Are drug targets with genetic support twice as likely to be approved? Revised estimates of the impact of genetic support for drug mechanisms on the probability of drug approval

Phenotypes associated with genes encoding drug targets are predictive of clinical trial side effects

(2019) Phuong A. Nguyen et al.   Nature Communications

The Post-GWAS Era: From Association to Function

(2018) Michael D. Gallagher et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Drug discovery effectiveness from the standpoint of therapeutic mechanisms and indications

(2017) Hsin-Pei Shih et al.   NATURE REVIEWS DRUG DISCOVERY

Changing R&D models in research-based pharmaceutical companies

(2016) Alexander Schuhmacher et al.   Journal of Translational Medicine

Impact of genetically supported target selection on R&D productivity

(2016) Mark R. Hurle et al.   NATURE REVIEWS DRUG DISCOVERY

The new NHGRI-EBI Catalog of published genome-wide association studies (GWAS Catalog)

(2016) Jacqueline MacArthur et al.   NUCLEIC ACIDS RESEARCH

A global reference for human genetic variation

(2015) Richard A. Gibbs et al.   NATURE

The support of human genetic evidence for approved drug indications

(2015) Matthew R Nelson et al.   NATURE GENETICS

The Genotype-Tissue Expression (GTEx) pilot analysis: Multitissue gene regulation in humans

(2015) et al.   SCIENCE

GWAS and drug targets

(2014) Chen Cao et al.   BMC GENOMICS

Clinical development success rates for investigational drugs

(2014) Michael Hay et al.   NATURE BIOTECHNOLOGY

Lessons learned from the fate of AstraZeneca's drug pipeline: a five-dimensional framework

(2014) David Cook et al.   NATURE REVIEWS DRUG DISCOVERY

Patterns of regulatory activity across diverse human cell types predict tissue identity, transcription factor binding, and long-range interactions

(2013) N. C. Sheffield et al.   GENOME RESEARCH

Validating therapeutic targets through human genetics

(2013) Robert M. Plenge et al.   NATURE REVIEWS DRUG DISCOVERY

The NHGRI GWAS Catalog, a curated resource of SNP-trait associations

(2013) Danielle Welter et al.   NUCLEIC ACIDS RESEARCH

Protein Replacement Therapies for Rare Diseases: A Breeze for Regulatory Approval?

(2013) J. A. Gorzelany et al.   Science Translational Medicine

Genic Intolerance to Functional Variation and the Interpretation of Personal Genomes

(2013) Slavé Petrovski et al.   PLoS Genetics

A program for annotating and predicting the effects of single nucleotide polymorphisms, SnpEff

(2012) Pablo Cingolani et al.   FLY

How to improve R&D productivity: the pharmaceutical industry's grand challenge

(2010) Steven M. Paul et al.   NATURE REVIEWS DRUG DISCOVERY