60 YEARS OF POMC: From the prohormone theory to pro-opiomelanocortin and to proprotein convertases (PCSK1 to PCSK9)

Update of Clinical Trials of Anti-PCSK9 Antibodies

(2015) Na-Qiong Wu et al.   CARDIOVASCULAR DRUGS AND THERAPY

Proprotein convertases in atherogenesis

(2015) Philipp Stawowy   CURRENT OPINION IN LIPIDOLOGY

PCSK9 Inhibitors and Neurocognitive Adverse Events: Exploring the FDA Directive and a Proposal for N-of-1 Trials

(2015) Kristopher J. Swiger et al.   DRUG SAFETY

Emerging PCSK9 inhibitors for treating dyslipidaemia: buttressing the gaps in coronary prevention

(2015) Michael M Page et al.   EXPERT OPINION ON EMERGING DRUGS

Contribution of common non-synonymous variants in PCSK1 to body mass index variation and risk of obesity: a systematic review and meta-analysis with evidence from up to 331 175 individuals

(2015) K. T. Nead et al.   HUMAN MOLECULAR GENETICS

The apoB-to-PCSK9 ratio: A new index for metabolic risk in humans

(2015) Hanny Wassef et al.   Journal of Clinical Lipidology

PCSK9 gene mutations and low-density lipoprotein cholesterol

(2014) Na-Qiong Wu et al.   CLINICA CHIMICA ACTA

A nonsense loss-of-function mutation in PCSK1 contributes to dominantly inherited human obesity

(2014) J Philippe et al.   INTERNATIONAL JOURNAL OF OBESITY

PCSK9 is a critical regulator of the innate immune response and septic shock outcome

(2014) K. R. Walley et al.   Science Translational Medicine

Viral envelope glycoprotein processing by proprotein convertases

(2013) Antonella Pasquato et al.   ANTIVIRAL RESEARCH

Proprotein Convertases Subtilisin/Kexin Type 9, an enzyme turned escort protein: Hepatic and extra hepatic functions (第9型前蛋白转换酶-枯草溶菌素/蛋白酶K，一种酶转变的护送蛋白：在肝脏与肝外的功能)

(2013) Majambu Mbikay et al.   Journal of Diabetes

My road to Damascus: how I converted to the prohormone theory and the proprotein convertases

(2012) Michel Chrétien   Biochemistry and Cell Biology

The biology and therapeutic targeting of the proprotein convertases

(2012) Nabil G. Seidah et al.   NATURE REVIEWS DRUG DISCOVERY

Proprotein convertases in human atherosclerotic plaques: The overexpression of FURIN and its substrate cytokines BAFF and APRIL

(2011) Hannu Turpeinen et al.   ATHEROSCLEROSIS

Novel Loss-of-Function PCSK9 Variant Is Associated with Low Plasma LDL Cholesterol in a French-Canadian Family and with Impaired Processing and Secretion in Cell Culture

(2011) J. Mayne et al.   CLINICAL CHEMISTRY

Differential gene expression profiles of POMC-related enzymes, transcription factors and receptors between non-pituitary and pituitary ACTH-secreting tumors

(2011) Yuji Tani et al.   ENDOCRINE JOURNAL

Association of type 2 diabetes susceptibility genes (TCF7L2, SLC30A8, PCSK1 and PCSK2) and proinsulin conversion in a Chinese population

(2011) Xiaoya Zheng et al.   MOLECULAR BIOLOGY REPORTS

Proprotein Convertases in Health and Disease

(2011) Andrew W. Artenstein et al.   NEW ENGLAND JOURNAL OF MEDICINE

Novel association to the proprotein convertase PCSK7 gene locus revealed by analysing soluble transferrin receptor (sTfR) levels

(2010) Konrad Oexle et al.   HUMAN MOLECULAR GENETICS

Genetic Variation at the Proprotein Convertase Subtilisin/Kexin Type 5 Gene Modulates High-Density Lipoprotein Cholesterol Levels

(2009) Iulia Iatan et al.   Circulation-Cardiovascular Genetics

PCSK9-deficient mice exhibit impaired glucose tolerance and pancreatic islet abnormalities

(2009) Majambu Mbikay et al.   FEBS LETTERS