Research Progress on the Role of RNA m6A Modification in Glial Cells in the Regulation of Neurological Diseases

Glial Cells Response in Stroke

(2022) Poonam Jadhav et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Oligodendrocytes and Myelin: Active players in Neurodegenerative brains?

(2022) Jing‐Fei Chen et al.   Developmental Neurobiology

Function and therapeutic value of astrocytes in neurological diseases

(2022) Hong-Gyun Lee et al.   NATURE REVIEWS DRUG DISCOVERY

RNA binding protein NKAP protects glioblastoma cells from ferroptosis by promoting SLC7A11 mRNA splicing in an m6A-dependent manner

(2022) Shicheng Sun et al.   Cell Death & Disease

The Blood–Brain Barrier, an Evolving Concept Based on Technological Advances and Cell–Cell Communications

(2022) Camille Menaceur et al.   Cells

IGF2BP2 Induces U251 Glioblastoma Cell Chemoresistance by Inhibiting FOXO1-Mediated PID1 Expression Through Stabilizing lncRNA DANCR

(2022) Junfei Han et al.   Frontiers in Cell and Developmental Biology

EGFR/SRC/ERK-stabilized YTHDF2 promotes cholesterol dysregulation and invasive growth of glioblastoma

(2021) Runping Fang et al.   Nature Communications

Astrocytes deliver CK1 to neurons via extracellular vesicles in response to inflammation promoting the translation and amyloidogenic processing of APP

(2021) Zhigang Li et al.   Journal of Extracellular Vesicles

Microglia and Neuroinflammation: What Place for P2RY12?

(2021) Albert Gómez Morillas et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Genome-Wide Detection of m6A-Associated Genetic Polymorphisms Associated with Ischemic Stroke

(2021) Ruixia Zhu et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

miRNA-mediated loss of m6A increases nascent translation in glioblastoma

(2021) John P. Zepecki et al.   PLoS Genetics

Role of Fto on CaMKII/CREB signaling pathway of hippocampus in depressive-like behaviors induced by chronic restraint stress mice

(2021) Jun Shen et al.   BEHAVIOURAL BRAIN RESEARCH

Small-Molecule Inhibitors of the RNA M6A Demethylases FTO Potently Support the Survival of Dopamine Neurons

(2021) Simona Selberg et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Microglia use TAM receptors to detect and engulf amyloid β plaques

(2021) Youtong Huang et al.   NATURE IMMUNOLOGY

Microglial identity and inflammatory responses are controlled by the combined effects of neurons and astrocytes

(2021) Paul S. Baxter et al.   Cell Reports

Macrophages and microglia: the cerberus of glioblastoma

(2021) Alice Buonfiglioli et al.   Acta Neuropathologica Communications

Streptozotocin-Induced Astrocyte Mitochondrial Dysfunction Is Ameliorated by FTO Inhibitor MO-I-500

(2021) Zuzana Cockova et al.   ACS Chemical Neuroscience

N6-methyladenosine (m6A) modification and its clinical relevance in cognitive dysfunctions

(2021) Bingying Du et al.   Aging-US

Long noncoding RNA just proximal to X‐inactive specific transcript facilitates aerobic glycolysis and temozolomide chemoresistance by promoting stability of PDK1 mRNA in an m6A‐dependent manner in glioblastoma multiforme cells

(2021) Xu Dong Li et al.   CANCER SCIENCE

Long non-coding RNA OIP5-AS1 inhibition upregulates microRNA-129-5p to repress resistance to temozolomide in glioblastoma cells via downregulating IGF2BP2

(2021) Xuan Wang et al.   CELL BIOLOGY AND TOXICOLOGY

Functional immune cell–astrocyte interactions

(2021) Liliana M. Sanmarco et al.   JOURNAL OF EXPERIMENTAL MEDICINE

YTHDF2 facilitates UBXN1 mRNA decay by recognizing METTL3-mediated m6A modification to activate NF-κB and promote the malignant progression of glioma

(2021) Rui-Chao Chai et al.   Journal of Hematology & Oncology

N6-Methyladenosine RNA modification in cerebrospinal fluid as a novel potential diagnostic biomarker for progressive multiple sclerosis

(2021) Fei Ye et al.   Journal of Translational Medicine

Genetic drivers of m6A methylation in human brain, lung, heart and muscle

(2021) Xushen Xiong et al.   NATURE GENETICS

A1/A2 astrocytes in central nervous system injuries and diseases: Angels or devils?

(2021) Yan-Ying Fan et al.   NEUROCHEMISTRY INTERNATIONAL

Hakai is required for stabilization of core components of the m6A mRNA methylation machinery

(2021) Praveen Bawankar et al.   Nature Communications

METTL3 Promotes the Resistance of Glioma to Temozolomide via Increasing MGMT and ANPG in a m6A Dependent Manner

(2021) Jia Shi et al.   Frontiers in Oncology

Identification of an N6-methyladenosine (m6A)-related signature associated with clinical prognosis, immune response, and chemotherapy in primary glioblastomas

(2021) Zhiqiang Cai et al.   Annals of Translational Medicine

Identification of the function and mechanism of m6A reader IGF2BP2 in Alzheimer’s disease

(2021) Yanyao Deng et al.   Aging-US

ALKBH5 Facilitates Hypoxia-Induced Paraspeckle Assembly and IL8 Secretion to Generate an Immunosuppressive Tumor Microenvironment

(2021) Feng Dong et al.   CANCER RESEARCH

Oligodendrocyte progenitor cell fate and function in development and disease

(2021) Benjamin L.L. Clayton et al.   CURRENT OPINION IN CELL BIOLOGY

The role of microglia in neuropsychiatric disorders and suicide

(2021) Ralf Brisch et al.   EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE

Reduced number of satellite oligodendrocytes of pyramidal neurons in layer 5 of the prefrontal cortex in schizophrenia

(2021) Natalya S. Kolomeets et al.   EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE

Contribution of astrocytes to familial risk and clinical manifestation of schizophrenia

(2021) Marja Koskuvi et al.   GLIA

Potential of Multiscale Astrocyte Imaging for Revealing Mechanisms Underlying Neurodevelopmental Disorders

(2021) Takuma Kumamoto et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

METTL3-dependent RNA m6A dysregulation contributes to neurodegeneration in Alzheimer’s disease through aberrant cell cycle events

(2021) Fanpeng Zhao et al.   Molecular Neurodegeneration

Modifying the m6A brain methylome by ALKBH5-mediated demethylation: a new contender for synaptic tagging

(2021) Braulio Martinez De La Cruz et al.   MOLECULAR PSYCHIATRY

Astrocyte Ca 2+ -evoked ATP release regulates myelinated axon excitability and conduction speed

(2021) Jonathan Lezmy et al.   SCIENCE

Astrocyte interleukin-3 preps microglia

(2021) Robyn S. Klein   TRENDS IN IMMUNOLOGY

Activation and Role of Astrocytes in Ischemic Stroke

(2021) Xin-Ya Shen et al.   Frontiers in Cellular Neuroscience

Fat mass and obesity-associated protein regulates RNA methylation associated with depression-like behavior in mice

(2021) Shu Liu et al.   Nature Communications

Influence of N6-Methyladenosine Modification Gene HNRNPC on Cell Phenotype in Parkinson’s Disease

(2021) Wei Quan et al.   Parkinsons Disease

Identification of IGF2BP3 as an Adverse Prognostic Biomarker of Gliomas

(2021) Chao Sun et al.   Frontiers in Genetics

Erasing m6A-dependent transcription signature of stress-sensitive genes triggers antidepressant actions

(2021) Peng-Fei Wu et al.   Neurobiology of Stress

m6A reader IGF2BP2-stabilized CASC9 accelerates glioblastoma aerobic glycolysis by enhancing HK2 mRNA stability

(2021) Hongjiang Liu et al.   Cell Death Discovery

Protective role of mRNA demethylase FTO on axon guidance molecules of nigro-striatal projection system in manganese-induced parkinsonism

(2021) Zhipeng Qi et al.   JOURNAL OF HAZARDOUS MATERIALS

N6-methyladenosine modification of FAAH mRNA in circSTAG1-regulated astrocyte dysfunction and depressive-like behaviors

(2020) Rongrong Huang et al.   BIOLOGICAL PSYCHIATRY

Microglial NMDA receptors drive pro‐inflammatory responses via PARP‐1/TRMP2 signaling

(2020) Prajwal Raghunatha et al.   GLIA

Epitranscriptomic profiling of N6-methyladenosine-related RNA methylation in rat cerebral cortex following traumatic brain injury

(2020) Jiangtao Yu et al.   Molecular Brain

Novel Treatment Strategies Targeting Myelin and Oligodendrocyte Dysfunction in Schizophrenia

(2020) Danielle Gouvêa-Junqueira et al.   Frontiers in Psychiatry

Malignant Evaluation and Clinical Prognostic Values of m6A RNA Methylation Regulators in Glioblastoma

(2020) Jianyang Du et al.   Frontiers in Oncology

Methyltransferase 3 Mediated miRNA m6A Methylation Promotes Stress Granule Formation in the Early Stage of Acute Ischemic Stroke

(2020) Wenwen Si et al.   Frontiers in Molecular Neuroscience

Microglia: Agents of the CNS Pro-Inflammatory Response

(2020) José A. Rodríguez-Gómez et al.   Cells

Microglia and astrocyte dysfunction in parkinson's disease

(2020) Tae-In Kam et al.   NEUROBIOLOGY OF DISEASE

m6A-Atlas: a comprehensive knowledgebase for unraveling the N6-methyladenosine (m6A) epitranscriptome

(2020) Yujiao Tang et al.   NUCLEIC ACIDS RESEARCH

Oxygen glucose deprivation/re-oxygenation-induced neuronal cell death is associated with Lnc-D63785 m6A methylation and miR-422a accumulation

(2020) Shu Xu et al.   Cell Death & Disease

The RNA m6A reader YTHDF2 maintains oncogene expression and is a targetable dependency in glioblastoma stem cells

(2020) Deobrat Dixit et al.   Cancer Discovery

Altered Expression of the m6A Methyltransferase METTL3 in Alzheimer’s Disease

(2020) He Huang et al.   eNeuro

Neuroinflammation in neurodegenerative disorders: the roles of microglia and astrocytes

(2020) Hyuk Sung Kwon et al.   Translational Neurodegeneration

The m6A RNA Demethylase ALKBH5 Promotes Radioresistance and Invasion Capability of Glioma Stem Cells

(2020) Aline Kowalski-Chauvel et al.   Cancers

Neuroprotective versus Neuroinflammatory Roles of Complement: From Development to Disease

(2020) Marlene Kanmogne et al.   TRENDS IN NEUROSCIENCES

N6-Methyladenosine Landscape of Glioma Stem-Like Cells: METTL3 Is Essential for the Expression of Actively Transcribed Genes and Sustenance of the Oncogenic Signaling

(2019) Abhirami Visvanathan et al.   Genes

Genome-wide screening of altered m6A-tagged transcript profiles in the hippocampus after traumatic brain injury in mice

(2019) Yiqin Wang et al.   Epigenomics

Down-Regulation of m6A mRNA Methylation Is Involved in Dopaminergic Neuronal Death

(2019) Xuechai Chen et al.   ACS Chemical Neuroscience

The role of m6A RNA methylation in human cancer

(2019) Xiao-Yu Chen et al.   Molecular Cancer

Molecular Control of Oligodendrocyte Development

(2019) Benayahu Elbaz et al.   TRENDS IN NEUROSCIENCES

P2X7 Receptor Signaling in Stress and Depression

(2019) Deidiane Elisa Ribeiro et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

FMRP Modulates Neural Differentiation through m6A-Dependent mRNA Nuclear Export

(2019) Brittany M. Edens et al.   Cell Reports

N6-methyladenosine Modulates Nonsense-mediated mRNA Decay in Human Glioblastoma

(2019) Fuxi Li et al.   CANCER RESEARCH

Reading, writing and erasing mRNA methylation

(2019) Sara Zaccara et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Recent advances in traumatic brain injury

(2019) Abdelhakim Khellaf et al.   JOURNAL OF NEUROLOGY

Transient Focal Ischemia Significantly Alters the m 6 A Epitranscriptomic Tagging of RNAs in the Brain

(2019) Anil K. Chokkalla et al.   STROKE

Oligodendrocytes in Development, Myelin Generation and Beyond

(2019) Sarah Kuhn et al.   Cells

m6A mRNA Methylation Is Essential for Oligodendrocyte Maturation and CNS Myelination

(2019) Huan Xu et al.   NEURON

Integrating genome-wide association study and methylation functional annotation data identified candidate genes and pathways for schizophrenia

(2019) Xin Qi et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Zc3h13/Flacc is required for adenosine methylation by bridging the mRNA-binding factor Rbm15/Spenito to the m6A machinery component Wtap/Fl(2)d

(2018) Philip Knuckles et al.   GENES & DEVELOPMENT

Mettl14 Is Essential for Epitranscriptomic Regulation of Striatal Function and Learning

(2018) Jessica L. Koranda et al.   NEURON

Microglia-Astrocyte Crosstalk: An Intimate Molecular Conversation

(2018) Mithilesh Kumar Jha et al.   NEUROSCIENTIST

Interactions, localization, and phosphorylation of the m 6 A generating METTL3–METTL14–WTAP complex

(2018) Eva Schöller et al.   RNA

Reading m 6 A in the Transcriptome: m 6 A-Binding Proteins

(2018) Deepak P. Patil et al.   TRENDS IN CELL BIOLOGY

VIRMA mediates preferential m6A mRNA methylation in 3′UTR and near stop codon and associates with alternative polyadenylation

(2018) Yanan Yue et al.   Cell Discovery

Astrocytes, the rising stars of the glioblastoma microenvironment

(2018) Mayra Brandao et al.   GLIA

The Role of m6A/m-RNA Methylation in Stress Response Regulation

(2018) Mareen Engel et al.   NEURON

Oligodendrocyte Bioenergetics in Health and Disease

(2018) Lauren Rosko et al.   NEUROSCIENTIST

A novel m6A reader Prrc2a controls oligodendroglial specification and myelination

(2018) Rong Wu et al.   CELL RESEARCH

Microglia in Central Nervous System Inflammation and Multiple Sclerosis Pathology

(2018) Sofie Voet et al.   TRENDS IN MOLECULAR MEDICINE

Multiple sclerosis

(2018) Massimo Filippi et al.   Nature Reviews Disease Primers

Fat mass and obesity-associated (FTO) protein regulates adult neurogenesis

(2017) Liping Li et al.   HUMAN MOLECULAR GENETICS

Microglia in Alzheimer’s disease

(2017) David V. Hansen et al.   JOURNAL OF CELL BIOLOGY

Microglia in steady state

(2017) Katrin Kierdorf et al.   JOURNAL OF CLINICAL INVESTIGATION

Activation of P2X7 receptor and NLRP3 inflammasome assembly in hippocampal glial cells mediates chronic stress-induced depressive-like behaviors

(2017) Na Yue et al.   Journal of Neuroinflammation

Astrocytic Orosomucoid-2 Modulates Microglial Activation and Neuroinflammation

(2017) Myungjin Jo et al.   JOURNAL OF NEUROSCIENCE

Neurotoxic reactive astrocytes are induced by activated microglia

(2017) Shane A. Liddelow et al.   NATURE

Dynamic m6A modification regulates local translation of mRNA in axons

(2017) Jun Yu et al.   NUCLEIC ACIDS RESEARCH

Essential role of METTL3-mediated m6A modification in glioma stem-like cells maintenance and radioresistance

(2017) A Visvanathan et al.   ONCOGENE

The biphasic function of microglia in ischemic stroke

(2017) Yuanyuan Ma et al.   PROGRESS IN NEUROBIOLOGY

m 6 A RNA Methylation Regulates the Self-Renewal and Tumorigenesis of Glioblastoma Stem Cells

(2017) Qi Cui et al.   Cell Reports

Parkinson disease

(2017) Werner Poewe et al.   Nature Reviews Disease Primers

Serum S100B as a Surrogate Biomarker in the Diagnoses of Burnout and Depression in Emergency Medicine Residents

(2016) Bedia Gulen et al.   ACADEMIC EMERGENCY MEDICINE

The hnRNP family: insights into their role in health and disease

(2016) Thomas Geuens et al.   HUMAN GENETICS

Nuclear m 6 A Reader YTHDC1 Regulates mRNA Splicing

(2016) Wen Xiao et al.   MOLECULAR CELL

Post-transcriptional gene regulation by mRNA modifications

(2016) Boxuan Simen Zhao et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Glioblastoma: pathology, molecular mechanisms and markers

(2015) Kenneth Aldape et al.   ACTA NEUROPATHOLOGICA

Glia in mammalian development and disease

(2015) J. Bradley Zuchero et al.   DEVELOPMENT

Mechanism of microglia neuroprotection: Involvement of P2X7, TNFα, and valproic acid

(2015) Annette Masuch et al.   GLIA

An association study of the m6A genes with major depressive disorder in Chinese Han population

(2015) Tingfu Du et al.   JOURNAL OF AFFECTIVE DISORDERS

Residual Symptoms in Depression

(2015) Andrew A. Nierenberg   JOURNAL OF CLINICAL PSYCHIATRY

Microglia-Mediated Inflammation and Neurodegenerative Disease

(2015) Ling Xu et al.   MOLECULAR NEUROBIOLOGY

Astrocytes in Neurodegenerative Disease: Table 1.

(2015) Hemali Phatnani et al.   Cold Spring Harbor Perspectives in Biology

Astrocyte Regulation of Synaptic Behavior

(2014) Nicola J. Allen   Annual Review of Cell and Developmental Biology

Regulation of oligodendrocyte precursor migration during development, in adulthood and in pathology

(2013) Fernando de Castro et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Wnt Signaling in Remyelination in Multiple Sclerosis: Friend or Foe?

(2013) Chong Xie et al.   MOLECULAR NEUROBIOLOGY

The fat mass and obesity associated gene (Fto) regulates activity of the dopaminergic midbrain circuitry

(2013) Martin E Hess et al.   NATURE NEUROSCIENCE

The effect of glia-glia interactions on oligodendrocyte precursor cell biology during development and in demyelinating diseases

(2013) Diego Clemente et al.   Frontiers in Cellular Neuroscience

Plasminogen activator inhibitor type 1 regulates microglial motility and phagocytic activity

(2012) Hyejin Jeon et al.   Journal of Neuroinflammation

The protective effect of the obesity-associated rs9939609 A variant in fat mass- and obesity-associated gene on depression

(2012) Z Samaan et al.   MOLECULAR PSYCHIATRY

Regulation of Oligodendrocyte Differentiation and Myelination

(2010) B. Emery   SCIENCE