The next-generation Open Targets Platform: reimagined, redesigned, rebuilt

Human transcription factor protein interaction networks

(2022) Helka Göös et al.   Nature Communications

The Gene Curation Coalition: A global effort to harmonize gene–disease evidence resources

(2022) Marina T. DiStefano et al.   GENETICS IN MEDICINE

Human genetics evidence supports two-thirds of the 2021 FDA-approved drugs

(2022) David Ochoa et al.   NATURE REVIEWS DRUG DISCOVERY

Drug Safety Data Curation and Modeling in ChEMBL: Boxed Warnings and Withdrawn Drugs

(2021) Fiona M.I. Hunter et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Rare variant contribution to human disease in 281,104 UK Biobank exomes

(2021) Quanli Wang et al.   NATURE

Trends in kinase drug discovery: targets, indications and inhibitor design

(2021) Misty M. Attwood et al.   NATURE REVIEWS DRUG DISCOVERY

The PROTACtable genome

(2021) Melanie Schneider et al.   NATURE REVIEWS DRUG DISCOVERY

Exome sequencing and analysis of 454,787 UK Biobank participants

(2021) Joshua D. Backman et al.   NATURE

An open approach to systematically prioritize causal variants and genes at all published human GWAS trait-associated loci

(2021) Edward Mountjoy et al.   NATURE GENETICS

AlphaFold Protein Structure Database: massively expanding the structural coverage of protein-sequence space with high-accuracy models

(2021) Mihaly Varadi et al.   NUCLEIC ACIDS RESEARCH

The European Variation Archive: a FAIR resource of genomic variation for all species

(2021) Timothe Cezard et al.   NUCLEIC ACIDS RESEARCH

Mapping the proteo-genomic convergence of human diseases

(2021) Maik Pietzner et al.   SCIENCE

The mutational constraint spectrum quantified from variation in 141,456 humans

(2020) Konrad J. Karczewski et al.   NATURE

Open Targets Genetics: systematic identification of trait-associated genes using large-scale genetics and functional genomics

(2020) Maya Ghoussaini et al.   NUCLEIC ACIDS RESEARCH

The GTEx Consortium atlas of genetic regulatory effects across human tissues

(2020)   SCIENCE

The STRING database in 2021: customizable protein–protein networks, and functional characterization of user-uploaded gene/measurement sets

(2020) Damian Szklarczyk et al.   NUCLEIC ACIDS RESEARCH

UniProt: the universal protein knowledgebase in 2021

(2020) et al.   NUCLEIC ACIDS RESEARCH

Open Targets Platform: supporting systematic drug–target identification and prioritisation

(2020) David Ochoa et al.   NUCLEIC ACIDS RESEARCH

ClinVar: improvements to accessing data

(2019) Melissa J Landrum et al.   NUCLEIC ACIDS RESEARCH

Are drug targets with genetic support twice as likely to be approved? Revised estimates of the impact of genetic support for drug mechanisms on the probability of drug approval

(2019) Emily A. King et al.   PLoS Genetics

Cancer Genome Interpreter annotates the biological and clinical relevance of tumor alterations

(2018) David Tamborero et al.   Genome Medicine

The NHGRI-EBI GWAS Catalog of published genome-wide association studies, targeted arrays and summary statistics 2019

(2018) Annalisa Buniello et al.   NUCLEIC ACIDS RESEARCH

COSMIC: the Catalogue Of Somatic Mutations In Cancer

(2018) John G Tate et al.   NUCLEIC ACIDS RESEARCH

ChEMBL: towards direct deposition of bioassay data

(2018) David Mendez et al.   NUCLEIC ACIDS RESEARCH

Probes & Drugs portal: an interactive, open data resource for chemical biology

(2017) Ctibor Skuta et al.   NATURE METHODS

Expression Atlas: gene and protein expression across multiple studies and organisms

(2017) Irene Papatheodorou et al.   NUCLEIC ACIDS RESEARCH

Literature evidence in open targets - a target validation platform

(2017) Şenay Kafkas et al.   Journal of Biomedical Semantics

Rare disease policies to improve care for patients in Europe

(2015) Charlotte Rodwell et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

The support of human genetic evidence for approved drug indications

(2015) Matthew R Nelson et al.   NATURE GENETICS

Modeling sample variables with an Experimental Factor Ontology

(2010) James Malone et al.   BIOINFORMATICS