Chaperonin 60 regulation of SOX9 ubiquitination mitigates the development of knee osteoarthritis

Phlpp1 facilitates post-traumatic osteoarthritis and is induced by inflammation and promoter demethylation in human osteoarthritis

(2016) E.W. Bradley et al.   OSTEOARTHRITIS AND CARTILAGE

Effects of insulin-like growth factor-1 and dexamethasone on cytokine-challenged cartilage: relevance to post-traumatic osteoarthritis

(2015) Y. Li et al.   OSTEOARTHRITIS AND CARTILAGE

Mitochondrial Biogenesis Is Impaired in Osteoarthritis Chondrocytes but Reversible via Peroxisome Proliferator-Activated Receptor γ Coactivator 1α

(2015) Yun Wang et al.   Arthritis & Rheumatology

Knee and hip articular cartilage have distinct epigenomic landscapes: implications for future cartilage regeneration approaches

(2014) W den Hollander et al.   ANNALS OF THE RHEUMATIC DISEASES

Protection against murine osteoarthritis by inhibition of the 26S proteasome and lysine-48 linked ubiquitination

(2014) Marta Radwan et al.   ANNALS OF THE RHEUMATIC DISEASES

Chemical chaperone ameliorates pathological protein aggregation in plectin-deficient muscle

(2014) Lilli Winter et al.   JOURNAL OF CLINICAL INVESTIGATION

HIF-1α-induced HSP70 regulates anabolic responses in articular chondrocytes under hypoxic conditions

(2014) Shinji Tsuchida et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

The role of heat shock proteins in atherosclerosis

(2014) Georg Wick et al.   Nature Reviews Cardiology

TRPV4-mediated mechanotransduction regulates the metabolic response of chondrocytes to dynamic loading

(2014) C. J. O'Conor et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeted Delivery to Cartilage Is Critical for In Vivo Efficacy of Insulin-like Growth Factor 1 in a Rat Model of Osteoarthritis

(2014) Francesco S. Loffredo et al.   Arthritis & Rheumatology

Characterization of the Cartilage DNA Methylome in Knee and Hip Osteoarthritis

(2014) Michael D. Rushton et al.   Arthritis & Rheumatology

Stimulation of Fibrotic Processes by the Infrapatellar Fat Pad in Cultured Synoviocytes From Patients With Osteoarthritis: A Possible Role for Prostaglandin F2α

(2013) Yvonne M. Bastiaansen-Jenniskens et al.   ARTHRITIS AND RHEUMATISM

Class I Histone Deacetylase Inhibition Modulates Metalloproteinase Expression and Blocks Cytokine-Induced Cartilage Degradation

(2013) Kirsty L. Culley et al.   ARTHRITIS AND RHEUMATISM

Hsp90 Inhibition Protects Against Biomechanically Induced Osteoarthritis in Rats

(2013) Michiel Siebelt et al.   ARTHRITIS AND RHEUMATISM

Osteoblastic cell secretome: A novel role for progranulin during risedronate treatment

(2013) Milena Romanello et al.   BONE

E6-AP/UBE3A Protein Acts as a Ubiquitin Ligase toward SOX9 Protein

(2013) Takako Hattori et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Leptin regulation of Hsp60 impacts hypothalamic insulin signaling

(2013) André Kleinridders et al.   JOURNAL OF CLINICAL INVESTIGATION

Amelioration of arthritis through mobilization of peptide-specific CD8+ regulatory T cells

(2013) Jianmei W. Leavenworth et al.   JOURNAL OF CLINICAL INVESTIGATION

Heat Shock Transcription Factor 1-Deficiency Attenuates Overloading-Associated Hypertrophy of Mouse Soleus Muscle

(2013) Tomoyuki Koya et al.   PLoS One

Acetylated hsp70 and KAP1-mediated Vps34 SUMOylation is required for autophagosome creation in autophagy

(2013) Y. Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TLR9 agonist CpG enhances protective nasal HSP60 peptide vaccine efficacy in experimental autoimmune arthritis

(2012) Evelien Zonneveld-Huijssoon et al.   ANNALS OF THE RHEUMATIC DISEASES

Progression of osteoarthritis as a state of inertia

(2012) David Felson et al.   ANNALS OF THE RHEUMATIC DISEASES

Dkk-1 promotes angiogenic responses and cartilage matrix proteinase secretion in synovial fibroblasts from osteoarthritic joints

(2012) Lin-Hsiu Weng et al.   ARTHRITIS AND RHEUMATISM

Genetic inhibition of fibroblast growth factor receptor 1 in knee cartilage attenuates the degeneration of articular cartilage in adult mice

(2012) Tujun Weng et al.   ARTHRITIS AND RHEUMATISM

Osteoarthritis: A disease of the joint as an organ

(2012) Richard F. Loeser et al.   ARTHRITIS AND RHEUMATISM

A novel pathogenic role of the ER chaperone GRP78/BiP in rheumatoid arthritis

(2012) Seung-Ah Yoo et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Immune Mechanism of the Antitumor Effects Generated by Bortezomib

(2012) C.-L. Chang et al.   JOURNAL OF IMMUNOLOGY

Synovial inflammation, immune cells and their cytokines in osteoarthritis: a review

(2012) B.J.E. de Lange-Brokaar et al.   OSTEOARTHRITIS AND CARTILAGE

Soluble guanylyl cyclase requires heat shock protein 90 for heme insertion during maturation of the NO-active enzyme

(2012) A. Ghosh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulatory T cells that recognize a ubiquitous stress-inducible self-antigen are long-lived suppressors of autoimmune arthritis

(2012) M. J. C. van Herwijnen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Fluorescence Imaging with Multifunctional Polyglycerol Sulfates: Novel Polymeric near-IR Probes Targeting Inflammation

(2011) Kai Licha et al.   BIOCONJUGATE CHEMISTRY

Heat shock protein 60 protects skeletal tissue against glucocorticoid-induced bone mass loss by regulating osteoblast survival

(2011) Feng-Sheng Wang et al.   BONE

Combined microwave irradiation and intraarticular glutamine administration-induced HSP70 expression therapy prevents cartilage degradation in a rat osteoarthritis model

(2011) Shinya Fujita et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

GDF5 deficiency in mice is associated with instability-driven joint damage, gait and subchondral bone changes

(2010) M. Daans et al.   ANNALS OF THE RHEUMATIC DISEASES

Inactivation of the hereditary spastic paraplegia-associated Hspd1 gene encoding the Hsp60 chaperone results in early embryonic lethality in mice

(2010) Jane H. Christensen et al.   CELL STRESS & CHAPERONES

Systems genetics analysis of mouse chondrocyte differentiation

(2010) Jaijam Suwanwela et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Role of proinflammatory cytokines in the pathophysiology of osteoarthritis

(2010) Mohit Kapoor et al.   Nature Reviews Rheumatology

Differential expression of αB-crystallin and evidence of its role as a mediator of matrix gene expression in osteoarthritis

(2009) Stijn Lambrecht et al.   ARTHRITIS AND RHEUMATISM

Interaction between HSP60 and β-catenin promotes metastasis

(2009) Ya-Ping Tsai et al.   CARCINOGENESIS

Migratory Chondrogenic Progenitor Cells from Repair Tissue during the Later Stages of Human Osteoarthritis

(2009) Sebastian Koelling et al.   Cell Stem Cell

Proteome characterization of human articular chondrocytes leads to novel insights in the function of small heat-shock proteins in chondrocyte homeostasis

(2009) S. Lambrecht et al.   OSTEOARTHRITIS AND CARTILAGE

Hsp90  and p130cas: novel regulatory factors of MMP-13 expression in human osteoarthritic chondrocytes

(2008) Z Fan et al.   ANNALS OF THE RHEUMATIC DISEASES