PLCβ2 negatively regulates the inflammatory response to virus infection by inhibiting phosphoinositide-mediated activation of TAK1

A prospective, comparative study of severe neurological and uncomplicated hand, foot and mouth forms of paediatric enterovirus 71 infections

(2017) Yoann Crabol et al.   INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES

Immunopathogenesis and Virus–Host Interactions of Enterovirus 71 in Patients with Hand, Foot and Mouth Disease

(2017) Jonathan A. Cox et al.   Frontiers in Microbiology

The kinase CK1ɛ controls the antiviral immune response by phosphorylating the signaling adaptor TRAF3

(2016) Yilong Zhou et al.   NATURE IMMUNOLOGY

Phosphatidylinositol 4-Phosphate 5-Kinase α Facilitates Toll-like Receptor 4-mediated Microglial Inflammation through Regulation of the Toll/Interleukin-1 Receptor Domain-containing Adaptor Protein (TIRAP) Location

(2013) Tu Thi Ngoc Nguyen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cell type-specific function of TAK1 in innate immune signaling

(2013) Adebusola A. Ajibade et al.   TRENDS IN IMMUNOLOGY

Pathogenicity of the Novel A/H7N9 Influenza Virus in Mice

(2013) C. K. P. Mok et al.   mBio

Gram-positive and gram-negative bacterial toxins in sepsis

(2013) Girish Ramachandran   Virulence

Into the Eye of the Cytokine Storm

(2012) J. R. Tisoncik et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

Multiple roles of phosphoinositide-specific phospholipase C isozymes

(2011) Pann-Ghill Suh et al.   BMB Reports

USP4 targets TAK1 to downregulate TNFα-induced NF-κB activation

(2011) Y-H Fan et al.   CELL DEATH AND DIFFERENTIATION

Sustained High Levels of Interleukin-6 Contribute to the Pathogenesis of Enterovirus 71 in a Neonate Mouse Model

(2011) W. X. Khong et al.   JOURNAL OF VIROLOGY

TAK1 regulates NF-ΚB and AP-1 activation in airway epithelial cells following RSV infection

(2011) Nilay Dey et al.   VIROLOGY

Pattern Recognition Receptors and Inflammation

(2010) Osamu Takeuchi et al.   CELL

Pathway-selective suppression of chemokine receptor signaling in B cells by LPS through downregulation of PLC-β2

(2010) Aiko-Konno Shirakawa et al.   Cellular & Molecular Immunology

Virology, epidemiology, pathogenesis, and control of enterovirus 71

(2010) Tom Solomon et al.   LANCET INFECTIOUS DISEASES

Direct binding of TRAF2 and TRAF6 to TICAM-1/TRIF adaptor participates in activation of the Toll-like receptor 3/4 pathway

(2010) Miwa Sasai et al.   MOLECULAR IMMUNOLOGY

Enhanced phosphatidylinositol 4-phosphate 5-kinase α expression and PI(4,5)P2 production in LPS-stimulated microglia

(2010) Sang Yoon Lee et al.   NEUROCHEMISTRY INTERNATIONAL

Regulation of Adaptive Immunity by the Innate Immune System

(2010) A. Iwasaki et al.   SCIENCE

Suppression of PLCβ2 by Endotoxin Plays a Role in the Adenosine A2A Receptor-Mediated Switch of Macrophages from an Inflammatory to an Angiogenic Phenotype

(2009) Stan Grinberg et al.   AMERICAN JOURNAL OF PATHOLOGY

RIG-I-mediated Activation of p38 MAPK Is Essential for Viral Induction of Interferon and Activation of Dendritic Cells

(2009) Susie S. Mikkelsen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

General and Versatile Autoinhibition of PLC Isozymes

(2008) Stephanie N. Hicks et al.   MOLECULAR CELL