Pooled screening of CAR T cells identifies diverse immune signaling domains for next-generation immunotherapies

A subset of cytotoxic effector memory T cells enhances CAR T cell efficacy in a model of pancreatic ductal adenocarcinoma

(2021) Vanaja Konduri et al.   Science Translational Medicine

CAR T-cell therapy in multiple myeloma: more room for improvement

(2021) Phaik Ju Teoh et al.   Blood Cancer Journal

Integrated analysis of multimodal single-cell data

(2021) Yuhan Hao et al.   CELL

CD29 Enriches for Cytotoxic Human CD4+ T Cells

(2021) Benoît P. Nicolet et al.   JOURNAL OF IMMUNOLOGY

THEMIS-SHP1 Recruitment by 4-1BB Tunes LCK-Mediated Priming of Chimeric Antigen Receptor-Redirected T Cells

(2020) Chuang Sun et al.   CANCER CELL

Clonal kinetics and single-cell transcriptional profiling of CAR-T cells in patients undergoing CD19 CAR-T immunotherapy

(2020) Alyssa Sheih et al.   Nature Communications

Pooled Knockin Targeting for Genome Engineering of Cellular Immunotherapies

(2020) Theodore L. Roth et al.   CELL

Single residue in CD28-costimulated CAR-T cells limits long-term persistence and antitumor durability

(2020) Sonia Guedan et al.   JOURNAL OF CLINICAL INVESTIGATION

CD29 identifies IFN-γ–producing human CD8+T cells with an increased cytotoxic potential

(2020) Benoît P. Nicolet et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Role of Calcium–Calcineurin–NFAT Signaling Pathway in Health and Autoimmune Diseases

(2020) Yune-Jung Park et al.   Frontiers in Immunology

Prolonged Persistence of Chimeric Antigen Receptor (CAR) T Cell in Adoptive Cancer Immunotherapy: Challenges and Ways Forward

(2020) Leila Jafarzadeh et al.   Frontiers in Immunology

CAR-T Cell Therapies: An Overview of Clinical Studies Supporting Their Approved Use against Acute Lymphoblastic Leukemia and Large B-Cell Lymphomas

(2020) Aamir Ahmad et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

A Distinct Transcriptional Program in Human CAR T Cells Bearing the 4-1BB Signaling Domain Revealed by scRNA-Seq

(2020) Angela C. Boroughs et al.   MOLECULAR THERAPY

Functional effects of chimeric antigen receptor co-receptor signaling domains in human regulatory T cells

(2020) Nicholas A. J. Dawson et al.   Science Translational Medicine

Efficacy and Safety of CD28- or 4-1BB-Based CD19 CAR-T Cells in B Cell Acute Lymphoblastic Leukemia

(2020) Xiangyu Zhao et al.   Molecular Therapy-Oncolytics

SCENITH: A Flow Cytometry-Based Method to Functionally Profile Energy Metabolism with Single-Cell Resolution

(2020) Rafael J. Argüello et al.   Cell Metabolism

AP-1 Transcription Factors as Regulators of Immune Responses in Cancer

(2019) Vasileios Atsaves et al.   Cancers

NextGen cell-based immunotherapies in cancer and other immune disorders

(2019) Camillia S. Azimi et al.   CURRENT OPINION IN IMMUNOLOGY

Parallel comparison of 4-1BB or CD28 co-stimulated CD19-targeted chimeric antigen receptor-T cells for B-cell non-Hodgkin lymphoma

(2019) Zhitao Ying et al.   Molecular Therapy-Oncolytics

A novel chimeric antigen receptor containing a JAK–STAT signaling domain mediates superior antitumor effects

(2018) Yuki Kagoya et al.   NATURE MEDICINE

Long-Term Follow-up of CD19 CAR Therapy in Acute Lymphoblastic Leukemia

(2018) Jae H. Park et al.   NEW ENGLAND JOURNAL OF MEDICINE

Tisagenlecleucel in Children and Young Adults with B-Cell Lymphoblastic Leukemia

(2018) Shannon L. Maude et al.   NEW ENGLAND JOURNAL OF MEDICINE

Chimeric antigen receptor T cells form nonclassical and potent immune synapses driving rapid cytotoxicity

(2018) A. J. Davenport et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tuning ITAM multiplicity on T cell receptors can control potency and selectivity to ligand density

(2018) John R. James   Science Signaling

Tuning ITAM multiplicity on T cell receptors can control potency and selectivity to ligand density

(2018) John R. James   Science Signaling

Phosphoproteomic analysis of chimeric antigen receptor signaling reveals kinetic and quantitative differences that affect cell function

(2018) Alexander I. Salter et al.   Science Signaling

Tumor Necrosis Factor Receptor-Associated Factor Regulation of Nuclear Factor κB and Mitogen-Activated Protein Kinase Pathways

(2018) Jian-Hong Shi et al.   Frontiers in Immunology

Structure of TRAF Family: Current Understanding of Receptor Recognition

(2018) Hyun H. Park   Frontiers in Immunology

Genome-wide CRISPR Screens in Primary Human T Cells Reveal Key Regulators of Immune Function

(2018) Eric Shifrut et al.   CELL

Calibration of CAR activation potential directs alternative T cell fates and therapeutic potency

(2018) Judith Feucht et al.   NATURE MEDICINE

Simultaneous epitope and transcriptome measurement in single cells

(2017) Marlon Stoeckius et al.   NATURE METHODS

Distinct Signaling of Coreceptors Regulates Specific Metabolism Pathways and Impacts Memory Development in CAR T Cells

(2016) Omkar U. Kawalekar et al.   IMMUNITY

CD28 Costimulation: From Mechanism to Therapy

(2016) Jonathan H. Esensten et al.   IMMUNITY

ICOS-based chimeric antigen receptors program bipolar TH17/TH1 cells

(2014) S. Guedan et al.   BLOOD

Induction of a VLA-2 (CD49b)-Expressing Effector T Cell Population by a Cell-Based Neuroblastoma Vaccine Expressing CD137L

(2014) X. Yan et al.   JOURNAL OF IMMUNOLOGY

Late Signals from CD27 Prevent Fas-Dependent Apoptosis of Primary CD8+ T Cells

(2014) D. V. Dolfi et al.   JOURNAL OF IMMUNOLOGY

Large-scale de novo DNA synthesis: technologies and applications

(2014) Sriram Kosuri et al.   NATURE METHODS

Chimeric Antigen Receptor T Cells for Sustained Remissions in Leukemia

(2014) Shannon L. Maude et al.   NEW ENGLAND JOURNAL OF MEDICINE

PhosphoSitePlus, 2014: mutations, PTMs and recalibrations

(2014) Peter V. Hornbeck et al.   NUCLEIC ACIDS RESEARCH

CD161 Defines a Transcriptional and Functional Phenotype across Distinct Human T Cell Lineages

(2014) Joannah R. Fergusson et al.   Cell Reports

Composability of regulatory sequences controlling transcription and translation inEscherichia coli

(2013) Sriram Kosuri et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PD-1- and CTLA-4-Based Inhibitory Chimeric Antigen Receptors (iCARs) Divert Off-Target Immunotherapy Responses

(2013) V. D. Fedorov et al.   Science Translational Medicine

A BAFF-R mutation associated with non-Hodgkin lymphoma alters TRAF recruitment and reveals new insights into BAFF-R signaling

(2010) Joanne M. Hildebrand et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Analysis of CD161 expression on human CD8+ T cells defines a distinct functional subset with tissue-homing properties

(2010) E. Billerbeck et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of T Cell Receptor Activation by Dynamic Membrane Binding of the CD3ɛ Cytoplasmic Tyrosine-Based Motif

(2008) Chenqi Xu et al.   CELL

Understanding eukaryotic linear motifs and their role in cell signaling and regulation

(2008) Francesca Diella   Frontiers in Bioscience-Landmark

Scalable signaling mediated by T cell antigen receptor–CD3 ITAMs ensures effective negative selection and prevents autoimmunity

(2008) Jeff Holst et al.   NATURE IMMUNOLOGY