Adipose-specific deletion of the cation channel TRPM7 inhibits TAK1 kinase-dependent inflammation and obesity in male mice

Low Chloride–Regulated ClC-5 Contributes to Arterial Smooth Muscle Cell Proliferation and Cerebrovascular Remodeling

(2022) Min Gao et al.   HYPERTENSION

Pharmacological and Genetic Blockade of Trpm7 in the Carotid Body Treats Obesity-Induced Hypertension

(2021) Mi-Kyung Shin et al.   HYPERTENSION

Advances in TRP channel drug discovery: from target validation to clinical studies

(2021) Ari-Pekka Koivisto et al.   NATURE REVIEWS DRUG DISCOVERY

LRRC8A is essential for volume‐regulated anion channel in smooth muscle cells contributing to cerebrovascular remodeling during hypertension

(2021) Xiang‐Yu Li et al.   CELL PROLIFERATION

TNFAIP3 Interacting Protein 3 Overexpression Suppresses Nonalcoholic Steatohepatitis by Blocking TAK1 Activation

(2020) Dan Liu et al.   Cell Metabolism

TRPM7 Mediates Neuronal Cell Death Upstream of Calcium/Calmodulin-Dependent Protein Kinase II and Calcineurin Mechanism in Neonatal Hypoxic-Ischemic Brain Injury

(2020) Ekaterina Turlova et al.   Translational Stroke Research

PLCβ2 negatively regulates the inflammatory response to virus infection by inhibiting phosphoinositide-mediated activation of TAK1

(2019) Lin Wang et al.   Nature Communications

FTY720/Fingolimod Decreases Hepatic Steatosis and Expression of Fatty Acid Synthase in Diet-Induced Non-Alcoholic Fatty Liver Disease in Mice

(2019) Timothy D. Rohrbach et al.   JOURNAL OF LIPID RESEARCH

Chanzyme TRPM7 protects against cardiovascular inflammation and fibrosis

(2019) Francisco J Rios et al.   CARDIOVASCULAR RESEARCH

Endophilin A2 regulates calcium-activated chloride channel activity via selective autophagy-mediated TMEM16A degradation

(2019) Can-zhao Liu et al.   ACTA PHARMACOLOGICA SINICA

Leptin Induces Hypertension Acting on Transient Receptor Potential Melastatin 7 Channel in the Carotid Body

(2019) Mi-Kyung Shin et al.   CIRCULATION RESEARCH

Magnesium-Induced Cell Survival Is Dependent on TRPM7 Expression and Function

(2019) Yuyang Sun et al.   MOLECULAR NEUROBIOLOGY

Multifaceted roles of TAK1 signaling in cancer

(2019) Himadri Mukhopadhyay et al.   ONCOGENE

Disruption of Pressure-Induced Ca 2+ Spark Vasoregulation of Resistance Arteries, Rather Than Endothelial Dysfunction, Underlies Obesity-Related Hypertension

(2019) Adam S. Greenstein et al.   HYPERTENSION

Chanzyme TRPM7 Mediates the Ca 2+ Influx Essential for Lipopolysaccharide-Induced Toll-Like Receptor 4 Endocytosis and Macrophage Activation

(2018) Michael S. Schappe et al.   IMMUNITY

Redox signal-mediated TRPM2 promotes Ang II-induced adipocyte insulin resistance via Ca 2+ -dependent CaMKII/JNK cascade

(2018) Min Gao et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Reactive astrocytes in multiple sclerosis impair neuronal outgrowth through TRPM7-mediated chondroitin sulfate proteoglycan production

(2018) Alwin Kamermans et al.   GLIA

TRPM7 and CaV3.2 channels mediate Ca2+ influx required for egg activation at fertilization

(2018) Miranda L. Bernhardt et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The E3 ligase tripartite motif 8 targets TAK1 to promote insulin resistance and steatohepatitis

(2017) Feng-Juan Yan et al.   HEPATOLOGY

The TRPC1 Ca2+-permeable channel inhibits exercise-induced protection against high-fat diet-induced obesity and type II diabetes

(2017) Danielle Krout et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The TRPM7 channel kinase regulates store-operated calcium entry

(2017) Malika Faouzi et al.   JOURNAL OF PHYSIOLOGY-LONDON

Adapting to obesity with adipose tissue inflammation

(2017) Shannon M. Reilly et al.   Nature Reviews Endocrinology

TRPM7 kinase activity is essential for T cell colonization and alloreactivity in the gut

(2017) Andrea Romagnani et al.   Nature Communications

Defective STIM-mediated store operated Ca2+ entry in hepatocytes leads to metabolic dysfunction in obesity

(2017) Ana Paula Arruda et al.   eLife

TRPM7 Kinase Controls Calcium Responses in Arterial Thrombosis and Stroke in Mice

(2017) Sanjeev K. Gotru et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Endophilin A2 Influences Volume-Regulated Chloride Current by Mediating ClC-3 Trafficking in Vascular Smooth Muscle Cells

(2016) Can-Zhao Liu et al.   CIRCULATION JOURNAL

Lack of TRPV2 impairs thermogenesis in mouse brown adipose tissue

(2016) Wuping Sun et al.   EMBO REPORTS

TIPE2 (Tumor Necrosis Factor α-induced Protein 8-like 2) Is a Novel Negative Regulator of TAK1 Signal

(2016) Michitaka Oho et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of TRPM7 Function by IL-6 through the JAK2-STAT3 Signaling Pathway

(2016) Aifen Liu et al.   PLoS One

Hepatocyte TRAF3 promotes liver steatosis and systemic insulin resistance through targeting TAK1-dependent signalling

(2016) Pi-Xiao Wang et al.   Nature Communications

The ubiquitin E3 ligase TRAF6 exacerbates pathological cardiac hypertrophy via TAK1-dependent signalling

(2016) Yan-Xiao Ji et al.   Nature Communications

A regulatory circuit of miR-125b/miR-20b and Wnt signalling controls glioblastoma phenotypes through FZD6-modulated pathways

(2016) Tianzhi Huang et al.   Nature Communications

Calcium Homeostasis and Organelle Function in the Pathogenesis of Obesity and Diabetes

(2015) Ana Paula Arruda et al.   Cell Metabolism

Ca2+Signaling but Not Store-Operated Ca2+Entry Is Required for the Function of Macrophages and Dendritic Cells

(2015) Martin Vaeth et al.   JOURNAL OF IMMUNOLOGY

Depletion of H2S during obesity enhances store-operated Ca2+entry in adipose tissue macrophages to increase cytokine production

(2015) Gopal V. Velmurugan et al.   Science Signaling

Depletion of H2S during obesity enhances store-operated Ca2+entry in adipose tissue macrophages to increase cytokine production

(2015) Gopal V. Velmurugan et al.   Science Signaling

The TRPM7 Chanzyme Is Cleaved to Release a Chromatin-Modifying Kinase

(2014) Grigory Krapivinsky et al.   CELL

What We Talk About When We Talk About Fat

(2014) Evan D. Rosen et al.   CELL

A Drosophila In Vivo Screen Identifies Store-Operated Calcium Entry as a Key Regulator of Adiposity

(2014) Jens Baumbach et al.   Cell Metabolism

Inhibition of transient receptor potential melastatin 7 (TRPM7) channel induces RA FLSs apoptosis through endoplasmic reticulum (ER) stress

(2014) Xiaofeng Li et al.   CLINICAL RHEUMATOLOGY

CaMKII: Claiming Center Stage in Postsynaptic Function and Organization

(2014) Johannes W. Hell   NEURON

TGF-β1-elevated TRPM7 channel regulates collagen expression in hepatic stellate cells via TGF-β1/Smad pathway

(2014) Ling Fang et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Activation of Calcium/Calmodulin-Dependent Protein Kinase II in Obesity Mediates Suppression of Hepatic Insulin Signaling

(2013) Lale Ozcan et al.   Cell Metabolism

Effects of Combination of Perindopril, Indapamide, and Calcium Channel Blockers in Patients With Type 2 Diabetes Mellitus

(2013) John Chalmers et al.   HYPERTENSION

Adipose tissue inflammation in glucose metabolism

(2013) H. L. Kammoun et al.   REVIEWS IN ENDOCRINE & METABOLIC DISORDERS

Upregulation of TRPM7 Channels by Angiotensin II Triggers Phenotypic Switching of Vascular Smooth Muscle Cells of Ascending Aorta

(2012) Zheng Zhang et al.   CIRCULATION RESEARCH

Cleavage of TRPM7 Releases the Kinase Domain from the Ion Channel and Regulates Its Participation in Fas-Induced Apoptosis

(2012) Bimal N. Desai et al.   DEVELOPMENTAL CELL

Structural basis for autoinhibition and phosphorylation-dependent activation of c-Cbl

(2012) Hao Dou et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The Size of Large Adipose Cells Is a Predictor of Insulin Resistance in First-Degree Relatives of Type 2 Diabetic Patients

(2012) Jian Yang et al.   Obesity

The Structure of an Arf-ArfGAP Complex Reveals a Ca2+ Regulatory Mechanism

(2010) Shehab A. Ismail et al.   CELL

TRPM7-Mediated Ca 2+ Signals Confer Fibrogenesis in Human Atrial Fibrillation

(2010) Jianyang Du et al.   CIRCULATION RESEARCH

Nuclear Orphan Receptor TAK1/TR4-Deficient Mice Are Protected Against Obesity-Linked Inflammation, Hepatic Steatosis, and Insulin Resistance

(2010) H. S. Kang et al.   DIABETES

High Glucose-Induced Oxidative Stress Increases Transient Receptor Potential Channel Expression in Human Monocytes

(2010) T. Wuensch et al.   DIABETES

Autoactivation of Transforming Growth Factor β-activated Kinase 1 Is a Sequential Bimolecular Process

(2010) Roland Scholz et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Fingolimod (FTY720): discovery and development of an oral drug to treat multiple sclerosis

(2010) Volker Brinkmann et al.   NATURE REVIEWS DRUG DISCOVERY

CaMKII promotes TLR-triggered proinflammatory cytokine and type I interferon production by directly binding and activating TAK1 and IRF3 in macrophages

(2008) X. Liu et al.   BLOOD

Downregulation of Renal TRPM7 and Increased Inflammation and Fibrosis in Aldosterone-Infused Mice

(2008) Bruno Sontia et al.   HYPERTENSION

Deletion of Trpm7 Disrupts Embryonic Development and Thymopoiesis Without Altering Mg2+ Homeostasis

(2008) J. Jin et al.   SCIENCE