Polysubstituted 3-trifluoromethylpyrazoles: regioselective (3 + 2)-cycloaddition of trifluoroacetonitrile imines with enol ethers and functional group transformations

Synthesis of Celecoxib, Mavacoxib, SC-560, Fluxapyroxad, and Bixafen Enabled by Continuous Flow Reaction Modules

(2017) Joshua Britton et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Expected and unexpected results in reactions of fluorinated nitrile imines with (cyclo)aliphatic thioketones

(2017) Greta Utecht et al.   JOURNAL OF FLUORINE CHEMISTRY

Selective, Metal-Free Approach to 3- or 5-CF3-Pyrazoles: Solvent Switchable Reaction of CF3-Ynones with Hydrazines

(2017) Vasiliy M. Muzalevskiy et al.   JOURNAL OF ORGANIC CHEMISTRY

Heptafluoroisopropyl diazomethane (i-C3F7CHN2): in situ generation and synthesis of pyrazoles

(2017) Pavel K. Mykhailiuk   ORGANIC & BIOMOLECULAR CHEMISTRY

First (3+2)-Cycloadditions of Thiochalcones as C=S Dipolarophiles: Efficient Synthesis of 1,3,4-Thiadiazoles via Reactions with Fluorinated Nitrile Imines

(2017) Grzegorz Mlostoń et al.   SYNTHESIS-STUTTGART

Next Generation of Fluorine-Containing Pharmaceuticals, Compounds Currently in Phase II–III Clinical Trials of Major Pharmaceutical Companies: New Structural Trends and Therapeutic Areas

(2016) Yu Zhou et al.   CHEMICAL REVIEWS

Trifluoromethylated 2,3-dihydro-1,3,4-thiadiazoles via the regioselective [3+2]-cycloadditions of fluorinated nitrile imines with aryl, hetaryl, and ferrocenyl thioketones

(2016) Grzegorz Mlostoń et al.   JOURNAL OF FLUORINE CHEMISTRY

Development of the novel pre-emergence herbicide pyroxasulfone

(2016) Masao Nakatani et al.   JOURNAL OF PESTICIDE SCIENCE

Synthesis of tetra-substituted 5-trifluoromethylpyrazoles via sequential halogenation/palladium-catalyzed C–C and C–N cross-coupling

(2016) Carson Wiethan et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Synthesis of trifluoromethylated isoxazoles and their elaboration through inter- and intra-molecular C–H arylation

(2016) Jian-Siang Poh et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Reactivity of 1-(2-bromobenzyl)-4-halopyrazoles in intermolecular and intramolecular Pd-catalysed direct arylations

(2016) Mariem Brahim et al.   TETRAHEDRON

Solvent- and Transition Metal Catalyst-Dependent Regioselectivity in the [3+2] Cyclocondensation of Trifluoromethyl-α,β-ynones with Hydrazines: Switchable Access to 3- and 5-Trifluoromethylpyrazoles

(2015) Min-Tsang Hsieh et al.   ADVANCED SYNTHESIS & CATALYSIS

Synthesis of 3-(Trifluoromethyl)pyrazoles and Polysubstituted Pyrazoles by atBuOK-Mediated Intramolecular Cycli­zation

(2015) Jia-Jie Wen et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Selective Incorporation of Fluorine in Pyrazoles

(2015) Joseph C. Sloop et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Efficient one-pot synthesis of 5-perfluoroalkylpyrazoles by cyclization of hydrazone dianions

(2015) Thang Ngoc Ngo et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

An efficient route to 3-trifluoromethylpyrazole via cyclization/1,5-H shift and its applications in the synthesis of bioactive compounds

(2015) Yongdong Wang et al.   TETRAHEDRON

Tautomeric equilibrium in trifluoroacetaldehyde arylhydrazones

(2015) Agata Wojciechowska et al.   TETRAHEDRON

Conditions for palladium-catalyzed direct arylations of 4-bromo and 4-iodo N-substituted pyrazoles without C–Br or C–I bond cleavage

(2015) Mariem Brahim et al.   Organic Chemistry Frontiers

Synthesis of trifluoromethyl-substituted pyrazolo[4,3-c]pyridines – sequential versus multicomponent reaction approach

(2014) Barbara Palka et al.   Beilstein Journal of Organic Chemistry

Synthesis of 3-trifluoromethylpyrazoles via trifluoromethylation/cyclization of α,β-alkynic hydrazones using a hypervalent iodine reagent

(2014) Guojing Ji et al.   CHEMICAL COMMUNICATIONS

Formyl Substituent at C-4 of Pyrazoles: A Temporary Protecting Group for Regioselective Palladium-Catalyzed Direct Arylation at C-5

(2014) Imen Smari et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Design and Synthesis of 3-Trifluoromethyl-3H-pyrazoles and Further Investigations of Their Transformation to 1H-Pyrazoles

(2014) Qiang Sha et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Regioselective and Guided C–H Activation of 4-Nitropyrazoles

(2014) Viktor O. Iaroshenko et al.   JOURNAL OF ORGANIC CHEMISTRY

Regioselective Cycloaddition of Trifluorodiazoethane with Electron-Deficient Allenic Esters and Ketones: Access to CF3-Substituted Pyrazolines and Pyrazoles

(2014) Fa-Guang Zhang et al.   ORGANIC LETTERS

Silver-Mediated Cycloaddition of Alkynes with CF3CHN2: Highly Regioselective Synthesis of 3-Trifluoromethylpyrazoles

(2013) Feng Li et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Fluorine in Pharmaceutical Industry: Fluorine-Containing Drugs Introduced to the Market in the Last Decade (2001–2011)

(2013) Jiang Wang et al.   CHEMICAL REVIEWS

A new and direct route to 3-fluoromethyl substituted pyrazol-4-acrylates via Pd-catalyzed C–H activation

(2013) Xiaoguang Wang et al.   TETRAHEDRON

Analogues of N,1-diphenyl-4,5-dihydro-1H-[1]benzothiepino[5,4-c]pyrazole-3-carboxamide and N,1-diphenyl-4,5-dihydro-1H-[1]benzothiepino[5,4-c]pyrazole-3-carboxamide-6,6-dioxide: syntheses, characterization, antimicrobial, antituberculosis, and antitumor activity

(2013) Pandaram Palanisamy et al.   RSC Advances

Synthesis of diversely fluorinated pyrazoles as novel active agrochemical ingredients

(2012) Florence Giornal et al.   JOURNAL OF FLUORINE CHEMISTRY

Palladium-Catalyzed Direct Arylation of 5-Chloropyrazoles: A Selective Access to 4-Aryl Pyrazoles

(2012) Tao Yan et al.   JOURNAL OF ORGANIC CHEMISTRY

Synthesis of Ynone Trifluoroborates toward Functionalized Pyrazoles

(2012) James D. Kirkham et al.   ORGANIC LETTERS

Solvent-controlled, regio-switchable formation of 3-/5-arylaminopyrazole isomer in cyclocondensation of β-aminoenones with hydrazides: intermolecular hydrogen bonding plays a role

(2012) Dexuan Xiang et al.   RSC Advances

From 2000 to Mid-2010: A Fruitful Decade for the Synthesis of Pyrazoles

(2011) Santos Fustero et al.   CHEMICAL REVIEWS

Fluorinated amino acids: compatibility with native protein structures and effects on protein–protein interactions

(2011) Mario Salwiczek et al.   CHEMICAL SOCIETY REVIEWS

Synthesis of Pyrazoles via Electrophilic Cyclization

(2011) Metin Zora et al.   JOURNAL OF ORGANIC CHEMISTRY

Synthesis and anti-microbial activity of some new fluorinated 1H-pyrazoles

(2010) Dun-Jia Wang et al.   JOURNAL OF FLUORINE CHEMISTRY

Direct, Catalytic Synthesis of Carbapenams via Cycloaddition/Rearrangement Cascade Reaction: Unexpected Acetylenes’ Structure Effect

(2010) Adam Mames et al.   JOURNAL OF ORGANIC CHEMISTRY

Pyrazole synthesis under microwave irradiation and solvent-free conditions

(2010) Lilian Buriol et al.   JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY

The pharmacokinetics of mavacoxib, a long-acting COX-2 inhibitor, in young adult laboratory dogs

(2010) S. R. COX et al.   JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS

General method for dehydration, intramolecular cyclization, and fluorination of trifluoromethyl-1H-pyrazoles using DAST

(2010) Helio G. Bonacorso et al.   TETRAHEDRON LETTERS

Trifluoromethyl-substituted pyridyl- and pyrazolylboronic acids and esters: synthesis and Suzuki–Miyaura cross-coupling reactions

(2009) Kate M. Clapham et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Room Temperature ICl-Induced Dehydration/Iodination of 1-Acyl-5-hydroxy-4,5-dihydro-1H-pyrazoles. A Selective Route to Substituted 1-Acyl-4-iodo-1H-pyrazoles

(2008) Jesse P. Waldo et al.   JOURNAL OF ORGANIC CHEMISTRY

Improved Regioselectivity in Pyrazole Formation through the Use of Fluorinated Alcohols as Solvents: Synthesis and Biological Activity of Fluorinated Tebufenpyrad Analogs

(2008) Santos Fustero et al.   JOURNAL OF ORGANIC CHEMISTRY

Effect of the new pyrazole carboxamide fungicide penthiopyrad on late leaf spot and stem rot of peanut

(2008) Albert K Culbreath et al.   PEST MANAGEMENT SCIENCE

Structure–activity relationship and pharmacokinetic profile of 5-ketopyrazole factor Xa inhibitors

(2007) Jeffrey G. Varnes et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS