   MOLECULAR AND CELLULAR BIOLOGY

Interruption of lactate uptake by inhibiting mitochondrial pyruvate transport unravels direct antitumor and radiosensitizing effects

(2018) Cyril Corbet et al.   Nature Communications

Human mitochondrial pyruvate carrier 2 as an autonomous membrane transporter

(2018) Raghavendra Sashi Krishna Nagampalli et al.   Scientific Reports

Identifying off-target effects of etomoxir reveals that carnitine palmitoyltransferase I is essential for cancer cell proliferation independent of β-oxidation

(2018) Cong-Hui Yao et al.   PLOS BIOLOGY

The beneficial metabolic effects of insulin sensitizers are not attenuated by mitochondrial pyruvate carrier 2 hypomorphism

(2017) Patrick A. Vigueira et al.   EXPERIMENTAL PHYSIOLOGY

Targeting the mitochondrial pyruvate carrier attenuates fibrosis in a mouse model of nonalcoholic steatohepatitis

(2017) Kyle S. McCommis et al.   HEPATOLOGY

Glutaminolysis is required for transforming growth factor-β1–induced myofibroblast differentiation and activation

(2017) Karen Bernard et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of hepatic stellate cell proliferation and activation by glutamine metabolism

(2017) Jiang Li et al.   PLoS One

The mitochondrial pyruvate carrier mediates high fat diet-induced increases in hepatic TCA cycle capacity

(2017) Adam J. Rauckhorst et al.   Molecular Metabolism

The anti-tumour agent lonidamine is a potent inhibitor of the mitochondrial pyruvate carrier and plasma membrane monocarboxylate transporters

(2016) B. Nancolas et al.   BIOCHEMICAL JOURNAL

Discoveries, metabolic roles and diseases of mitochondrial carriers: A review

(2016) Ferdinando Palmieri et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Metabolic Reprogramming Mediated by the mTORC2-IRF4 Signaling Axis Is Essential for Macrophage Alternative Activation

(2016) Stanley Ching-Cheng Huang et al.   IMMUNITY

Requirement for the Mitochondrial Pyruvate Carrier in Mammalian Development Revealed by a Hypomorphic Allelic Series

(2016) Caitlyn E. Bowman et al.   MOLECULAR AND CELLULAR BIOLOGY

Establishment of mitochondrial pyruvate carrier 1 (MPC1) gene knockout mice with preliminary gene function analyses

(2016) Xiaoli Li et al.   Oncotarget

Embryonic Lethality of Mitochondrial Pyruvate Carrier 1 Deficient Mouse Can Be Rescued by a Ketogenic Diet

(2016) Benoît Vanderperre et al.   PLoS Genetics

Hepatic Mitochondrial Pyruvate Carrier 1 Is Required for Efficient Regulation of Gluconeogenesis and Whole-Body Glucose Homeostasis

(2015) Lawrence R. Gray et al.   Cell Metabolism

Loss of Mitochondrial Pyruvate Carrier 2 in the Liver Leads to Defects in Gluconeogenesis and Compensation via Pyruvate-Alanine Cycling

(2015) Kyle S. McCommis et al.   Cell Metabolism

Pro-inflammatory Macrophages Sustain Pyruvate Oxidation through Pyruvate Dehydrogenase for the Synthesis of Itaconate and to Enable Cytokine Expression

(2015) Johannes Meiser et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mitochondrial metabolism mediates oxidative stress and inflammation in fatty liver

(2015) Santhosh Satapati et al.   JOURNAL OF CLINICAL INVESTIGATION

Monitoring Mitochondrial Pyruvate Carrier Activity in Real Time Using a BRET-Based Biosensor: Investigation of the Warburg Effect

(2015) Vincent Compan et al.   MOLECULAR CELL

An Evaluation of MSDC-0160, A Prototype mTOT Modulating Insulin Sensitizer, in Patients with Mild Alzheimer’s Disease

(2014) Raj Shah et al.   Current Alzheimer Research

Glutamine Oxidation Maintains the TCA Cycle and Cell Survival during Impaired Mitochondrial Pyruvate Transport

(2014) Chendong Yang et al.   MOLECULAR CELL

UCP2 transports C4 metabolites out of mitochondria, regulating glucose and glutamine oxidation

(2014) A. Vozza et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitochondrial Pyruvate Carrier 2 Hypomorphism in Mice Leads to Defects in Glucose-Stimulated Insulin Secretion

(2014) Patrick A. Vigueira et al.   Cell Reports

Clinical Proof-of-Concept Study With MSDC-0160, a Prototype mTOT-Modulating Insulin Sensitizer

(2013) J R Colca et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Identification of a Mitochondrial Target of Thiazolidinedione Insulin Sensitizers (mTOT)—Relationship to Newly Identified Mitochondrial Pyruvate Carrier Proteins

(2013) Jerry R. Colca et al.   PLoS One

Thiazolidinediones are acute, specific inhibitors of the mitochondrial pyruvate carrier

(2013) A. S. Divakaruni et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Efficient Hepatic Delivery of Drugs: Novel Strategies and Their Significance

(2013) Nidhi Mishra et al.   Biomed Research International

Insulin Resistance and Metabolic Derangements in Obese Mice Are Ameliorated by a Novel Peroxisome Proliferator-activated Receptor γ-sparing Thiazolidinedione

(2012) Zhouji Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Elevated TCA cycle function in the pathology of diet-induced hepatic insulin resistance and fatty liver

(2012) Santhosh Satapati et al.   JOURNAL OF LIPID RESEARCH

Identification and Functional Expression of the Mitochondrial Pyruvate Carrier

(2012) S. Herzig et al.   SCIENCE

A Mitochondrial Pyruvate Carrier Required for Pyruvate Uptake in Yeast, Drosophila, and Humans

(2012) D. K. Bricker et al.   SCIENCE

Thiazolidinediones on PPARγ: The Roles in Bone Remodeling

(2011) Wei Wei et al.   PPAR Research