Ferroptosis and Its Potential Role in Glioma: From Molecular Mechanisms to Therapeutic Opportunities

Ferroptosis, as the most enriched programmed cell death process in glioma, induces immunosuppression and immunotherapy resistance

(2022) Tianqi Liu et al.   NEURO-ONCOLOGY

Targeting NQO1/GPX4-mediated ferroptosis by plumbagin suppresses in vitro and in vivo glioma growth

(2022) Sheng Zhan et al.   BRITISH JOURNAL OF CANCER

Iron oxide nanoparticles loaded with paclitaxel inhibits glioblastoma by enhancing autophagy-dependent ferroptosis pathway

(2022) Hanren Chen et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

The mechanism of HMGB1 secretion and release

(2022) Ruochan Chen et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Artesunate induces ferroptosis via modulation of p38 and ERK signaling pathway in glioblastoma cells

(2022) Qingxin Song et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Capsaicin induces redox imbalance and ferroptosis through ACSL4/GPx4 signaling pathways in U87-MG and U251 glioblastoma cells

(2022) Ceyhan Hacioglu et al.   METABOLIC BRAIN DISEASE

Synchronous Disintegration of Ferroptosis Defense Axis via Engineered Exosome‐Conjugated Magnetic Nanoparticles for Glioblastoma Therapy

(2022) Boyan Li et al.   Advanced Science

Activation and Regulation of NLRP3 by Sterile and Infectious Insults

(2022) Srijon K. Banerjee et al.   Frontiers in Immunology

Astrocyte-derived hepcidin controls iron traffic at the blood-brain-barrier via regulating ferroportin 1 of microvascular endothelial cells

(2022) Linhao You et al.   Cell Death & Disease

Ferroptosis: mechanisms, biology and role in disease

(2021) Xuejun Jiang et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Broadening horizons: the role of ferroptosis in cancer

(2021) Xin Chen et al.   Nature Reviews Clinical Oncology

Diffuse Glioma Heterogeneity and Its Therapeutic Implications

(2021) James G. Nicholson et al.   Cancer Discovery

Inhibiting Ferroptosis through Disrupting the NCOA4–FTH1 Interaction: A New Mechanism of Action

(2021) Yuying Fang et al.   ACS Central Science

DHODH and cancer: promising prospects to be explored

(2021) Yue Zhou et al.   Cancer & Metabolism

Iron induces two distinct Ca2+ signalling cascades in astrocytes

(2021) Wenzheng Guan et al.   Communications Biology

Signaling pathways and defense mechanisms of ferroptosis

(2021) Jiao Liu et al.   FEBS Journal

Overview of Ferroptosis and Synthetic Lethality Strategies

(2021) Yuko Kinowaki et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Nanoparticles Targeting Innate Immune Cells in Tumor Microenvironment

(2021) Hochung Jang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The E3 Ubiquitin Ligase NEDD4-1 Mediates Temozolomide-Resistant Glioblastoma through PTEN Attenuation and Redox Imbalance in Nrf2–HO-1 Axis

(2021) Hao-Yu Chuang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Author Correction: DHODH-mediated ferroptosis defence is a targetable vulnerability in cancer

(2021) Chao Mao et al.   NATURE

Mechanism of Ferroptosis and Its Role in Type 2 Diabetes Mellitus

(2021) Wenxin Sha et al.   Journal of Diabetes Research

Biologic and pathologic aspects of osteocytes in the setting of medication-related osteonecrosis of the jaw (MRONJ)

(2021) J.I. Aguirre et al.   BONE

Epigenetic encoding, heritability and plasticity of glioma transcriptional cell states

(2021) Ronan Chaligne et al.   NATURE GENETICS

Ferroptosis: A New Promising Target for Lung Cancer Therapy

(2021) Rui Xiong et al.   Oxidative Medicine and Cellular Longevity

A Ferroptosis-Related Prognostic Risk Score Model to Predict Clinical Significance and Immunogenic Characteristics in Glioblastoma Multiforme

(2021) Dongdong Xiao et al.   Oxidative Medicine and Cellular Longevity

Transcriptional Regulation of Amino Acid Transport in Glioblastoma Multiforme

(2021) Robyn A. Umans et al.   Cancers

Ferroptosis and Its Potential Role in Lung Cancer: Updated Evidence from Pathogenesis to Therapy

(2021) Kang Chen et al.   Journal of Inflammation Research

Autophagy-dependent ferroptosis drives tumor-associated macrophage polarization via release and uptake of oncogenic KRAS protein

(2020) Enyong Dai et al.   Autophagy

Ferroptosis, a novel pharmacological mechanism of anti-cancer drugs

(2020) Yanwei Su et al.   CANCER LETTERS

The role of ferroptosis in ionizing radiation-induced cell death and tumor suppression

(2020) Guang Lei et al.   CELL RESEARCH

Immunotherapy for Malignant Glioma: Current Status and Future Directions

(2020) Hongxiang Wang et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Ferroptosis: past, present and future

(2020) Jie Li et al.   Cell Death & Disease

Targeting of immunosuppressive myeloid cells from glioblastoma patients by modulation of size and surface charge of lipid nanocapsules

(2020) Laura Pinton et al.   JOURNAL OF NANOBIOTECHNOLOGY

Dihydroartemisinin initiates ferroptosis in glioblastoma through GPX4 inhibition

(2020) Renxin Yi et al.   BIOSCIENCE REPORTS

Immunotherapy for glioma: Current management and future application

(2020) Shengchao Xu et al.   CANCER LETTERS

SnapShot: Ferroptosis

(2020) Kamyar Hadian et al.   CELL

Inhibitor of apoptosis-stimulating protein of p53 inhibits ferroptosis and alleviates intestinal ischemia/reperfusion-induced acute lung injury

(2020) Yingchuan Li et al.   CELL DEATH AND DIFFERENTIATION

High cell density increases glioblastoma cell viability under glucose deprivation via degradation of the cystine/glutamate transporter xCT (SLC7A11)

(2020) Itsuki Yamaguchi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Triptolide suppresses IDH1-mutated malignancy via Nrf2-driven glutathione metabolism

(2020) Di Yu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dihydrotanshinone I inhibits human glioma cell proliferation via the activation of ferroptosis

(2020) Shougang Tan et al.   Oncology Letters

Arsenic trioxide as a novel anti-glioma drug: a review

(2020) Yi Fang et al.   CELLULAR & MOLECULAR BIOLOGY LETTERS

STEAP3 (Six-Transmembrane Epithelial Antigen of Prostate 3) Inhibits Pathological Cardiac Hypertrophy

(2020) Peng-Long Li et al.   HYPERTENSION

Comprehensive landscape of STEAP family functions and prognostic prediction value in glioblastoma

(2020) Huaijun Chen et al.   JOURNAL OF CELLULAR PHYSIOLOGY

The cardinal roles of ferroportin and its partners in controlling cellular iron in and out

(2020) Qiuyuan Yang et al.   LIFE SCIENCES

Optimal treatment strategy for adult patients with newly diagnosed glioblastoma: a systematic review and network meta-analysis

(2020) Lei Jin et al.   NEUROSURGICAL REVIEW

Glioma-derived IL-33 orchestrates an inflammatory brain tumor microenvironment that accelerates glioma progression

(2020) Astrid De Boeck et al.   Nature Communications

Cystine transporter SLC7A11/xCT in cancer: ferroptosis, nutrient dependency, and cancer therapy

(2020) Pranavi Koppula et al.   Protein & Cell

Targeted exosome coating gene-chem nanocomplex as “nanoscavenger” for clearing α-synuclein and immune activation of Parkinson’s disease

(2020) Linying Liu et al.   Science Advances

Antioxidant Effect of Propofol in Gliomas and Its Association With Divalent Metal Transporter 1

(2020) Chenyi Yang et al.   Frontiers in Oncology

Epidermal growth factor promotes glioblastoma cell death under glucose deprivation via upregulation of xCT (SLC7A11)

(2020) Marina Yamamoto et al.   CELLULAR SIGNALLING

GPX4 at the Crossroads of Lipid Homeostasis and Ferroptosis

(2019) Giovanni C. Forcina et al.   PROTEOMICS

Chaperone-mediated autophagy is involved in the execution of ferroptosis

(2019) Zheming Wu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Engineered immune cells as highly sensitive cancer diagnostics

(2019) Amin Aalipour et al.   NATURE BIOTECHNOLOGY

Ischemia-induced ACSL4 activation contributes to ferroptosis-mediated tissue injury in intestinal ischemia/reperfusion

(2019) Yang Li et al.   CELL DEATH AND DIFFERENTIATION

Quantitative Characterization of the Regulation of Iron Metabolism in Glioblastoma Stem‐Like Cells using Magnetophoresis

(2019) Kyoung‐Joo Jenny Park et al.   BIOTECHNOLOGY AND BIOENGINEERING

Combining Nanomedicine and Immunotherapy

(2019) Yang Shi et al.   ACCOUNTS OF CHEMICAL RESEARCH

Nanoparticle-mediated intratumoral inhibition of miR-21 for improved survival in glioblastoma

(2019) Young-Eun Seo et al.   BIOMATERIALS

The cystine/glutamate antiporter xCT is a key regulator of EphA2 S897 phosphorylation under glucose-limited conditions

(2019) Koji Teramoto et al.   CELLULAR SIGNALLING

Redox biology of regulated cell death in cancer: A focus on necroptosis and ferroptosis

(2019) Cristina Florean et al.   FREE RADICAL BIOLOGY AND MEDICINE

CD8+ T cells regulate tumour ferroptosis during cancer immunotherapy

(2019) Weimin Wang et al.   NATURE

ALOX12 is required for p53-mediated tumour suppression through a distinct ferroptosis pathway

(2019) Bo Chu et al.   NATURE CELL BIOLOGY

A Physiological Function for Ferroptosis in Tumor Suppression by the Immune System

(2019) Brent R. Stockwell et al.   Cell Metabolism

Ibuprofen induces ferroptosis of glioblastoma cells via downregulation of nuclear factor erythroid 2-related factor 2 signaling pathway

(2019) Xingchun Gao et al.   ANTI-CANCER DRUGS

Delivery luteolin with folacin-modified nanoparticle for glioma therapy

(2019) Cong Wu et al.   International Journal of Nanomedicine

Blockade of glutathione metabolism in IDH1-mutated glioma

(2019) Xiaoying Tang et al.   MOLECULAR CANCER THERAPEUTICS

Radiotherapy and immunotherapy promote tumoral lipid oxidation and ferroptosis via synergistic repression of SLC7A11

(2019) Xueting Lang et al.   Cancer Discovery

DMT1 Expression and Iron Levels at the Crossroads Between Aging and Neurodegeneration

(2019) Rosaria Ingrassia et al.   Frontiers in Neuroscience

Programmed Cell-Death by Ferroptosis: Antioxidants as Mitigators

(2019) Kajarabille et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

FSP1 is a glutathione-independent ferroptosis suppressor

(2019) Sebastian Doll et al.   NATURE

The CoQ oxidoreductase FSP1 acts parallel to GPX4 to inhibit ferroptosis

(2019) Kirill Bersuker et al.   NATURE

ROS-mediated autophagy increases intracellular iron levels and ferroptosis by ferritin and transferrin receptor regulation

(2019) Eunhee Park et al.   Cell Death & Disease

AR ubiquitination induced by the curcumin analog suppresses growth of temozolomide-resistant glioblastoma through disrupting GPX4-Mediated redox homeostasis

(2019) Tzu-Chi Chen et al.   Redox Biology

Landscape of Conditional eQTL in Dorsolateral Prefrontal Cortex and Co-localization with Schizophrenia GWAS

(2018) Amanda Dobbyn et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Receptor-mediated PLGA nanoparticles for glioblastoma multiforme treatment

(2018) M.J. Ramalho et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Autophagy is activated and involved in cell death with participation of cathepsins during stress-induced microspore embryogenesis in barley

(2018) Ivett Bárány et al.   JOURNAL OF EXPERIMENTAL BOTANY

PKN2 in colon cancer cells inhibits M2 phenotype polarization of tumor-associated macrophages via regulating DUSP6-Erk1/2 pathway

(2018) Yang Cheng et al.   Molecular Cancer

Functional effects of TrkA inhibition on system xC−-mediated glutamate release and cancer-induced bone pain

(2018) Tanya Miladinovic et al.   Molecular Pain

Current state of immunotherapy for glioblastoma

(2018) Michael Lim et al.   Nature Reviews Clinical Oncology

Fatty acid activation in carcinogenesis and cancer development: Essential roles of long‑chain acyl‑CoA synthetases (Review)

(2018) Yue Tang et al.   Oncology Letters

Mutually exclusive acetylation and ubiquitylation of the splicing factor SRSF5 control tumor growth

(2018) Yuhan Chen et al.   Nature Communications

In vivo delineation of glioblastoma by targeting tumor-associated macrophages with near-infrared fluorescent silica coated iron oxide nanoparticles in orthotopic xenografts for surgical guidance

(2018) Chaedong Lee et al.   Scientific Reports

Six-Transmembrane Epithelial Antigen of Prostate 3 Predicts Poor Prognosis and Promotes Glioblastoma Growth and Invasion

(2018) Mingzhi Han et al.   NEOPLASIA

Resolving the Role of Lipoxygenases in the Initiation and Execution of Ferroptosis

(2018) Ron Shah et al.   ACS Central Science

Activation of ferritinophagy is required for the RNA-binding protein ELAVL1/HuR to regulate ferroptosis in hepatic stellate cells

(2018) Zili Zhang et al.   Autophagy

AMPK-Mediated BECN1 Phosphorylation Promotes Ferroptosis by Directly Blocking System Xc– Activity

(2018) Xinxin Song et al.   CURRENT BIOLOGY

Glioblastoma Chemoresistance: The Double Play by Microenvironment and Blood-Brain Barrier

(2018) Martina Da Ros et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

CBTRUS Statistical Report: Primary Brain and Other Central Nervous System Tumors Diagnosed in the United States in 2011–2015

(2018) Quinn T Ostrom et al.   NEURO-ONCOLOGY

The p53 Pathway in Glioblastoma

(2018) Ying Zhang et al.   Cancers

Fenton-Reaction-Acceleratable Magnetic Nanoparticles for Ferroptosis Therapy of Orthotopic Brain Tumors

(2018) Zheyu Shen et al.   ACS Nano

Nrf2 inhibition reverses resistance to GPX4 inhibitor-induced ferroptosis in head and neck cancer

(2018) Daiha Shin et al.   FREE RADICAL BIOLOGY AND MEDICINE

Cryo-EM structures of human STEAP4 reveal mechanism of iron(III) reduction

(2018) Wout Oosterheert et al.   Nature Communications

Single tumor-initiating cells evade immune clearance by recruiting type II macrophages

(2017) Xiaocan Guo et al.   GENES & DEVELOPMENT

Cystine uptake through the cystine/glutamate antiporter xCT triggers glioblastoma cell death under glucose deprivation

(2017) Takeo Goji et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PCBP1 and NCOA4 regulate erythroid iron storage and heme biosynthesis

(2017) Moon-Suhn Ryu et al.   JOURNAL OF CLINICAL INVESTIGATION

Defect-Induced Near-Infrared Photoluminescence of Single-Walled Carbon Nanotubes Treated with Polyunsaturated Fatty Acids

(2017) Cheuk Fai Chiu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Dietary iron loading negatively affects liver mitochondrial function

(2017) Chiara Volani et al.   Metallomics

Cancer Stem Cells and Their Microenvironment: Biology and Therapeutic Implications

(2017) Eunice Yuen-Ting Lau et al.   Stem Cells International

Nrf2-Keap1 pathway promotes cell proliferation and diminishes ferroptosis

(2017) Z Fan et al.   Oncogenesis

The Impact of the Tumor Microenvironment on the Properties of Glioma Stem-Like Cells

(2017) Alessandra Audia et al.   Frontiers in Oncology

Blood–Brain-Barrier-Penetrating Albumin Nanoparticles for Biomimetic Drug Delivery via Albumin-Binding Protein Pathways for Antiglioma Therapy

(2016) Tingting Lin et al.   ACS Nano

The 2016 World Health Organization Classification of Tumors of the Central Nervous System: a summary

(2016) David N. Louis et al.   ACTA NEUROPATHOLOGICA

Ferroptosis: process and function

(2016) Y Xie et al.   CELL DEATH AND DIFFERENTIATION

Mechanisms of ferroptosis

(2016) Jennifer Yinuo Cao et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Increased Expression of System x c − in Glioblastoma Confers an Altered Metabolic State and Temozolomide Resistance

(2016) Monika D. Polewski et al.   MOLECULAR CANCER RESEARCH

Oxidized arachidonic and adrenic PEs navigate cells to ferroptosis

(2016) Valerian E Kagan et al.   Nature Chemical Biology

The role of microglia and macrophages in glioma maintenance and progression

(2016) Dolores Hambardzumyan et al.   NATURE NEUROSCIENCE

Transferrin receptors and glioblastoma multiforme: Current findings and potential for treatment

(2015) Brittany Voth et al.   JOURNAL OF CLINICAL NEUROSCIENCE

Lysosomal mTORC2/PHLPP1/Akt Regulate Chaperone-Mediated Autophagy

(2015) Esperanza Arias et al.   MOLECULAR CELL

Drug repurposing: sulfasalazine sensitizes gliomas to gamma knife radiosurgery by blocking cystine uptake through system Xc−, leading to glutathione depletion

(2015) L Sleire et al.   ONCOGENE

Dihydroartemisinin increases temozolomide efficacy in glioma cells by inducing autophagy

(2015) ZE-SHUN ZHANG et al.   Oncology Letters

Candidate genes for COPD: current evidence and research

(2015) Sang Do Lee et al.   International Journal of Chronic Obstructive Pulmonary Disease

The natural compound oblongifolin C inhibits autophagic flux and enhances antitumor efficacy of nutrient deprivation

(2014) Yuanzhi Lao et al.   Autophagy

Regulation of Ferroptotic Cancer Cell Death by GPX4

(2014) Wan Seok Yang et al.   CELL

Multiple Mechanisms Modulate Distinct Cellular Susceptibilities toward Apoptosis in the Developing Drosophila Eye

(2014) Yun Fan et al.   DEVELOPMENTAL CELL

Quantitative proteomics identifies NCOA4 as the cargo receptor mediating ferritinophagy

(2014) Joseph D. Mancias et al.   NATURE

Dihydroartemisinin suppresses glioma proliferation and invasion via inhibition of the ADAM17 pathway

(2014) Junyan Chen et al.   NEUROLOGICAL SCIENCES

Evolution of Malignant Glioma Treatment

(2014) Richard Lee Price et al.   NEUROSURGERY

Abnormal Brain Iron Metabolism in Irp2 Deficient Mice Is Associated with Mild Neurological and Behavioral Impairments

(2014) Kimberly B. Zumbrennen-Bullough et al.   PLoS One

Transferrin Receptor 2 Is Frequently and Highly Expressed in Glioblastomas

(2014) Alessia Calzolari et al.   Translational Oncology

Human regulatory T cells against minor histocompatibility antigens: ex vivo expansion for prevention of graft-versus-host disease

(2013) A. Veerapathran et al.   BLOOD

Transferrin modified PEG-PLA-resveratrol conjugates: In vitro and in vivo studies for glioma

(2013) Wanhua Guo et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

The emerging role of the Nrf2-Keap1 signaling pathway in cancer

(2013) M. C. Jaramillo et al.   GENES & DEVELOPMENT

RNA-binding protein PCBP2 modulates glioma growth by regulating FHL3

(2013) Wei Han et al.   JOURNAL OF CLINICAL INVESTIGATION

Iron metabolism in the CNS: implications for neurodegenerative diseases

(2013) Tracey A. Rouault   NATURE REVIEWS NEUROSCIENCE

Glutathione participates in the modulation of starvation-induced autophagy in carcinoma cells

(2012) Enrico Desideri et al.   Autophagy

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

(2012) Scott J. Dixon et al.   CELL

Metalloreductase Steap3 coordinates the regulation of iron homeostasis and inflammatory responses

(2012) F. Zhang et al.   HAEMATOLOGICA

Recent advances in the molecular understanding of glioblastoma

(2012) Fonnet E. Bleeker et al.   JOURNAL OF NEURO-ONCOLOGY

Increased xCT Expression Correlates With Tumor Invasion and Outcome in Patients With Glioblastomas

(2012) Satoru Takeuchi et al.   NEUROSURGERY

The Functional Interaction between Acyl-CoA Synthetase 4, 5-Lipooxygenase and Cyclooxygenase-2 Controls Tumor Growth: A Novel Therapeutic Target

(2012) Ulises D. Orlando et al.   PLoS One

Tumor-associated macrophages regulate tumorigenicity and anticancer drug responses of cancer stem/initiating cells

(2011) M. Jinushi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Myeloid-derived suppressor cells: more mechanisms for inhibiting antitumor immunity

(2010) Suzanne Ostrand-Rosenberg   CANCER IMMUNOLOGY IMMUNOTHERAPY

CD206-Positive M2 Macrophages That Express Heme Oxygenase-1 Protect Against Diabetic Gastroparesis in Mice

(2010) Kyoung Moo Choi et al.   GASTROENTEROLOGY

The Complex Role of Multivalency in Nanoparticles Targeting the Transferrin Receptor for Cancer Therapies

(2010) Jin Wang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Expression of iron-related genes in human brain and brain tumors

(2009) Milla M Hänninen et al.   BMC NEUROSCIENCE

The unusual amino acid L-ergothioneine is a physiologic cytoprotectant

(2009) B D Paul et al.   CELL DEATH AND DIFFERENTIATION

Role of hepcidin in murine brain iron metabolism

(2009) S.-M. Wang et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Dysregulation of glutathione synthesis during cholestasis in mice: Molecular mechanisms and therapeutic implications

(2009) Heping Yang et al.   HEPATOLOGY

Primary spinal cord glioma: a Surveillance, Epidemiology, and End Results database study

(2009) Michael T. Milano et al.   JOURNAL OF NEURO-ONCOLOGY

Nrf2 enhances resistance of cancer cells to chemotherapeutic drugs, the dark side of Nrf2

(2008) X.-J. Wang et al.   CARCINOGENESIS