eRF1 mediates codon usage effects on mRNA translation efficiency through premature termination at rare codons

Mechanism of premature translation termination on a sense codon

(2018) Egor Svidritskiy et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The cell free protein synthesis system from the model filamentous fungus Neurospora crassa

(2018) Cheng Wu et al.   METHODS

Roadblocks and resolutions in eukaryotic translation

(2018) Anthony P. Schuller et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Translation Termination and Ribosome Recycling in Eukaryotes

(2018) Christopher U.T. Hellen   Cold Spring Harbor Perspectives in Biology

Codon usage biases co-evolve with transcription termination machinery to suppress premature cleavage and polyadenylation

(2018) Zhipeng Zhou et al.   eLife

Codon usage bias controls mRNA and protein abundance in trypanosomatids

(2018) Laura Jeacock et al.   eLife

Codon usage regulates human KRAS expression at both transcriptional and translational levels

(2018) Jingjing Fu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Codon usage regulates protein structure and function by affecting translation elongation speed in Drosophila cells

(2017) Fangzhou Zhao et al.   NUCLEIC ACIDS RESEARCH

Ubiquitination of stalled ribosome triggers ribosome-associated quality control

(2017) Yoshitaka Matsuo et al.   Nature Communications

Alteration of protein function by a silent polymorphism linked to tRNA abundance

(2017) Sebastian Kirchner et al.   PLOS BIOLOGY

Real-Time Imaging of Translation on Single mRNA Transcripts in Live Cells

(2016) Chong Wang et al.   CELL

Dynamics of Translation of Single mRNA Molecules In Vivo

(2016) Xiaowei Yan et al.   CELL

Adjacent Codons Act in Concert to Modulate Translation Efficiency in Yeast

(2016) Caitlin E. Gamble et al.   CELL

Codon identity regulates mRNA stability and translation efficiency during the maternal‐to‐zygotic transition

(2016) Ariel A Bazzini et al.   EMBO JOURNAL

Codon usage affects the structure and function of theDrosophilacircadian clock protein PERIOD

(2016) Jingjing Fu et al.   GENES & DEVELOPMENT

Synonymous Codons Direct Cotranslational Folding toward Different Protein Conformations

(2016) Florian Buhr et al.   MOLECULAR CELL

Codon influence on protein expression in E. coli correlates with mRNA levels

(2016) Grégory Boël et al.   NATURE

Distinct types of translation termination generate substrates for ribosome-associated quality control

(2016) Natalia Shcherbik et al.   NUCLEIC ACIDS RESEARCH

Codon usage is an important determinant of gene expression levels largely through its effects on transcription

(2016) Zhipeng Zhou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural insights into ribosomal rescue by Dom34 and Hbs1 at near-atomic resolution

(2016) Tarek Hilal et al.   Nature Communications

Improved Ribosome-Footprint and mRNA Measurements Provide Insights into Dynamics and Regulation of Yeast Translation

(2016) David E. Weinberg et al.   Cell Reports

A comparative genomics study on the effect of individual amino acids on ribosome stalling

(2015) Renana Sabi et al.   BMC GENOMICS

Codon Optimality Is a Major Determinant of mRNA Stability

(2015) Vladimir Presnyak et al.   CELL

Codon Usage Influences the Local Rate of Translation Elongation to Regulate Co-translational Protein Folding

(2015) Chien-Hung Yu et al.   MOLECULAR CELL

Codon Bias as a Means to Fine-Tune Gene Expression

(2015) Tessa E.F. Quax et al.   MOLECULAR CELL

Nonoptimal codon usage influences protein structure in intrinsically disordered regions

(2015) Mian Zhou et al.   MOLECULAR MICROBIOLOGY

Structural basis for stop codon recognition in eukaryotes

(2015) Alan Brown et al.   NATURE

Rqc2p and 60S ribosomal subunits mediate mRNA-independent elongation of nascent chains

(2015) P. S. Shen et al.   SCIENCE

Understanding Biases in Ribosome Profiling Experiments Reveals Signatures of Translation Dynamics in Yeast

(2015) Jeffrey A. Hussmann et al.   PLoS Genetics

A Dual Program for Translation Regulation in Cellular Proliferation and Differentiation

(2014) Hila Gingold et al.   CELL

Expanding Anfinsen’s Principle: Contributions of Synonymous Codon Selection to Rational Protein Design

(2014) Ian M. Sander et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Release Factor eRF3 Mediates Premature Translation Termination on Polylysine-Stalled Ribosomes in Saccharomyces cerevisiae

(2014) M. Chiabudini et al.   MOLECULAR AND CELLULAR BIOLOGY

Causal signals between codon bias, mRNA structure, and the efficiency of translation and elongation

(2014) C. Pop et al.   Molecular Systems Biology

Kinetic modelling indicates that fast-translating codons can coordinate cotranslational protein folding by avoiding misfolded intermediates

(2014) Edward P. O’Brien et al.   Nature Communications

The Stringency of Start Codon Selection in the Filamentous FungusNeurospora crassa

(2013) Jiajie Wei et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Eukaryotic Release Factor 3 Is Required for Multiple Turnovers of Peptide Release Catalysis by Eukaryotic Release Factor 1

(2013) Daniel E. Eyler et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Non-optimal codon usage affects expression, structure and function of clock protein FRQ

(2013) Mian Zhou et al.   NATURE

Non-optimal codon usage is a mechanism to achieve circadian clock conditionality

(2013) Yao Xu et al.   NATURE

Two-step model of stop codon recognition by eukaryotic release factor eRF1

(2013) Polina Kryuchkova et al.   NUCLEIC ACIDS RESEARCH

Rare Codons Regulate KRas Oncogenesis

(2012) Benjamin L. Lampson et al.   CURRENT BIOLOGY

Protein Synthesis Factors (RF1, RF2, RF3, RRF, and tmRNA) and Peptidyl-tRNA Hydrolase Rescue Stalled Ribosomes at Sense Codons

(2012) Serafín Vivanco-Domínguez et al.   JOURNAL OF MOLECULAR BIOLOGY

Silent Substitutions Predictably Alter Translation Elongation Rates and Protein Folding Efficiencies

(2012) Paige S. Spencer et al.   JOURNAL OF MOLECULAR BIOLOGY

Dom34:Hbs1 Plays a General Role in Quality-Control Systems by Dissociation of a Stalled Ribosome at the 3′ End of Aberrant mRNA

(2012) Tatsuhisa Tsuboi et al.   MOLECULAR CELL

The Elongation, Termination, and Recycling Phases of Translation in Eukaryotes

(2012) T. E. Dever et al.   Cold Spring Harbor Perspectives in Biology

Dissociation by Pelota, Hbs1 and ABCE1 of mammalian vacant 80S ribosomes and stalled elongation complexes

(2011) Vera P Pisareva et al.   EMBO JOURNAL

Determinants of translation efficiency and accuracy

(2011) H. Gingold et al.   Molecular Systems Biology

2A peptides provide distinct solutions to driving stop-carry on translational recoding

(2011) Pamila Sharma et al.   NUCLEIC ACIDS RESEARCH

Kinetic analysis reveals the ordered coupling of translation termination and ribosome recycling in yeast

(2011) C. J. Shoemaker et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Generation of stable Drosophila cell lines using multicistronic vectors

(2011) Monika González et al.   Scientific Reports

Synonymous but not the same: the causes and consequences of codon bias

(2010) Joshua B. Plotkin et al.   NATURE REVIEWS GENETICS

Translation efficiency is determined by both codon bias and folding energy

(2010) Tamir Tuller et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Control of translation efficiency in yeast by codon-anticodon interactions

(2010) D. P. Letzring et al.   RNA

Dom34:Hbs1 Promotes Subunit Dissociation and Peptidyl-tRNA Drop-Off to Initiate No-Go Decay

(2010) C. J. Shoemaker et al.   SCIENCE

Evolutionary Roles of Upstream Open Reading Frames in Mediating Gene Regulation in Fungi

(2009) Heather M. Hood et al.   Annual Review of Microbiology

Regulation of Translation Initiation in Eukaryotes: Mechanisms and Biological Targets

(2009) Nahum Sonenberg et al.   CELL

Experimentally Increased Codon Bias in the Drosophila Adh Gene Leads to an Increase in Larval, But Not Adult, Alcohol Dehydrogenase Activity

(2009) W. Hense et al.   GENETICS

Genetic Identification of Nascent Peptides That Induce Ribosome Stalling

(2009) Douglas R. Tanner et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Coding-Sequence Determinants of Gene Expression in Escherichia coli

(2009) G. Kudla et al.   SCIENCE

Genome-Wide Analysis in Vivo of Translation with Nucleotide Resolution Using Ribosome Profiling

(2009) N. T. Ingolia et al.   SCIENCE

Mistranslation-Induced Protein Misfolding as a Dominant Constraint on Coding-Sequence Evolution

(2008) D. Allan Drummond et al.   CELL

Structure of Yeast Dom34

(2008) Marc Graille et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Electrostatics in the Ribosomal Tunnel Modulate Chain Elongation Rates

(2008) Jianli Lu et al.   JOURNAL OF MOLECULAR BIOLOGY

Site-Specific Release of Nascent Chains from Ribosomes at a Sense Codon

(2008) V. A. Doronina et al.   MOLECULAR AND CELLULAR BIOLOGY

Distinct eRF3 Requirements Suggest Alternate eRF1 Conformations Mediate Peptide Release during Eukaryotic Translation Termination

(2008) Hua Fan-Minogue et al.   MOLECULAR CELL

Quality control by the ribosome following peptide bond formation

(2008) Hani S. Zaher et al.   NATURE