Planarians to schistosomes: an overview of flatworm cell-types and regulators

Schistosoma mansoni α-N-acetylgalactosaminidase (SmNAGAL) regulates coordinated parasite movement and egg production

(2022) Benjamin J. Hulme et al.   PLoS Pathogens

FoxK1 is Required for Ectodermal Cell Differentiation During Planarian Regeneration

(2022) Pablo Coronel-Córdoba et al.   Frontiers in Cell and Developmental Biology

A male-derived nonribosomal peptide pheromone controls female schistosome development

(2022) Rui Chen et al.   CELL

Somatic regulation of female germ cell regeneration and development in planarians

(2022) Umair W. Khan et al.   Cell Reports

The emerging landscape of spatial profiling technologies

(2022) Jeffrey R. Moffitt et al.   NATURE REVIEWS GENETICS

A Krüppel-like factor is required for development and regeneration of germline and yolk cells from somatic stem cells in planarians

(2022) Melanie Issigonis et al.   PLOS BIOLOGY

Single-cell analysis of Schistosoma mansoni identifies a conserved genetic program controlling germline stem cell fate

(2021) Pengyang Li et al.   Nature Communications

Planarian stem cells specify fate yet retain potency during the cell cycle

(2021) Amelie A. Raz et al.   Cell Stem Cell

Single-cell deconstruction of stem-cell-driven schistosome development

(2021) Dania Nanes Sarfati et al.   TRENDS IN PARASITOLOGY

Mapping single-cell atlases throughout Metazoa unravels cell type evolution

(2021) Alexander J Tarashansky et al.   eLife

Principles of regeneration revealed by the planarian eye

(2021) Peter W. Reddien   CURRENT OPINION IN CELL BIOLOGY

Fifty years of the schistosome tegument: discoveries, controversies, and outstanding questions

(2021) R. Alan Wilson et al.   INTERNATIONAL JOURNAL FOR PARASITOLOGY

Genetic analysis of praziquantel response in schistosome parasites implicates a transient receptor potential channel

(2021) Winka Le Clec’h et al.   Science Translational Medicine

Mechanism of praziquantel action at a parasitic flatworm ion channel

(2021) Sang-Kyu Park et al.   Science Translational Medicine

The Schistosoma mansoni nuclear receptor FTZ-F1 maintains esophageal gland function via transcriptional regulation of meg-8.3

(2021) Aracely A. Romero et al.   PLoS Pathogens

Mapping the epitopes of Schistosoma japonicum esophageal gland proteins for incorporation into vaccine constructs

(2020) Xiao-Hong Li et al.   PLoS One

Cell-type diversity and regionalized gene expression in the planarian intestine

(2020) David J Forsthoefel et al.   eLife

The esophageal gland mediates host immune evasion by the human parasiteSchistosoma mansoni

(2020) Jayhun Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CRISPR/Cas9‐mediated genome editing of Schistosoma mansoni acetylcholinesterase

(2020) Hong You et al.   FASEB JOURNAL

Single-cell atlas of the first intra-mammalian developmental stage of the human parasite Schistosoma mansoni

(2020) Carmen Lidia Diaz Soria et al.   Nature Communications

Programmed genome editing of the omega-1 ribonuclease of the blood fluke, Schistosoma mansoni

(2019) Wannaporn Ittiprasert et al.   eLife

Systematically improved in vitro culture conditions reveal new insights into the reproductive biology of the human parasite Schistosoma mansoni

(2019) Jipeng Wang et al.   PLOS BIOLOGY

Nuclear receptor NR4A is required for patterning at the ends of the planarian anterior-posterior axis

(2019) Dayan J Li et al.   eLife

Self-assembling manifolds in single-cell RNA sequencing data

(2019) Alexander J Tarashansky et al.   eLife

Region-specific regulation of stem cell-driven regeneration in tapeworms

(2019) Tania Rozario et al.   eLife

The anthelmintic drug praziquantel activates a schistosome transient receptor potential channel

(2019) Sang-Kyu Park et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Quantitative Proteomics of Enriched Esophageal and Gut Tissues from the Human Blood Fluke Schistosoma mansoni Pinpoints Secreted Proteins for Vaccine Development

(2019) Leandro X. Neves et al.   JOURNAL OF PROTEOME RESEARCH

Prospectively Isolated Tetraspanin + Neoblasts Are Adult Pluripotent Stem Cells Underlying Planaria Regeneration

(2018) An Zeng et al.   CELL

Cellular, ultrastructural and molecular analyses of epidermal cell development in the planarian Schmidtea mediterranea

(2018) Li-Chun Cheng et al.   DEVELOPMENTAL BIOLOGY

Cell type transcriptome atlas for the planarianSchmidtea mediterranea

(2018) Christopher T. Fincher et al.   SCIENCE

Cell type atlas and lineage tree of a whole complex animal by single-cell transcriptomics

(2018) Mireya Plass et al.   SCIENCE

Microexon gene transcriptional profiles and evolution provide insights into blood processing by the Schistosoma japonicum esophagus

(2018) Xiao-Hong Li et al.   PLoS Neglected Tropical Diseases

Stem cell heterogeneity drives the parasitic life cycle of Schistosoma mansoni

(2018) Bo Wang et al.   eLife

Flatworm-specific transcriptional regulators promote the specification of tegumental progenitors in Schistosoma mansoni

(2018) George R Wendt et al.   eLife

Schistosomiasis

(2018) Donald P. McManus et al.   Nature Reviews Disease Primers

The Cellular and Molecular Basis for Planarian Regeneration

(2018) Peter W. Reddien   CELL

foxF-1 Controls Specification of Non-body Wall Muscle and Phagocytic Cells in Planarians

(2018) M. Lucila Scimone et al.   CURRENT BIOLOGY

SoxB1 Activity Regulates Sensory Neuron Regeneration, Maintenance, and Function in Planarians

(2018) Kelly G. Ross et al.   DEVELOPMENTAL CELL

Smed-myb-1 Specifies Early Temporal Identity during Planarian Epidermal Differentiation

(2018) Shu Jun Zhu et al.   Cell Reports

Orthogonal muscle fibres have different instructive roles in planarian regeneration

(2017) M. Lucila Scimone et al.   NATURE

Embryonic origin of adult stem cells required for tissue homeostasis and regeneration

(2017) Erin L Davies et al.   eLife

Schistosomiasis as a disease of stem cells

(2016) George R Wendt et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Identification of new markers for the Schistosoma mansoni vitelline lineage

(2016) Jipeng Wang et al.   INTERNATIONAL JOURNAL FOR PARASITOLOGY

NF-YB Regulates Spermatogonial Stem Cell Self-Renewal and Proliferation in the Planarian Schmidtea mediterranea

(2016) Harini Iyer et al.   PLoS Genetics

Stimulating Neoblast-Like Cell Proliferation in Juvenile Fasciola hepatica Supports Growth and Progression towards the Adult Phenotype In Vitro

(2016) Paul McCusker et al.   PLoS Neglected Tropical Diseases

Tissue Degeneration following Loss of Schistosoma mansoni cbp1 Is Associated with Increased Stem Cell Proliferation and Parasite Death In Vivo

(2016) Julie N. R. Collins et al.   PLoS Pathogens

Stem cell progeny contribute to the schistosome host-parasite interface

(2016) James J Collins et al.   eLife

On the organ trail: insights into organ regeneration in the planarian

(2015) Rachel H Roberts-Galbraith et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

A Generic and Cell-Type-Specific Wound Response Precedes Regeneration in Planarians

(2015) Omri Wurtzel et al.   DEVELOPMENTAL CELL

Types or States? Cellular Dynamics and Regenerative Potential

(2015) Carolyn E. Adler et al.   TRENDS IN CELL BIOLOGY

Evidence That Rhesus Macaques Self-Cure from a Schistosoma japonicum Infection by Disrupting Worm Esophageal Function: A New Route to an Effective Vaccine?

(2015) Xiao-Hong Li et al.   PLoS Neglected Tropical Diseases

The Schistosome Esophagus Is a ‘Hotspot’ for Microexon and Lysosomal Hydrolase Gene Expression: Implications for Blood Processing

(2015) R. Alan Wilson et al.   PLoS Neglected Tropical Diseases

Stem cells and fluid flow drive cyst formation in an invertebrate excretory organ

(2015) Hanh Thi-Kim Vu et al.   eLife

Nuclear genomic signals of the ‘microturbellarian’ roots of platyhelminth evolutionary innovation

(2015) Christopher E Laumer et al.   eLife

A mex3 homolog is required for differentiation during planarian stem cell lineage development

(2015) Shu Jun Zhu et al.   eLife

Egr-5 is a post-mitotic regulator of planarian epidermal differentiation

(2015) Kimberly C Tu et al.   eLife

Kicking in the Guts: Schistosoma mansoni Digestive Tract Proteins are Potential Candidates for Vaccine Development

(2015) Barbara Castro-Pimentel Figueiredo et al.   Frontiers in Immunology

Single-Cell Analysis Reveals Functionally Distinct Classes within the Planarian Stem Cell Compartment

(2014) Josien C. van Wolfswinkel et al.   Cell Stem Cell

PIWI homologs mediate Histone H4 mRNA localization to planarian chromatoid bodies

(2014) L. Rouhana et al.   DEVELOPMENT

A lophotrochozoan-specific nuclear hormone receptor is required for reproductive system development in the planarian

(2014) Marla E. Tharp et al.   DEVELOPMENTAL BIOLOGY

Human schistosomiasis

(2014) Daniel G Colley et al.   LANCET

COE Loss-of-Function Analysis Reveals a Genetic Program Underlying Maintenance and Regeneration of the Nervous System in Planarians

(2014) Martis W. Cowles et al.   PLoS Genetics

Schistosome Feeding and Regurgitation

(2014) Patrick J. Skelly et al.   PLoS Pathogens

Selective amputation of the pharynx identifies a FoxA-dependent regeneration program in planaria

(2014) Carolyn E Adler et al.   eLife

Neoblast Specialization in Regeneration of the Planarian Schmidtea mediterranea

(2014) M. Lucila Scimone et al.   Stem Cell Reports

Specialized progenitors and regeneration

(2013) P. W. Reddien   DEVELOPMENT

Transcription factors lhx1/5-1 and pitx are required for the maintenance and regeneration of serotonergic neurons in planarians

(2013) K. W. Currie et al.   DEVELOPMENT

A Pitx transcription factor controls the establishment and maintenance of the serotonergic lineage in planarians

(2013) M. Marz et al.   DEVELOPMENT

Genome-wide analysis of the bHLH gene family in planarians identifies factors required for adult neurogenesis and neuronal regeneration

(2013) M. W. Cowles et al.   DEVELOPMENT

Adult somatic stem cells in the human parasite Schistosoma mansoni

(2013) James J. Collins III et al.   NATURE

A sex-specific transcription factor controls male identity in a simultaneous hermaphrodite

(2013) Tracy Chong et al.   Nature Communications

Muscle Cells Provide Instructions for Planarian Regeneration

(2013) Jessica N. Witchley et al.   Cell Reports

The Schistosome Oesophageal Gland: Initiator of Blood Processing

(2013) Xiao-Hong Li et al.   PLoS Neglected Tropical Diseases

It's No Fluke: The Planarian as a Model for Understanding Schistosomes

(2013) James J. Collins et al.   PLoS Pathogens

Functional genomic characterization of neoblast-like stem cells in larval Schistosoma mansoni

(2013) Bo Wang et al.   eLife

Genetic Regulators of a Pluripotent Adult Stem Cell System in Planarians Identified by RNAi and Clonal Analysis

(2012) Daniel E. Wagner et al.   Cell Stem Cell

An RNAi Screen Reveals Intestinal Regulators of Branching Morphogenesis, Differentiation, and Stem Cell Proliferation in Planarians

(2012) David J. Forsthoefel et al.   DEVELOPMENTAL CELL

A molecular wound response program associated with regeneration initiation in planarians

(2012) D. Wenemoser et al.   GENES & DEVELOPMENT

Transcriptome Analysis of the Planarian Eye Identifies ovo as a Specific Regulator of Eye Regeneration

(2012) Sylvain W. Lapan et al.   Cell Reports

Evolutionarily Ancient Association of the FoxJ1 Transcription Factor with the Motile Ciliogenic Program

(2012) Shubha Vij et al.   PLoS Genetics

The maintenance and regeneration of the planarian excretory system are regulated by EGFR signaling

(2011) J. C. Rink et al.   DEVELOPMENT

A regulatory program for excretory system regeneration in planarians

(2011) M. L. Scimone et al.   DEVELOPMENT

EGFR signaling regulates cell proliferation, differentiation and morphogenesis during planarian regeneration and homeostasis

(2011) Susanna Fraguas et al.   DEVELOPMENTAL BIOLOGY

Clonogenic Neoblasts Are Pluripotent Adult Stem Cells That Underlie Planarian Regeneration

(2011) D. E. Wagner et al.   SCIENCE

Polarized notum Activation at Wounds Inhibits Wnt Function to Promote Planarian Head Regeneration

(2011) C. P. Petersen et al.   SCIENCE

Constitutive gene expression and the specification of tissue identity in adult planarian biology

(2011) Peter W. Reddien   TRENDS IN GENETICS

dlx and sp6-9 Control Optic Cup Regeneration in a Prototypic Eye

(2011) Sylvain W. Lapan et al.   PLoS Genetics

An Atlas for Schistosoma mansoni Organs and Life-Cycle Stages Using Cell Type-Specific Markers and Confocal Microscopy

(2011) James J. Collins et al.   PLoS Neglected Tropical Diseases

A functional genomic screen in planarians identifies novel regulators of germ cell development

(2010) Y. Wang et al.   GENES & DEVELOPMENT

An Outer Arm Dynein Conformational Switch Is Required for Metachronal Synchrony of Motile Cilia in Planaria

(2010) Panteleimon Rompolas et al.   MOLECULAR BIOLOGY OF THE CELL

Genome-Wide Analyses Reveal a Role for Peptide Hormones in Planarian Germline Development

(2010) James J. Collins et al.   PLOS BIOLOGY

A planarian p53 homolog regulates proliferation and self-renewal in adult stem cell lineages

(2009) Bret J. Pearson et al.   DEVELOPMENT

Molecular Analysis of Stem Cells and Their Descendants during Cell Turnover and Regeneration in the Planarian Schmidtea mediterranea

(2008) George T. Eisenhoffer et al.   Cell Stem Cell

 -Catenin Defines Head Versus Tail Identity During Planarian Regeneration and Homeostasis

(2007) K. A. Gurley et al.   SCIENCE

Smed- catenin-1 Is Required for Anteroposterior Blastema Polarity in Planarian Regeneration

(2007) C. P. Petersen et al.   SCIENCE