Notum leads to potential pro-survival of OSCC through crosstalk between Shh and Wnt/β-catenin signaling via p-GSK3β

Prednisolone induces osteocytes apoptosis by promoting Notum expression and inhibiting PI3K/AKT/GSK3β/β-catenin pathway

(2021) Congshan Li et al.   JOURNAL OF MOLECULAR HISTOLOGY

Notum suppresses the osteogenic differentiation of periodontal ligament stem cells through the Wnt/Beta catenin signaling pathway

(2021) Panpan Yang et al.   ARCHIVES OF ORAL BIOLOGY

Blocking SHH/Patched interaction triggers tumor growth inhibition through Patched-induced apoptosis

(2020) Pierre-Antoine Bissey et al.   CANCER RESEARCH

Targeting the β-catenin signaling for cancer therapy

(2020) Xue Zhang et al.   PHARMACOLOGICAL RESEARCH

GDE2-Dependent Activation of Canonical Wnt Signaling in Neurons Regulates Oligodendrocyte Maturation

(2020) Bo-Ran Choi et al.   Cell Reports

Assembly of lung progenitors into developmentally-inspired geometry drives differentiation via cellular tension

(2020) John P. Soleas et al.   BIOMATERIALS

RNA-Binding Proteins as Regulators of Migration, Invasion and Metastasis in Oral Squamous Cell Carcinoma

(2020) Jonas Weiße et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Downregulation of RNF128 activates Wnt/β-catenin signaling to induce cellular EMT and stemness via CD44 and CTTN ubiquitination in melanoma

(2019) Chuan-Yuan Wei et al.   Journal of Hematology & Oncology

Muscone Promotes The Adipogenic Differentiation Of Human Gingival Mesenchymal Stem Cells By Inhibiting The Wnt/β-Catenin Signaling Pathway

(2019) Wen-Xiu Yuan et al.   Drug Design Development and Therapy

Emerging insights of tumor heterogeneity and drug resistance mechanisms in lung cancer targeted therapy

(2019) Zuan-Fu Lim et al.   Journal of Hematology & Oncology

A loss-of-function genetic screening reveals synergistic targeting of AKT/mTOR and WTN/β-catenin pathways for treatment of AML with high PRL-3 phosphatase

(2018) Jianbiao Zhou et al.   Journal of Hematology & Oncology

Association between expression of MMP-7 and MMP-9 and pelvic lymph node and para-aortic lymph node metastasis in early cervical cancer

(2018) Hui Guo et al.   JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH

Global, Regional, and National Cancer Incidence, Mortality, Years of Life Lost, Years Lived With Disability, and Disability-Adjusted Life-Years for 29 Cancer Groups, 1990 to 2016

(2018) et al.   JAMA Oncology

Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

(2018) Freddie Bray et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Dihydroartemisinin induces apoptosis and inhibits proliferation, migration, and invasion in epithelial ovarian cancer via inhibition of the hedgehog signaling pathway

(2018) Yanmei Liu et al.   Cancer Medicine

Lycium barbarumPolysaccharides Protect against Trimethyltin Chloride-Induced Apoptosis via Sonic Hedgehog and PI3K/Akt Signaling Pathways in Mouse Neuro-2a Cells

(2016) Wanyun Zhao et al.   Oxidative Medicine and Cellular Longevity

May High MMP-2 and TIMP-2 Expressions Increase or Decrease the Aggressivity of Oral Cancer?

(2016) Bijayatha Shrestha et al.   PATHOLOGY & ONCOLOGY RESEARCH

NOTUM is a potential pharmacodynamic biomarker of Wnt pathway inhibition

(2016) Babita Madan et al.   Oncotarget

Generation of Mice with Hepatocyte-Specific Conditional Deletion of Notum

(2016) Frédéric Canal et al.   PLoS One

Notum Is Required for Neural and Head Induction via Wnt Deacylation, Oxidation, and Inactivation

(2015) Xinjun Zhang et al.   DEVELOPMENTAL CELL

Notum deacylates Wnt proteins to suppress signalling activity

(2015) Satoshi Kakugawa et al.   NATURE

Molecular Signalling in Hepatocellular Carcinoma: Role of and Crosstalk among Wnt/β-Catenin, Sonic Hedgehog, Notch and Dickkopf-1

(2015) Alexandros Giakoustidis et al.   Canadian Journal of Gastroenterology and Hepatology

Overexpression of MMP Family Members Functions as Prognostic Biomarker for Breast Cancer Patients: A Systematic Review and Meta-Analysis

(2015) Fanghui Ren et al.   PLoS One

Activator or inhibitor? GSK-3 as a new drug target

(2013) Fumi Takahashi-Yanaga   BIOCHEMICAL PHARMACOLOGY

Phosphorylated EGFR at tyrosine 1173 correlates with poor prognosis in oral squamous cell carcinomas

(2013) LS Monteiro et al.   ORAL DISEASES

Dally and Notum regulate the switch between low and high level Hedgehog pathway signalling

(2012) K. L. Ayers et al.   DEVELOPMENT

clusterProfiler: an R Package for Comparing Biological Themes Among Gene Clusters

(2012) Guangchuang Yu et al.   OMICS-A JOURNAL OF INTEGRATIVE BIOLOGY

Structure of the protein core of the glypican Dally-like and localization of a region important for hedgehog signaling

(2011) Min-Sung Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hedgehog Target Genes: Mechanisms of Carcinogenesis Induced by Aberrant Hedgehog Signaling Activation

(2009) Y. Katoh et al.   CURRENT MOLECULAR MEDICINE

Wnt/β-Catenin Signaling: Components, Mechanisms, and Diseases

(2009) Bryan T. MacDonald et al.   DEVELOPMENTAL CELL

Upregulation of vimentin and aberrant expression of E-cadherin/β-catenin complex in oral squamous cell carcinomas: correlation with the clinicopathological features and patient outcome

(2009) Lai-Kui Liu et al.   MODERN PATHOLOGY

GSK3: a multifaceted kinase in Wnt signaling

(2009) Dianqing Wu et al.   TRENDS IN BIOCHEMICAL SCIENCES

Mammalian Notum induces the release of glypicans and other GPI-anchored proteins from the cell surface

(2008) Alexandra Traister et al.   BIOCHEMICAL JOURNAL

Human homolog of NOTUM, overexpressed in hepatocellular carcinoma, is regulated transcriptionally by β-catenin/TCF

(2008) Yuichi Torisu et al.   CANCER SCIENCE