SIK3 and Wnk converge on Fray to regulate glial K+ buffering and seizure susceptibility

WNKs are potassium-sensitive kinases

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Bidirectional regulation of glial potassium buffering – glioprotection versus neuroprotection

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Neuron–glia interaction in the Drosophila nervous system

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Transcriptomic and proteomic profiling of glial versus neuronal Dube3a overexpression reveals common molecular changes in gliopathic epilepsies

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Physiological Processes Modulated by the Chloride-Sensitive WNK-SPAK/OSR1 Kinase Signaling Pathway and the Cation-Coupled Chloride Cotransporters

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Glial Ca2+signaling links endocytosis to K+ buffering around neuronal somas to regulate excitability

(2019) Shirley Weiss et al.   eLife

Roles of glial ion transporters in brain diseases

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SIK3 suppresses neuronal hyperexcitability by regulating the glial capacity to buffer K+ and water

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Defective cortex glia plasma membrane structure underlies light-induced epilepsy in cpes mutants

(2018) Govind Kunduri et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Drosophila glia: Few cell types and many conserved functions

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The glia of the adult Drosophila nervous system

(2017) Malte C. Kremer et al.   GLIA

Glial overexpression of Dube3a causes seizures and synaptic impairments in Drosophila concomitant with down regulation of the Na + /K + pump ATPα

(2017) Kevin A. Hope et al.   NEUROBIOLOGY OF DISEASE

K-Cl cotransporters, cell volume homeostasis, and neurological disease

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Ion dynamics during seizures

(2015) Joseph V. Raimondo et al.   Frontiers in Cellular Neuroscience

The WNK-regulated SPAK/OSR1 kinases directly phosphorylate and inhibit the K+–Cl−co-transporters

(2014) Paola de los Heros et al.   BIOCHEMICAL JOURNAL

WNK-SPAK-NCC Cascade Revisited

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Hypotonicity Stimulates Potassium Flux through the WNK-SPAK/OSR1 Kinase Cascade and the Ncc69 Sodium-Potassium-2-Chloride Cotransporter in theDrosophilaRenal Tubule

(2014) Yipin Wu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Modeling Glial Contributions to Seizures and Epileptogenesis: Cation-Chloride Cotransporters in Drosophila melanogaster

(2014) Zeid M. Rusan et al.   PLoS One

The WNK-SPAK/OSR1 pathway: Master regulator of cation-chloride cotransporters

(2014) D. R. Alessi et al.   Science Signaling

Mutation of a NCKX Eliminates Glial Microdomain Calcium Oscillations and Enhances Seizure Susceptibility

(2013) J. E. Melom et al.   JOURNAL OF NEUROSCIENCE

SPAK/OSR1 regulate NKCC1 and WNK activity: analysis of WNK isoform interactions and activation by T-loop trans-autophosphorylation

(2011) Jacob O. Thastrup et al.   BIOCHEMICAL JOURNAL

Drosophila glia use a conserved cotransporter mechanism to regulate extracellular volume

(2010) William M. Leiserson et al.   GLIA

Roles of the cation–chloride cotransporters in neurological disease

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