Article
Multidisciplinary Sciences
Meiling Zheng, Zhi Hu, Xiaole Mei, Lianlian Ouyang, Yang Song, Wenhui Zhou, Yi Kong, Ruifang Wu, Shijia Rao, Hai Long, Wei Shi, Hui Jing, Shuang Lu, Haijing Wu, Sujie Jia, Qianjin Lu, Ming Zhao
Summary: This study compares the differences between cutaneous lesions from DLE and SLE patients and healthy controls using single-cell RNA sequencing data. The findings reveal differential immune cell recruitment, cell type, and gene expression, highlighting potential therapeutic targets for lupus erythematosus.
NATURE COMMUNICATIONS
(2022)
Review
Medicine, Research & Experimental
Sarthak Gupta, Mariana J. Kaplan
Summary: The etiopathogenesis of systemic lupus erythematosus involves a complex interplay between genetic susceptibility factors and the environment, leading to abnormal cell death and immune dysregulation. Recent research has highlighted the important roles of components of the innate immune system, such as neutrophils and interferons, in the pathogenesis of lupus and their potential for novel therapeutic strategies.
JOURNAL OF CLINICAL INVESTIGATION
(2021)
Review
Dermatology
Toshiyuki Yamamoto
Summary: There are different types of cutaneous lupus erythematosus, some of which involve neutrophil infiltration. The formation of neutrophil extracellular traps (NETs) may play a role in the pathogenesis of lupus erythematosus and the associated skin lesions.
JOURNAL OF DERMATOLOGY
(2023)
Article
Immunology
Jessica M. Jones, Frances Smith, Emily Littlejohn, Trine N. Jorgensen
Summary: This study aims to investigate the relative role of sex and sex hormones on the frequency and function of pDCs, MDSCs, and LDGs in SLE patients. The results showed that regardless of sex and sex hormone levels, male and female SLE patients exhibited similar alterations in the frequencies of pDCs, MDSCs, and LDGs, expression of TLR7 and TLR9, and production of TLR9-driven cytokines.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Cell Biology
Guoping Shi, Dan Li, Dongya Zhang, Yujun Xu, Yuchen Pan, Li Lu, Jingman Li, Xiaoyu Xia, Huan Dou, Yayi Hou
Summary: This study found that the percentage of M-MDSCs increased in pristane-induced lupus mice, and the differentiation of M-MDSCs was promoted by Toll-like receptor 7 signal activation and high interferon-alpha levels. Additionally, the AMPK agonist metformin and mTOR inhibitors were found to inhibit M-MDSC percentages in lupus mice as well as in vitro differentiation into MDSCs induced by TLR7 and IFN-alpha.
CELL DEATH DISCOVERY
(2021)
Article
Immunology
Ee Shan Pang, Ghazal Daraj, Katherine R. Balka, Dominic De Nardo, Christophe Macri, Hubertus Hochrein, Kelly-Anne Masterman, Peck S. Tan, Angus Shoppee, Zoe Magill, Nazneen Jahan, Mariam Bafit, Yifan Zhan, Benjamin T. Kile, Kate E. Lawlor, Kristen J. Radford, Mark D. Wright, Meredith O'Keeffe
Summary: This study compared the responses of mouse and human plasmacytoid DCs and conventional DC subsets upon STING activation. It was found that both mouse and human DC subsets were activated by STING stimulation and produced Type I interferons. However, only human DCs produced large amounts of IFN-lambda 1, which is not expressed in the mouse genome. Additionally, mouse plasmacytoid DCs underwent rapid cell death upon STING activation, while human plasmacytoid DCs did not.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Qiao Zhou, Jayakumar Vadakekolathu, Abdulla Watad, Kassem Sharif, Tobias Russell, Hannah Rowe, Almas Khan, Peter A. Millner, Peter Loughenbury, Abhay Rao, Robert Dunsmuir, Jake Timothy, Giovanni Damiani, Paolo D. M. Pigatto, Piergiorgio Malagoli, Giuseppe Banfi, Yasser M. El-Sherbiny, Charlie Bridgewood, Dennis McGonagle
Summary: The study found a connection between spinal entheseal plasmacytoid dendritic cells and TNF/IFN alpha production in response to microbes, with SARS-CoV-2 infection associated with PsA flares. JAK inhibition can suppress activated entheseal plasmacytoid dendritic Type-1 interferon responses, indicating a novel mechanism of PsA and SpA-related arthropathy.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Pathology
Jahg Wong, Simon F. Roy, Jennifer M. Mcniff, Mina L. Xu
Summary: This study explored the expression of IRF8, CD123, and CD20 as markers in cutaneous biopsies to differentiate lupus erythematosus panniculitis (LEP) from subcutaneous panniculitis-like T-cell lymphoma (SPTCL). The combination of IRF8, CD123, and CD20 demonstrated higher accuracy in distinguishing LEP from SPTCL compared to individual markers.
AMERICAN JOURNAL OF SURGICAL PATHOLOGY
(2023)
Article
Cell Biology
Youzhou Tang, Xinyu Li, Yafang Wei, Yongchao Sun, Yeyi Yang, Xianming Zhang, Zhihao Gao, Jishi Liu, Quan Zhuang
Summary: This study identified significant differential expression of eight acetyltransferase and deacetylase family members in SLE, with KAT2A being upregulated and positively correlated with disease activity index. KAT2A was found to modulate cGAS pathway through increasing expression and post-translational modification, specifically in certain immune cell subsets in SLE.
CELL DEATH & DISEASE
(2021)
Article
Biochemistry & Molecular Biology
Rebeca Arroyo Hornero, Juliana Idoyaga
Summary: Since their discovery, the identity and classification of plasmacytoid dendritic cells (pDCs) have been a subject of debate in the field. pDCs are distinct from other dendritic cell family members and may have dual origin from myeloid and lymphoid progenitors. They have the unique ability to quickly secrete abundant levels of type I interferon in response to viral infections and can activate T cells independently. This article provides an overview of the historic and current understanding of pDCs and argues for their inclusion within the dendritic cell network due to their role in linking innate and adaptive immune responses.
MOLECULAR IMMUNOLOGY
(2023)
Article
Immunology
Kerstin H. Mair, Maria Stadler, Mahsa Adib Razavi, Armin Saalmuller, Wilhelm Gerner
Summary: This study demonstrates the expression and function of NKp46 on porcine plasmacytoid dendritic cells (pDCs). It was found that the majority of porcine pDCs express NKp46 and have an active signaling pathway upon NKp46 triggering, leading to cytokine production. However, unlike NK cells, NKp46 on porcine pDCs does not seem to be involved in cytotoxicity.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Nadine Szumilas, Odilia B. J. Corneth, Christian H. K. Lehmann, Heike Schmitt, Svenia Cunz, Jolie G. Cullen, Talyn Chu, Anita Marosan, Attila Mocsai, Vladimir Benes, Dietmar Zehn, Diana Dudziak, Rudi W. Hendriks, Lars Nitschke
Summary: Siglec-H regulates TLR-9-dependent inflammatory responses after virus infections, but not TLR-7 dependent responses. Lack of Siglec-H in pDCs leads to impaired Hck expression and downregulation of chemokine receptor CCR9, affecting pDC function.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Pathology
Luisa Lorenzi, Silvia Lonardi, Donatella Vairo, Andrea Bernardelli, Michela Tomaselli, Mattia Bugatti, Sara Licini, Mariachiara Arisi, Lorenzo Cerroni, Alessandra Tucci, William Vermi, Silvia Clara Giliani, Fabio Facchetti
Summary: This study identifies EC as a novel pDC marker of diagnostic relevance in BPDCN. The results suggest a scenario where malignant pDCs promote the blunting of IFN-I signaling through EC-driven signaling, leading to a poorly immunogenic tumor microenvironment.
AMERICAN JOURNAL OF SURGICAL PATHOLOGY
(2021)
Article
Immunology
Shifei Li, Qijun Wu, Zhuyan Jiang, Yaguang Wu, Yuhong Li, Bing Ni, Jun Xiao, Zhifang Zhai
Summary: The study found that miR-31-5p may be involved in the pathogenesis of SLE by negatively regulating SLC15A4, thereby increasing the levels of IFN-alpha and ISGs in pDCs.
JOURNAL OF INFLAMMATION RESEARCH
(2022)
Review
Medicine, General & Internal
Tanja Fetter, Christine Braegelmann, Luka de Vos, Joerg Wenzel
Summary: Cutaneous lupus erythematosus (CLE) is an interferon-driven autoimmune disease that can be limited to the skin or associated with systemic lupus erythematosus (SLE). It has various morphologic subtypes with distinct histopathologic patterns. The chronic reactivation of immune pathways, especially the recognition of endogenous nucleic acids, plays a critical role in CLE pathogenesis. Crucial cells involved in CLE include plasmacytoid dendritic cells, cytotoxic T cells, and B cells with additional functions.
FRONTIERS IN MEDICINE
(2022)
