TRPA1 channels: molecular sentinels of cellular stress and tissue damage

Naturally Produced Defensive Alkenal Compounds Activate TRPA1

(2016) Nathaniel T. Blair et al.   CHEMICAL SENSES

How the TRPA1 receptor transmits painful stimuli: Inner workings revealed by electron cryomicroscopy

(2015) Monique S. J. Brewster et al.   BIOESSAYS

Oxygen Sensing by Arterial Chemoreceptors Depends on Mitochondrial Complex I Signaling

(2015) M. Carmen Fernández-Agüera et al.   Cell Metabolism

Deciphering Subtype-Selective Modulations in TRPA1 Biosensor Channels

(2015) Daisuke Kozai et al.   Current Neuropharmacology

Streptozotocin Stimulates the Ion Channel TRPA1 Directly

(2015) David A. Andersson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

In Vivo Patch-Clamp Analysis of the Antinociceptive Actions of TRPA1 Activation in the Spinal Dorsal Horn

(2015) Manabu Yamanaka et al.   Molecular Pain

Erratum: Structure of the TRPA1 ion channel suggests regulatory mechanisms

(2015) Candice E. Paulsen et al.   NATURE

Physical basis of apparent pore dilation of ATP-activated P2X receptor channels

(2015) Mufeng Li et al.   NATURE NEUROSCIENCE

TRPA1 as a drug target—promise and challenges

(2015) Jun Chen et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

Tmem100 Is a Regulator of TRPA1-TRPV1 Complex and Contributes to Persistent Pain

(2015) Hao-Jui Weng et al.   NEURON

Silencing Nociceptor Neurons Reduces Allergic Airway Inflammation

(2015) Sébastien Talbot et al.   NEURON

Structural modeling and patch-clamp analysis of pain-related mutation TRPA1-N855S reveal inter-subunit salt bridges stabilizing the channel open state

(2015) Vlastimil Zíma et al.   NEUROPHARMACOLOGY

The role of TRPA1 in muscle pain and mechanical hypersensitivity under inflammatory conditions in rats

(2015) J. Asgar et al.   NEUROSCIENCE

Hydrogen sulfide determines HNO-induced stimulation of trigeminal afferents

(2015) Vanessa Wild et al.   NEUROSCIENCE LETTERS

Differential Contribution of TRPA1, TRPV4 and TRPM8 to Colonic Nociception in Mice

(2015) Sonja M. Mueller-Tribbensee et al.   PLoS One

DrosophilaTRPA1 isoforms detect UV light via photochemical production of H2O2

(2015) Ananya R. Guntur et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Localized TRPA1 channel Ca2+signals stimulated by reactive oxygen species promote cerebral artery dilation

(2015) Michelle N. Sullivan et al.   Science Signaling

The Regulation of Immunological Processes by Peripheral Neurons in Homeostasis and Disease

(2015) Jose Ordovas-Montanes et al.   TRENDS IN IMMUNOLOGY

Environmental Temperature Differentially Modulates C. elegans Longevity through a Thermosensitive TRP Channel

(2015) Bi Zhang et al.   Cell Reports

Localized TRPA1 channel Ca2+signals stimulated by reactive oxygen species promote cerebral artery dilation

(2015) Michelle N. Sullivan et al.   Science Signaling

Urate Crystal Induced Inflammation and Joint Pain Are Reduced in Transient Receptor Potential Ankyrin 1 Deficient Mice – Potential Role for Transient Receptor Potential Ankyrin 1 in Gout

(2015) Lauri J. Moilanen et al.   PLoS One

H2S and NO cooperatively regulate vascular tone by activating a neuroendocrine HNO–TRPA1–CGRP signalling pathway

(2015) Mirjam Eberhardt et al.   Nature Communications

A Molecular Framework for Temperature-Dependent Gating of Ion Channels

(2014) Sandipan Chowdhury et al.   CELL

ROS Function in Redox Signaling and Oxidative Stress

(2014) Michael Schieber et al.   CURRENT BIOLOGY

Activation of TLR-4 to produce tumour necrosis factor-α in neuropathic pain caused by paclitaxel

(2014) Z. Wu et al.   EUROPEAN JOURNAL OF PAIN

TRPA1 receptor stimulation by hydrogen peroxide is critical to trigger hyperalgesia and inflammation in a model of acute gout

(2014) Gabriela Trevisan et al.   FREE RADICAL BIOLOGY AND MEDICINE

The Bile Acid Receptor TGR5 Activates the TRPA1 Channel to Induce Itch in Mice

(2014) TinaMarie Lieu et al.   GASTROENTEROLOGY

TRPA1 and TRPV4 Activation in Human Odontoblasts Stimulates ATP Release

(2014) O. Egbuniwe et al.   JOURNAL OF DENTAL RESEARCH

UV light activates a Gαq/11-coupled phototransduction pathway in human melanocytes

(2014) Nicholas W. Bellono et al.   JOURNAL OF GENERAL PHYSIOLOGY

TRPA1 is required for TGF-β signaling and its loss blocks inflammatory fibrosis in mouse corneal stroma

(2014) Yuka Okada et al.   LABORATORY INVESTIGATION

Directionality of Temperature Activation in Mouse TRPA1 Ion Channel Can Be Inverted by Single-Point Mutations in Ankyrin Repeat Six

(2014) Sairam Jabba et al.   NEURON

Extracellular MicroRNAs Activate Nociceptor Neurons to Elicit Pain via TLR7 and TRPA1

(2014) Chul-Kyu Park et al.   NEURON

Upregulation of the Transient Receptor Potential Ankyrin 1 Ion Channel in the Inflamed Human and Mouse Colon and Its Protective Roles

(2014) József Kun et al.   PLoS One

Human TRPA1 is intrinsically cold- and chemosensitive with and without its N-terminal ankyrin repeat domain

(2014) Lavanya Moparthi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Steroidal and non-steroidal third-generation aromatase inhibitors induce pain-like symptoms via TRPA1

(2014) Camilla Fusi et al.   Nature Communications

TRPA1 channels mediate acute neurogenic inflammation and pain produced by bacterial endotoxins

(2014) Victor Meseguer et al.   Nature Communications

TRPA1 is essential for the vascular response to environmental cold exposure

(2014) Aisah A. Aubdool et al.   Nature Communications

Differential methylation of the TRPA1 promoter in pain sensitivity

(2014) J.T. Bell et al.   Nature Communications

High temperature sensitivity is intrinsic to voltage-gated potassium channels

(2014) Fan Yang et al.   eLife

Contribution of Transient Receptor Potential Ankyrin 1 to Chronic Pain in Aged Mice With Complete Freund's Adjuvant-Induced Arthritis

(2014) Sheldon R. Garrison et al.   Arthritis & Rheumatology

Defining the nociceptor transcriptome

(2014) Matthew Thakur et al.   Frontiers in Molecular Neuroscience

TRP Channels and Pain

(2013) David Julius   Annual Review of Cell and Developmental Biology

Novel Therapeutic Strategy to Prevent Chemotherapy-Induced Persistent Sensory Neuropathy By TRPA1 Blockade

(2013) G. Trevisan et al.   CANCER RESEARCH

A Genetic Program Promotes C. elegans Longevity at Cold Temperatures via a Thermosensitive TRP Channel

(2013) Rui Xiao et al.   CELL

The Molecular Basis for Species-specific Activation of Human TRPA1 Protein by Protons Involves Poorly Conserved Residues within Transmembrane Domains 5 and 6

(2013) Jeanne de la Roche et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TRPA1-Dependent Pruritus in IL-13-Induced Chronic Atopic Dermatitis

(2013) M.-H. Oh et al.   JOURNAL OF IMMUNOLOGY

Modulation of TRP Channels by Resveratrol and other Stilbenoids

(2013) Lina Yu et al.   Molecular Pain

Bacteria activate sensory neurons that modulate pain and inflammation

(2013) Isaac M. Chiu et al.   NATURE

Structure of the TRPV1 ion channel determined by electron cryo-microscopy

(2013) Maofu Liao et al.   NATURE

Activity-dependent silencing reveals functionally distinct itch-generating sensory neurons

(2013) David P Roberson et al.   NATURE NEUROSCIENCE

UV light phototransduction activates transient receptor potential A1 ion channels in human melanocytes

(2013) N. W. Bellono et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Rhinovirus upregulates transient receptor potential channels in a human neuronal cell line: implications for respiratory virus-induced cough reflex sensitivity

(2013) H Abdullah et al.   THORAX

Species differences and molecular determinant of TRPA1 cold sensitivity

(2013) Jun Chen et al.   Nature Communications

A TRPA1 antagonist reverts oxaliplatin-induced neuropathic pain

(2013) Cristina Nativi et al.   Scientific Reports

Transient Receptor Potential Ankyrin 1 Ion Channel Contributes to Guarding Pain and Mechanical Hypersensitivity in a Rat Model of Postoperative Pain

(2012) Hong Wei et al.   ANESTHESIOLOGY

TRPA1: A Gatekeeper for Inflammation

(2012) Diana M. Bautista et al.   Annual Review of Physiology

The functions of TRPA1 and TRPV1: moving away from sensory nerves

(2012) ES Fernandes et al.   BRITISH JOURNAL OF PHARMACOLOGY

Hydrogen sulfide-induced mechanical hyperalgesia and allodynia require activation of both Cav3.2 and TRPA1 channels in mice

(2012) Kazumasa Okubo et al.   BRITISH JOURNAL OF PHARMACOLOGY

TRPA1 channels in the vasculature

(2012) Scott Earley   BRITISH JOURNAL OF PHARMACOLOGY

Ciguatoxins activate specific cold pain pathways to elicit burning pain from cooling

(2012) Irina Vetter et al.   EMBO JOURNAL

Differential Expression and Functionality of TRPA1 Protein Genetic Variants in Conditions of Thermal Stimulation

(2012) Denisa May et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

C-terminal Acidic Cluster Is Involved in Ca2+-induced Regulation of Human Transient Receptor Potential Ankyrin 1 Channel

(2012) Lucie Sura et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hypoxia-inducible Factor-1α (HIF1α) Switches on Transient Receptor Potential Ankyrin Repeat 1 (TRPA1) Gene Expression via a Hypoxia Response Element-like Motif to Modulate Cytokine Release

(2012) Noriyuki Hatano et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Methylglyoxal Activates Nociceptors through Transient Receptor Potential Channel A1 (TRPA1)

(2012) Mirjam J. Eberhardt et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Residues in the pore region ofDrosophilatransient receptor potential A1 dictate sensitivity to thermal stimuli

(2012) Hong Wang et al.   JOURNAL OF PHYSIOLOGY-LONDON

Neurogenic inflammation and the peripheral nervous system in host defense and immunopathology

(2012) Isaac M Chiu et al.   NATURE NEUROSCIENCE

TRPA1 and TRPV4 mediate paclitaxel-induced peripheral neuropathy in mice via a glutathione-sensitive mechanism

(2012) Serena Materazzi et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

The transient receptor potential channel TRPA1: from gene to pathophysiology

(2012) Bernd Nilius et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

The Ankyrin Repeat Domain of the TRPA Protein Painless Is Important for Thermal Nociception but Not Mechanical Nociception

(2012) Richard Y. Hwang et al.   PLoS One

TRPA1 Is a Polyunsaturated Fatty Acid Sensor in Mammals

(2012) Arianne L. Motter et al.   PLoS One

Transient Receptor Potential Ankyrin 1 Channel Localized to Non-Neuronal Airway Cells Promotes Non-Neurogenic Inflammation

(2012) Romina Nassini et al.   PLoS One

TRPA1 Mediates Mechanical Sensitization in Nociceptors during Inflammation

(2012) Richard C. Lennertz et al.   PLoS One

TRPA1 Has a Key Role in the Somatic Pro-Nociceptive Actions of Hydrogen Sulfide

(2012) David A. Andersson et al.   PLoS One

Oxidative stress induces itch via activation of transient receptor potential subtype ankyrin 1 in mice

(2012) Tong Liu et al.   Neuroscience Bulletin

Thermosensory and Nonthermosensory Isoforms of Drosophila melanogaster TRPA1 Reveal Heat-Sensor Domains of a ThermoTRP Channel

(2012) Lixian Zhong et al.   Cell Reports

Activation of TRPA1 by luminal stimuli induces EP4-mediated anion secretion in human and rat colon

(2011) Izumi Kaji et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Transient Receptor Potential A1 Channels

(2011) Maria G. Belvisi et al.   CHEST

Properties and Therapeutic Potential of Transient Receptor Potential Channels with Putative Roles in Adversity: Focus on TRPC5, TRPM2 and TRPA1

(2011) L. H. Jiang et al.   CURRENT DRUG TARGETS

TRPA1 and Substance P Mediate Colitis in Mice

(2011) Matthias A. Engel et al.   GASTROENTEROLOGY

Could an Allosteric Gating Model Explain the Role of TRPA1 in Cold Hypersensitivity?

(2011) M. Salazar et al.   JOURNAL OF NEUROSCIENCE

Resolvin D2 Is a Potent Endogenous Inhibitor for Transient Receptor Potential Subtype V1/A1, Inflammatory Pain, and Spinal Cord Synaptic Plasticity in Mice: Distinct Roles of Resolvin D1, D2, and E1

(2011) C.-K. Park et al.   JOURNAL OF NEUROSCIENCE

TRPA1 contributes to specific mechanically activated currents and sensory neuron mechanical hypersensitivity

(2011) Stuart M. Brierley et al.   JOURNAL OF PHYSIOLOGY-LONDON

TRPA1 underlies a sensing mechanism for O2

(2011) Nobuaki Takahashi et al.   Nature Chemical Biology

TRPA1 channels regulate astrocyte resting calcium and inhibitory synapse efficacy through GAT-3

(2011) Eiji Shigetomi et al.   NATURE NEUROSCIENCE

Selective blockade of TRPA1 channel attenuates pathological pain without altering noxious cold sensation or body temperature regulation

(2011) Jun Chen et al.   PAIN

Transient Receptor Potential Channel Polymorphisms Are Associated with the Somatosensory Function in Neuropathic Pain Patients

(2011) Andreas Binder et al.   PLoS One

Cytoplasmic ankyrin repeats of transient receptor potential A1 (TRPA1) dictate sensitivity to thermal and chemical stimuli

(2011) J. F. Cordero-Morales et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A thermodynamic framework for understanding temperature sensing by transient receptor potential (TRP) channels

(2011) D. E. Clapham et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TRPA1 mediates spinal antinociception induced by acetaminophen and the cannabinoid Δ9-tetrahydrocannabiorcol

(2011) David A Andersson et al.   Nature Communications

TRP Channels as Sensors and Signal Integrators of Redox Status Changes

(2011) Nobuaki Takahashi et al.   Frontiers in Pharmacology

Chemosensory Properties of the Trigeminal System

(2010) Félix Viana   ACS Chemical Neuroscience

A distinct role for transient receptor potential ankyrin 1, in addition to transient receptor potential vanilloid 1, in tumor necrosis factor α-induced inflammatory hyperalgesia and Freund's complete adjuvant-induced monarthritis

(2010) Elizabeth S. Fernandes et al.   ARTHRITIS AND RHEUMATISM

Agonist-Induced Changes in Ca2+ Permeation through the Nociceptor Cation Channel TRPA1

(2010) Yuji Karashima et al.   BIOPHYSICAL JOURNAL

Resolvin D1 attenuates activation of sensory transient receptor potential channels leading to multiple anti-nociception

(2010) S Bang et al.   BRITISH JOURNAL OF PHARMACOLOGY

TRPA1 channels: Novel targets of 1,4-dihydropyridines

(2010) Otto Fajardo et al.   Channels

Regulation of Nociceptive Transmission at the Periphery Via TRPA1-TRPV1 Interactions

(2010) Armen N. Akopian   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

Exposure to Low Temperature Induces Elevation of Intracellular Calcium in Cultured Human Keratinocytes

(2010) Moe Tsutsumi et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

TRPA1 Contributes to Cold Hypersensitivity

(2010) D. del Camino et al.   JOURNAL OF NEUROSCIENCE

TRPA1 Is a Component of the Nociceptive Response to CO2

(2010) Y. Y. Wang et al.   JOURNAL OF NEUROSCIENCE

TRPA1 Modulation of Spontaneous and Mechanically Evoked Firing of Spinal Neurons in Uninjured, Osteoarthritic, and Inflamed Rats

(2010) Steve McGaraughty et al.   Molecular Pain

Interactions between the immune and nervous systems in pain

(2010) Ke Ren et al.   NATURE MEDICINE

A Gain-of-Function Mutation in TRPA1 Causes Familial Episodic Pain Syndrome

(2010) Barbara Kremeyer et al.   NEURON

Attenuation of Mechanical Hypersensitivity by an Antagonist of the TRPA1 Ion Channel in Diabetic Animals

(2009) Hong Wei et al.   ANESTHESIOLOGY

Cellular and Molecular Mechanisms of Pain

(2009) Allan I. Basbaum et al.   CELL

Endothelium-Dependent Cerebral Artery Dilation Mediated by TRPA1 and Ca 2+ -Activated K + Channels

(2009) Scott Earley et al.   CIRCULATION RESEARCH

TRPA1 modulators in preclinical development

(2009) Félix Viana et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Burning Cold: Involvement of TRPA1 in Noxious Cold Sensation

(2009) Kelvin Y. Kwan et al.   JOURNAL OF GENERAL PHYSIOLOGY

Non-Neuronal Expression of Transient Receptor Potential Type A1 (TRPA1) in Human Skin

(2009) Ruzanna Atoyan et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Nitrooleic Acid, an Endogenous Product of Nitrative Stress, Activates Nociceptive Sensory Nerves via the Direct Activation of TRPA1

(2009) T. E. Taylor-Clark et al.   MOLECULAR PHARMACOLOGY

Zinc activates damage-sensing TRPA1 ion channels

(2009) Hongzhen Hu et al.   Nature Chemical Biology

Nociceptive Signals Induce Trafficking of TRPA1 to the Plasma Membrane

(2009) Manuela Schmidt et al.   NEURON

The involvement of the transient receptor potential A1 (TRPA1) in the maintenance of mechanical and cold hyperalgesia in persistent inflammation

(2009) Diogo Santos M. da Costa et al.   PAIN

TRPV1 and TRPA1 Mediate Peripheral Nitric Oxide-Induced Nociception in Mice

(2009) Takashi Miyamoto et al.   PLoS One

A sensory neuronal ion channel essential for airway inflammation and hyperreactivity in asthma

(2009) A. I. Caceres et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Clioquinol and pyrithione activate TRPA1 by increasing intracellular Zn2+

(2009) D. A. Andersson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TRPA1: A potential target for anti-tussive therapy

(2009) Thomas E. Taylor-Clark et al.   PULMONARY PHARMACOLOGY & THERAPEUTICS

Critical role of nociceptor plasticity in chronic pain

(2009) David B. Reichling et al.   TRENDS IN NEUROSCIENCES

The concept of neurogenic inflammation

(2008) Pierangelo Geppetti et al.   BJU INTERNATIONAL

Phospholipase C and protein kinase A mediate bradykinin sensitization of TRPA1: a molecular mechanism of inflammatory pain

(2008) Shenglan Wang et al.   BRAIN

Transient Receptor Potential A1 (TRPA1) Activity in the Human Urethra—Evidence for a Functional Role for TRPA1 in the Outflow Region

(2008) Christian Gratzke et al.   EUROPEAN UROLOGY

The Nociceptor Ion Channel TRPA1 Is Potentiated and Inactivated by Permeating Calcium Ions

(2008) Yuanyuan Y. Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Intracellular alkalization causes pain sensation through activation of TRPA1 in mice

(2008) Fumitaka Fujita et al.   JOURNAL OF CLINICAL INVESTIGATION

Identification of Transmembrane Domain 5 as a Critical Molecular Determinant of Menthol Sensitivity in Mammalian TRPA1 Channels

(2008) B. Xiao et al.   JOURNAL OF NEUROSCIENCE

Transient Receptor Potential A1 Is a Sensory Receptor for Multiple Products of Oxidative Stress

(2008) D. A. Andersson et al.   JOURNAL OF NEUROSCIENCE

HC-030031, a TRPA1 Selective Antagonist, Attenuates Inflammatory- and Neuropathy-Induced Mechanical Hypersensitivity

(2008) Samer R Eid et al.   Molecular Pain

Transient receptor potential ankyrin-1 participates in visceral hyperalgesia following experimental colitis

(2008) Jing Yang et al.   NEUROSCIENCE LETTERS

Breathtaking TRP Channels: TRPA1 and TRPV1 in Airway Chemosensation and Reflex Control

(2008) Bret F. Bessac et al.   PHYSIOLOGY

Cox-dependent fatty acid metabolites cause pain through activation of the irritant receptor TRPA1

(2008) S. Materazzi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Distribution and Function of the Hydrogen Sulfide–Sensitive TRPA1 Ion Channel in Rat Urinary Bladder

(2007) Tomi Streng et al.   EUROPEAN UROLOGY