Facile Synthesis of Fully Substituted 1,2,4‐Triazoles via [3+2] Cycloaddition of Nitrileimines with Amidine under Transition Metal‐Free Conditions

Quadruple Functionalized Pyrazole Pharmacophores via One‐pot Regioselective [3 + 2] Cycloaddition of Fluorinated Nitrile Imines and Dicyanoalkenes

(2022) Yin Zhou et al.   Chemistry-An Asian Journal

Trifluoromethylated Pyrazoles via Sequential (3 + 2)-Cycloaddition of Fluorinated Nitrile Imines with Chalcones and Solvent-Dependent Deacylative Oxidation Reactions

(2022) Anna Kowalczyk et al.   ORGANIC LETTERS

Regioselective Synthesis of 3‐Trifluoromethyl 4‐Subtituted Pyrazoles by [3+2] Cycloaddition of Trifluoroacetonitrile Imines and Nitroalkenes

(2022) Ke‐Hu Wang et al.   Asian Journal of Organic Chemistry

Base-Promoted (3 + 2) Cycloaddition of Trifluoroacetohydrazonoyl Chlorides with Imidates En Route to Trifluoromethyl-1,2,4-Triazoles

(2022) Yue Zhang et al.   JOURNAL OF ORGANIC CHEMISTRY

Regioselective Synthesis of 5-Trifluoromethyl 1,2,4-Triazoles via [3 + 2]-Cycloaddition of Nitrile Imines with CF3CN

(2022) Bo Lin et al.   MOLECULES

Switchable In Situ SO2 Capture and CF3 Migration of Enol Triflates with Peroxyl Compounds under Iron Catalysis

(2022) Qi-Chao Shan et al.   ORGANIC LETTERS

Fluorinated Pyrazoles: From Synthesis to Applications

(2021) Pavel K. Mykhailiuk   CHEMICAL REVIEWS

Regioselective Decarboxylative Cycloaddition Route to Fully Substituted 3‐CF 3 ‐Pyrazoles from Nitrilimines and Isoxazolidinediones

(2021) Yu‐Chen Tian et al.   ADVANCED SYNTHESIS & CATALYSIS

Synthesis of 5‐Trifluoromethyl‐1,2,4‐Triazoles via Metal‐Free Annulation of Trifluoroacetimidohydrazides and Methyl Ketones

(2021) Jiajun Zhang et al.   ADVANCED SYNTHESIS & CATALYSIS

Trifluoromethyl Thianthrenium Triflate: A Readily Available Trifluoromethylating Reagent with Formal CF3+, CF3•, and CF3– Reactivity

(2021) Hao Jia et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Nucleophilic and Radical Heptafluoroisopropoxylation with Redox‐Active Reagents

(2021) Chao‐Lai Tong et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Iron-Catalyzed Enantioselective Radical Carboazidation and Diazidation of α,β-Unsaturated Carbonyl Compounds

(2021) Wen Liu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Mechanistic Insight into Copper-Mediated Trifluoromethylation of Aryl Halides: The Role of CuI

(2021) He Liu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Elemental Sulfur and Dimethyl Sulfoxide‐Promoted Oxidative Cyclization of Trifluoroacetimidohydrazides with Methylhetarenes for the Synthesis of 3‐Hetaryl ‐5‐trifluoromethyl‐1,2,4‐triazoles

(2021) Jiajun Zhang et al.   CHINESE JOURNAL OF CHEMISTRY

Stereoselective Synthesis of CF3‐Containing Spirooxindoles via 1,3‐Dipolar Cycloaddition by Dipeptide‐based Phosphonium Salt Catalysis

(2020) Xin Liu et al.   ADVANCED SYNTHESIS & CATALYSIS

Synthesis of Both Mirror Images of 9-Membered CF3-Heterocycles using a Single Antipode of Chiral Ligand under Pd-catalyzed Decarboxylative Ring-expansion with Kinetic Resolution

(2020) Hiroto Uno et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

CF3SO2Na Acted as a Bifunctional Reagent: Electrochemical Trifluoromethylation of Alkenes Accompanied by SO2-Insertion to Access Trifluoromethylated Cyclic N-Sulfonylimines

(2020) Wei-Wei Liao et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

N ‐Trifluoromethyl Hydrazines, Indoles and Their Derivatives

(2020) Samir Bouayad‐Gervais et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Cu‐Catalysed Three‐Component Reaction of Aryldiazonium Salts with Fluorinated Diazo Reagents and Nitriles: Access to Difluoro‐ and Trifluoromethylated N1‐Aryl‐1,2,4‐triazoles

(2020) Xing Peng et al.   ADVANCED SYNTHESIS & CATALYSIS

A straightforward access to 3-trifluoromethyl-1H-indazoles via (3+2)-cycloaddition of arynes with nitrile imines derived from trifluoroacetonitrile

(2020) Anna Kowalczyk et al.   JOURNAL OF FLUORINE CHEMISTRY

Two C(sp3)–F Bond Activation in a CF3 Group: ipso-Defluorinative Amination Triggered 1,3-Diamination of (Trifluoromethyl)alkenes with Indoles, Carbazoles, Pyrroles, and Sulfonamides

(2020) Hao Zeng et al.   ORGANIC LETTERS

Highly fluorinated 2,3-dihydro-1,3,4-thiadiazole derivatives via [3+2]-cycloadditions of tertiary thioamides with nitrile imines derived from trifluoroacetonitrile

(2020) Greta Utecht-Jarzyńska et al.   JOURNAL OF FLUORINE CHEMISTRY

Single C(sp3)–F Bond Activation in a CF3 Group: Ipso-Defluorooxylation of (Trifluoromethyl)alkenes with Oximes

(2019) Hao Zeng et al.   ORGANIC LETTERS

Copper-Catalyzed 1,2-Bistrifluoromethylation of Terminal Alkenes

(2019) Hyunseok Oh et al.   ADVANCED SYNTHESIS & CATALYSIS

Trapping of trifluoroacetonitrile imines with mercaptoacetaldehyde and mercaptocarboxylic acids: An access to fluorinated 1,3,4-thiadiazine derivatives via (3+3)-annulation

(2019) Greta Utecht-Jarzyńska et al.   JOURNAL OF FLUORINE CHEMISTRY

Metal‐Free Synthesis of 5‐Trifluoromethyl‐1,2,4‐Triazoles from Iodine‐Mediated Annulation of Trifluoroacetimidoyl Chlorides and Hydrazones

(2019) Sipei Hu et al.   ADVANCED SYNTHESIS & CATALYSIS

Copper-Catalyzed Three-Component Domino Cyclization for the Synthesis of 4-Aryl-5-(arythio)-2-(trifluoromethyl)oxazoles

(2019) Fuhong Xiao et al.   ORGANIC LETTERS

Trifluoromethanesulfonic Anhydride as a Low-Cost and Versatile Trifluoromethylation Reagent

(2018) Yao Ouyang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Polysubstituted 3-trifluoromethylpyrazoles: regioselective (3 + 2)-cycloaddition of trifluoroacetonitrile imines with enol ethers and functional group transformations

(2018) Greta Utecht et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

A Straightforward Access to Trifluoromethylated Spirobipyrazolines through a Double (3+2)-Cycloaddition of Fluorinated Nitrile Imines with Alkoxyallenes

(2018) Marcin Jasiński et al.   SYNLETT

Transition-Metal-Free Decarboxylation of 3,3,3-Trifluoro-2,2-dimethylpropanoic Acid for the Preparation of C(CF3)Me2-Containing Heteroarenes

(2018) Shuai Liu et al.   ORGANIC LETTERS

Intramolecular Nitrone Cycloaddition of α-(Trifluoromethyl)styrenes. Role of the CF3 Group in the Regioselectivity

(2017) Fernando Rabasa-Alcañiz et al.   JOURNAL OF ORGANIC CHEMISTRY

Transition-Metal-Free N–O Reduction of Oximes: A Modular Synthesis of Fluorinated Pyridines

(2017) Huawen Huang et al.   ORGANIC LETTERS

First (3+2)-Cycloadditions of Thiochalcones as C=S Dipolarophiles: Efficient Synthesis of 1,3,4-Thiadiazoles via Reactions with Fluorinated Nitrile Imines

(2017) Grzegorz Mlostoń et al.   SYNTHESIS-STUTTGART

Trifluoromethylated 2,3-dihydro-1,3,4-thiadiazoles via the regioselective [3+2]-cycloadditions of fluorinated nitrile imines with aryl, hetaryl, and ferrocenyl thioketones

(2016) Grzegorz Mlostoń et al.   JOURNAL OF FLUORINE CHEMISTRY

I2-Catalyzed Oxidative Coupling Reactions of Hydrazones and Amines and the Application in the Synthesis of 1,3,5-Trisubstituted 1,2,4-Triazoles

(2016) Zhengkai Chen et al.   ORGANIC LETTERS

Palladium-catalyzed amination of 2,3,3-trifluoroallyl esters: synthesis of trifluoromethylenamines via an intramolecular fluorine shift and CF3 group construction

(2015) Kazuki Isa et al.   CHEMICAL COMMUNICATIONS

Core-structure-inspired asymmetric addition reactions: enantioselective synthesis of dihydrobenzoxazinone- and dihydroquinazolinone-based anti-HIV agents

(2015) Shen Li et al.   CHEMICAL SOCIETY REVIEWS

Trifluoromethylpyrazoles as anti-inflammatory and antibacterial agents: A review

(2015) Kamalneet Kaur et al.   JOURNAL OF FLUORINE CHEMISTRY

One-pot synthesis of 1,3-enynes with a CF3 group on the terminal sp2 carbon by an oxidative Sonogashira cross-coupling reaction

(2015) Akari Ikeda et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Oxidative Trifluoromethylation and Trifluoromethylthiolation Reactions Using (Trifluoromethyl)trimethylsilane as a Nucleophilic CF3 Source

(2014) Lingling Chu et al.   ACCOUNTS OF CHEMICAL RESEARCH

Trifluoromethylation of Alkenes with Concomitant Introduction of Additional Functional Groups

(2014) Hiromichi Egami et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Trifluoromethyltrimethylsilane: Nucleophilic Trifluoromethylation and Beyond

(2014) Xiao Liu et al.   CHEMICAL REVIEWS

Addition of CF3 across unsaturated moieties: a powerful functionalization tool

(2014) Estíbaliz Merino et al.   CHEMICAL SOCIETY REVIEWS

Successful fluorine-containing herbicide agrochemicals

(2014) Tomoya Fujiwara et al.   JOURNAL OF FLUORINE CHEMISTRY

Chiral Phosphoric Acid Catalyzed Transfer Hydrogenation: Facile Synthetic Access to Highly Optically Active Trifluoromethylated Amines

(2011) Alexander Henseler et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Aromatic Trifluoromethylation with Metal Complexes

(2011) Olesya A. Tomashenko et al.   CHEMICAL REVIEWS

Shelf-stable electrophilic trifluoromethylating reagents: A brief historical perspective

(2010) Norio Shibata et al.   Beilstein Journal of Organic Chemistry

Trifluoroacetylation in Organic Synthesis: Reagents, Developments and Applications in the Construction of Trifluoromethylated Compounds

(2010) Simon Lopez et al.   CURRENT ORGANIC SYNTHESIS

Synthesis of β-amino-α-trifluoromethyl alcohols and their applications in organic synthesis

(2010) Grzegorz Mlostoń et al.   JOURNAL OF FLUORINE CHEMISTRY

α-Trifluoromethylated Carbanion Synthons

(2008) Kenji Uneyama et al.   ACCOUNTS OF CHEMICAL RESEARCH