Mitochondrial pyruvate carrier inhibitors improve metabolic parameters in diet-induced obese mice
出版年份 2021 全文链接
标题
Mitochondrial pyruvate carrier inhibitors improve metabolic parameters in diet-induced obese mice
作者
关键词
mitochondrial metabolism, pyruvate, diabetes, gluconeogenesis, metabolic disease
出版物
JOURNAL OF BIOLOGICAL CHEMISTRY
Volume 298, Issue 2, Pages 101554
出版商
Elsevier BV
发表日期
2021-12-30
DOI
10.1016/j.jbc.2021.101554
参考文献
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- Inhibition of pyruvate oxidation as a versatile stimulator of the hair cycle in models of alopecia
- (2021) Aimee Flores et al. EXPERIMENTAL DERMATOLOGY
- Novel insulin sensitizer MSDC-0602K improves insulinemia and fatty liver disease in mice, alone and in combination with liraglutide
- (2021) Dakota R. Kamm et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Skyline for Small Molecules: A Unifying Software Package for Quantitative Metabolomics
- (2020) Kendra J. Adams et al. JOURNAL OF PROTEOME RESEARCH
- Mitochondrial pyruvate carrier is required for optimal brown fat thermogenesis
- (2020) Vanja Panic et al. eLife
- Blocking mitochondrial pyruvate import in brown adipocytes induces energy wasting via lipid cycling
- (2020) Michaela Veliova et al. EMBO REPORTS
- Impaired skeletal muscle mitochondrial pyruvate uptake rewires glucose metabolism to drive whole-body leanness
- (2019) Arpit Sharma et al. eLife
- Insulin sensitizer MSDC-0602K in non-alcoholic steatohepatitis: A randomized, double-blind, placebo-controlled phase IIb study
- (2019) Stephen A. Harrison et al. JOURNAL OF HEPATOLOGY
- Interruption of lactate uptake by inhibiting mitochondrial pyruvate transport unravels direct antitumor and radiosensitizing effects
- (2018) Cyril Corbet et al. Nature Communications
- The beneficial metabolic effects of insulin sensitizers are not attenuated by mitochondrial pyruvate carrier 2 hypomorphism
- (2017) Patrick A. Vigueira et al. EXPERIMENTAL PHYSIOLOGY
- Targeting the mitochondrial pyruvate carrier attenuates fibrosis in a mouse model of nonalcoholic steatohepatitis
- (2017) Kyle S. McCommis et al. HEPATOLOGY
- The mitochondrial pyruvate carrier mediates high fat diet-induced increases in hepatic TCA cycle capacity
- (2017) Adam J. Rauckhorst et al. Molecular Metabolism
- Requirement for the Mitochondrial Pyruvate Carrier in Mammalian Development Revealed by a Hypomorphic Allelic Series
- (2016) Caitlyn E. Bowman et al. MOLECULAR AND CELLULAR BIOLOGY
- An ancestral role for the mitochondrial pyruvate carrier in glucose-stimulated insulin secretion
- (2016) Kyle S. McCommis et al. Molecular Metabolism
- Mitochondrial pyruvate transport: a historical perspective and future research directions
- (2015) Kyle S. McCommis et al. BIOCHEMICAL JOURNAL
- Hepatic Mitochondrial Pyruvate Carrier 1 Is Required for Efficient Regulation of Gluconeogenesis and Whole-Body Glucose Homeostasis
- (2015) Lawrence R. Gray et al. Cell Metabolism
- Loss of Mitochondrial Pyruvate Carrier 2 in the Liver Leads to Defects in Gluconeogenesis and Compensation via Pyruvate-Alanine Cycling
- (2015) Kyle S. McCommis et al. Cell Metabolism
- Monitoring Mitochondrial Pyruvate Carrier Activity in Real Time Using a BRET-Based Biosensor: Investigation of the Warburg Effect
- (2015) Vincent Compan et al. MOLECULAR CELL
- Mitochondrial Metabolism of Pyruvate Is Essential for Regulating Glucose-stimulated Insulin Secretion
- (2014) Jessica N. Patterson et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Antitumor Activity of 7-Aminocarboxycoumarin Derivatives, a New Class of Potent Inhibitors of Lactate Influx but Not Efflux
- (2014) N. Draoui et al. MOLECULAR CANCER THERAPEUTICS
- A High-Throughput Fluorimetric Assay for 2-Hydroxyglutarate Identifies Zaprinast as a Glutaminase Inhibitor
- (2014) A. Elhammali et al. Cancer Discovery
- Mitochondrial Pyruvate Carrier 2 Hypomorphism in Mice Leads to Defects in Glucose-Stimulated Insulin Secretion
- (2014) Patrick A. Vigueira et al. Cell Reports
- Inhibition of Mitochondrial Pyruvate Transport by Zaprinast Causes Massive Accumulation of Aspartate at the Expense of Glutamate in the Retina
- (2013) Jianhai Du et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Topoisomerase IV-quinolone interactions are mediated through a water-metal ion bridge: mechanistic basis of quinolone resistance
- (2013) Katie J. Aldred et al. NUCLEIC ACIDS RESEARCH
- Identification of a Mitochondrial Target of Thiazolidinedione Insulin Sensitizers (mTOT)—Relationship to Newly Identified Mitochondrial Pyruvate Carrier Proteins
- (2013) Jerry R. Colca et al. PLoS One
- Thiazolidinediones are acute, specific inhibitors of the mitochondrial pyruvate carrier
- (2013) A. S. Divakaruni et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Insulin Resistance and Metabolic Derangements in Obese Mice Are Ameliorated by a Novel Peroxisome Proliferator-activated Receptor γ-sparing Thiazolidinedione
- (2012) Zhouji Chen et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Identification and Functional Expression of the Mitochondrial Pyruvate Carrier
- (2012) S. Herzig et al. SCIENCE
- A Mitochondrial Pyruvate Carrier Required for Pyruvate Uptake in Yeast, Drosophila, and Humans
- (2012) D. K. Bricker et al. SCIENCE
- cGMP phosphodiesterase inhibition improves the vascular and metabolic actions of insulin in skeletal muscle
- (2011) A. J. Genders et al. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
- Quinolone-induced Hypoglycemia: A Life-threatening but Potentially Reversible Side Effect
- (2010) Theodoros Kelesidis et al. AMERICAN JOURNAL OF MEDICINE
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