Article
Immunology
Zimeng Wei, Xingruo Zeng, Yufei Lei, Hengjing He, Muhammad Jamal, Chengjie Zhang, Haiyan Tan, Songping Xie, Qiuping Zhang
Summary: This study reveals the diagnostic and prognostic value of TTYH3 in lung cancer and provides a TTYH3-based estimation of immunotherapy response for lung cancer patients.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Cell Biology
Hongxu Li, Jie Gao, Shuijun Zhang
Summary: CADM1, a cell adhesion molecule, plays a crucial role in tumor development by regulating apoptosis and malignant proliferation of tumor cells. It participates in regulating multiple signaling pathways with cell cycle-related proteins, inhibiting tumor invasion and migration. It could be a potential biomarker for early cancer diagnosis and a target for cancer treatment in future clinical practices.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Cell Biology
Hongxu Li, Jie Gao, Shuijun Zhang
Summary: CADM1, a cell adhesion molecule, plays a regulatory role in tumor development by promoting tumor cell apoptosis and inhibiting malignant proliferation. Low CADM1 expression is associated with aggressive tumors and poor prognosis, and CADM1 functions differently in various cancer types.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Cell Biology
Bent Gruen, Michaela Tirre, Simon Pyschny, Vijay Singh, Hans-Gerd Kehl, Christian Jux, Joerg-Detlef Drenckhahn
Summary: Maintaining myocardial tissue homeostasis is critical for heart development and function, with mitochondrial dysfunction potentially leading to irreversible damage to the heart.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Cell Biology
Jiawei Lu, Huixia Li, Debing Yu, Peng Zhao, Yuan Liu
Summary: Heat stress inhibits proliferation and differentiation, induces apoptosis by impairing mitochondrial function and promoting autophagy, thus affecting skeletal muscle development.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Cell Biology
Qiang Chen, Xiaorong Yang, Binbin Gong, Wenjie Xie, Ming Ma, Shengqiang Fu, Siyuan Wang, Yutang Liu, Zhicheng Zhang, Ting Sun, Zhilong Li
Summary: The study revealed that SNHG10 is overexpressed in prostate cancer and is associated with advanced clinical parameters, showing significant diagnostic ability. SNHG10 expression is also correlated with oxidative phosphorylation and immune infiltrated cells, affecting cell proliferation, migration, and invasion of PC.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Cell Biology
Fan Chao, Shiyu Wang, Cong Zhang, Dunsheng Han, Guoxiong Xu, Gang Chen
Summary: circRNAs play a crucial role in prostate cancer, being involved in processes such as the growth, migration, and drug resistance of cancer cells, as well as serving as prognostic and diagnostic biomarkers.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Oncology
Milena Perrone, Claudia Chiodoni, Mara Lecchi, Laura Botti, Barbara Bassani, Annamaria Piva, Elena Jachetti, Matteo Milani, Daniele Lecis, Elda Tagliabue, Paolo Verderio, Sabina Sangaletti, Mario P. Colombo
Summary: Cancer can reprogram the bone marrow niche through the BM mesenchymal stem cells (MSC) and IL-1B/ATF3 signaling pathway, which promotes myeloid cell differentiation and tumor development. The expression of CD11b thorn population in the peripheral blood can be used as a potential biomarker for early diagnosis of breast cancer. This study suggests that targeting IL-1B or ATF3 may have therapeutic benefits for breast cancer patients.
Article
Biochemistry & Molecular Biology
Cheng-Chin Lee, Kuei-Yen Tsai, Ai-Wei Lee, Po-Li Wei, Chien-Yu Huang, Uyanga Batzorig, Yu-Jia Chang
Summary: Colorectal cancer is a common and deadly form of cancer. The expression of CWH43 is reduced in colorectal cancer and is associated with poorer prognosis. Inhibition of CWH43 promotes cancer cell proliferation, migration, and invasiveness, while its overexpression has inhibitory effects. CWH43 appears to regulate the TTK-mediated cell cycle, impacting the development of colorectal cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Physical
Chong Yu, Qiong Liu, Jin Wang
Summary: Heterogeneity is common in stem cells, cancer cells, and cancer stem cells, and it poses a significant obstacle to successful anticancer therapy. Understanding the origins and effects of heterogeneity is important for the treatment response, therapeutic resistance, and cancer metastasis.
JOURNAL OF CHEMICAL PHYSICS
(2022)
Article
Medicine, Research & Experimental
Hui Zhang, Chenxin Xu, Chen Shi, Junying Zhang, Ting Qian, Zhuo Wang, Rong Ma, Jianzhong Wu, Feng Jiang, Jifeng Feng
Summary: In this study, HPSE2 was identified as a novel tumor suppressor gene frequently inactivated through promoter methylation in CRC, with its hypermethylation-low expression associated with poor patient prognosis. HPSE2 exerts its tumor suppressive function by activating the p53/p21 signaling cascade to inhibit tumor growth. Promoter hypermethylation of HPSE2 represents a potential therapeutic target in patients with CRC, especially those with late-stage disease.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Review
Medical Laboratory Technology
Tian Zeng, Yang Guan, Yu-kun Li, Qing Wu, Xiao-jun Tang, Xin Zeng, Hui Ling, Juan Zou
Summary: MCM6 plays a significant role in the development of hepatocellular carcinoma by regulating cell cycle, proliferation, and metastasis. Enhanced expression of MCM6 contributes to cancer progression, while inhibition of MCM6 may be an effective treatment method. Further research on the carcinogenic functions of MCM6 could offer new insights into cancer biology and lead to novel approaches for cancer diagnosis and treatment.
CLINICA CHIMICA ACTA
(2021)
Review
Biochemistry & Molecular Biology
Sajad Najafi
Summary: This review highlights the significant role of circRNAs in cervical cancer, including their regulatory functions in gene expression, impact on cell growth and apoptosis, as well as their potential for prognosis, diagnosis, and treatment in cervical cancer patients.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Biochemistry & Molecular Biology
Li-Ming Xu, Jiao Zhang, Yue Ma, Ya-Jing Yuan, Hao Yu, Jun Wang, Xu-Chen Cao, Li Zhu, Ping Wang
Summary: This study found that the miR-135/ZNF217/METTL3/NANOG axis plays a significant role in the progression of breast cancer. Modulating the expression of this axis can effectively inhibit the malignant behavior of breast cancer cells, highlighting the potential value of ZNF217 silencing and miR-135 upregulation in the prevention and treatment of breast cancer.
Article
Oncology
Lin Xiu, Yuxi Zhao, Ning Li, Jia Zeng, Jing Liu, Yongliang Fu, Qiao Gao, Lingying Wu
Summary: This study reveals that high expression of retinoic acid receptor gamma (RARG) promotes ovarian cancer cell proliferation and is an independent predictor of poor prognosis in patients. RARG may serve as a potential molecular target and biomarker for individualized diagnosis and treatment in ovarian cancer patients.
FRONTIERS IN ONCOLOGY
(2022)
Article
Urology & Nephrology
Solomon L. Woldu, Casey K. Ng, Ronald K. Loo, Jeff M. Slezak, Steven J. Jacobsen, Wei Shen Tan, John D. Kelly, Tony Lough, David Darling, Kim E. M. van Kessel, Joep J. de Jong, Wim van Criekinge, Shahrokh F. Shariat, Andrew Hiar, Sarah Brown, Stephen A. Boorjian, Daniel A. Barocas, Robert S. Svatek, Yair Lotan
Summary: This study evaluated the American Urological Association's new risk-stratified approach for microhematuria patients and found a higher proportion of high-risk patients with bladder cancer incidence. It suggests evaluating low, intermediate, and high-risk groups with different intensities, providing valuable information for patient counseling.
JOURNAL OF UROLOGY
(2021)
Review
Oncology
Simone L. Schonkeren, Meike S. Thijssen, Nathalie Vaes, Werend Boesmans, Veerle Melotte
Summary: Nerves play a significant role in influencing the progression of colorectal cancer by secreting signaling molecules or stimulating nerve growth. Understanding the role of the nervous system in colorectal cancer can lead to the development of novel therapeutic approaches.
Article
Biochemistry & Molecular Biology
Sam Kint, Wim Van Criekinge, Linos Vandekerckhove, Winnok H. De Vos, Karol Bomsztyk, Diane S. Krause, Oleg Denisenko
Summary: Characterization of individual cells' epigenetic status remains challenging due to limited coverage of current sequencing approaches. A targeted microscopy-based epigenetic visualization assay (EVA) was developed to overcome these limitations, allowing for detection and quantification of epigenetic marks at genes of interest in single cells. By linking epigenetic marks to gene transcription, the efficacy of the method was validated.
NUCLEIC ACIDS RESEARCH
(2021)
Review
Biochemistry & Molecular Biology
Amy Marie Holland, Ana Carina Bon-Frauches, Daniel Keszthelyi, Veerle Melotte, Werend Boesmans
Summary: The enteric nervous system (ENS) plays a crucial role in regulating gastrointestinal function, and its dysfunction is closely linked to gastrointestinal diseases. Recent research indicates that the multifaceted connections between the ENS, intestinal epithelium, immune system, and gut microbiome are essential for maintaining gastrointestinal homeostasis. Therefore, the ENS plays a significant role in the pathogenesis of enteric neuropathies, inflammatory bowel diseases, and colorectal cancer.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Sindhu Naik, Andrew R. Wood, Mate Ongenaert, Paniz Saidiyan, Edo D. Elstak, Henriette L. Lanz, Jan Stallen, Richard Janssen, Elizabeth Smythe, Kai S. Erdmann
Summary: Research demonstrates that in a proximal tubule organ on chip model replicating characteristics of Lowe syndrome/Dent II disease, proximal tubule cells lacking OCRL expression upregulate markers associated with epithelial-mesenchymal transition (EMT) and exhibit increased collagen expression and deposition.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Rianne J. Hendriks, Marloes M. G. van der Leest, Bas Israel, Gerjon Hannink, Anglita YantiSetiasti, Erik B. Cornel, Christina A. Hulsbergen-van de Kaa, O. Sjoerd Klaver, J. P. Michiel Sedelaar, Wim Van Criekinge, Hans de Jong, Peter F. A. Mulders, E. David Crawford, Jeroen Veltman, Jack A. Schalken, Jelle O. Barentsz, Inge M. van Oort
Summary: This study evaluated the SelectMDx test as a tool to detect high-grade prostate cancer in biopsy-naive men, showing that it can avoid unnecessary biopsies in 38% of cases and minimize detection of low-grade PCa. The combination strategy with mpMRI showed the highest net benefit in clinical utility.
PROSTATE CANCER AND PROSTATIC DISEASES
(2021)
Article
Cell Biology
Jolien Diddens, Louis Coussement, Carolina Frankl-Vilches, Gaurav Majumdar, Sandra Steyaert, Sita M. Ter Haar, Jeroen Galle, Ellen De Meester, Sarah De Keulenaer, Wim Van Criekinge, Charlotte A. Cornil, Jacques Balthazart, Annemie Van der Linden, Tim De Meyer, Wim Vanden Berghe
Summary: The study reveals extensive neurodevelopmental changes and increasing DNA methylation levels in zebra finch telencephalon during postnatal development, with only a small fraction of differential expression explained by DNA methylation. Sexually dimorphic gene expression is largely influenced by incomplete dosage compensation, independent of DNA methylation, and increases throughout life. DNA methylation regulates neurodevelopmental gene expression dynamics through steering transcription factor activity, but does not explain sexually dimorphic gene expression patterns.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Gastroenterology & Hepatology
Simone L. Schonkeren, Tara T. Kuthe, Musa Idris, Ana C. Bon-Frauches, Werend Boesmans, Veerle Melotte
Summary: This review focuses on summarizing and comparing available culture protocols for the generation of primary ENS cells from adult mice, as well as discussing the potential of human ENS cultures.
NEUROGASTROENTEROLOGY AND MOTILITY
(2022)
Article
Virology
Bjorn Criel, Steff Taelman, Wim Van Criekinge, Michiel Stock, Yves Briers
Summary: Phage lytic proteins are a type of advanced antibiotic known as enzybiotics, and PhaLP database offers comprehensive and easily accessible information on these proteins, serving as a valuable resource for researchers in the field.
Article
Cell Biology
Tom G. Keulers, Alexander Koch, Marike W. van Gisbergen, Lydie M. O. Barbeau, Marijke Zonneveld, Monique C. de Jong, Kim G. M. Savelkouls, Roel G. Wanders, Johan Bussink, Veerle Melotte, Kasper M. A. Rouschop
Summary: Tumor hypoxia is associated with tumor progression, resistance to therapy, and metastasis. ATG12 loss in head and neck squamous cell carcinoma is linked to absence of hypoxia, improved prognosis after therapy, and decreased hypoxia tolerance.
Article
Oncology
Maartje Massen, Kim Lommen, Kim A. D. Wouters, Johan Vandersmissen, Wim van Criekinge, James G. Herman, Veerle Melotte, Leo J. Schouten, Manon van Engeland, Kim M. Smits
Summary: DNA methylation biomarkers for cancer have great potential for early detection and treatment response, but their clinical implementation is limited. This study evaluated technical pitfalls in the development of DNA methylation biomarkers for colorectal cancer, including variation in assay location and design quality.
CLINICAL EPIGENETICS
(2022)
Review
Gastroenterology & Hepatology
Nathalie Vaes, Musa Idris, Werend Boesmans, Maria M. Alves, Veerle Melotte
Summary: Maintaining gastrointestinal health is challenging due to the complex and dynamic nature of the gastrointestinal tract. Disturbances in this environment can lead to gastrointestinal cancers, which account for a significant proportion of cancer cases and deaths worldwide. While the role of the tumor microenvironment has been extensively studied, the importance of the nervous system in gastrointestinal cancers has only recently been recognized. This article sheds light on the neural influences during gastrointestinal carcinogenesis, focusing on interactions between neurons and components of the gastrointestinal tract and tumor microenvironment, neural signaling pathways, and the impact on cancer hallmarks. Neural-related therapies for gastrointestinal cancer management are also discussed.
NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY
(2022)
Article
Multidisciplinary Sciences
Laurentijn Tilleman, Kaat Rubben, Wim Van Criekinge, Dieter Deforce, Filip Van Nieuwerburgh
Summary: This study tested the effectiveness of Targeted Locus Amplification (TLA) combined with Illumina or Nanopore sequencing in accurate genotyping and phasing of pharmacogenes. The results showed limited nucleotide mapping on target and incomplete coverage of genes with both sequencing methods. However, the optimized primer pair for the CYP2D6 gene in the Nanopore dataset resulted in correct haplotypes, indicating the potential reliability of this method with patient-specific primer design and optimization.
SCIENTIFIC REPORTS
(2022)
Article
Gastroenterology & Hepatology
Simone L. L. Schonkeren, Saskia Seeldrayers, Meike S. S. Thijssen, Werend Boesmans, Ramon C. J. Langen, Veerle Melotte
Summary: This study aimed to develop a refined whole-gut transit assay for measuring gastrointestinal motility in mice under more physiological conditions. The refined method showed reduced variability compared to the standard method and allowed for accurate assessment of differences in fecal pellet number, weight, and water content.
NEUROGASTROENTEROLOGY AND MOTILITY
(2023)
Review
Oncology
Kim Lommen, Nathalie Vaes, Maureen J. Aarts, Joep G. van Roermund, Leo J. Schouten, Egbert Oosterwijk, Veerle Melotte, Vivianne C. Tjan-Heijnen, Manon van Engeland, Kim M. Smits
Summary: This systematic review examined the diagnostic value of DNA methylation biomarkers for RCC, indicating a lack of independently validated biomarkers and inadequate reporting in the majority of studies.
EUROPEAN UROLOGY ONCOLOGY
(2021)