Dual modulators of aggregation and dissociation of amyloid beta and tau: In vitro, in vivo, and in silico studies of Uncaria rhynchophylla and its bioactive components

Cryo-EM structures of amyloid-β 42 filaments from human brains

(2022) Yang Yang et al.   SCIENCE

AMYLOID-β AND TAU AGGREGATION DUAL-INHIBITORS: A SYNTHETIC AND STRUCTURE-ACTIVITY RELATIONSHIP FOCUSED REVIEW

(2021) Daniela Malafaia et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

The Main Alkaloids in Uncaria rhynchophylla and Their Anti-Alzheimer’s Disease Mechanism Determined by a Network Pharmacology Approach

(2021) Peng Zeng et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Dual Inhibitors of Amyloid-β and Tau Aggregation with Amyloid-β Disaggregating Properties: Extended In Cellulo, In Silico, and Kinetic Studies of Multifunctional Anti-Alzheimer’s Agents

(2021) Anna Pasieka et al.   ACS Chemical Neuroscience

Properties, Pharmacology, and Pharmacokinetics of Active Indole and Oxindole Alkaloids in Uncaria Hook

(2021) Hirotaka Kushida et al.   Frontiers in Pharmacology

Heterotypic Amyloid β interactions facilitate amyloid assembly and modify amyloid structure

(2021) Katerina Konstantoulea et al.   EMBO JOURNAL

Microglia contribute to the propagation of Aβ into unaffected brain tissue

(2021) Paolo d’Errico et al.   NATURE NEUROSCIENCE

Comparison of the chemical constituents and anti-Alzheimer’s disease effects of Uncaria rhynchophylla and Uncaria tomentosa

(2021) Qing-Qing Xu et al.   Chinese Medicine

Therapeutic Mechanism and Key Alkaloids of Uncaria rhynchophylla in Alzheimer’s Disease From the Perspective of Pathophysiological Processes

(2021) Peng Zeng et al.   Frontiers in Pharmacology

Direct Interaction between the β-Amyloid Core and Tau Facilitates Cross-Seeding: A Novel Target for Therapeutic Intervention

(2020) Timir Tripathi et al.   BIOCHEMISTRY

Calorimetric studies of binary and ternary molecular interactions between transthyretin, Aβ peptides and small-molecule chaperones towards an alternative strategy for Alzheimer's Disease drug discovery

(2020) Ellen Y. Cotrina et al.   JOURNAL OF MEDICINAL CHEMISTRY

Investigation of memory-enhancing botanical mixture and their isolated compounds for inhibition of amyloid-β and tau aggregation

(2020) Seungyeop Baek et al.   Applied Biological Chemistry

Red Ginseng Inhibits Tau Aggregation and Promotes Tau Dissociation In Vitro

(2020) Soo Jung Shin et al.   Oxidative Medicine and Cellular Longevity

Accumulation of amyloid precursor protein C-terminal fragments triggers mitochondrial structure, function, and mitophagy defects in Alzheimer’s disease models and human brains

(2020) Loan Vaillant-Beuchot et al.   ACTA NEUROPATHOLOGICA

Mechanisms of Pathogenic Tau and Aβ Protein Spreading in Alzheimer’s Disease

(2020) Paolo d‘Errico et al.   Frontiers in Aging Neuroscience

Treatment Combinations for Alzheimer’s Disease: Current And Future Pharmacotherapy Options

(2019) Jeffrey L. Cummings et al.   JOURNAL OF ALZHEIMERS DISEASE

Methylene Blue Inhibits Formation of Tau Fibrils but not of Granular Tau Oligomers: A Plausible Key to Understanding Failure of a Clinical Trial for Alzheimer’s Disease

(2019) Yoshiyuki Soeda et al.   JOURNAL OF ALZHEIMERS DISEASE

Uncaria rhynchophylla and Its Major Constituents on Central Nervous System: A Review on Their Pharmacological Actions

(2019) Wen Yang et al.   Current Vascular Pharmacology

Multi-target design strategies for the improved treatment of Alzheimer's disease

(2019) Pengfei Zhang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Uncaria rhynchophylla Ameliorates Parkinson’s Disease by Inhibiting HSP90 Expression: Insights from Quantitative Proteomics

(2018) Yu-Long Lan et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Crucial role of protein oligomerization in the pathogenesis of Alzheimer's and Parkinson's diseases

(2018) Minee L. Choi et al.   FEBS Journal

Alzheimer’s Disease, Oligomers, and Inflammation

(2018) Gianluigi Forloni et al.   JOURNAL OF ALZHEIMERS DISEASE

The role of phenolic OH groups of flavonoid compounds with H-bond formation ability to suppress amyloid mature fibrils by destabilizing β-sheet conformation of monomeric Aβ17-42

(2018) Sahar Andarzi Gargari et al.   PLoS One

Neuroprotection Against MPP+-Induced Cytotoxicity Through the Activation of PI3-K/Akt/GSK3β/MEF2D Signaling Pathway by Rhynchophylline, the Major Tetracyclic Oxindole Alkaloid Isolated From Uncaria rhynchophylla

(2018) Shengquan Hu et al.   Frontiers in Pharmacology

Tau and neuroinflammation: What impact for Alzheimer's Disease and Tauopathies?

(2018) Cyril Laurent et al.   Biomedical Journal

Isorhynchophylline Treatment Improves the Amyloid-β-Induced Cognitive Impairment in Rats via Inhibition of Neuronal Apoptosis and Tau Protein Hyperphosphorylation

(2018) Yan-Fang Xian et al.   JOURNAL OF ALZHEIMERS DISEASE

Recent advances in multi-target anti-Alzheimer disease compounds (2013 up to present)

(2018) Ning Wang et al.   CURRENT MEDICINAL CHEMISTRY

Uncaria rhynchophylla ameliorates amyloid beta deposition and amyloid beta-mediated pathology in 5XFAD mice

(2018) Soo Jung Shin et al.   NEUROCHEMISTRY INTERNATIONAL

Cryo-EM structures of tau filaments from Alzheimer’s disease

(2017) Anthony W. P. Fitzpatrick et al.   NATURE

Structure-based inhibitors of tau aggregation

(2017) P. M. Seidler et al.   Nature Chemistry

Fibril structure of amyloid-β(1–42) by cryo–electron microscopy

(2017) Lothar Gremer et al.   SCIENCE

Photochemical Identification of Molecular Binding Sites on the Surface of Amyloid-β Fibrillar Aggregates

(2017) Amir Aliyan et al.   Chem

Tau Oligomers Associate with Inflammation in the Brain and Retina of Tauopathy Mice and in Neurodegenerative Diseases

(2016) Ashley N. Nilson et al.   JOURNAL OF ALZHEIMERS DISEASE

Protein aggregation in Alzheimer’s disease: Aβ and τ and their potential roles in the pathogenesis of AD

(2015) Dietmar Rudolf Thal et al.   ACTA NEUROPATHOLOGICA

Randomized double-blind placebo-controlled multicenter trial of Yokukansan for neuropsychiatric symptoms in Alzheimer's disease

(2015) Katsutoshi Furukawa et al.   Geriatrics & Gerontology International

The contribution of neuroinflammation to amyloid toxicity in Alzheimer's disease

(2015) Myles R. Minter et al.   JOURNAL OF NEUROCHEMISTRY

Identification and Characterization of the Binding Site of the Respiratory Syncytial Virus Phosphoprotein to RNA-Free Nucleoprotein

(2015) Marie Galloux et al.   JOURNAL OF VIROLOGY

Neuroinflammation in Alzheimer's disease

(2015) Michael T Heneka et al.   LANCET NEUROLOGY

Pathogenesis of synaptic degeneration in Alzheimer's disease and Lewy body disease

(2014) Cassia R. Overk et al.   BIOCHEMICAL PHARMACOLOGY

Atomic force microscopy to study molecular mechanisms of amyloid fibril formation and toxicity in Alzheimer’s disease

(2014) Elizabeth Drolle et al.   DRUG METABOLISM REVIEWS

Isorhynchophylline Protects PC12 Cells Against Beta-Amyloid-Induced Apoptosis via PI3K/Akt Signaling Pathway

(2013) Yan-Fang Xian et al.   Evidence-based Complementary and Alternative Medicine

Accelerated tau pathology with synaptic and neuronal loss in a novel triple transgenic mouse model of Alzheimer's disease

(2013) Anika Saul et al.   NEUROBIOLOGY OF AGING

Hyperphosphorylation-Induced Tau Oligomers

(2013) Khalid Iqbal et al.   Frontiers in Neurology

How to Improve Docking Accuracy of AutoDock4.2: A Case Study Using Different Electrostatic Potentials

(2012) Xuben Hou et al.   Journal of Chemical Information and Modeling

Morin hydrate inhibits amyloid formation by islet amyloid polypeptide and disaggregates amyloid fibers

(2012) Harris Noor et al.   PROTEIN SCIENCE

Protective Effect of Isorhynchophylline Against β-Amyloid-Induced Neurotoxicity in PC12 Cells

(2011) Yan-Fang Xian et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Aβ Oligomer-Induced Synapse Degeneration in Alzheimer’s Disease

(2011) Kyle C. Wilcox et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Yokukansan, a traditional Japanese medicine, ameliorates memory disturbance and abnormal social interaction with anti-aggregation effect of cerebral amyloid β proteins in amyloid precursor protein transgenic mice

(2011) H. Fujiwara et al.   NEUROSCIENCE

Effect of Surfaces on Amyloid Fibril Formation

(2011) Bradley Moores et al.   PLoS One

Amyloid-β and tau — a toxic pas de deux in Alzheimer's disease

(2010) Lars M. Ittner et al.   NATURE REVIEWS NEUROSCIENCE

Alzheimer's Disease

(2010) Henry W. Querfurth et al.   NEW ENGLAND JOURNAL OF MEDICINE

Effects of Yokukansan on behavioral and psychological symptoms of dementia in regular treatment for Alzheimer's disease

(2010) Kazunori Okahara et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Treatment of behavioral and psychological symptoms of Alzheimer-type dementia with Yokukansan in clinical practice

(2010) Yoshihito Hayashi et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Mechanisms of tau-induced neurodegeneration

(2009) Khalid Iqbal et al.   ACTA NEUROPATHOLOGICA

Amyloid-  and tau synergistically impair the oxidative phosphorylation system in triple transgenic Alzheimer's disease mice

(2009) V. Rhein et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A randomized cross-over study of a traditional Japanese medicine (kampo), yokukansan, in the treatment of the behavioural and psychological symptoms of dementia

(2008) Katsuyoshi Mizukami et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Effect of Yi-Gan San on psychiatric symptoms and sleep structure at patients with behavioral and psychological symptoms of dementia

(2008) Hideto Shinno et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY