Proline biosynthesis is a vent for TGFβ‐induced mitochondrial redox stress

mTORC1 amplifies the ATF4-dependent de novo serine-glycine pathway to supply glycine during TGF-β1–induced collagen biosynthesis

(2019) Brintha Selvarajah et al.   Science Signaling

Metformin alleviates bleomycin-induced pulmonary fibrosis in rats: Pharmacological effects and molecular mechanisms

(2018) Nanda Gamad et al.   BIOMEDICINE & PHARMACOTHERAPY

Rewiring of Glutamine Metabolism Is a Bioenergetic Adaptation of Human Cells with Mitochondrial DNA Mutations

(2018) Qiuying Chen et al.   Cell Metabolism

Metformin reverses established lung fibrosis in a bleomycin model

(2018) Sunad Rangarajan et al.   NATURE MEDICINE

Metformin selectively targets redox control of complex I energy transduction

(2018) Amy R. Cameron et al.   Redox Biology

Quantifying intracellular rates of glycolytic and oxidative ATP production and consumption using extracellular flux measurements

(2017) Shona A. Mookerjee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Glutaminolysis is required for transforming growth factor-β1–induced myofibroblast differentiation and activation

(2017) Karen Bernard et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A genetically encoded tool for manipulation of NADP+/NADPH in living cells

(2017) Valentin Cracan et al.   Nature Chemical Biology

Proline Starvation Induces Unresolved ER Stress and Hinders mTORC1-Dependent Tumorigenesis

(2016) Nisebita Sahu et al.   Cell Metabolism

Amino Acids Rather than Glucose Account for the Majority of Cell Mass in Proliferating Mammalian Cells

(2016) Aaron M. Hosios et al.   DEVELOPMENTAL CELL

Profibrotic up-regulation of glucose transporter 1 by TGF-β involves activation of MEK and mammalian target of rapamycin complex 2 pathways

(2016) Mahefatiana Andrianifahanana et al.   FASEB JOURNAL

Transforming Growth Factor (TGF)-β Promotesde NovoSerine Synthesis for Collagen Production

(2016) Recep Nigdelioglu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tumour-specific proline vulnerability uncovered by differential ribosome codon reading

(2016) Fabricio Loayza-Puch et al.   NATURE

Glutathione biosynthesis is a metabolic vulnerability in PI(3)K/Akt-driven breast cancer

(2016) Evan C. Lien et al.   NATURE CELL BIOLOGY

Complementation of mitochondrial electron transport chain by manipulation of the NAD+/NADH ratio

(2016) D. V. Titov et al.   SCIENCE

An Essential Role of the Mitochondrial Electron Transport Chain in Cell Proliferation Is to Enable Aspartate Synthesis

(2015) Kıvanç Birsoy et al.   CELL

Supporting Aspartate Biosynthesis Is an Essential Function of Respiration in Proliferating Cells

(2015) Lucas B. Sullivan et al.   CELL

ROS Function in Redox Signaling and Oxidative Stress

(2014) Michael Schieber et al.   CURRENT BIOLOGY

Oxidation of Alpha-Ketoglutarate Is Required for Reductive Carboxylation in Cancer Cells with Mitochondrial Defects

(2014) Andrew R. Mullen et al.   Cell Reports

Expression of cilium-associated genes defines novel molecular subtypes of idiopathic pulmonary fibrosis

(2013) Ivana V Yang et al.   THORAX

IsoCor: correcting MS data in isotope labeling experiments

(2012) P. Millard et al.   BIOINFORMATICS

Proline dehydrogenase is essential for proline protection against hydrogen peroxide-induced cell death

(2012) Sathish Kumar Natarajan et al.   FREE RADICAL BIOLOGY AND MEDICINE

TGFβ signalling in context

(2012) Joan Massagué   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Functional Specialization in Proline Biosynthesis of Melanoma

(2012) Jessica De Ingeniis et al.   PLoS One

Cellular Metabolic Stress: Considering How Cells Respond to Nutrient Excess

(2010) Kathryn E. Wellen et al.   MOLECULAR CELL

Inhibitors of the Mitochondrial Citrate Transport Protein: Validation of the Role of Substrate Binding Residues and Discovery of the First Purely Competitive Inhibitor

(2009) S. Aluvila et al.   MOLECULAR PHARMACOLOGY

c-Myc suppression of miR-23a/b enhances mitochondrial glutaminase expression and glutamine metabolism

(2009) Ping Gao et al.   NATURE

The iron-sulfur clusters of dehydratases are primary intracellular targets of copper toxicity

(2009) L. Macomber et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

(2009) M. G. Vander Heiden et al.   SCIENCE

How mitochondria produce reactive oxygen species

(2008) Michael P. Murphy   BIOCHEMICAL JOURNAL

Histone 2B (H2B) Expression Is Confined to a Proper NAD+/NADH Redox Status

(2008) Ru-Ping Dai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Real-time imaging of the intracellular glutathione redox potential

(2008) Marcus Gutscher et al.   NATURE METHODS

Kinetic flux profiling for quantitation of cellular metabolic fluxes

(2008) Jie Yuan et al.   Nature Protocols

Myc regulates a transcriptional program that stimulates mitochondrial glutaminolysis and leads to glutamine addiction

(2008) D. R. Wise et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PERSPECTIVE ARTICLE: Growth factors and cytokines in wound healing

(2008) Stephan Barrientos et al.   WOUND REPAIR AND REGENERATION

Proline modulates the intracellular redox environment and protects mammalian cells against oxidative stress

(2007) Navasona Krishnan et al.   FREE RADICAL BIOLOGY AND MEDICINE

DuplicatedP5CSgenes of Arabidopsis play distinct roles in stress regulation and developmental control of proline biosynthesis

(2007) Gyöngyi Székely et al.   PLANT JOURNAL