UCHL1 provides diagnostic and antimetastatic strategies due to its deubiquitinating effect on HIF-1α

Non-terminal respiratory unit type lung adenocarcinoma has three distinct subtypes and is associated with poor prognosis

(2014) Shinji Sumiyoshi et al.   LUNG CANCER

Unique DNA Methylation Loci Distinguish Anatomic Site and HPV Status in Head and Neck Squamous Cell Carcinoma

(2013) R. A. Lleras et al.   CLINICAL CANCER RESEARCH

Stromal plasma cells expressing immunoglobulin G4 subclass in non–small cell lung cancer

(2013) Masakazu Fujimoto et al.   HUMAN PATHOLOGY

Prognostic relevance of ubiquitin C-terminal hydrolase L1 (UCH-L1) mRNA and protein expression in breast cancer patients

(2013) Christine Schröder et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

Frequent CpG methylation of ubiquitin carboxyl-terminal hydrolase 1 (UCHL1) in sporadic and hereditary Tunisian breast cancer patients: clinical significance

(2013) Fatma Trifa et al.   MEDICAL ONCOLOGY

Ubiquitin C-Terminal Hydrolase-L1 Potentiates Cancer Chemosensitivity by Stabilizing NOXA

(2013) Kerstin Brinkmann et al.   Cell Reports

Ubiquitin C-terminal hydrolase-L1 interacts with adhesion complexes and promotes cell migration, survival, and anchorage independent growth

(2012) Teresa Frisan et al.   FASEB JOURNAL

Involvement of decreased hypoxia-inducible factor 1 activity and resultant G1–S cell cycle transition in radioresistance of perinecrotic tumor cells

(2012) Y Zhu et al.   ONCOGENE

Molecular mechanisms mediating metastasis of hypoxic breast cancer cells

(2012) Gregg L. Semenza   TRENDS IN MOLECULAR MEDICINE

Hypoxia-inducible factors: mediators of cancer progression and targets for cancer therapy

(2012) Gregg L. Semenza   TRENDS IN PHARMACOLOGICAL SCIENCES

Cancer cells that survive radiation therapy acquire HIF-1 activity and translocate towards tumour blood vessels

(2012) Hiroshi Harada et al.   Nature Communications

UCH-L1 promotes cancer metastasis in prostate cancer cells through EMT induction

(2011) Min Jung Jang et al.   CANCER LETTERS

A Perspective on Cancer Cell Metastasis

(2011) C. L. Chaffer et al.   SCIENCE

The Tumor Suppressor UCHL1 Forms a Complex with p53/MDM2/ARF to Promote p53 Signaling and Is Frequently Silenced in Nasopharyngeal Carcinoma

(2010) L. Li et al.   CLINICAL CANCER RESEARCH

The de-ubiquitinase UCH-L1 is an oncogene that drives the development of lymphoma in vivo by deregulating PHLPP1 and Akt signaling

(2010) S Hussain et al.   LEUKEMIA

PrognoScan: a new database for meta-analysis of the prognostic value of genes

(2009) Hideaki Mizuno et al.   BMC Medical Genomics

The intravenous anesthetics barbiturates inhibit hypoxia-inducible factor 1 activation

(2009) Takuhiko Wakamatsu et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Defining the role of hypoxia-inducible factor 1 in cancer biology and therapeutics

(2009) G L Semenza   ONCOGENE

The Akt/mTOR Pathway Assures the Synthesis of HIF-1α Protein in a Glucose- and Reoxygenation-dependent Manner in Irradiated Tumors

(2008) Hiroshi Harada et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ubiquitin C-terminal hydrolase-L1 is a key regulator of tumor cell invasion and metastasis

(2008) H J Kim et al.   ONCOGENE