Humanized DRAGA mice immunized with Plasmodium falciparum sporozoites and chloroquine elicit protective pre-erythrocytic immunity

Rare PfCSP C-terminal antibodies induced by live sporozoite vaccination are ineffective against malaria infection

(2017) Stephen W. Scally et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Generation and testing anti-influenza human monoclonal antibodies in a new humanized mouse model (DRAGA: HLA-A2. HLA-DR4. Rag1 KO. IL-2Rγc KO. NOD)

(2017) Mirian Mendoza et al.   Human Vaccines & Immunotherapeutics

Tracking Human Immunodeficiency Virus-1 Infection in the Humanized DRAG Mouse Model

(2017) Jiae Kim et al.   Frontiers in Immunology

A DNA Vaccine Protects Human Immune Cells against Zika Virus Infection in Humanized Mice

(2017) Guohua Yi et al.   EBioMedicine

Differential regulation of polysaccharide-specific antibody responses to isolated polysaccharides, conjugate vaccines, and intact Gram-positive versus Gram-negative extracellular bacteria

(2016) Clifford M. Snapper   VACCINE

Differential effect of HLA class-I versus class-II transgenes on human T and B cell reconstitution and function in NRG mice

(2016) Sai Majji et al.   Scientific Reports

From the draining lymph node to the liver: the induction and effector mechanisms of malaria-specific CD8+ T cells

(2015) Andrea J. Radtke et al.   Seminars in Immunopathology

Blood-stage immunity to Plasmodium chabaudi malaria following chemoprophylaxis and sporozoite immunization

(2015) Wiebke Nahrendorf et al.   eLife

TFH cells accumulate in mucosal tissues of humanized-DRAG mice and are highly permissive to HIV-1

(2015) Atef Allam et al.   Scientific Reports

Malarial hemozoin: From target to tool

(2014) Lorena M. Coronado et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

CD28 Signaling in T Regulatory Precursors Requires p56lck and Rafts Integrity to Stabilize the Foxp3 Message

(2014) C. Nazarov-Stoica et al.   JOURNAL OF IMMUNOLOGY

Artesunate versus Chloroquine Infection-Treatment-Vaccination Defines Stage-Specific Immune Responses Associated with Prolonged Sterile Protection against Both Pre-erythrocytic and Erythrocytic Plasmodium yoelii Infection

(2014) X. Peng et al.   JOURNAL OF IMMUNOLOGY

Cytotoxic Markers Associate With Protection Against Malaria in Human Volunteers Immunized WithPlasmodium falciparumSporozoites

(2014) Else M. Bijker et al.   JOURNAL OF INFECTIOUS DISEASES

Humanized HLA-DR4.RagKO.IL2RγcKO.NOD (DRAG) mice sustain the complex vertebrate life cycle of Plasmodium falciparum malaria

(2014) Wathsala Wijayalath et al.   MALARIA JOURNAL

CD8+ T Cells Mediate Robust Stage-Specific Immunity to P. berghei under Chemoprophylaxis and This Protective Environment Is Not Downregulated by the Presence of Blood-Stage Infection

(2014) Matthew D. Lewis et al.   PLoS One

Sporozoite Immunization of Human Volunteers under Mefloquine Prophylaxis Is Safe, Immunogenic and Protective: A Double-Blind Randomized Controlled Clinical Trial

(2014) Else M. Bijker et al.   PLoS One

Pacientes com lúpus eritematoso sistêmico e síndrome antifosfolípide secundária possuem números reduzidos de células B CD4+ CD25+ Foxp3+ (células Treg) e células B CD3– CD19+ circulantes

(2014) Ester Rosári Raphaelli Dal Ben et al.   Revista Brasileira De Reumatologia

HLA Class II (DR0401) Molecules Induce Foxp3+Regulatory T Cell Suppression of B Cells in Plasmodium yoelii Strain 17XNL Malaria

(2013) Wathsala Wijayalath et al.   INFECTION AND IMMUNITY

Hydroxychloroquine preferentially induces apoptosis of CD45RO+ effector T cells by inhibiting autophagy: A possible mechanism for therapeutic modulation of T cells

(2013) Jorg van Loosdregt et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Towards an optimized inhibition of liver stage development assay (ILSDA) for Plasmodium falciparum

(2013) Xiaoyan Zou et al.   MALARIA JOURNAL

Protection against malaria after immunization by chloroquine prophylaxis and sporozoites is mediated by preerythrocytic immunity

(2013) E. M. Bijker et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CD8 T cell independent immunity after single dose infection-treatment-vaccination (ITV) against Plasmodium yoelii

(2013) Katherine L. Doll et al.   VACCINE

Pre-erythrocytic antibody profiles induced by controlled human malaria infections in healthy volunteers under chloroquine prophylaxis

(2013) Philip L. Felgner et al.   Scientific Reports

The where and when of T cell regulation in transplantation

(2012) Fadi Issa et al.   TRENDS IN IMMUNOLOGY

Disruption of the Plasmodium falciparum liver-stage antigen-1 locus causes a differentiation defect in late liver-stage parasites

(2011) Sebastian A. Mikolajczak et al.   CELLULAR MICROBIOLOGY

Organelle segregation into Plasmodium liver stage merozoites

(2011) Rebecca R. Stanway et al.   CELLULAR MICROBIOLOGY

Development of a Highly Sensitive Genus-Specific Quantitative Reverse Transcriptase Real-Time PCR Assay for Detection and Quantitation of Plasmodium by Amplifying RNA and DNA of the 18S rRNA Genes

(2011) E. Kamau et al.   JOURNAL OF CLINICAL MICROBIOLOGY

Long-term protection against malaria after experimental sporozoite inoculation: an open-label follow-up study

(2011) Meta Roestenberg et al.   LANCET

Expression of HLA Class II Molecules in Humanized NOD.Rag1KO.IL2RgcKO Mice Is Critical for Development and Function of Human T and B Cells

(2011) Rebecca Danner et al.   PLoS One

Plasmodium falciparum PF10_0164 (ETRAMP10.3) Is an Essential Parasitophorous Vacuole and Exported Protein in Blood Stages

(2010) Drew C. MacKellar et al.   EUKARYOTIC CELL

Identification and localization of minimal MHC-restricted CD8+ T cell epitopes within the Plasmodium falciparum AMA1 protein

(2010) Martha Sedegah et al.   MALARIA JOURNAL

Immune evasion by malaria parasites: a challenge for vaccine development

(2009) Sofia Casares et al.   CURRENT OPINION IN IMMUNOLOGY

Cutting Edge: Regulatory T Cells Directly Suppress B Cells in Systemic Lupus Erythematosus

(2009) N. Iikuni et al.   JOURNAL OF IMMUNOLOGY

Protection against a Malaria Challenge by Sporozoite Inoculation

(2009) Meta Roestenberg et al.   NEW ENGLAND JOURNAL OF MEDICINE

The beginning of the end for chimpanzee experiments?

(2008) Andrew Knight   Philosophy Ethics and Humanities in Medicine