Screening for CD19-specific chimaeric antigen receptors with enhanced signalling via a barcoded library of intracellular domains

A chimeric antigen receptor with antigen-independent OX40 signaling mediates potent antitumor activity

(2021) Huihui Zhang et al.   Science Translational Medicine

IFNg is Critical for CAR T Cell Mediated Myeloid Activation and Induction of Endogenous Immunity

(2021) Darya Alizadeh et al.   Cancer Discovery

The therapeutic landscape for cells engineered with chimeric antigen receptors

(2020) Matthew MacKay et al.   NATURE BIOTECHNOLOGY

Human chimeric antigen receptor macrophages for cancer immunotherapy

(2020) Michael Klichinsky et al.   NATURE BIOTECHNOLOGY

4-1BB costimulation promotes CAR T cell survival through noncanonical NF-κB signaling

(2020) Benjamin I. Philipson et al.   Science Signaling

GPC1 specific CAR-T cells eradicate established solid tumor without adverse effects and synergize with anti-PD-1 Ab

(2020) Daiki Kato et al.   eLife

Chimeric antigen receptor signaling: Functional consequences and design implications

(2020) S. E. Lindner et al.   Science Advances

Multiple Signaling Roles of CD3ε and Its Application in CAR-T Cell Therapy

(2020) Wei Wu et al.   CELL

A Distinct Transcriptional Program in Human CAR T Cells Bearing the 4-1BB Signaling Domain Revealed by scRNA-Seq

(2020) Angela C. Boroughs et al.   MOLECULAR THERAPY

Noncanonical binding of Lck to CD3ε promotes TCR signaling and CAR function

(2020) Frederike A. Hartl et al.   NATURE IMMUNOLOGY

T Cells Expressing NKG2D CAR with a DAP12 Signaling Domain Stimulate Lower Cytokine Production While Effective in Tumor Eradication

(2020) Yu-Yang Ng et al.   MOLECULAR THERAPY

BATF3 programs CD8+ T cell memory

(2020) Marco A. Ataide et al.   NATURE IMMUNOLOGY

Characteristics of anti-CD19 CAR T cell infusion products associated with efficacy and toxicity in patients with large B cell lymphomas

(2020) Qing Deng et al.   NATURE MEDICINE

Next-generation cell therapies: the emerging role of CAR-NK cells

(2020) Rafet Basar et al.   Hematology-American Society of Hematology Education Program

Comprehensive Integration of Single-Cell Data

(2019) Tim Stuart et al.   CELL

Clinical lessons learned from the first leg of the CAR T cell journey

(2019) Robbie G. Majzner et al.   NATURE MEDICINE

Determinants of response and resistance to CAR T cell therapy

(2019) Stefanie Lesch et al.   SEMINARS IN CANCER BIOLOGY

Preclinical Models in Chimeric Antigen Receptor–Engineered T-Cell Therapy

(2018) Elizabeth Louise Siegler et al.   HUMAN GENE THERAPY

Understanding the tumor immune microenvironment (TIME) for effective therapy

(2018) Mikhail Binnewies et al.   NATURE MEDICINE

A novel chimeric antigen receptor containing a JAK–STAT signaling domain mediates superior antitumor effects

(2018) Yuki Kagoya et al.   NATURE MEDICINE

CAR-T cells: the long and winding road to solid tumors

(2018) Maria Michela D’Aloia et al.   Cell Death & Disease

Cytokine release syndrome

(2018) Alexander Shimabukuro-Vornhagen et al.   Journal for ImmunoTherapy of Cancer

Strategies to Address Chimeric Antigen Receptor Tonic Signaling

(2018) Adam Ajina et al.   MOLECULAR CANCER THERAPEUTICS

Dysfunctional CD8 T Cells Form a Proliferative, Dynamically Regulated Compartment within Human Melanoma

(2018) Hanjie Li et al.   CELL

Defining T Cell States Associated with Response to Checkpoint Immunotherapy in Melanoma

(2018) Moshe Sade-Feldman et al.   CELL

Calibration of CAR activation potential directs alternative T cell fates and therapeutic potency

(2018) Judith Feucht et al.   NATURE MEDICINE

Expansion and Activation of CD103 + Dendritic Cell Progenitors at the Tumor Site Enhances Tumor Responses to Therapeutic PD-L1 and BRAF Inhibition

(2016) Hélène Salmon et al.   IMMUNITY

Chimeric antigen receptor T-cell therapy for solid tumors

(2016) Kheng Newick et al.   Molecular Therapy-Oncolytics

Structural Design of Engineered Costimulation Determines Tumor Rejection Kinetics and Persistence of CAR T Cells

(2015) Zeguo Zhao et al.   CANCER CELL

DAP12-Based Activating Chimeric Antigen Receptor for NK Cell Tumor Immunotherapy

(2015) Katrin Töpfer et al.   JOURNAL OF IMMUNOLOGY

Melanoma-intrinsic β-catenin signalling prevents anti-tumour immunity

(2015) Stefani Spranger et al.   NATURE

4-1BB costimulation ameliorates T cell exhaustion induced by tonic signaling of chimeric antigen receptors

(2015) Adrienne H Long et al.   NATURE MEDICINE

Generation of Potent T-cell Immunotherapy for Cancer Using DAP12-Based, Multichain, Chimeric Immunoreceptors

(2015) E. Wang et al.   Cancer Immunology Research

GSVA: gene set variation analysis for microarray and RNA-Seq data

(2013) Sonja Hänzelmann et al.   BMC BIOINFORMATICS

A Cell-Intrinsic Requirement for NF- B-Inducing Kinase in CD4 and CD8 T Cell Memory

(2013) A. M. Rowe et al.   JOURNAL OF IMMUNOLOGY

Engineering T Cell Function Using Chimeric Antigen Receptors Identified Using a DNA Library Approach

(2013) Connie P. M. Duong et al.   PLoS One

OX40 costimulation by a chimeric antigen receptor abrogates CD28 and IL-2 induced IL-10 secretion by redirected CD4+T cells

(2012) Andreas A. Hombach et al.   OncoImmunology

Costimulation by chimeric antigen receptors revisited the T cell antitumor response benefits from combined CD28-OX40 signalling

(2011) Andreas A. Hombach et al.   INTERNATIONAL JOURNAL OF CANCER

Differentiation and Persistence of Memory CD8+ T Cells Depend on T Cell Factor 1

(2010) Xinyuan Zhou et al.   IMMUNITY

Chimeric Antigen Receptors Combining 4-1BB and CD28 Signaling Domains Augment PI3kinase/AKT/Bcl-XL Activation and CD8+ T Cell–mediated Tumor Eradication

(2009) Xiao-Song Zhong et al.   MOLECULAR THERAPY

Comparison of T Cell Receptor-Induced Proximal Signaling and Downstream Functions in Immortalized and Primary T Cells

(2009) Rebekah R. Bartelt et al.   PLoS One