Atomic force microscopy to study molecular mechanisms of amyloid fibril formation and toxicity in Alzheimer’s disease

New ELISAs with high specificity for soluble oligomers of amyloid β-protein detect natural Aβ oligomers in human brain but not CSF

(2013) Ting Yang et al.   Alzheimers & Dementia

Amyloid-Forming Proteins Alter the Local Mechanical Properties of Lipid Membranes

(2013) Kathleen A. Burke et al.   BIOCHEMISTRY

Analytical model and multiscale simulations of Aβ peptide aggregation in lipid membranes: towards a unifying description of conformational transitions, oligomerization and membrane damage

(2013) Martina Pannuzzo et al.   PHYSICAL CHEMISTRY CHEMICAL PHYSICS

Effects of membrane interaction and aggregation of amyloid β-peptide on lipid mobility and membrane domain structure

(2013) Kenji Sasahara et al.   PHYSICAL CHEMISTRY CHEMICAL PHYSICS

Cu2+ Affects Amyloid-β (1–42) Aggregation by Increasing Peptide-Peptide Binding Forces

(2013) Francis Hane et al.   PLoS One

Neuropathological Alterations in Alzheimer Disease

(2013) A. Serrano-Pozo et al.   Cold Spring Harbor Perspectives in Medicine

Evolution of the Amyloid Fiber over Multiple Length Scales

(2012) Devin M. Ridgley et al.   ACS Nano

Detailed Analysis of the Energy Barriers for Amyloid Fibril Growth

(2012) Alexander K. Buell et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Amyloid-beta oligomerization in Alzheimer dementia versus high-pathology controls

(2012) Thomas J. Esparza et al.   ANNALS OF NEUROLOGY

How the amyloid-β peptide and membranes affect each other: An extensive simulation study

(2012) Chetan Poojari et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Effect of the surface charge of artificial model membranes on the aggregation of amyloid β-peptide

(2012) Raimon Sabaté et al.   BIOCHIMIE

What does make an amyloid toxic: Morphology, structure or interaction with membrane?

(2012) Karine Berthelot et al.   BIOCHIMIE

Different Fates of Alzheimer’s Disease Amyloid-β Fibrils Remodeled by Biocompatible Small Molecules

(2012) Jacob A. Irwin et al.   BIOMACROMOLECULES

Nanoscale Electrostatic Domains in Cholesterol-Laden Lipid Membranes Create a Target for Amyloid Binding

(2012) Elizabeth Drolle et al.   BIOPHYSICAL JOURNAL

Binding of β-Amyloid (1–42) Peptide to Negatively Charged Phospholipid Membranes in the Liquid-Ordered State: Modeling and Experimental Studies

(2012) Hasna Ahyayauch et al.   BIOPHYSICAL JOURNAL

The Toxicity of Amyloid ß Oligomers

(2012) Li Na Zhao et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Small Amphipathic Molecules Modulate Secondary Structure and Amyloid Fibril-forming Kinetics of Alzheimer Disease Peptide Aβ1–42

(2012) Timothy M. Ryan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Generic Crystallization-like Model That Describes the Kinetics of Amyloid Fibril Formation

(2012) Rosa Crespo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mechanisms for the Insertion of Toxic, Fibril-like β-Amyloid Oligomers into the Membrane

(2012) Hyunbum Jang et al.   Journal of Chemical Theory and Computation

Aggregation and fibril morphology of the Arctic mutation of Alzheimer’s Aβ peptide by CD, TEM, STEM and in situ AFM

(2012) Nils Norlin et al.   JOURNAL OF STRUCTURAL BIOLOGY

A Mobile Precursor Determines Amyloid-β Peptide Fibril Formation at Interfaces

(2012) Lei Shen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Structure, Orientation, and Surface Interaction of Alzheimer Amyloid-β Peptides on the Graphite

(2012) Xiang Yu et al.   LANGMUIR

Metal dyshomeostasis and oxidative stress in Alzheimer’s disease

(2012) Mark A. Greenough et al.   NEUROCHEMISTRY INTERNATIONAL

Structure and Dynamics of Amyloid-β Segmental Polymorphisms

(2012) Workalemahu M. Berhanu et al.   PLoS One

Alzheimer Aβ peptide interactions with lipid membranes

(2012) Florentina Tofoleanu et al.   Prion

Structural features and cytotoxicity of amyloid oligomers: Implications in Alzheimer's disease and other diseases with amyloid deposits

(2012) Massimo Stefani   PROGRESS IN NEUROBIOLOGY

Membrane cholesterol content plays a key role in the neurotoxicity of β-amyloid: implications for Alzheimer’s disease

(2011) Andrey Y. Abramov et al.   AGING CELL

Amyloid Precursor Protein Processing and Alzheimer's Disease

(2011) Richard J. O'Brien et al.   Annual Review of Neuroscience

Aβ42 oligomers, but not fibrils, simultaneously bind to and cause damage to ganglioside-containing lipid membranes

(2011) Thomas L. Williams et al.   BIOCHEMICAL JOURNAL

Antimicrobial Protegrin-1 Forms Amyloid-Like Fibrils with Rapid Kinetics Suggesting a Functional Link

(2011) Hyunbum Jang et al.   BIOPHYSICAL JOURNAL

Differing modes of interaction between monomeric Aβ1–40 peptides and model lipid membranes: an AFM study

(2011) Khizar Sheikh et al.   CHEMISTRY AND PHYSICS OF LIPIDS

Cholesterol Promotes the Interaction of Alzheimer β-Amyloid Monomer with Lipid Bilayer

(2011) Xiang Yu et al.   JOURNAL OF MOLECULAR BIOLOGY

Molecular Dynamics Simulations Reveal the Protective Role of Cholesterol in β-Amyloid Protein-Induced Membrane Disruptions in Neuronal Membrane Mimics

(2011) Liming Qiu et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Effect of Surfaces on Amyloid Fibril Formation

(2011) Bradley Moores et al.   PLoS One

Influence of amyloid-β peptides with different lengths and amino acid sequences on the lateral diffusion of lipids in model membranes

(2011) Alexandra Buchsteiner et al.   Soft Matter

The "Alzheimer's disease signature": potential perspectives for novel biomarkers

(2011) Sergio Davinelli et al.   Immunity & Ageing

Amyloid fibril protein nomenclature: 2010 recommendations from the nomenclature committee of the International Society of Amyloidosis

(2010) Jean D. Sipe et al.   AMYLOID-JOURNAL OF PROTEIN FOLDING DISORDERS

Diagnosis-Independent Alzheimer Disease Biomarker Signature in Cognitively Normal Elderly People

(2010) Geert De Meyer   ARCHIVES OF NEUROLOGY

A Disulfide-Linked Amyloid-β Peptide Dimer Forms a Protofibril-like Oligomer through a Distinct Pathway from Amyloid Fibril Formation

(2010) Takahiro Yamaguchi et al.   BIOCHEMISTRY

Hexokinase II detachment from the mitochondria potentiates cisplatin induced cytotoxicity through a caspase-2 dependent mechanism

(2010) Nataly Shulga et al.   CELL CYCLE

Alzheimer's disease amyloid beta converting left-handed Z-DNA back to right-handed B-form

(2010) Jie Geng et al.   CHEMICAL COMMUNICATIONS

Lipid rafts are primary mediators of amyloid oxidative attack on plasma membrane

(2010) Mariagioia Zampagni et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

In Vitro Formation of Amyloid from α-Synuclein Is Dominated by Reactions at Hydrophobic Interfaces

(2010) Jeremy Pronchik et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Alzheimer Aβ1−42Monomer Adsorbed on the Self-Assembled Monolayers

(2010) Qiuming Wang et al.   LANGMUIR

Effect of Cholesterol on Electrostatics in Lipid−Protein Films of a Pulmonary Surfactant

(2010) Eric Finot et al.   LANGMUIR

A causative link between the structure of aberrant protein oligomers and their toxicity

(2010) Silvia Campioni et al.   Nature Chemical Biology

Understanding amyloid aggregation by statistical analysis of atomic force microscopy images

(2010) Jozef Adamcik et al.   Nature Nanotechnology

Nanoanalysis of graphene layers using scanning probe techniques

(2010) M. R. Connolly et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY A-MATHEMATICAL PHYSICAL AND ENGINEERING SCIENCES

The Alzheimer's Disease-Associated Amyloid β-Protein Is an Antimicrobial Peptide

(2010) Stephanie J. Soscia et al.   PLoS One

Synaptotoxicity of Alzheimer Beta Amyloid Can Be Explained by Its Membrane Perforating Property

(2010) Fernando J. Sepulveda et al.   PLoS One

Truncated  -amyloid peptide channels provide an alternative mechanism for Alzheimer's Disease and Down syndrome

(2010) H. Jang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lipid Rafts As a Membrane-Organizing Principle

(2010) D. Lingwood et al.   SCIENCE

A protective role for lipid raft cholesterol against amyloid-induced membrane damage in human neuroblastoma cells

(2009) Cristina Cecchi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

The chemistry of Alzheimer’s disease

(2009) Arvi Rauk   CHEMICAL SOCIETY REVIEWS

The VDAC1 N-terminus is essential both for apoptosis and the protective effect of anti-apoptotic proteins

(2009) S. Abu-Hamad et al.   JOURNAL OF CELL SCIENCE

Effect of amyloid beta peptides Aβ1–28 and Aβ25–40 on model lipid membranes

(2009) Maksim Ionov et al.   JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY

Multidimensional atomic force microscopy for drug discovery: A versatile tool for defining targets, designing therapeutics and monitoring their efficacy

(2009) Ratnesh Lal et al.   LIFE SCIENCES

Structure-neurotoxicity relationships of amyloid  -protein oligomers

(2009) K. Ono et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The two-fold aspect of the interplay of amyloidogenic proteins with lipid membranes

(2008) Annalisa Relini et al.   CHEMISTRY AND PHYSICS OF LIPIDS

Annular Protofibrils Are a Structurally and Functionally Distinct Type of Amyloid Oligomer

(2008) Rakez Kayed et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cholesterol Location and Orientation in Aqueous Suspension of Large Unilamellar Vesicles of Phospholipid Revealed by Intermolecular Nuclear Overhauser Effect

(2008) Cristiano Giordani et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Therapeutics for Alzheimer’s disease based on the metal hypothesis

(2008) Ashley I. Bush et al.   Neurotherapeutics

Molecular structural basis for polymorphism in Alzheimer's  -amyloid fibrils

(2008) A. K. Paravastu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Membrane-bound β-amyloid oligomers are recruited into lipid rafts by a fyn-dependent mechanism

(2007) Ritchie Williamson et al.   FASEB JOURNAL