Study of an RNA-Focused DNA-Encoded Library Informs Design of a Degrader of a r(CUG) Repeat Expansion

Synthesis and Screening of a DNA‐Encoded Library of Non‐Peptidic Macrocycles

(2022) Eric Koesema et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

DNA-encoded library versus RNA-encoded library selection enables design of an oncogenic noncoding RNA inhibitor

(2022) Raphael I. Benhamou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Scope of on-DNA nucleophilic aromatic substitution on weakly-activated heterocyclic substrates for the synthesis of DNA-encoded libraries

(2022) Isaline F.S.F. Castan et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Selective and Reversible Ligand Assembly on the DNA and RNA Repeat Sequences in Myotonic Dystrophy

(2022) Sarah B. Krueger et al.   CHEMBIOCHEM

Transcriptome-Wide Mapping of Small-Molecule RNA-Binding Sites in Cells Informs an Isoform-Specific Degrader of QSOX1 mRNA

(2022) Yuquan Tong et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Screening strategies for identifying RNA- and ribonucleoprotein-targeted compounds

(2021) William J. Martin et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Dimensionality reduction by UMAP to visualize physical and genetic interactions

(2020) Michael W. Dorrity et al.   Nature Communications

Target-Directed Approaches for Screening Small Molecules against RNA Targets

(2020) Hafeez S. Haniff et al.   SLAS Discovery

The hallmarks of myotonic dystrophy type 1 muscle dysfunction

(2020) Lauren L. Ozimski et al.   BIOLOGICAL REVIEWS

Novel Nucleic Acid Binding Small Molecules Discovered Using DNA-Encoded Chemistry

(2019) Litovchick et al.   MOLECULES

Precise small-molecule cleavage of an r(CUG) repeat expansion in a myotonic dystrophy mouse model

(2019) Alicia J. Angelbello et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Developments with bead-based screening for novel drug discovery

(2019) Dehua Pei et al.   Expert Opinion on Drug Discovery

(CTG)n repeat-mediated dysregulation of MBNL1 and MBNL2 expression during myogenesis in DM1 occurs already at the myoblast stage

(2019) Laurène M. André et al.   PLoS One

A CTG repeat-selective chemical screen identifies microtubule inhibitors as selective modulators of toxic CUG RNA levels

(2019) Kaalak Reddy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Small Molecule Inhibition of MicroRNA miR-21 Rescues Chemosensitivity of Renal-Cell Carcinoma to Topotecan

(2018) Yuta Naro et al.   JOURNAL OF MEDICINAL CHEMISTRY

Mechanistic studies of a small-molecule modulator of SMN2 splicing

(2018) Jingxin Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Quantitative Methods to Monitor RNA Biomarkers in Myotonic Dystrophy

(2018) Marzena Wojciechowska et al.   Scientific Reports

Precise Small Molecule Degradation of a Noncoding RNA Identifies Cellular Binding Sites and Modulates an Oncogenic Phenotype

(2018) Yue Li et al.   ACS Chemical Biology

Poisson Statistics of Combinatorial Library Sampling Predict False Discovery Rates of Screening

(2017) Andrew B. MacConnell et al.   ACS Combinatorial Science

An Integrated Microfluidic Processor for DNA-Encoded Combinatorial Library Functional Screening

(2017) Andrew B. MacConnell et al.   ACS Combinatorial Science

Inforna 2.0: A Platform for the Sequence-Based Design of Small Molecules Targeting Structured RNAs

(2016) Matthew D. Disney et al.   ACS Chemical Biology

High-throughput Identification of DNA-Encoded IgG Ligands that Distinguish Active and Latent Mycobacterium tuberculosis Infections

(2016) Kimberly R. Mendes et al.   ACS Chemical Biology

Precise small-molecule recognition of a toxic CUG RNA repeat expansion

(2016) Suzanne G Rzuczek et al.   Nature Chemical Biology

Mechanistic determinants of MBNL activity

(2016) Łukasz J. Sznajder et al.   NUCLEIC ACIDS RESEARCH

What is a “DNA-Compatible” Reaction?

(2016) Marie L. Malone et al.   ACS Combinatorial Science

Inhibition of Non-ATG Translational Events in Cells via Covalent Small Molecules Targeting RNA

(2015) Wang-Yong Yang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Structural imprints in vivo decode RNA regulatory mechanisms

(2015) Robert C. Spitale et al.   NATURE

Short antisense-locked nucleic acids (all-LNAs) correct alternative splicing abnormalities in myotonic dystrophy

(2015) Agnieszka Wojtkowiak-Szlachcic et al.   NUCLEIC ACIDS RESEARCH

DNA-Encoded Solid-Phase Synthesis: Encoding Language Design and Complex Oligomer Library Synthesis

(2015) Andrew B. MacConnell et al.   ACS Combinatorial Science

Lomofungin and dilomofungin: inhibitors of MBNL1-CUG RNA binding with distinct cellular effects

(2014) Jason W. Hoskins et al.   NUCLEIC ACIDS RESEARCH

Promoter-Bound Trinucleotide Repeat mRNA Drives Epigenetic Silencing in Fragile X Syndrome

(2014) D. Colak et al.   SCIENCE

Covalent Small-Molecule-RNA Complex Formation Enables Cellular Profiling of Small-Molecule-RNA Interactions

(2013) Lirui Guan et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Two high-throughput screening assays for aberrant RNA–protein interactions in myotonic dystrophy type 1

(2012) Catherine Z. Chen et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

The myotonic dystrophies: molecular, clinical, and therapeutic challenges

(2012) Bjarne Udd et al.   LANCET NEUROLOGY

RNA Splicing Is Responsive to MBNL1 Dose

(2012) Sonali P. Jog et al.   PLoS One

20 years of DNA-encoded chemical libraries

(2011) Luca Mannocci et al.   CHEMICAL COMMUNICATIONS

Small-molecule discovery from DNA-encoded chemical libraries

(2011) Ralph E. Kleiner et al.   CHEMICAL SOCIETY REVIEWS

Design, synthesis and selection of DNA-encoded small-molecule libraries

(2009) Matthew A Clark et al.   Nature Chemical Biology