Dynamic m6A modification regulates local translation of mRNA in axons

m 6 A mRNA modifications are deposited in nascent pre-mRNA and are not required for splicing but do specify cytoplasmic turnover

(2017) Shengdong Ke et al.   GENES & DEVELOPMENT

Fat mass and obesity-associated (FTO) protein regulates adult neurogenesis

(2017) Liping Li et al.   HUMAN MOLECULAR GENETICS

Sonic Hedgehog Guides Axons via Zipcode Binding Protein 1-Mediated Local Translation

(2017) Léa Lepelletier et al.   JOURNAL OF NEUROSCIENCE

m6A mRNA methylation controls T cell homeostasis by targeting the IL-7/STAT5/SOCS pathways

(2017) Hua-Bing Li et al.   NATURE

RNA m6A methylation regulates the ultraviolet-induced DNA damage response

(2017) Yang Xiang et al.   NATURE

m6A modulates haematopoietic stem and progenitor cell specification

(2017) Chunxia Zhang et al.   NATURE

A new cis -acting motif is required for the axonal SMN-dependent Anxa2 mRNA localization

(2017) Khalil Rihan et al.   RNA

miR-182 Regulates Slit2-Mediated Axon Guidance by Modulating the Local Translation of a Specific mRNA

(2017) Anaïs Bellon et al.   Cell Reports

Dynamic Axonal Translation in Developing and Mature Visual Circuits

(2016) Toshiaki Shigeoka et al.   CELL

N6-Methyladenosine Sequencing Highlights the Involvement of mRNA Methylation in Oocyte Meiotic Maturation and Embryo Development by Regulating Translation inXenopus laevis

(2016) Shu-Tao Qi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Experience-Dependent Accumulation of N 6 -Methyladenosine in the Prefrontal Cortex Is Associated with Memory Processes in Mice

(2016) Jocelyn Widagdo et al.   JOURNAL OF NEUROSCIENCE

m6A potentiates Sxl alternative pre-mRNA splicing for robust Drosophila sex determination

(2016) Irmgard U. Haussmann et al.   NATURE

m6A modulates neuronal functions and sex determination in Drosophila

(2016) Tina Lence et al.   NATURE

Reversible methylation of m6Am in the 5′ cap controls mRNA stability

(2016) Jan Mauer et al.   NATURE

SRAMP: prediction of mammalian N6-methyladenosine (m6A) sites based on sequence-derived features

(2016) Yuan Zhou et al.   NUCLEIC ACIDS RESEARCH

Recent advances in dynamic m6A RNA modification

(2016) Guangchao Cao et al.   Open Biology

m6A RNA Methylation Is Regulated by MicroRNAs and Promotes Reprogramming to Pluripotency

(2015) Tong Chen et al.   Cell Stem Cell

Coordination of m 6 A mRNA Methylation and Gene Transcription by ZFP217 Regulates Pluripotency and Reprogramming

(2015) Francesca Aguilo et al.   Cell Stem Cell

Dynamic m6A mRNA methylation directs translational control of heat shock response

(2015) Jun Zhou et al.   NATURE

m6A mRNA methylation facilitates resolution of naïve pluripotency toward differentiation

(2015) Shay Geula et al.   SCIENCE

FMRP-Mediated Axonal Delivery of miR-181d Regulates Axon Elongation by Locally Targeting Map1b and Calm1

(2015) Bin Wang et al.   Cell Reports

Emerging Roles of RNA Modification: m 6 A and U-Tail

(2014) Mihye Lee et al.   CELL

Axonally Synthesized ATF4 Transmits a Neurodegenerative Signal across Brain Regions

(2014) Jimena Baleriola et al.   CELL

Remote Control of Gene Function by Local Translation

(2014) Hosung Jung et al.   CELL

MicroRNA-132 Is Enriched in Developing Axons, Locally Regulates Rasa1 mRNA, and Promotes Axon Extension

(2014) M. L. Hancock et al.   JOURNAL OF NEUROSCIENCE

N6-methyladenosine modification destabilizes developmental regulators in embryonic stem cells

(2014) Yang Wang et al.   NATURE CELL BIOLOGY

Gene expression regulation mediated through reversible m6A RNA methylation

(2014) Ye Fu et al.   NATURE REVIEWS GENETICS

Asymmetric mRNA localization contributes to fidelity and sensitivity of spatially localized systems

(2014) Robert J Weatheritt et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Local translation of TC10 is required for membrane expansion during axon outgrowth

(2014) Neilia G. Gracias et al.   Nature Communications

The RNA-binding protein Fus directs translation of localized mRNAs in APC-RNP granules

(2013) Kyota Yasuda et al.   JOURNAL OF CELL BIOLOGY

Axonally Synthesized  -Actin and GAP-43 Proteins Support Distinct Modes of Axonal Growth

(2013) C. J. Donnelly et al.   JOURNAL OF NEUROSCIENCE

N6-methyladenosine-dependent regulation of messenger RNA stability

(2013) Xiao Wang et al.   NATURE

A METTL3–METTL14 complex mediates mammalian nuclear RNA N6-adenosine methylation

(2013) Jianzhao Liu et al.   Nature Chemical Biology

The fat mass and obesity associated gene (Fto) regulates activity of the dopaminergic midbrain circuitry

(2013) Martin E Hess et al.   NATURE NEUROSCIENCE

Transcriptome-wide mapping of N6-methyladenosine by m6A-seq based on immunocapturing and massively parallel sequencing

(2013) Dan Dominissini et al.   Nature Protocols

Comprehensive Analysis of mRNA Methylation Reveals Enrichment in 3′ UTRs and near Stop Codons

(2012) Kate D. Meyer et al.   CELL

Intra-Axonal Translation of RhoA Promotes Axon Growth Inhibition by CSPG

(2012) B. A. Walker et al.   JOURNAL OF NEUROSCIENCE

Development of Cell-Active N6-Methyladenosine RNA Demethylase FTO Inhibitor

(2012) Baoen Chen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

ALKBH5 Is a Mammalian RNA Demethylase that Impacts RNA Metabolism and Mouse Fertility

(2012) Guanqun Zheng et al.   MOLECULAR CELL

Topology of the human and mouse m6A RNA methylomes revealed by m6A-seq

(2012) Dan Dominissini et al.   NATURE

Intra-axonal Translation of SMAD1/5/8 Mediates Retrograde Regulation of Trigeminal Ganglia Subtype Specification

(2012) Sheng-Jian Ji et al.   NEURON

Subcellular Knockout of Importin β1 Perturbs Axonal Retrograde Signaling

(2012) Rotem Ben-Tov Perry et al.   NEURON

Netrin-1-Induced Local  -Actin Synthesis and Growth Cone Guidance Requires Zipcode Binding Protein 1

(2011) K. Welshhans et al.   JOURNAL OF NEUROSCIENCE

N6-Methyladenosine in nuclear RNA is a major substrate of the obesity-associated FTO

(2011) Guifang Jia et al.   Nature Chemical Biology

Transmembrane Receptor DCC Associates with Protein Synthesis Machinery and Regulates Translation

(2010) Joseph Tcherkezian et al.   CELL

An NGF-responsive element targets myo-inositol monophosphatase-1 mRNA to sympathetic neuron axons

(2010) Catia Andreassi et al.   NATURE NEUROSCIENCE

The Fat Mass and Obesity Associated Gene FTO Functions in the Brain to Regulate Postnatal Growth in Mice

(2010) Xue Gao et al.   PLoS One

A commonly carried allele of the obesity-related FTO gene is associated with reduced brain volume in the healthy elderly

(2010) A. J. Ho et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Transcriptome analysis of embryonic and adult sensory axons reveals changes in mRNA repertoire localization

(2010) L. F. Gumy et al.   RNA

Microfluidic compartmentalized co-culture platform for CNS axon myelination research

(2009) Jaewon Park et al.   BIOMEDICAL MICRODEVICES

The DLK-1 Kinase Promotes mRNA Stability and Local Translation in C. elegans Synapses and Axon Regeneration

(2009) Dong Yan et al.   CELL

Inactivation of the Fto gene protects from obesity

(2009) Julia Fischer et al.   NATURE

Axonal elongation triggered by stimulus-induced local translation of a polarity complex protein

(2009) Ulrich Hengst et al.   NATURE CELL BIOLOGY

Subcellular mRNA Localization in Animal Cells and Why It Matters

(2009) C. E. Holt et al.   SCIENCE

Intra-axonal translation and retrograde trafficking of CREB promotes neuronal survival

(2008) Llewellyn J. Cox et al.   NATURE CELL BIOLOGY