Hypotonicity Stimulates Potassium Flux through the WNK-SPAK/OSR1 Kinase Cascade and the Ncc69 Sodium-Potassium-2-Chloride Cotransporter in theDrosophilaRenal Tubule

WNK4 is the major WNK positively regulating NCC in the mouse kidney

(2014) Daiei Takahashi et al.   BIOSCIENCE REPORTS

SWELL1, a Plasma Membrane Protein, Is an Essential Component of Volume-Regulated Anion Channel

(2014) Zhaozhu Qiu et al.   CELL

Identification of LRRC8 Heteromers as an Essential Component of the Volume-Regulated Anion Channel VRAC

(2014) F. K. Voss et al.   SCIENCE

Chloride Sensing by WNK1 Involves Inhibition of Autophosphorylation

(2014) A. T. Piala et al.   Science Signaling

Wnk kinases are positive regulators of canonical Wnt/β-catenin signalling

(2013) Ekatherina Serysheva et al.   EMBO REPORTS

WNK Signaling Is Involved in Neural Development via Lhx8/Awh Expression

(2013) Atsushi Sato et al.   PLoS One

The Drosophila NKCC Ncc69 is required for normal renal tubule function

(2012) Aylin R. Rodan et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Calcium-binding protein 39 facilitates molecular interaction between Ste20p proline alanine-rich kinase and oxidative stress response 1 monomers

(2012) José Ponce-Coria et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

WNK3-SPAK Interaction is Required for the Modulation of NCC and other Members of the SLC12 Family

(2012) Diana Pacheco-Alvarez et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

SPAK Isoforms and OSR1 Regulate Sodium-Chloride Co-transporters in a Nephron-specific Manner

(2012) P. Richard Grimm et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Anion-Sensitive Fluorophore Identifies the Drosophila Swell-Activated Chloride Channel in a Genome-Wide RNA Interference Screen

(2012) Stephanie C. Stotz et al.   PLoS One

Activation of the renal Na+:Cl- cotransporter by angiotensin II is a WNK4-dependent process

(2012) M. Castaneda-Bueno et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

WNK3 is a Putative Chloride-sensing Kinase

(2011) Diana Pacheco-Alvarez et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

MO25 is a master regulator of SPAK/OSR1 and MST3/MST4/YSK1 protein kinases

(2011) Beatrice M Filippi et al.   EMBO JOURNAL

Regulation of the NKCC2 ion cotransporter by SPAK-OSR1-dependent and -independent pathways

(2011) C. Richardson et al.   JOURNAL OF CELL SCIENCE

Epigenetic modulation of the renal β-adrenergic–WNK4 pathway in salt-sensitive hypertension

(2011) ShengYu Mu et al.   NATURE MEDICINE

A genome-scale shRNA resource for transgenic RNAi in Drosophila

(2011) Jian-Quan Ni et al.   NATURE METHODS

Impaired phosphorylation of Na+-K+-2Cl- cotransporter by oxidative stress-responsive kinase-1 deficiency manifests hypotension and Bartter-like syndrome

(2011) S.-H. Lin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of WNK1 kinase by extracellular potassium

(2010) Shotaro Naito et al.   Clinical and Experimental Nephrology

Role of the WNK-activated SPAK kinase in regulating blood pressure

(2010) Fatema H. Rafiqi et al.   EMBO Molecular Medicine

Drosophila glia use a conserved cotransporter mechanism to regulate extracellular volume

(2010) William M. Leiserson et al.   GLIA

SPAK-Knockout Mice Manifest Gitelman Syndrome and Impaired Vasoconstriction

(2010) S.-S. Yang et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Targeted disruption of the Wnk4 gene decreases phosphorylation of Na-Cl cotransporter, increases Na excretion and lowers blood pressure

(2009) Akihito Ohta et al.   HUMAN MOLECULAR GENETICS

WNK4 Diverts the Thiazide-sensitive NaCl Cotransporter to the Lysosome and Stimulates AP-3 Interaction

(2009) Arohan R. Subramanya et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The role of aquaporins in excretion in insects

(2009) J. H. Spring et al.   JOURNAL OF EXPERIMENTAL BIOLOGY

WNK4 Enhances the Degradation of NCC through a Sortilin-Mediated Lysosomal Pathway

(2009) B. Zhou et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Physiology of Cell Volume Regulation in Vertebrates

(2009) Else K. Hoffmann et al.   PHYSIOLOGICAL REVIEWS

Characterization of optimized Na+ and Cl− liquid membranes for use with extracellular, self-referencing microelectrodes

(2008) Mark A. Messerli et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Activation of the thiazide-sensitive Na+-Cl- cotransporter by the WNK-regulated kinases SPAK and OSR1

(2008) C. Richardson et al.   JOURNAL OF CELL SCIENCE

Rescue of Volume-regulated Anion Current by Bestrophin Mutants with Altered Charge Selectivity

(2008) Li-Ting Chien et al.   JOURNAL OF GENERAL PHYSIOLOGY

Regulation of NKCC2 by a chloride-sensing mechanism involving the WNK3 and SPAK kinases

(2008) J. Ponce-Coria et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The GC kinase Fray and Mo25 regulate Drosophila asymmetric divisions

(2007) Yoshihiro Yamamoto et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS