Production of 21-hydroxy-20-methyl-pregna-1,4-dien-3-one by modifying multiple genes in Mycolicibacterium

Coexpression of VHb and MceG genes in Mycobacterium sp. Strain LZ2 enhances androstenone production via immobilized repeated batch fermentation

(2021) Yang Zhang et al.   BIORESOURCE TECHNOLOGY

Mycolicibacterium cell factory for the production of steroid-based drug intermediates

(2021) Anqi Zhao et al.   BIOTECHNOLOGY ADVANCES

Production of 9,21-dihydroxy-20-methyl-pregna-4-en-3-one from phytosterols in Mycobacterium neoaurum by modifying multiple genes and improving the intracellular environment

(2021) Chen-Yang Yuan et al.   Microbial Cell Factories

The sterol carrier hydroxypropyl-β-cyclodextrin enhances metabolism of phytosterols by Mycobacterium neoaurum

(2020) Liqiu Su et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Efficient repeated batch production of androstenedione using untreated cane molasses by Mycobacterium neoaurum driven by ATP futile cycle

(2020) Xiuling Zhou et al.   BIORESOURCE TECHNOLOGY

Biotransformation of Phytosterols to Androst-1,4-Diene-3,17-Dione by Mycobacterium sp. ZFZ Expressing 3-Ketosteroid-Δ1-Dehydrogenase

(2020) Xiangcen Liu et al.   Catalysts

A Dual Role Reductase from Phytosterols Catabolism Enables the Efficient Production of Valuable Steroid Precursors

(2020) Haidong Peng et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Intracellular Environment Improvement of Mycobacterium neoaurum for Enhancing Androst-1,4-Diene-3,17-Dione Production by Manipulating NADH and Reactive Oxygen Species Levels

(2019) Minglong Shao et al.   MOLECULES

Characterization and engineering control of the effects of reactive oxygen species on the conversion of sterols to steroid synthons in Mycobacterium neoaurum

(2019) Wan-Ju Sun et al.   METABOLIC ENGINEERING

Identification, function, and application of 3-ketosteroid Δ1-dehydrogenase isozymes in Mycobacterium neoaurum DSM 1381 for the production of steroidic synthons

(2018) Ruijie Zhang et al.   Microbial Cell Factories

New Insights on Steroid Biotechnology

(2018) Lorena Fernández-Cabezón et al.   Frontiers in Microbiology

Engineered 3-Ketosteroid 9α-Hydroxylases in Mycobacterium neoaurum : an Efficient Platform for Production of Steroid Drugs

(2018) Hao-Hao Liu et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Enhancing Expression of 3-Ketosteroid-9α-Hydroxylase Oxygenase, an Enzyme with Broad Substrate Range and High Hydroxylation Ability, in Mycobacterium sp. LY-1

(2018) Hui Li et al.   APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY

A CRISPR-Cpf1-Assisted Non-Homologous End Joining Genome Editing System of Mycobacterium smegmatis

(2018) Bingbing Sun et al.   Biotechnology Journal

Cofactor engineering to regulate NAD+/NADH ratio with its application to phytosterols biotransformation

(2017) Liqiu Su et al.   Microbial Cell Factories

Oxidative stress, protein damage and repair in bacteria

(2017) Benjamin Ezraty et al.   NATURE REVIEWS MICROBIOLOGY

Ultrastructural Characterization of the Lower Motor System in a Mouse Model of Krabbe Disease

(2016) Valentina Cappello et al.   Scientific Reports

3-Ketosteroid 9α-hydroxylase enzymes: Rieske non-heme monooxygenases essential for bacterial steroid degradation

(2014) Mirjan Petrusma et al.   ANTONIE VAN LEEUWENHOEK INTERNATIONAL JOURNAL OF GENERAL AND MOLECULAR MICROBIOLOGY

Substrate Specificities and Conformational Flexibility of 3-Ketosteroid 9α-Hydroxylases

(2014) Jonathan S. Penfield et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of NAD(H) pool and NADH/NAD+ ratio by overexpression of nicotinic acid phosphoribosyltransferase for succinic acid production in Escherichia coli NZN111

(2012) Liya Liang et al.   ENZYME AND MICROBIAL TECHNOLOGY

Initial step in the catabolism of cholesterol by Mycobacterium smegmatis mc2155

(2011) I. Uhía et al.   ENVIRONMENTAL MICROBIOLOGY

Structural Features in the KshA Terminal Oxygenase Protein That Determine Substrate Preference of 3-Ketosteroid 9 -Hydroxylase Enzymes

(2011) M. Petrusma et al.   JOURNAL OF BACTERIOLOGY

Activity of 3-Ketosteroid 9α-Hydroxylase (KshAB) Indicates Cholesterol Side Chain and Ring Degradation Occur Simultaneously inMycobacterium tuberculosis

(2011) Jenna K. Capyk et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Rhodococcus rhodochrous DSM 43269 3-Ketosteroid 9 -Hydroxylase, a Two-Component Iron-Sulfur-Containing Monooxygenase with Subtle Steroid Substrate Specificity

(2009) M. Petrusma et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

A Thiolase of Mycobacterium tuberculosis Is Required for Virulence and Production of Androstenedione and Androstadienedione from Cholesterol

(2009) N. M. Nesbitt et al.   INFECTION AND IMMUNITY

Characterization of 3-Ketosteroid 9α-Hydroxylase, a Rieske Oxygenase in the Cholesterol Degradation Pathway ofMycobacterium tuberculosis

(2009) Jenna K. Capyk et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Androstenedione production by biotransformation of phytosterols

(2008) Alok Malaviya et al.   BIORESOURCE TECHNOLOGY