Decoding CAR T cell phenotype using combinatorial signaling motif libraries and machine learning

The relative binding position of Nck and Grb2 adaptors impacts actin-based motility of Vaccinia virus

(2022) Angika Basant et al.   eLife

Screening for CD19-specific chimaeric antigen receptors with enhanced signalling via a barcoded library of intracellular domains

(2022) Khloe S. Gordon et al.   Nature Biomedical Engineering

speedingCARs: accelerating the engineering of CAR T cells by signaling domain shuffling and single-cell sequencing

(2022) Rocío Castellanos-Rueda et al.   Nature Communications

Pooled screening of CAR T cells identifies diverse immune signaling domains for next-generation immunotherapies

(2022) Daniel B. Goodman et al.   Science Translational Medicine

PLCγ1 promotes phase separation of T cell signaling components

(2021) Longhui Zeng et al.   JOURNAL OF CELL BIOLOGY

Expression of KLRG1 and CD127 defines distinct CD8+ subsets that differentially impact patient outcome in follicular lymphoma

(2021) Hongyan Wu et al.   Journal for ImmunoTherapy of Cancer

Expression of IL‐7Rα and KLRG1 defines functionally distinct CD8 + T‐cell populations in humans

(2019) Ester B. M. Remmerswaal et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Modulation of asymmetric cell division as a mechanism to boost CD8+ T cell memory

(2019) Mariana Borsa et al.   Science Immunology

Massive computational acceleration by using neural networks to emulate mechanism-based biological models

(2019) Shangying Wang et al.   Nature Communications

KLRG1 + Effector CD8 + T Cells Lose KLRG1, Differentiate into All Memory T Cell Lineages, and Convey Enhanced Protective Immunity

(2018) Dietmar Herndler-Brandstetter et al.   IMMUNITY

A novel chimeric antigen receptor containing a JAK–STAT signaling domain mediates superior antitumor effects

(2018) Yuki Kagoya et al.   NATURE MEDICINE

In vivo fate and activity of second versus third-generation D19-specific CAR-T cells in B-cell non-Hodgkin lymphomas

(2018) Carlos A. Ramos et al.   MOLECULAR THERAPY

Structure of TRAF Family: Current Understanding of Receptor Recognition

(2018) Hyun H. Park   Frontiers in Immunology

NFκB–Pim-1–Eomesodermin axis is critical for maintaining CD8 T-cell memory quality

(2017) Karin M. Knudson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Distinct Signaling of Coreceptors Regulates Specific Metabolism Pathways and Impacts Memory Development in CAR T Cells

(2016) Omkar U. Kawalekar et al.   IMMUNITY

AK-fold averaging cross-validation procedure

(2015) Yoonsuh Jung et al.   JOURNAL OF NONPARAMETRIC STATISTICS

Chimeric Antigen Receptor Therapy for Cancer

(2013) David M. Barrett et al.   Annual Review of Medicine

ELM--the database of eukaryotic linear motifs

(2011) H. Dinkel et al.   NUCLEIC ACIDS RESEARCH