Deubiquitinase OTUD1 Resolves Stalled Translation on polyA and Rare Codon Rich mRNAs

Ribosome slowdown triggers codon‐mediated mRNA decay independently of ribosome quality control

(2022) Yuichiro Mishima et al.   EMBO JOURNAL

OTUD1 deubiquitinase regulates NF-κB- and KEAP1-mediated inflammatory responses and reactive oxygen species-associated cell death pathways

(2022) Daisuke Oikawa et al.   Cell Death & Disease

The deubiquitinase OTUD1 enhances iron transport and potentiates host antitumor immunity

(2021) Jia Song et al.   EMBO REPORTS

OTUD1 Regulates Antifungal Innate Immunity through Deubiquitination of CARD9

(2021) Xiaorong Chen et al.   JOURNAL OF IMMUNOLOGY

Ribosome dynamics and mRNA turnover, a complex relationship under constant cellular scrutiny

(2021) Christelle Morris et al.   Wiley Interdisciplinary Reviews-RNA

The G3BP1-Family-USP10 Deubiquitinase Complex Rescues Ubiquitinated 40S Subunits of Ribosomes Stalled in Translation from Lysosomal Degradation

(2020) Cindy Meyer et al.   MOLECULAR CELL

Distinct Regulatory Ribosomal Ubiquitylation events are reversible and hierarchically organized

(2020) Danielle M Garshott et al.   eLife

Transcriptome-wide sites of collided ribosomes reveal principles of translational pausing

(2020) Alaaddin Bulak Arpat et al.   GENOME RESEARCH

Ribosome quality control antagonizes the activation of the integrated stress response on colliding ribosomes

(2020) Liewei L. Yan et al.   MOLECULAR CELL

Recent Progress on the Molecular Mechanism of Quality Controls Induced by Ribosome Stalling

(2019) Ken Ikeuchi et al.   Frontiers in Genetics

Breaking the chains: deubiquitylating enzyme specificity begets function

(2019) Michael J. Clague et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Quality and quantity control of gene expression by nonsense-mediated mRNA decay

(2019) Tatsuaki Kurosaki et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

eRF1 mediates codon usage effects on mRNA translation efficiency through premature termination at rare codons

(2019) Qian Yang et al.   NUCLEIC ACIDS RESEARCH

Ribosome Collisions Result in +1 Frameshifting in the Absence of No-Go Decay

(2019) Carrie L. Simms et al.   Cell Reports

Identification of Deubiquitinase OTUD1 As a Novel Player in Resistance of Multiple Myeloma to Bortezomib

(2019) Alexander Vdovin et al.   BLOOD

Mechanism of ribosome stalling during translation of a poly(A) tail

(2019) Viswanathan Chandrasekaran et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

mRNA structure regulates protein expression through changes in functional half-life

(2019) David M. Mauger et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Signaling Pathways Involved in the Regulation of mRNA Translation

(2018) Philippe P. Roux et al.   MOLECULAR AND CELLULAR BIOLOGY

SKP2- and OTUD1-regulated non-proteolytic ubiquitination of YAP promotes YAP nuclear localization and activity

(2018) Fan Yao et al.   Nature Communications

Active site alanine mutations convert deubiquitinases into high‐affinity ubiquitin‐binding proteins

(2018) Marie E Morrow et al.   EMBO REPORTS

Efficient analysis of mammalian polysomes in cells and tissues using Ribo Mega-SEC

(2018) Harunori Yoshikawa et al.   eLife

ZNF598 Is a Quality Control Sensor of Collided Ribosomes

(2018) Szymon Juszkiewicz et al.   MOLECULAR CELL

Lost in Translation: Ribosome-Associated mRNA and Protein Quality Controls

(2018) Andrey L. Karamyshev et al.   Frontiers in Genetics

Initiation of Quality Control during Poly(A) Translation Requires Site-Specific Ribosome Ubiquitination

(2017) Szymon Juszkiewicz et al.   MOLECULAR CELL

ZNF598 and RACK1 Regulate Mammalian Ribosome-Associated Quality Control Function by Mediating Regulatory 40S Ribosomal Ubiquitylation

(2017) Elayanambi Sundaramoorthy et al.   MOLECULAR CELL

The E3 ubiquitin ligase and RNA-binding protein ZNF598 orchestrates ribosome quality control of premature polyadenylated mRNAs

(2017) Aitor Garzia et al.   Nature Communications

Breast cancer metastasis suppressor OTUD1 deubiquitinates SMAD7

(2017) Zhengkui Zhang et al.   Nature Communications

The DEAD-Box Protein Dhh1p Couples mRNA Decay and Translation by Monitoring Codon Optimality

(2016) Aditya Radhakrishnan et al.   CELL

Codon Optimality Is a Major Determinant of mRNA Stability

(2015) Vladimir Presnyak et al.   CELL

Structure and Assembly Pathway of the Ribosome Quality Control Complex

(2015) Sichen Shao et al.   MOLECULAR CELL

O6-Methylguanosine leads to position-dependent effects on ribosome speed and fidelity

(2015) Benjamin H. Hudson et al.   RNA

A putative OTU domain-containing protein 1 deubiquitinating enzyme is differentially expressed in thyroid cancer and identifies less-aggressive tumours

(2014) A P Carneiro et al.   BRITISH JOURNAL OF CANCER

Translation drives mRNA quality control

(2012) Christopher J Shoemaker et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Comprehensive Polyadenylation Site Maps in Yeast and Human Reveal Pervasive Alternative Polyadenylation

(2010) Fatih Ozsolak et al.   CELL

Time-dependent increase in ribosome processivity

(2010) J. M. Bonderoff et al.   NUCLEIC ACIDS RESEARCH

The Synthesis of Truncated Polypeptides for Immune Surveillance and Viral Evasion

(2010) Sylvain Cardinaud et al.   PLoS One

Regulation of Translation Initiation in Eukaryotes: Mechanisms and Biological Targets

(2009) Nahum Sonenberg et al.   CELL