Schistosoma mansoni α-N-acetylgalactosaminidase (SmNAGAL) regulates coordinated parasite movement and egg production

Characterization of class II fumarase from Schistosoma mansoni provides the molecular basis for selective inhibition

(2021) Iara Aimê Cardoso et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

In silico repositioning of approved drugs against Schistosoma mansoni energy metabolism targets

(2019) Nicole Melo Calixto et al.   PLoS One

Programmed knockout mutation of liver fluke granulin attenuates virulence of infection-induced hepatobiliary morbidity

(2019) Patpicha Arunsan et al.   eLife

Programmed genome editing of the omega-1 ribonuclease of the blood fluke, Schistosoma mansoni

(2019) Wannaporn Ittiprasert et al.   eLife

CRISPResso2 provides accurate and rapid genome editing sequence analysis

(2019) Kendell Clement et al.   NATURE BIOTECHNOLOGY

Systematically improved in vitro culture conditions reveal new insights into the reproductive biology of the human parasite Schistosoma mansoni

(2019) Jipeng Wang et al.   PLOS BIOLOGY

Comprehensive Integration of Single-Cell Data

(2019) Tim Stuart et al.   CELL

The anthelmintic drug praziquantel activates a schistosome transient receptor potential channel

(2019) Sang-Kyu Park et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nicotiana benthamianaα-galactosidase A1.1 can functionally complement human α-galactosidase A deficiency associated with Fabry disease

(2018) Kassiani Kytidou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

MEGA X: Molecular Evolutionary Genetics Analysis across Computing Platforms

(2018) Sudhir Kumar et al.   MOLECULAR BIOLOGY AND EVOLUTION

Repair of double-strand breaks induced by CRISPR–Cas9 leads to large deletions and complex rearrangements

(2018) Michael Kosicki et al.   NATURE BIOTECHNOLOGY

Screening a repurposing library, the Medicines for Malaria Venture Stasis Box, against Schistosoma mansoni

(2018) Valérian Pasche et al.   Parasites & Vectors

Flatworm-specific transcriptional regulators promote the specification of tegumental progenitors in Schistosoma mansoni

(2018) George R Wendt et al.   eLife

Schistosomiasis

(2018) Donald P. McManus et al.   Nature Reviews Disease Primers

Computationally-guided drug repurposing enables the discovery of kinase targets and inhibitors as new schistosomicidal agents

(2018) Sandra Giuliani et al.   PLoS Computational Biology

Combining bioinformatics, cheminformatics, functional genomics and whole organism approaches for identifying epigenetic drug targets in Schistosoma mansoni

(2018) Gilda Padalino et al.   International Journal for Parasitology-Drugs and Drug Resistance

Early Antischistosomal Leads Identified from in Vitro and in Vivo Screening of the Medicines for Malaria Venture Pathogen Box

(2018) Valérian Pasche et al.   ACS Infectious Diseases

WormBase ParaSite − a comprehensive resource for helminth genomics

(2017) Kevin L. Howe et al.   MOLECULAR AND BIOCHEMICAL PARASITOLOGY

MiR-277/4989 regulate transcriptional landscape during juvenile to adult transition in the parasitic helminth Schistosoma mansoni

(2017) Anna V. Protasio et al.   PLoS Neglected Tropical Diseases

Targeted mutagenesis in a human-parasitic nematode

(2017) Spencer S. Gang et al.   PLoS Pathogens

Precise and efficient siRNA design: a key point in competent gene silencing

(2016) E Fakhr et al.   CANCER GENE THERAPY

Identification of new markers for the Schistosoma mansoni vitelline lineage

(2016) Jipeng Wang et al.   INTERNATIONAL JOURNAL FOR PARASITOLOGY

Analyzing CRISPR genome-editing experiments with CRISPResso

(2016) Luca Pinello et al.   NATURE BIOTECHNOLOGY

Breaking-Cas—interactive design of guide RNAs for CRISPR-Cas experiments for ENSEMBL genomes

(2016) Juan C. Oliveros et al.   NUCLEIC ACIDS RESEARCH

Schistosome sex matters: a deep view into gonad-specific and pairing-dependent transcriptomes reveals a complex gender interplay

(2016) Zhigang Lu et al.   Scientific Reports

Crystal Structure and Mutational Analysis of Isomalto-dextranase, a Member of Glycoside Hydrolase Family 27

(2015) Yuka Okazawa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Glycomic Analysis of Life Stages of the Human ParasiteSchistosoma mansoniReveals Developmental Expression Profiles of Functional and Antigenic Glycan Motifs

(2015) Cornelis H. Smit et al.   MOLECULAR & CELLULAR PROTEOMICS

Cas9 specifies functional viral targets during CRISPR–Cas adaptation

(2015) Robert Heler et al.   NATURE

Schistosoma mansoni Egg, Adult Male and Female Comparative Gene Expression Analysis and Identification of Novel Genes by RNA-Seq

(2015) Letícia Anderson et al.   PLoS Neglected Tropical Diseases

Automated chip-nanoelectrospray mass spectrometry for glycourinomics in Schindler disease type I

(2014) Mirela Sarbu et al.   CARBOHYDRATE RESEARCH

Schistosoma mansoni: a method for inducing resistance to praziquantel using infected Biomphalaria glabrata snails

(2014) Flávia FB Couto et al.   MEMORIAS DO INSTITUTO OSWALDO CRUZ

Halting harmful helminths

(2014) K. F. Hoffmann et al.   SCIENCE

Deciphering the glycogenome of schistosomes

(2014) Megan L. Mickum et al.   Frontiers in Genetics

Schistosomiasis Chemotherapy

(2013) Sophie A.-L. Thétiot-Laurent et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Transgene-Free Genome Editing in Caenorhabditis elegans Using CRISPR-Cas

(2013) Hui Chiu et al.   GENETICS

Adult somatic stem cells in the human parasite Schistosoma mansoni

(2013) James J. Collins III et al.   NATURE

Genome engineering using the CRISPR-Cas9 system

(2013) F Ann Ran et al.   Nature Protocols

Functional genomic characterization of neoblast-like stem cells in larval Schistosoma mansoni

(2013) Bo Wang et al.   eLife

Specific glycan elements determine differential binding of individual egg glycoproteins of the human parasite Schistosoma mansoni by host C-type lectin receptors

(2012) Moniek H.J. Meevissen et al.   INTERNATIONAL JOURNAL FOR PARASITOLOGY

MrBayes 3.2: Efficient Bayesian Phylogenetic Inference and Model Choice Across a Large Model Space

(2012) Fredrik Ronquist et al.   SYSTEMATIC BIOLOGY

WormAssay: A Novel Computer Application for Whole-Plate Motion-based Screening of Macroscopic Parasites

(2012) Chris Marcellino et al.   PLoS Neglected Tropical Diseases

A Systematically Improved High Quality Genome and Transcriptome of the Human Blood Fluke Schistosoma mansoni

(2012) Anna V. Protasio et al.   PLoS Neglected Tropical Diseases

The proteome of the insoluble Schistosoma mansoni eggshell skeleton

(2011) Saskia deWalick et al.   INTERNATIONAL JOURNAL FOR PARASITOLOGY

Whole mount in situ hybridization methodology for Schistosoma mansoni

(2011) Alexis A. Cogswell et al.   MOLECULAR AND BIOCHEMICAL PARASITOLOGY

The Pfam protein families database

(2011) M. Punta et al.   NUCLEIC ACIDS RESEARCH

Cytosine methylation regulates oviposition in the pathogenic blood fluke Schistosoma mansoni

(2011) Kathrin K. Geyer et al.   Nature Communications

Gene Atlasing of Digestive and Reproductive Tissues in Schistosoma mansoni

(2011) Sujeevi S. K. Nawaratna et al.   PLoS Neglected Tropical Diseases

mRNA turnover rate limits siRNA and microRNA efficacy

(2010) Erik Larsson et al.   Molecular Systems Biology

Prediction of the responsiveness to pharmacological chaperones: lysosomal human alpha-galactosidase, a case of study

(2010) Giuseppina Andreotti et al.   Orphanet Journal of Rare Diseases

Genome-Wide Analyses Reveal a Role for Peptide Hormones in Planarian Germline Development

(2010) James J. Collins et al.   PLOS BIOLOGY

Glycotope analysis in miracidia and primary sporocysts of Schistosoma mansoni: Differential expression during the miracidium-to-sporocyst transformation

(2009) Nathan A. Peterson et al.   INTERNATIONAL JOURNAL FOR PARASITOLOGY

Omega-1, a glycoprotein secreted bySchistosoma mansonieggs, drives Th2 responses

(2009) Bart Everts et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The 1.9 Å Structure of Human α-N-Acetylgalactosaminidase: The Molecular Basis of Schindler and Kanzaki Diseases

(2009) Nathaniel E. Clark et al.   JOURNAL OF MOLECULAR BIOLOGY

The Universal Protein Resource (UniProt) in 2010

(2009)   NUCLEIC ACIDS RESEARCH

Anti-schistosomal Intervention Targets Identified by Lifecycle Transcriptomic Analyses

(2009) Jennifer M. Fitzpatrick et al.   PLoS Neglected Tropical Diseases

Developmentally regulated expression, alternative splicing and distinct sub-groupings in members of the Schistosoma mansoni venom allergen-like (SmVAL) gene family

(2008) Iain W Chalmers et al.   BMC GENOMICS

Genomic-scale prioritization of drug targets: the TDR Targets database

(2008) Fernán Agüero et al.   NATURE REVIEWS DRUG DISCOVERY