IAP-targeted therapies for cancer

The Proapoptotic Protein Smac/DIABLO Dimer Has the Highest Stability As Measured by Pressure and Urea Denaturation†

(2008) Rafael B. Gonçalves et al.   BIOCHEMISTRY

Demonstration of direct binding of cIAP1 degradation-promoting bestatin analogs to BIR3 domain: Synthesis and application of fluorescent bestatin ester analogs

(2008) Shinichi Sato et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Final Stages of Cytokinesis and Midbody Ring Formation Are Controlled by BRUCE

(2008) Christian Pohl et al.   CELL

TNF-α Induces Two Distinct Caspase-8 Activation Pathways

(2008) Lai Wang et al.   CELL

Altered Cytoplasmic-to-Nuclear Ratio of Survivin Is a Prognostic Indicator in Breast Cancer

(2008) D. J. Brennan et al.   CLINICAL CANCER RESEARCH

LKB1 and AMPK and the regulation of skeletal muscle metabolism

(2008) Ho-Jin Koh et al.   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

TWEAK-FN14 signaling induces lysosomal degradation of a cIAP1–TRAF2 complex to sensitize tumor cells to TNFα

(2008) James E. Vince et al.   JOURNAL OF CELL BIOLOGY

Protein-protein recognition as a first step towards the inhibition of XIAP and Survivin anti-apoptotic proteins

(2008) Cristian Obiol-Pardo et al.   JOURNAL OF MOLECULAR RECOGNITION

The RING Domain of cIAP1 Mediates the Degradation of RING-bearing Inhibitor of Apoptosis Proteins by Distinct Pathways

(2008) Herman H. Cheung et al.   MOLECULAR BIOLOGY OF THE CELL

cIAP1 and cIAP2 Facilitate Cancer Cell Survival by Functioning as E3 Ligases that Promote RIP1 Ubiquitination

(2008) Mathieu J.M. Bertrand et al.   MOLECULAR CELL

T cell antigen receptor stimulation induces MALT1 paracaspase–mediated cleavage of the NF-κB inhibitor A20

(2008) Beatrice Coornaert et al.   NATURE IMMUNOLOGY

The proteolytic activity of the paracaspase MALT1 is key in T cell activation

(2008) Fabien Rebeaud et al.   NATURE IMMUNOLOGY

Both cIAP1 and cIAP2 regulate TNF -mediated NF- B activation

(2008) D. J. Mahoney et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

AMPK activation with AICAR provokes an acute fall in plasma [K+]

(2007) Dan Zheng et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Nuclear and cytoplasmic cellular distribution of survivin as survival predictor in resected non-small-cell lung cancer

(2007) E. Bria et al.   EJSO

Survivin inhibition induces human neural tumor cell death through caspase-independent and -dependent pathways

(2003) Sai Latha Shankar et al.   JOURNAL OF NEUROCHEMISTRY