Disruption of Pressure-Induced Ca 2+ Spark Vasoregulation of Resistance Arteries, Rather Than Endothelial Dysfunction, Underlies Obesity-Related Hypertension

Engaging parents using web-based feedback on child growth to reduce childhood obesity: a mixed methods study

(2019) Rinita Dam et al.   BMC PUBLIC HEALTH

Examining a role for PKG Iα oxidation in the pathogenesis of cardiovascular dysfunction during diet-induced obesity

(2017) Olena Rudyk et al.   FREE RADICAL BIOLOGY AND MEDICINE

Proof of Principle for a Novel Class of Antihypertensives That Target the Oxidative Activation of PKG Iα (Protein Kinase G Iα)Novelty and Significance

(2017) Joseph R. Burgoyne et al.   HYPERTENSION

Ser 1928 phosphorylation by PKA stimulates the L-type Ca 2+ channel Ca V 1.2 and vasoconstriction during acute hyperglycemia and diabetes

(2017) Matthew A. Nystoriak et al.   Science Signaling

Ser 1928 phosphorylation by PKA stimulates the L-type Ca 2+ channel Ca V 1.2 and vasoconstriction during acute hyperglycemia and diabetes

(2017) Matthew A. Nystoriak et al.   Science Signaling

Impaired BKCa channel function in native vascular smooth muscle from humans with type 2 diabetes

(2017) Madeline Nieves-Cintrón et al.   Scientific Reports

Measurement of Reactive Oxygen Species, Reactive Nitrogen Species, and Redox-Dependent Signaling in the Cardiovascular System

(2016) Kathy K. Griendling et al.   CIRCULATION RESEARCH

Adipocyte-Specific Mineralocorticoid Receptor Overexpression in Mice Is Associated With Metabolic Syndrome and Vascular Dysfunction: Role of Redox-Sensitive PKG-1 and Rho Kinase

(2016) Aurelie Nguyen Dinh Cat et al.   DIABETES

Pressure-induced oxidative activation of PKG enables vasoregulation by Ca2+ sparks and BK channels

(2016) K. Khavandi et al.   Science Signaling

Interactive Effects of Physical Fitness and Body Mass Index on the Risk of Hypertension

(2016) Casey Crump et al.   JAMA Internal Medicine

Pressure-induced oxidative activation of PKG enables vasoregulation by Ca2+ sparks and BK channels

(2016) K. Khavandi et al.   Science Signaling

Selective Down-regulation of KV2.1 Function Contributes to Enhanced Arterial Tone during Diabetes

(2015) Madeline Nieves-Cintrón et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

AKAP150-dependent cooperative TRPV4 channel gating is central to endothelium-dependent vasodilation and is disrupted in hypertension

(2014) S. K. Sonkusare et al.   Science Signaling

AKAP150 Contributes to Enhanced Vascular Tone by Facilitating Large-Conductance Ca 2+ -Activated K + Channel Remodeling in Hyperglycemia and Diabetes Mellitus

(2013) Matthew A. Nystoriak et al.   CIRCULATION RESEARCH

Abnormal Ca2+ Spark/STOC Coupling in Cerebral Artery Smooth Muscle Cells of Obese Type 2 Diabetic Mice

(2013) Angélica Rueda et al.   PLoS One

Single atom substitution in mouse protein kinase G eliminates oxidant sensing to cause hypertension

(2012) Oleksandra Prysyazhna et al.   NATURE MEDICINE

Elementary Ca2+ Signals Through Endothelial TRPV4 Channels Regulate Vascular Function

(2012) S. K. Sonkusare et al.   SCIENCE

Differential effects of diet-induced obesity on BKCa β1-subunit expression and function in rat skeletal muscle arterioles and small cerebral arteries

(2011) Lauren Howitt et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Structural Alterations in Small Resistance Arteries in Obesity

(2011) Damiano Rizzoni et al.   BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY

Childhood Adiposity, Adult Adiposity, and Cardiovascular Risk Factors

(2011) Markus Juonala et al.   NEW ENGLAND JOURNAL OF MEDICINE

Diet-Induced Obesity Impairs Endothelium-Derived Hyperpolarization via Altered Potassium Channel Signaling Mechanisms

(2011) Rebecca E. Haddock et al.   PLoS One

X-ROS Signaling: Rapid Mechano-Chemo Transduction in Heart

(2011) B. L. Prosser et al.   SCIENCE

Enhanced myogenic response in the afferent arteriole of spontaneously hypertensive rats

(2010) YiLin Ren et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Impact of the metabolic syndrome on subcutaneous microcirculation in obese patients

(2010) Guido Grassi et al.   JOURNAL OF HYPERTENSION

Obesity Up-Regulates Intermediate Conductance Calcium-Activated Potassium Channels and Myoendothelial Gap Junctions to Maintain Endothelial Vasodilator Function

(2010) P. S. Chadha et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Impaired function of coronary BKCa channels in metabolic syndrome

(2009) Léna Borbouse et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

BK channels in cardiovascular disease: a complex story of channel dysregulation

(2009) Nancy J. Rusch   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Local Inflammation and Hypoxia Abolish the Protective Anticontractile Properties of Perivascular Fat in Obese Patients

(2009) Adam S. Greenstein et al.   CIRCULATION

Structural and Functional Alterations of Subcutaneous Small Resistance Arteries in Severe Human Obesity

(2009) Guido Grassi et al.   Obesity

Functional architecture of inositol 1,4,5-trisphosphate signaling in restricted spaces of myoendothelial projections

(2008) J. Ledoux et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA