Immunoregulation of synovial macrophages for the treatment of osteoarthritis

Phenotype Diversity of Macrophages in Osteoarthritis: Implications for Development of Macrophage Modulating Therapies

(2022) Nataliya V. Mushenkova et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Single-cell RNA-Seq reveals changes in immune landscape in post-traumatic osteoarthritis

(2022) Aimy Sebastian et al.   Frontiers in Immunology

The E3 ubiquitin ligase Itch limits the progression of post-traumatic osteoarthritis in mice by inhibiting macrophage polarization

(2021) X. Lin et al.   OSTEOARTHRITIS AND CARTILAGE

Alpha defensin-1 attenuates surgically induced osteoarthritis in association with promoting M1 to M2 macrophage polarization

(2021) J.W. Xie et al.   OSTEOARTHRITIS AND CARTILAGE

TRPV1 alleviates osteoarthritis by inhibiting M1 macrophage polarization via Ca2+/CaMKII/Nrf2 signaling pathway

(2021) Zhongyang Lv et al.   Cell Death & Disease

Artificial M2 macrophages for disease-modifying osteoarthritis therapeutics

(2021) Yandong Ma et al.   BIOMATERIALS

Interleukin 4 promotes anti-inflammatory macrophages that clear cartilage debris and inhibits osteoclast development to protect against osteoarthritis

(2021) Ericka P. von Kaeppler et al.   CLINICAL IMMUNOLOGY

Anti-Inflammatory Therapeutic Approaches to Prevent or Delay Post-Traumatic Osteoarthritis (PTOA) of the Knee Joint with a Focus on Sustained Delivery Approaches

(2021) Christine M. Khella et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Genetic deficiency of nuclear factor of activated T cells 5 attenuates the development of osteoarthritis in mice

(2021) Jinhee Lee et al.   JOINT BONE SPINE

Phytochemical Analysis and Anti-Inflammatory and Anti-Osteoarthritic Bioactive Potential of Verbascum thapsus L. (Scrophulariaceae) Leaf Extract Evaluated in Two In Vitro Models of Inflammation and Osteoarthritis

(2021) Giovanna Calabrese et al.   MOLECULES

A novel placental tissue biologic, PTP-001, inhibits inflammatory and catabolic responses in vitro and prevents pain and cartilage degeneration in a rat model of osteoarthritis

(2021) C.R. Flannery et al.   OSTEOARTHRITIS AND CARTILAGE

Angelicin Alleviates Post-Trauma Osteoarthritis Progression by Regulating Macrophage Polarization via STAT3 Signaling Pathway

(2021) Zhansong Tian et al.   Frontiers in Pharmacology

Synovial Macrophages in Osteoarthritis: The Key to Understanding Pathogenesis?

(2021) Amanda Thomson et al.   Frontiers in Immunology

Macrophages regulate the progression of osteoarthritis

(2020) H. Zhang et al.   OSTEOARTHRITIS AND CARTILAGE

Intra-articular depletion of macrophages increases acute synovitis and alters macrophage polarity in the injured mouse knee

(2020) K.N. Bailey et al.   OSTEOARTHRITIS AND CARTILAGE

Targeting GM-CSF for collagenase-induced osteoarthritis pain and disease in mice

(2020) K.M.-C. Lee et al.   OSTEOARTHRITIS AND CARTILAGE

Macrophage: A Potential Target on Cartilage Regeneration

(2020) Tiago Lazzaretti Fernandes et al.   Frontiers in Immunology

Bone marrow mesenchymal stem cell-derived exosomes prevent osteoarthritis by regulating synovial macrophage polarization

(2020) Jiyong Zhang et al.   Aging-US

Macrophage Activation in the Synovium of Healthy and Osteoarthritic Equine Joints

(2020) Bruno C. Menarim et al.   Frontiers in Veterinary Science

Kinsenoside attenuates osteoarthritis by repolarizing macrophages through inactivating NF-κB/MAPK signaling and protecting chondrocytes

(2019) Feng Zhou et al.   Acta Pharmaceutica Sinica B

Clinical implications of macrophage dysfunction in the development of osteoarthritis of the knee

(2019) Jinwei Xie et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Therapeutic options for targeting inflammatory osteoarthritis pain

(2019) Philip G. Conaghan et al.   Nature Reviews Rheumatology

Bone Marrow Mesenchymal Stromal Cells in Patients with Osteoarthritis Results in Overall Improvement in Pain and Symptoms and Reduces Synovial Inflammation

(2019) Jaskarndip Chahal et al.   Stem Cells Translational Medicine

Human and murine macrophages exhibit differential metabolic responses to lipopolysaccharide - A divergent role for glycolysis

(2019) Vijith Vijayan et al.   Redox Biology

INVOSSA-K induces an anti-inflammatory intra-articular environment in a rat MIA model via macrophage polarization

(2019) H. Lee et al.   OSTEOARTHRITIS AND CARTILAGE

Osteoarthritis-associated basic calcium phosphate crystals alter immune cell metabolism and promote M1 macrophage polarization

(2019) O.R. Mahon et al.   OSTEOARTHRITIS AND CARTILAGE

Lumican is upregulated in osteoarthritis and contributes to TLR4-induced pro-inflammatory activation of cartilage degradation and macrophage polarization

(2019) G. Barreto et al.   OSTEOARTHRITIS AND CARTILAGE

Synovial macrophage M1 polarisation exacerbates experimental osteoarthritis partially through R-spondin-2

(2018) Haiyan Zhang et al.   ANNALS OF THE RHEUMATIC DISEASES

Cartilage repair in degenerative osteoarthritis mediated by squid type II collagen via immunomodulating activation of M2 macrophages, inhibiting apoptosis and hypertrophy of chondrocytes

(2018) Meilu Dai et al.   BIOMATERIALS

Microglia Gone Rogue: Impacts on Psychiatric Disorders across the Lifespan

(2018) Tuan Leng Tay et al.   Frontiers in Molecular Neuroscience

Imbalance of M1/M2 macrophages is linked to severity level of knee osteoarthritis

(2018) Baolong Liu et al.   Experimental and Therapeutic Medicine

Pillars Article: M-1/M-2 Macrophages and the Th1/Th2 Paradigm.J. Immunol. 2000. 164: 6166–6173

(2017) Charles D. Mills et al.   JOURNAL OF IMMUNOLOGY

Amniotic mesenchymal stem cells mitigate osteoarthritis progression in a synovial macrophage-mediated in vitro explant coculture model

(2017) Natasha Topoluk et al.   Journal of Tissue Engineering and Regenerative Medicine

CCL2 and CCR2 regulate pain-related behaviour and early gene expression in post-traumatic murine osteoarthritis but contribute little to chondropathy

(2017) J. Miotla Zarebska et al.   OSTEOARTHRITIS AND CARTILAGE

A Three-Dimensional Chondrocyte-Macrophage Coculture System to Probe Inflammation in Experimental Osteoarthritis

(2017) Satyavrata Samavedi et al.   TISSUE ENGINEERING PART A

Mesenchymal stem cells derived exosomes and microparticles protect cartilage and bone from degradation in osteoarthritis

(2017) Stella Cosenza et al.   Scientific Reports

Conditional Macrophage Depletion Increases Inflammation and Does Not Inhibit the Development of Osteoarthritis in Obese Macrophage Fas-Induced Apoptosis-Transgenic Mice

(2017) Chia-Lung Wu et al.   Arthritis & Rheumatology

Role of mesenchymal stem cells in osteoarthritis treatment

(2017) Ling Kong et al.   Journal of Orthopaedic Translation

CCL2/CCR2, but not CCL5/CCR5, mediates monocyte recruitment, inflammation and cartilage destruction in osteoarthritis

(2016) Harini Raghu et al.   ANNALS OF THE RHEUMATIC DISEASES

Low-grade inflammation as a key mediator of the pathogenesis of osteoarthritis

(2016) William H. Robinson et al.   Nature Reviews Rheumatology

Cartilage inflammation and degeneration is enhanced by pro-inflammatory (M1) macrophages in vitro , but not inhibited directly by anti-inflammatory (M2) macrophages

(2016) L. Utomo et al.   OSTEOARTHRITIS AND CARTILAGE

Guiding synovial inflammation by macrophage phenotype modulation: an in vitro study towards a therapy for osteoarthritis

(2016) L. Utomo et al.   OSTEOARTHRITIS AND CARTILAGE

Osteoarthritis in the XXIst Century: Risk Factors and Behaviours that Influence Disease Onset and Progression

(2015) Giuseppe Musumeci et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Osteoarthritis

(2015) S Glyn-Jones et al.   LANCET

Understanding the Mysterious M2 Macrophage through Activation Markers and Effector Mechanisms

(2015) Tamás Rőszer   MEDIATORS OF INFLAMMATION

Soluble Macrophage Biomarkers Indicate Inflammatory Phenotypes in Patients With Knee Osteoarthritis

(2015) Hikmat N. Daghestani et al.   Arthritis & Rheumatology

Synovitis in knee osteoarthritis: a precursor of disease?

(2014) I Atukorala et al.   ANNALS OF THE RHEUMATIC DISEASES

M1 and M2 Macrophages: The Chicken and the Egg of Immunity

(2014) Charles D. Mills et al.   Journal of Innate Immunity

Targeting macrophages rescues age-related immune deficiencies in C57BL/6J geriatric mice

(2013) Connie Jackaman et al.   AGING CELL

Polarization profiles of human M-CSF-generated macrophages and comparison of M1-markers in classically activated macrophages from GM-CSF and M-CSF origin

(2013) Marie Jaguin et al.   CELLULAR IMMUNOLOGY

Macrophages in inflammatory multiple sclerosis lesions have an intermediate activation status

(2013) Daphne YS Vogel et al.   Journal of Neuroinflammation

Defining and mapping the person with osteoarthritis for population studies and public health

(2013) E. Thomas et al.   RHEUMATOLOGY

Subchondral bone in osteoarthritis: insight into risk factors and microstructural changes

(2013) Guangyi Li et al.   ARTHRITIS RESEARCH & THERAPY

Aging is associated with chronic innate immune activation and dysregulation of monocyte phenotype and function

(2012) Anna C. Hearps et al.   AGING CELL

CCR2 chemokine receptor signaling mediates pain in experimental osteoarthritis

(2012) R. E. Miller et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The role of synovial macrophages and macrophage-produced mediators in driving inflammatory and destructive responses in osteoarthritis

(2010) Jan Bondeson et al.   ARTHRITIS AND RHEUMATISM

Ageing is associated with diminished apoptotic cell clearance in vivo

(2010) T. Aprahamian et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

The influence of macrophage depletion on ligament healing

(2010) Connie S. Chamberlain et al.   CONNECTIVE TISSUE RESEARCH

Anatomical distribution of synovitis in knee osteoarthritis and its association with joint effusion assessed on non-enhanced and contrast-enhanced MRI

(2010) F.W. Roemer et al.   OSTEOARTHRITIS AND CARTILAGE