Molecular Anti-inflammatory Mechanisms of Retinoids and Carotenoids in Alzheimer’s Disease: a Review of Current Evidence

Nutritional Biomarkers in Alzheimer's Disease: The Association between Carotenoids, n-3 Fatty Acids, and Dementia Severity

(2017) Wei Wang et al.   JOURNAL OF ALZHEIMERS DISEASE

The Molecular Mechanisms of Vitamin A Deficiency in Multiple Sclerosis

(2016) Ahmad Reza Dorosty-Motlagh et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Oxidative stress and Parkinson's disease: New hopes in treatment with herbal antioxidants

(2015) Amir Sarrafchi et al.   CURRENT PHARMACEUTICAL DESIGN

All-trans-retinoic Acid ReducesBACE1Expression under Inflammatory Conditions via Modulation of Nuclear Factor κB (NFκB) Signaling

(2015) Ruishan Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Effect of Vitamin A Supplementation on FoxP3 and TGF-β Gene Expression in Avonex-Treated Multiple Sclerosis Patients

(2015) Ali Akbar Saboor-Yaraghi et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Molecular Mechanisms of the Action of Vitamin A in Th17/Treg Axis in Multiple Sclerosis

(2015) Mina Abdolahi et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

All-trans-Retinoic Acid Modulates Nitric Oxide and Interleukin-17A Production by Peripheral Blood Mononuclear Cells from Patients with Alzheimer's Disease

(2015) Nassima Behairi et al.   NEUROIMMUNOMODULATION

Neuroprotective effect of astaxanthin against glutamate-induced cytotoxicity in HT22 cells: Involvement of the Akt/GSK-3β pathway

(2015) X. Wen et al.   NEUROSCIENCE

Lycopene attenuates Aβ1–42 secretion and its toxicity in human cell and Caenorhabditis elegans models of Alzheimer disease

(2015) Wei Chen et al.   NEUROSCIENCE LETTERS

A review on Alzheimer's disease pathophysiology and its management: an update

(2015) Anil Kumar et al.   Pharmacological Reports

Reversal effects of crocin on amyloid β-induced memory deficit: Modification of autophagy or apoptosis markers

(2015) Farideh Asadi et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

The Protective Effects of Crocetin on Aβ1-42-Induced Toxicity in Ht22 Cells

(2014) Yan Kong et al.   CNS & Neurological Disorders-Drug Targets

Retinoic Acid Isomers Facilitate Apolipoprotein E Production and Lipidation in Astrocytes through the Retinoid X Receptor/Retinoic Acid Receptor Pathway

(2014) Jing Zhao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Fibrillar Amyloid-  Peptides Activate Microglia via TLR2: Implications for Alzheimer's Disease

(2014) M. Jana et al.   JOURNAL OF IMMUNOLOGY

Astaxanthin offers neuroprotection and reduces neuroinflammation in experimental subarachnoid hemorrhage

(2014) Xiang-Sheng Zhang et al.   JOURNAL OF SURGICAL RESEARCH

Dietary Intake of Carotenoids and Their Antioxidant and Anti-Inflammatory Effects in Cardiovascular Care

(2014) Marco Matteo Ciccone et al.   MEDIATORS OF INFLAMMATION

Protective Effects of Bexarotene against Amyloid-�25-35-Induced Dysfunction in Hippocampal Neurons through the Insulin Signaling Pathway

(2014) Weiwei Dai et al.   Neurodegenerative Diseases

Increased CSF APPs-  levels in patients with Alzheimer disease treated with acitretin

(2014) K. Endres et al.   NEUROLOGY

Do Astrocytes Collaborate with Neurons in Spreading the “Infectious” Aβ and Tau Drivers of Alzheimer’s Disease?

(2014) Ilaria Dal Prà et al.   NEUROSCIENTIST

Carotenoids, inflammation, and oxidative stress—implications of cellular signaling pathways and relation to chronic disease prevention

(2014) Anouk Kaulmann et al.   NUTRITION RESEARCH

Retinoids as potential targets for Alzheimer's disease

(2014) Rupinder K. Sodhi et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Retinoic Acid-Elicited RARα/RXRα Signaling Attenuates Aβ Production by Directly Inhibiting γ-Secretase-Mediated Cleavage of Amyloid Precursor Protein

(2013) Arun Kapoor et al.   ACS Chemical Neuroscience

NLRP3 inflammasome is activated in mononuclear blood cells from patients with major depressive disorder

(2013) Elísabet Alcocer-Gómez et al.   BRAIN BEHAVIOR AND IMMUNITY

Involvement of Inflammasome Activation in Lipopolysaccharide-induced Mice Depressive-like Behaviors

(2013) Yi Zhang et al.   CNS Neuroscience & Therapeutics

Serum Lycopene, Lutein and Zeaxanthin, and the Risk of Alzheimer's Disease Mortality in Older Adults

(2013) Jin-young Min et al.   DEMENTIA AND GERIATRIC COGNITIVE DISORDERS

Amyloid β inhibits retinoic acid synthesis exacerbating Alzheimer disease pathology which can be attenuated by an retinoic acid receptor α agonist

(2013) Maria B. Goncalves et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

In Vitro Effect of Human Serum and Fetal Calf Serum on CD4+ T Cells Proliferation in Response to Myelin Oligodendrocyte Glycoprotein (MOG) in Correlation with RBP/TTR Ratio in Multiple Sclerotic Patients

(2013) Niyaz Mohammadzadeh Honarvar et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

The Effect of Vitamin A Supplementation on Retinoic Acid-Related Orphan Receptor γt (RORγt) and Interleukin-17 (IL-17) Gene Expression in Avonex-Treated Multiple Sclerotic Patients

(2013) Niyaz Mohammadzadeh Honarvar et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Immunotherapy against amyloid pathology in Alzheimer's disease

(2013) Daniela Galimberti et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Treatment with bexarotene, a compound that increases apolipoprotein-E, provides no cognitive benefit in mutant APP/PS1 mice

(2013) Katherine D LaClair et al.   Molecular Neurodegeneration

Therapeutics of Alzheimer's disease: Past, present and future

(2013) R. Anand et al.   NEUROPHARMACOLOGY

Neuroinflammation: The role and consequences

(2013) Monty Lyman et al.   NEUROSCIENCE RESEARCH

Dietary Antioxidants, Cognitive Function and Dementia - A Systematic Review

(2013) Georgina E. Crichton et al.   PLANT FOODS FOR HUMAN NUTRITION

Comment on "ApoE-Directed Therapeutics Rapidly Clear  -Amyloid and Reverse Deficits in AD Mouse Models"

(2013) N. F. Fitz et al.   SCIENCE

Comment on "ApoE-Directed Therapeutics Rapidly Clear  -Amyloid and Reverse Deficits in AD Mouse Models"

(2013) I. Tesseur et al.   SCIENCE

Comment on "ApoE-Directed Therapeutics Rapidly Clear  -Amyloid and Reverse Deficits in AD Mouse Models"

(2013) K. Veeraraghavalu et al.   SCIENCE

Comment on "ApoE-Directed Therapeutics Rapidly Clear  -Amyloid and Reverse Deficits in AD Mouse Models"

(2013) A. R. Price et al.   SCIENCE

Alzheimer's Disease: Critical Notes on the History of a Medical Concept

(2012) Jesus Ramirez-Bermudez   ARCHIVES OF MEDICAL RESEARCH

Retinoids for treatment of Alzheimer's disease

(2012) Alan J. Lerner et al.   BIOFACTORS

Tamibarotene: A Candidate Retinoid Drug for Alzheimer’s Disease

(2012) Hiroshi Fukasawa et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Central nervous system inflammation in disease related conditions: Mechanistic prospects

(2012) Anthony Fung et al.   BRAIN RESEARCH

Evidence for metabolic imbalance of vitamin A2 in wild fish chronically exposed to metals

(2012) Michel A. Defo et al.   ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY

The synergistic anti-inflammatory effects of lycopene, lutein, β-carotene, and carnosic acid combinations via redox-based inhibition of NF-κB signaling

(2012) Nurit Hadad et al.   FREE RADICAL BIOLOGY AND MEDICINE

Current insights into the pathophysiology of Alzheimer's disease: selecting targets for early therapeutic intervention

(2012) Harald Hampel   INTERNATIONAL PSYCHOGERIATRICS

Shrimp Waste Extract and Astaxanthin: Rat Alveolar Macrophage, Oxidative Stress and Inflammation

(2012) Suzan D. Santos et al.   JOURNAL OF FOOD SCIENCE

Early intervention with a small molecule inhibitor for tumor nefosis factor-α prevents cognitive deficits in a triple transgenic mouse model of Alzheimer’s disease

(2012) S Prasad Gabbita et al.   Journal of Neuroinflammation

The neuroprogressive nature of major depressive disorder: pathways to disease evolution and resistance and therapeutic implications

(2012) S Moylan et al.   MOLECULAR PSYCHIATRY

Drug repositioning for Alzheimer's disease

(2012) Anne Corbett et al.   NATURE REVIEWS DRUG DISCOVERY

Age-dependent neuroinflammatory responses and deficits in long-term potentiation in the hippocampus during systemic inflammation

(2012) X. Liu et al.   NEUROSCIENCE

Lutein decreases oxidative stress and inflammation in liver and eyes of guinea pigs fed a hypercholesterolemic diet

(2012) Jung Eun Kim et al.   Nutrition Research and Practice

Ascorbic acid, alpha-tocopherol, and beta-carotene reduce oxidative stress and proinflammatory cytokines in mononuclear cells of Alzheimer's disease patients

(2012) Barbara Fonseca de Oliveira et al.   NUTRITIONAL NEUROSCIENCE

Amyloid β Levels in Human Red Blood Cells

(2012) Takehiro Kiko et al.   PLoS One

Alzheimer’s pathogenesis: is there neuron-to-neuron propagation?

(2011) Heiko Braak et al.   ACTA NEUROPATHOLOGICA

Resolving postoperative neuroinflammation and cognitive decline

(2011) Niccolò Terrando et al.   ANNALS OF NEUROLOGY

New pharmacological strategies for treatment of Alzheimer's disease: focus on disease modifying drugs

(2011) Salvatore Salomone et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Hepatic retinoid levels in seven fish species (teleosts) from a tropical coastal lagoon receiving effluents from iron-ore mining and processing

(2011) Adriana A. Pereira et al.   ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY

Amyloid β-induced erythrocytic damage and its attenuation by carotenoids

(2011) Kiyotaka Nakagawa et al.   FEBS LETTERS

Apricot Carotenoids Possess Potent Anti-amyloidogenic Activity in Vitro

(2011) Shigeru Katayama et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Are amyloid-degrading enzymes viable therapeutic targets in Alzheimer’s disease?

(2011) Natalia N. Nalivaeva et al.   JOURNAL OF NEUROCHEMISTRY

Microglial p38α MAPK is critical for LPS-induced neuron degeneration, through a mechanism involving TNFα

(2011) Bin Xing et al.   Molecular Neurodegeneration

Genetic variations involved in interindividual variability in carotenoid status

(2011) Patrick Borel   MOLECULAR NUTRITION & FOOD RESEARCH

Antioxidant Activity of β-Carotene Compounds in Different in Vitro Assays

(2011) Lars Mueller et al.   MOLECULES

Retinoic acid-induced upregulation of the metalloendopeptidase nardilysin is accelerated by co-expression of the brain-specific protein p42IP4 (centaurin α1; ADAP1) in neuroblastoma cells

(2011) Claudia Borrmann et al.   NEUROCHEMISTRY INTERNATIONAL

Carotenoids and Alzheimer’s Disease: An insight into therapeutic role of retinoids in animal models

(2011) M. Obulesu et al.   NEUROCHEMISTRY INTERNATIONAL

The Effect of Antidepressant Medication Treatment on Serum Levels of Inflammatory Cytokines: A Meta-Analysis

(2011) Jonas Hannestad et al.   NEUROPSYCHOPHARMACOLOGY

A transgenic mouse model for Alzheimer's disease has impaired synaptic gain but normal synaptic dynamics

(2011) Ulises M. Ricoy et al.   NEUROSCIENCE LETTERS

Protective effects of lycopene against amyloid β-induced neurotoxicity in cultured rat cortical neurons

(2011) Mingyue Qu et al.   NEUROSCIENCE LETTERS

Neuroinflammation in Parkinson's disease

(2011) Etienne C. Hirsch et al.   PARKINSONISM & RELATED DISORDERS

An intervention study in obese mice with astaxanthin, a marine carotenoid – effects on insulin signaling and pro-inflammatory cytokines

(2011) Elumalai Arunkumar et al.   Food & Function

Environmentally induced oxidative stress in aquatic animals

(2010) Volodymyr I. Lushchak   AQUATIC TOXICOLOGY

YKL-40: A Novel Prognostic Fluid Biomarker for Preclinical Alzheimer's Disease

(2010) Rebecca Craig-Schapiro et al.   BIOLOGICAL PSYCHIATRY

Both MHC and non-MHC genes regulate inflammation and T-cell response after traumatic brain injury

(2010) Faiez Al Nimer et al.   BRAIN BEHAVIOR AND IMMUNITY

Inflammation 2010: New Adventures of an Old Flame

(2010) Ruslan Medzhitov   CELL

Retinoic acid receptor-α signalling antagonizes both intracellular and extracellular amyloid-β production and prevents neuronal cell death caused by amyloid-β

(2010) C. I. Jarvis et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Astaxanthine Secured Apoptotic Death of PC12 Cells Induced by β-Amyloid Peptide 25–35: Its Molecular Action Targets

(2010) Chi-Huang Chang et al.   JOURNAL OF MEDICINAL FOOD

Neuroinflammatory processes in Alzheimer’s disease

(2010) Michael T. Heneka et al.   JOURNAL OF NEURAL TRANSMISSION

Inflammatory cytokine release of astrocytes in vitro is reduced by all-trans retinoic acid

(2010) Sabien van Neerven et al.   JOURNAL OF NEUROIMMUNOLOGY

LRP1 mediates bidirectional transcytosis of amyloid-β across the blood-brain barrier

(2010) Thorsten Pflanzner et al.   NEUROBIOLOGY OF AGING

Novel insights for the treatment of Alzheimer's disease

(2010) Alexander Kurz et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Peripherally Applied A -Containing Inoculates Induce Cerebral  -Amyloidosis

(2010) Y. S. Eisele et al.   SCIENCE

Cerebrospinal fluid biomarker signature in Alzheimer's disease neuroimaging initiative subjects

(2009) Leslie M. Shaw et al.   ANNALS OF NEUROLOGY

Oral Administration of Synthetic Retinoid Am80 (Tamibarotene) Decreases Brain β-Amyloid Peptides in APP23 Mice

(2009) Kohichi Kawahara et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

A Meta-Analysis of Cytokines in Major Depression

(2009) Yekta Dowlati et al.   BIOLOGICAL PSYCHIATRY

Recent developments in Alzheimer's disease therapeutics

(2009) Michael S Rafii et al.   BMC Medicine

Lipopolysaccharide alters the blood–brain barrier transport of amyloid β protein: A mechanism for inflammation in the progression of Alzheimer’s disease

(2009) Laura B. Jaeger et al.   BRAIN BEHAVIOR AND IMMUNITY

Towards Retinoid Therapy for Alzheimers Disease

(2009) K. Shudo et al.   Current Alzheimer Research

Neuropathology and therapeutic management of Alzheimer's disease - An update

(2009) A. Kumar et al.   DRUGS OF THE FUTURE

Regulation of secretases by all-trans-retinoic acid

(2009) Anna Koryakina et al.   FEBS Journal

Retinoic acid receptor stimulation protects midbrain dopaminergic neurons from inflammatory degeneration via BDNF-mediated signaling

(2009) Hiroshi Katsuki et al.   JOURNAL OF NEUROCHEMISTRY

Retinoid X receptor-α mediates (R )-flurbiprofen’s effect on the levels of Alzheimer’s β-amyloid

(2009) Xiaoqing You et al.   JOURNAL OF NEUROCHEMISTRY

The amyloid hypothesis for Alzheimer’s disease: a critical reappraisal

(2009) John Hardy   JOURNAL OF NEUROCHEMISTRY

Expression of inflammatory genes induced by beta-amyloid peptides in human brain endothelial cells and in Alzheimer's brain is mediated by the JNK-AP1 signaling pathway

(2009) Vanja Vukic et al.   NEUROBIOLOGY OF DISEASE

Systemic inflammation and disease progression in Alzheimer disease

(2009) C. Holmes et al.   NEUROLOGY

Associations of Depression With C-Reactive Protein, IL-1, and IL-6: A Meta-Analysis

(2009) M Bryant Howren et al.   PSYCHOSOMATIC MEDICINE

The antioxidant effects of vitamin A, C, and E on aflatoxin B1-induced oxidative stress in human lymphocytes

(2009) L Alpsoy et al.   TOXICOLOGY AND INDUSTRIAL HEALTH

Systemic Inflammation Induces Acute Behavioral and Cognitive Changes and Accelerates Neurodegenerative Disease

(2008) Colm Cunningham et al.   BIOLOGICAL PSYCHIATRY

Cyclooxygenase-2 inhibition improves amyloid-β-mediated suppression of memory and synaptic plasticity

(2008) Linda A. Kotilinek et al.   BRAIN

Biochemical characterization of human epidermal retinol dehydrogenase 2

(2008) Seung-Ah Lee et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Aging, microglial cell priming, and the discordant central inflammatory response to signals from the peripheral immune system

(2008) Ryan N. Dilger et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Brain-Region-Specific Astroglial Responses In Vitro After LPS Exposure

(2008) Markus Kipp et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Anti-inflammatory effect of retinoic acid on prostaglandin synthesis in cultured cortical astrocytes

(2008) Eric Kampmann et al.   JOURNAL OF NEUROCHEMISTRY

Retinoic Acid Attenuates  -Amyloid Deposition and Rescues Memory Deficits in an Alzheimer's Disease Transgenic Mouse Model

(2008) Y. Ding et al.   JOURNAL OF NEUROSCIENCE

Origin and physiological roles of inflammation

(2008) Ruslan Medzhitov   NATURE

Exaggerated sickness behavior and brain proinflammatory cytokine expression in aged mice in response to intracerebroventricular lipopolysaccharide

(2007) Y. Huang et al.   NEUROBIOLOGY OF AGING