The progress and prospect of natural components in rhubarb (Rheum ribes L.) in the treatment of renal fibrosis

Rhein Inhibits NF-κB Signaling Pathway to Alleviate Inflammatory Response and Oxidative Stress of Rats with Chronic Glomerulonephritis

(2022) Qian Chen et al.   Applied Bionics and Biomechanics

Rhein protects 5/6 nephrectomized rat against renal injury by reducing inflammation via NF-κB signaling

(2021) Meiyou Liu et al.   INTERNATIONAL UROLOGY AND NEPHROLOGY

Key metalloproteinase-mediated pathways in the kidney

(2021) Justyna Wozniak et al.   Nature Reviews Nephrology

Emodin Ameliorates Renal Damage and Podocyte Injury in a Rat Model of Diabetic Nephropathy via Regulating AMPK/mTOR-Mediated Autophagy Signaling Pathway

(2021) Hong Liu et al.   Diabetes Metabolic Syndrome and Obesity-Targets and Therapy

Rhubarb extract relieves constipation by stimulating mucus production in the colon and altering the intestinal flora

(2021) Chen-Chen Gao et al.   BIOMEDICINE & PHARMACOTHERAPY

Update on Pharmacological Activities, Security, and Pharmacokinetics of Rhein

(2021) Gang-Min Li et al.   Evidence-based Complementary and Alternative Medicine

Emodin-induced autophagic cell death hinders epithelial–mesenchymal transition via regulation of BMP-7/TGF-β1 in renal fibrosis

(2021) Wei Liu et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Subcritical Water Extraction of Natural Products

(2021) Yan Cheng et al.   MOLECULES

Advances in the study of emodin: an update on pharmacological properties and mechanistic basis

(2021) Qi Zheng et al.   Chinese Medicine

Chrysophanol Relieves Cisplatin-Induced Nephrotoxicity via Concomitant Inhibition of Oxidative Stress, Apoptosis, and Inflammation

(2021) Siqing Ma et al.   Frontiers in Physiology

Renal protection of rhein against 5/6 nephrectomied‐induced chronic kidney disease: role of SIRT3‐FOXO3α signalling pathway

(2020) Xiaoxiao Wu et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

Therapeutic Emergence of Rhein as a Potential Anticancer Drug: A Review of Its Molecular Targets and Anticancer Properties

(2020) Sahu Henamayee et al.   MOLECULES

TGF-β Signaling

(2020) Kalliopi Tzavlaki et al.   Biomolecules

Hepatoprotection and hepatotoxicity of Chinese herb Rhubarb (Dahuang): How to properly control the “General (Jiang Jun)” in Chinese medical herb

(2020) Tongxi Zhuang et al.   BIOMEDICINE & PHARMACOTHERAPY

Autophagy in kidney homeostasis and disease

(2020) Chengyuan Tang et al.   Nature Reviews Nephrology

Chrysophanol ameliorates renal interstitial fibrosis by inhibiting the TGF-β/Smad signaling pathway

(2020) Fang Dou et al.   BIOCHEMICAL PHARMACOLOGY

Mitochondrial dysfunction and endoplasmic reticulum stress in the promotion of fibrosis in obstructive nephropathy induced by unilateral ureteral obstruction

(2020) Elena Martínez‐Klimova et al.   BIOFACTORS

The effect of emodin on liver disease -- comprehensive advances in molecular mechanisms

(2020) Naihua Hu et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Emodin in atherosclerosis prevention: Pharmacological actions and therapeutic potential

(2020) Ning Luo et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Emodin Retarded Renal Fibrosis Through Regulating HGF and TGFβ–Smad Signaling Pathway

(2020) Fan Yang et al.   Drug Design Development and Therapy

What we already know about rhubarb: a comprehensive review

(2020) Hong Xiang et al.   Chinese Medicine

Pharmacokinetics and Pharmacodynamics of the Combination of Rhein and Curcumin in the Treatment of Chronic Kidney Disease in Rats

(2020) Xiaoying He et al.   Frontiers in Pharmacology

Macrophages: versatile players in renal inflammation and fibrosis

(2019) Patrick Ming-Kuen Tang et al.   Nature Reviews Nephrology

Neuroprotective Effects of Anthraquinones from Rhubarb in Central Nervous System Diseases

(2019) Xun Li et al.   Evidence-based Complementary and Alternative Medicine

Renal Inflammation and Fibrosis: A Double-edged Sword

(2019) Laurence M. Black et al.   JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY

Extracellular Matrix in Kidney Fibrosis: More Than Just a Scaffold

(2019) Roman David Bülow et al.   JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY

Chrysophanol: a review of its pharmacology, toxicity and pharmacokinetics

(2019) Long Xie et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

Aloe‐emodin: A review of its pharmacology, toxicity, and pharmacokinetics

(2019) Xiaoxv Dong et al.   PHYTOTHERAPY RESEARCH

The role of the immune system in kidney disease

(2018) J. Tecklenborg et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Wnt signaling in development and tissue homeostasis

(2018) Zachary Steinhart et al.   DEVELOPMENT

Inflammation and renal fibrosis: Recent developments on key signaling molecules as potential therapeutic targets

(2018) Wenshan Lv et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

DNA methylation and the potential role of demethylating agents in prevention of progressive chronic kidney disease

(2018) Benjamin P. Larkin et al.   FASEB JOURNAL

Natural Products for Drug Discovery in the 21st Century: Innovations for Novel Drug Discovery

(2018) Nicholas Thomford et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The roles of Wnt/β-catenin pathway in tissue development and regenerative medicine

(2018) Maryam Majidinia et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Klotho preservation by Rhein promotes toll-like receptor 4 proteolysis and attenuates lipopolysaccharide-induced acute kidney injury

(2018) Fangfang Bi et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Renal tubule injury: a driving force toward chronic kidney disease

(2018) Bi-Cheng Liu et al.   KIDNEY INTERNATIONAL

Obesity and Kidney Disease

(2018) Jay I. Lakkis et al.   PROGRESS IN CARDIOVASCULAR DISEASES

Emodin mitigates podocytes apoptosis induced by endoplasmic reticulum stress through the inhibition of the PERK pathway in diabetic nephropathy

(2018) Nianxiu Tian et al.   Drug Design Development and Therapy

Targeting TGF-β Signaling in Kidney Fibrosis

(2018) Yoshitaka Isaka   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Aloe-emodin ameliorates renal fibrosis via inhibiting PI3K/Akt/mTOR signaling pathway in vivo and in vitro

(2018) Fang Dou et al.   REJUVENATION RESEARCH

Epigenetic Modification Mechanisms Involved in Inflammation and Fibrosis in Renal Pathology

(2018) Jose Luis Morgado-Pascual et al.   MEDIATORS OF INFLAMMATION

New insights into the role and mechanism of Wnt/β-catenin signalling in kidney fibrosis

(2018) Yangyang Zuo et al.   NEPHROLOGY

Emodin ameliorates renal fibrosis in rats via TGF-β1/Smad signaling pathway and function study of Smurf 2

(2017) Libin Ma et al.   INTERNATIONAL UROLOGY AND NEPHROLOGY

Glomerular Hyperfiltration in Diabetes: Mechanisms, Clinical Significance, and Treatment

(2017) Lennart Tonneijck et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Chronic Kidney Disease

(2017) Angela C Webster et al.   LANCET

Emodin protects against oxidative stress and apoptosis in HK-2 renal tubular epithelial cells after hypoxia/reoxygenation

(2017) Hui Chen et al.   Experimental and Therapeutic Medicine

Matrix Metalloproteinases-7 and Kidney Fibrosis

(2017) Ben Ke et al.   Frontiers in Physiology

Persistent activation of autophagy in kidney tubular cells promotes renal interstitial fibrosis during unilateral ureteral obstruction

(2016) Man J. Livingston et al.   Autophagy

The origin of renal fibroblasts/myofibroblasts and the signals that trigger fibrosis

(2016) Yu Bo Yang Sun et al.   DIFFERENTIATION

TGF-β1/Smads and miR-21 in Renal Fibrosis and Inflammation

(2016) Agnieszka Loboda et al.   MEDIATORS OF INFLAMMATION

Inhibitory effects of Shenkang injection and its main component emodin on the proliferation of high glucose-induced renal mesangial cells through cell cycle regulation and induction of apoptosis

(2016) Shouzhu Xu et al.   Molecular Medicine Reports

Matrix metalloproteinase 9-dependent Notch signaling contributes to kidney fibrosis through peritubular endothelial–mesenchymal transition

(2016) Ye Zhao et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

The Inhibitory Effect of Rhein on Proliferation of High Glucose-induced Mesangial Cell Through Cell Cycle Regulation and Induction of Cell Apoptosis

(2016) Siwang Wang et al.   Pharmacognosy Magazine

Emodin: A Review of its Pharmacology, Toxicity and Pharmacokinetics

(2016) Xiaoxv Dong et al.   PHYTOTHERAPY RESEARCH

Non-Smad Signaling Pathways of the TGF-β Family

(2016) Ying E. Zhang   Cold Spring Harbor Perspectives in Biology

Rhein reversal of DNA hypermethylation-associated Klotho suppression ameliorates renal fibrosis in mice

(2016) Qin Zhang et al.   Scientific Reports

A Comprehensive and System Review for the Pharmacological Mechanism of Action of Rhein, an Active Anthraquinone Ingredient

(2016) Hao Sun et al.   Frontiers in Pharmacology

MAPK/JNK signaling: A potential autophagy regulation pathway

(2015) Yuan-Yuan Zhou et al.   BIOSCIENCE REPORTS

Emodin Ameliorates High Glucose Induced-Podocyte Epithelial-Mesenchymal Transition In-Vitro and In-Vivo

(2015) Tingfang Chen et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Gallic acid ameliorates renal functions by inhibiting the activation of p38 MAPK in experimentally induced type 2 diabetic rats and cultured rat proximal tubular epithelial cells

(2015) Amjid Ahad et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Rhein: A Review of Pharmacological Activities

(2015) Yan-Xi Zhou et al.   Evidence-based Complementary and Alternative Medicine

mTOR: a pharmacologic target for autophagy regulation

(2015) Young Chul Kim et al.   JOURNAL OF CLINICAL INVESTIGATION

The wnt/β-catenin signaling pathway participates in rhein ameliorating kidney injury in DN mice

(2015) Suyan Duan et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Analysis of anthraquinones in rhubarb (Rheum palmatum and Rheum officinale) by supercritical fluid chromatography

(2015) Dorothea Aichner et al.   TALANTA

Hypermethylation of RASAL1: A Key for Renal Fibrosis

(2015) Yuanjie Mao   EBioMedicine

Tet3-Mediated Hydroxymethylation of Epigenetically Silenced Genes Contributes to Bone Morphogenic Protein 7-Induced Reversal of Kidney Fibrosis

(2014) B. Tampe et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Inflammatory processes in renal fibrosis

(2014) Xiao-Ming Meng et al.   Nature Reviews Nephrology

DNA methylation profile associated with rapid decline in kidney function: findings from the CRIC Study

(2014) M. R. Wing et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Emodin Suppresses Hyperglycemia-Induced Proliferation and Fibronectin Expression in Mesangial Cells via Inhibiting cFLIP

(2014) Junjie Gao et al.   PLoS One

Efficacy of rhubarb combined with early enteral nutrition for the treatment of severe acute pancreatitis: a randomized controlled trial

(2014) Bing Wan et al.   SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY

Regulation of NF-κB by TNF family cytokines

(2014) Matthew S. Hayden et al.   SEMINARS IN IMMUNOLOGY

Kidney Pericytes: Roles in Regeneration and Fibrosis

(2014) Rafael Kramann et al.   SEMINARS IN NEPHROLOGY

Key fibrogenic mediators: old players. Renin–angiotensin system

(2014) Daniela Macconi et al.   Kidney International Supplements

Wnt/β-catenin signaling and kidney fibrosis

(2014) Roderick J. Tan et al.   Kidney International Supplements

The kinase triad, AMPK, mTORC1 and ULK1, maintains energy and nutrient homoeostasis

(2013) Elaine A. Dunlop et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Natural products: A continuing source of novel drug leads

(2013) Gordon M. Cragg et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Role of the endothelial-to-mesenchymal transition in renal fibrosis of chronic kidney disease

(2013) Jianhua He et al.   Clinical and Experimental Nephrology

Emodin attenuates high glucose-induced TGF-β1 and fibronectin expression in mesangial cells through inhibition of NF-κB pathway

(2013) Jie Yang et al.   EXPERIMENTAL CELL RESEARCH

Autophagy and apoptosis in tubular cells following unilateral ureteral obstruction are associated with mitochondrial oxidative stress

(2013) YANFANG XU et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Hypertension and kidneys: unraveling complex molecular mechanisms underlying hypertensive renal damage

(2013) S Mennuni et al.   JOURNAL OF HUMAN HYPERTENSION

Evidence for the involvement of epigenetics in the progression of renal fibrogenesis

(2013) B. Tampe et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Contribution of genetics and epigenetics to progression of kidney fibrosis

(2013) B. Tampe et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Elevated Klotho Promoter Methylation Is Associated with Severity of Chronic Kidney Disease

(2013) Jing Chen et al.   PLoS One

Transforming Growth Factor β-1 Stimulates Profibrotic Epithelial Signaling to Activate Pericyte-Myofibroblast Transition in Obstructive Kidney Fibrosis

(2012) Ching-Fang Wu et al.   AMERICAN JOURNAL OF PATHOLOGY

Mitophagy: mechanisms, pathophysiological roles, and analysis

(2012) Wen-Xing Ding et al.   BIOLOGICAL CHEMISTRY

The many faces and functions of β-catenin

(2012) Tomas Valenta et al.   EMBO JOURNAL

Autophagy Promotes Intracellular Degradation of Type I Collagen Induced by Transforming Growth Factor (TGF)-β1

(2012) Sung Il Kim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Alcohol and kidney damage: a Janus-faced relationship

(2012) Elke Schaeffner et al.   KIDNEY INTERNATIONAL

Suppression of lipopolysaccharide-induced upregulation of toll-like receptor 4 by emodin in mouse proximal tubular epithelial cells

(2012) XIAO-LING ZHU et al.   Molecular Medicine Reports

Preventive Effects and Mechanisms of Rhein on Renal Interstitial Fibrosis in Obstructive Nephropathy

(2011) Dongyuan He et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Regulation of the autophagy initiating kinase ULK1 by nutrients: Roles of mTORC1 and AMPK

(2011) Joungmok Kim et al.   CELL CYCLE

E-Cadherin/β-Catenin Complex and the Epithelial Barrier

(2011) Xinrui Tian et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

Targeted Inhibition of  -Catenin/CBP Signaling Ameliorates Renal Interstitial Fibrosis

(2011) S. Hao et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Smad3-Mediated Upregulation of miR-21 Promotes Renal Fibrosis

(2011) X. Zhong et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Canonical Wnt/β-catenin signaling mediates transforming growth factor-β1-driven podocyte injury and proteinuria

(2011) Dan Wang et al.   KIDNEY INTERNATIONAL

Cellular and molecular mechanisms of renal fibrosis

(2011) Youhua Liu   Nature Reviews Nephrology

Macrophages and Immunologic Inflammation of the Kidney

(2010) Jeremy S. Duffield   SEMINARS IN NEPHROLOGY

Emodin ameliorates high-glucose induced mesangial p38 over-activation and hypocontractility via activation of PPARγ

(2009) Yi Liu et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

The Mesangial Cell Revisited: No Cell Is an Island

(2009) D. Schlondorff et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Emodin suppresses cell proliferation and fibronectin expression via p38MAPK pathway in rat mesangial cells cultured under high glucose

(2009) Xuejuan Li et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Connective Tissue Growth Factor-(CTGF, CCN2) – A Marker, Mediator and Therapeutic Target for Renal Fibrosis

(2009) Mysore K. Phanish et al.   NEPHRON EXPERIMENTAL NEPHROLOGY

Interplay of Cadherin-Mediated Cell Adhesion and Canonical Wnt Signaling

(2009) J. Heuberger et al.   Cold Spring Harbor Perspectives in Biology

Snail promotes Wnt target gene expression and interacts with β-catenin

(2008) V Stemmer et al.   ONCOGENE