HIV-1 infected humanized DRAGA mice develop HIV-specific antibodies despite lack of canonical germinal centers in secondary lymphoid tissues

Building the Next Generation of Humanized Hemato-Lymphoid System Mice

(2021) Tijana Martinov et al.   Frontiers in Immunology

Characterization of human FDCs reveals regulation of T cells and antigen presentation to B cells

(2021) Balthasar A. Heesters et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Gut germinal center regeneration and enhanced antiviral immunity by mesenchymal stem/stromal cells in SIV infection

(2021) Mariana G. Weber et al.   JCI Insight

Interests of the Non-Human Primate Models for HIV Cure Research

(2021) Gauthier Terrade et al.   Vaccines

Toward a Macaque Model of HIV-1 Infection: Roadblocks, Progress, and Future Strategies

(2020) Rajesh Thippeshappa et al.   Frontiers in Microbiology

Repertoire characterization and validation of gB-specific human IgGs directly cloned from humanized mice vaccinated with dendritic cells and protected against HCMV

(2020) Sebastian J. Theobald et al.   PLoS Pathogens

Exit from germinal center to become quiescent memory B cells depends on metabolic reprograming and provision of a survival signal

(2020) Takeshi Inoue et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Characterization of immune responses to anti-PD-1 mono and combination immunotherapy in hematopoietic humanized mice implanted with tumor xenografts

(2019) A. Capasso et al.   Journal for ImmunoTherapy of Cancer

A humanized mouse model of HIV-1 latency with enrichment of latent virus in PD-1+ and TIGIT+ CD4 T cells

(2019) George N. Llewellyn et al.   JOURNAL OF VIROLOGY

T Follicular Helper Cell-Germinal Center B Cell Interaction Strength Regulates Entry into Plasma Cell or Recycling Germinal Center Cell Fate

(2018) Wataru Ise et al.   IMMUNITY

Liposome-Encapsulated Human Immunodeficiency Virus-1 gp120 Induces Potent V1V2-Specific Antibodies in Humans

(2018) Mangala Rao et al.   JOURNAL OF INFECTIOUS DISEASES

Humanized DRAGA mice immunized with Plasmodium falciparum sporozoites and chloroquine elicit protective pre-erythrocytic immunity

(2018) Sai Majji et al.   MALARIA JOURNAL

A human immune system mouse model with robust lymph node development

(2018) Yan Li et al.   NATURE METHODS

Germinal center entry not selection of B cells is controlled by peptide-MHCII complex density

(2018) Chen-Hao Yeh et al.   Nature Communications

Dissemination of Orientia tsutsugamushi, a Causative Agent of Scrub Typhus, and Immunological Responses in the Humanized DRAGA Mouse

(2018) Le Jiang et al.   Frontiers in Immunology

The B-Cell Follicle in HIV Infection: Barrier to a Cure

(2018) Matthew P. Bronnimann et al.   Frontiers in Immunology

B Cells Are the Dominant Antigen-Presenting Cells that Activate Naive CD4+ T Cells upon Immunization with a Virus-Derived Nanoparticle Antigen

(2018) Sheng Hong et al.   IMMUNITY

Follicular Regulatory T Cells Are Highly Permissive to R5-Tropic HIV-1

(2017) Shannon M. Miller et al.   JOURNAL OF VIROLOGY

Generation and testing anti-influenza human monoclonal antibodies in a new humanized mouse model (DRAGA: HLA-A2. HLA-DR4. Rag1 KO. IL-2Rγc KO. NOD)

(2017) Mirian Mendoza et al.   Human Vaccines & Immunotherapeutics

Tracking Human Immunodeficiency Virus-1 Infection in the Humanized DRAG Mouse Model

(2017) Jiae Kim et al.   Frontiers in Immunology

PD-1 Controls Tonic Signaling and Lymphopenia-Induced Proliferation of T Lymphocytes

(2017) Kristofor K. Ellestad et al.   Frontiers in Immunology

Germinal Center B Cell Dynamics

(2016) Luka Mesin et al.   IMMUNITY

Differential effect of HLA class-I versus class-II transgenes on human T and B cell reconstitution and function in NRG mice

(2016) Sai Majji et al.   Scientific Reports

TFH cells accumulate in mucosal tissues of humanized-DRAG mice and are highly permissive to HIV-1

(2015) Atef Allam et al.   Scientific Reports

Compartmentalization of Simian Immunodeficiency Virus Replication within Secondary Lymphoid Tissues of Rhesus Macaques Is Linked to Disease Stage and Inversely Related to Localization of Virus-Specific CTL

(2014) Elizabeth Connick et al.   JOURNAL OF IMMUNOLOGY

Safety of Excisional Inguinal Lymph Node Biopsies Performed for Research Purposes in HIV-1-Infected Women and Men

(2014) Amie L. Meditz et al.   Surgical Infections

Designing a Soluble Near Full-length HIV-1 gp41 Trimer

(2012) Guofen Gao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Expansion of HIV-specific T follicular helper cells in chronic HIV infection

(2012) Madelene Lindqvist et al.   JOURNAL OF CLINICAL INVESTIGATION

An anti-phosphoinositide-specific monoclonal antibody that neutralizes HIV-1 infection of human monocyte-derived macrophages

(2012) Ousman Jobe et al.   VIROLOGY

Expression of HLA Class II Molecules in Humanized NOD.Rag1KO.IL2RgcKO Mice Is Critical for Development and Function of Human T and B Cells

(2011) Rebecca Danner et al.   PLoS One

Cytokine-secreting follicular T cells shape the antibody repertoire

(2009) R Lee Reinhardt et al.   NATURE IMMUNOLOGY